Gene sharing and evolution: the diversity of protein functions
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, Mass. [u.a.]
Harvard University Press
2007
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XV, 320 S. Ill., graph. Darst. |
| ISBN: | 0674023412 9780674023413 |
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MARC
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| 100 | 1 | |a Piatigorsky, Joram |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Gene sharing and evolution |b the diversity of protein functions |c Joram Piatigorsky |
| 264 | 1 | |a Cambridge, Mass. [u.a.] |b Harvard University Press |c 2007 | |
| 300 | |a XV, 320 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Cristallin | |
| 650 | 7 | |a Crystallines |2 gtt | |
| 650 | 7 | |a Evolutie |2 gtt | |
| 650 | 7 | |a Genen |2 gtt | |
| 650 | 7 | |a Genexpressie |2 gtt | |
| 650 | 7 | |a Homologie |2 gtt | |
| 650 | 4 | |a Protéines - Évolution | |
| 650 | 4 | |a Régulation génétique | |
| 650 | 7 | |a Taxonomie |2 gtt | |
| 650 | 4 | |a Œil - Aspect moléculaire | |
| 650 | 4 | |a Genetic regulation | |
| 650 | 4 | |a Proteins |x Evolution | |
| 650 | 4 | |a Eye |x Molecular aspects | |
| 650 | 4 | |a Crystalline lens | |
| 650 | 0 | 7 | |a Genexpression |0 (DE-588)4020136-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Augenlinse |0 (DE-588)4003601-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekulare Evolution |0 (DE-588)4812902-1 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804136458893656064 |
|---|---|
| adam_text | Contents
Illustrations
Preface
1.
New Functions for Old Proteins and the Question
of Gene Duplication
Origin of the Term Gene Sharing
Gene Sharing: General Definition and Implications
Protein Location and Gene Regulation
Why the Term Gene Sharing ?
Mechanisms for Diversifying Gene Functions
Posttranslational Modifications
Conditions for Initiating Gene Sharing
Contrasting Phenotype with Protein Function
Take-Home Message
2.
from the Past
Preadaptation, Prospective Adaptation, and Hopeful Monsters
Quirky Functional Shifts and Exaptation
Spandrels and Gene Sharing
Gene Regulation and Tinkering
Take-Home Message
3.
The Classical Gene Concept
The Mendel-Morgan Chromosomal Theory of the Gene
Later Developments: One Gene/One Enzyme/One
Polypeptide
Contents
The Molecular Era of the Gene: So Much Data,
So Many Possibilities
Quantifying Genes before the Molecular Era
Quantifying Genes in the Molecular Era: Fewer than Expected
Noncoding Regulatory Genes
Protein Diversity
The Ambiguous Gene
The Molecular Gene Concept
The Molecular Process Gene Concept
The Evolutionary Gene Concept
Two Concepts for One Gene: Gene-P/Gene-D
Gene Sharing: A Concept Incorporating an Open Gene
Take-Home Message
4.
Eye Diversity: Many Forms to Perform a Function
The Lens
Crystallins and the Optical Properties of the Lens
Diversity and Taxon-Specificity of Lens Crystallins
Crystallins and Gene Sharing
The /Jy-Crystallins: A Superfamily with Distant
Stress Connections
The Enzyme-Crystallins of Vertebrates
Crystallins of Invertebrates
Crystallin Gene Regulation in Vertebrates: A Similar Cast
of Transcription Factors
Convergent Evolution of Crystallin Gene Expression
Evolution of Gene Sharing by shsp/aB-Crystallin
Convergent Evolution of Invertebrate and Vertebrate Crystallin
Promoters
Potential for Lens-Specific Promoter Activity
Convergent Evolution and Relaxed Stringency for Crystallins
Take-Home Message
5.
of Gene Sharing
The Cornea
Aldehyde Dehydrogenase: A Candidate
Contents
Other Candidate
Dehydrogenase, and Cyclophilin
C/L-Gelsolin:
A Signaling Role for C/L-Gelsolin
Corneal Gene
The Refracton Hypothesis: Implications for Gene Sharing
Take-Home Message
6.
Multifunctional Proteins
Glycolytic Enzymes and the Versatile Hexokinases 111
Citrate Synthase: An Enzyme and a Cytoskeletal Structure
Lactate
Regulation of mRNA Translation by Enzyme Binding
Glyceraldehye-S-phosphate Dehydrogenase:
Constant Surprises
Enolase: Another Versatile Protein
Bacterial Surface Enzymes
Xanthine Oxidoreductase: Enzyme and Envelope
The Thioredoxin/Ribonucleotide
and Thioredoxin Family Members: From
Morphogenesis
Serum Albumin: Transport Protein, Enzymatic Vasodilator
and Detoxifier
Gelsolin: Roles in Cytoskeletal Structure, Gene Expression,
Cell Death, and Signal Transduction
Cytochrome c: Roles in Electron Transport, Cell Death,
and Light Filtration
Take-Home Message
7.
Complexity of Transcription
Nuclear Receptors
Metabolic Enzymes and Gene Expression
Y-Box Proteins
Transcription Factors as Translational Regulators: Bicoid
Translation Factors for
Homeoproteins, Chromosomal Proteins and Actin
The Dynamic Flux of Nuclear Proteins
Take-Home Message
Contents
8. Gene Sharing
Antifreeze Proteins and Hemoglobins
Antifreeze Proteins
Hemoglobins
Take-Home Message
9.
Gene Duplication and Retention of Redundant Genes
Birth-and-Death of Duplicated Genes
Adaptive Evolution by Positive Selection: New Functions
after Gene Duplication
Subfunctionalization and Gene Sharing
Rapid Subfunctionalization with Slow Neofunctionalization
Gene Sharing Is Independent of Gene Duplication
Lens Crystalline: Gene Sharing at Different Stages
of Duplication
Take-Home Message
10.
and Speculations
Networks
Evolvability
Selective Pressure Affecting Gene Regulation
Functional Switching and the Notion of Functional
Trespassing
Functional Noise
Genetic Differences in Levels of Gene Expression
The Molecular Clock
Gene Knockout Experiments
Gene Deletion of
Horizontal Gene Transfer
Take-Home Message
11.
Ambiguity of Cause and Effect
Natural Selection and Random Drift
Gene Sharing and Robustness: When Is a Mutation Neutral?
Inconsistency with Design
Naming Is Not Knowing
Contents
The Question of Tissue Homology
Phylogenetic Trees: The Complication of Function
Defining and Counting Genes
Definition of Polypeptide Function: The Ambiguity
of Molecular Mechanism
Between Genotype and Phenotype
Gene Sharing and the Importance of Research on
Diverse Species
Medical Implications
Glossary
|
| adam_txt |
Contents
Illustrations
Preface
1.
New Functions for Old Proteins and the Question
of Gene Duplication
Origin of the Term "Gene Sharing"
Gene Sharing: General Definition and Implications
Protein Location and Gene Regulation
Why the Term "Gene Sharing"?
Mechanisms for Diversifying Gene Functions
Posttranslational Modifications
Conditions for Initiating Gene Sharing
Contrasting Phenotype with Protein Function
Take-Home Message
2.
from the Past
Preadaptation, Prospective Adaptation, and Hopeful Monsters
Quirky Functional Shifts and Exaptation
Spandrels and Gene Sharing
Gene Regulation and Tinkering
Take-Home Message
3.
The Classical Gene Concept
The Mendel-Morgan Chromosomal Theory of the Gene
Later Developments: One Gene/One Enzyme/One
Polypeptide
Contents
The Molecular Era of the Gene: So Much Data,
So Many Possibilities
Quantifying Genes before the Molecular Era
Quantifying Genes in the Molecular Era: Fewer than Expected
Noncoding Regulatory Genes
Protein Diversity
The Ambiguous Gene
The "Molecular Gene" Concept
The "Molecular Process Gene" Concept
The "Evolutionary Gene" Concept
Two Concepts for One Gene: Gene-P/Gene-D
Gene Sharing: A Concept Incorporating an "Open Gene"
Take-Home Message
4.
Eye Diversity: Many Forms to Perform a Function
The Lens
Crystallins and the Optical Properties of the Lens
Diversity and Taxon-Specificity of Lens Crystallins
Crystallins and Gene Sharing
The /Jy-Crystallins: A Superfamily with Distant
Stress Connections
The Enzyme-Crystallins of Vertebrates
Crystallins of Invertebrates
Crystallin Gene Regulation in Vertebrates: A Similar Cast
of Transcription Factors
Convergent Evolution of Crystallin Gene Expression
Evolution of Gene Sharing by shsp/aB-Crystallin
Convergent Evolution of Invertebrate and Vertebrate Crystallin
Promoters
Potential for Lens-Specific Promoter Activity
Convergent Evolution and Relaxed Stringency for Crystallins
Take-Home Message
5.
of Gene Sharing
The Cornea
Aldehyde Dehydrogenase: A Candidate
Contents
Other Candidate
Dehydrogenase, and Cyclophilin
C/L-Gelsolin:
A Signaling Role for C/L-Gelsolin
Corneal Gene
The Refracton Hypothesis: Implications for Gene Sharing
Take-Home Message
6.
Multifunctional Proteins
Glycolytic Enzymes and the Versatile Hexokinases 111
Citrate Synthase: An Enzyme and a Cytoskeletal Structure
Lactate
Regulation of mRNA Translation by Enzyme Binding
Glyceraldehye-S-phosphate Dehydrogenase:
Constant Surprises
Enolase: Another Versatile Protein
Bacterial Surface Enzymes
Xanthine Oxidoreductase: Enzyme and Envelope
The Thioredoxin/Ribonucleotide
and Thioredoxin Family Members: From
Morphogenesis
Serum Albumin: Transport Protein, Enzymatic Vasodilator
and Detoxifier
Gelsolin: Roles in Cytoskeletal Structure, Gene Expression,
Cell Death, and Signal Transduction
Cytochrome c: Roles in Electron Transport, Cell Death,
and Light Filtration
Take-Home Message
7.
Complexity of Transcription
Nuclear Receptors
Metabolic Enzymes and Gene Expression
Y-Box Proteins
Transcription Factors as Translational Regulators: Bicoid
Translation Factors for
Homeoproteins, Chromosomal Proteins and Actin
The Dynamic Flux of Nuclear Proteins
Take-Home Message
Contents
8. Gene Sharing
Antifreeze Proteins and Hemoglobins
Antifreeze Proteins
Hemoglobins
Take-Home Message
9.
Gene Duplication and Retention of Redundant Genes
Birth-and-Death of Duplicated Genes
Adaptive Evolution by Positive Selection: New Functions
after Gene Duplication
Subfunctionalization and Gene Sharing
Rapid Subfunctionalization with Slow Neofunctionalization
Gene Sharing Is Independent of Gene Duplication
Lens Crystalline: Gene Sharing at Different Stages
of Duplication
Take-Home Message
10.
and Speculations
Networks
Evolvability
Selective Pressure Affecting Gene Regulation
Functional Switching and the Notion of Functional
"Trespassing"
Functional Noise
Genetic Differences in Levels of Gene Expression
The Molecular Clock
Gene Knockout Experiments
Gene Deletion of
Horizontal Gene Transfer
Take-Home Message
11.
Ambiguity of Cause and Effect
Natural Selection and Random Drift
Gene Sharing and Robustness: When Is a Mutation Neutral?
Inconsistency with Design
Naming Is Not Knowing
Contents
The Question of Tissue Homology
Phylogenetic Trees: The Complication of Function
Defining and Counting Genes
Definition of Polypeptide Function: The Ambiguity
of Molecular Mechanism
Between Genotype and Phenotype
Gene Sharing and the Importance of Research on
Diverse Species
Medical Implications
Glossary |
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| author | Piatigorsky, Joram |
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| id | DE-604.BV022398192 |
| illustrated | Illustrated |
| index_date | 2024-07-02T17:17:19Z |
| indexdate | 2024-07-09T20:56:44Z |
| institution | BVB |
| isbn | 0674023412 9780674023413 |
| language | English |
| lccn | 2006045769 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015606902 |
| oclc_num | 69680142 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XV, 320 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Harvard University Press |
| record_format | marc |
| spelling | Piatigorsky, Joram Verfasser aut Gene sharing and evolution the diversity of protein functions Joram Piatigorsky Cambridge, Mass. [u.a.] Harvard University Press 2007 XV, 320 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Cristallin Crystallines gtt Evolutie gtt Genen gtt Genexpressie gtt Homologie gtt Protéines - Évolution Régulation génétique Taxonomie gtt Œil - Aspect moléculaire Genetic regulation Proteins Evolution Eye Molecular aspects Crystalline lens Genexpression (DE-588)4020136-3 gnd rswk-swf Augenlinse (DE-588)4003601-7 gnd rswk-swf Molekulare Evolution (DE-588)4812902-1 gnd rswk-swf Auge (DE-588)4122841-8 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Evolution (DE-588)4071050-6 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Proteine (DE-588)4076388-2 s Molekulare Evolution (DE-588)4812902-1 s Genexpression (DE-588)4020136-3 s DE-604 Augenlinse (DE-588)4003601-7 s Genregulation (DE-588)4122166-7 s Evolution (DE-588)4071050-6 s Auge (DE-588)4122841-8 s 1\p DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015606902&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Piatigorsky, Joram Gene sharing and evolution the diversity of protein functions Cristallin Crystallines gtt Evolutie gtt Genen gtt Genexpressie gtt Homologie gtt Protéines - Évolution Régulation génétique Taxonomie gtt Œil - Aspect moléculaire Genetic regulation Proteins Evolution Eye Molecular aspects Crystalline lens Genexpression (DE-588)4020136-3 gnd Augenlinse (DE-588)4003601-7 gnd Molekulare Evolution (DE-588)4812902-1 gnd Auge (DE-588)4122841-8 gnd Proteine (DE-588)4076388-2 gnd Evolution (DE-588)4071050-6 gnd Genregulation (DE-588)4122166-7 gnd |
| subject_GND | (DE-588)4020136-3 (DE-588)4003601-7 (DE-588)4812902-1 (DE-588)4122841-8 (DE-588)4076388-2 (DE-588)4071050-6 (DE-588)4122166-7 |
| title | Gene sharing and evolution the diversity of protein functions |
| title_auth | Gene sharing and evolution the diversity of protein functions |
| title_exact_search | Gene sharing and evolution the diversity of protein functions |
| title_exact_search_txtP | Gene sharing and evolution the diversity of protein functions |
| title_full | Gene sharing and evolution the diversity of protein functions Joram Piatigorsky |
| title_fullStr | Gene sharing and evolution the diversity of protein functions Joram Piatigorsky |
| title_full_unstemmed | Gene sharing and evolution the diversity of protein functions Joram Piatigorsky |
| title_short | Gene sharing and evolution |
| title_sort | gene sharing and evolution the diversity of protein functions |
| title_sub | the diversity of protein functions |
| topic | Cristallin Crystallines gtt Evolutie gtt Genen gtt Genexpressie gtt Homologie gtt Protéines - Évolution Régulation génétique Taxonomie gtt Œil - Aspect moléculaire Genetic regulation Proteins Evolution Eye Molecular aspects Crystalline lens Genexpression (DE-588)4020136-3 gnd Augenlinse (DE-588)4003601-7 gnd Molekulare Evolution (DE-588)4812902-1 gnd Auge (DE-588)4122841-8 gnd Proteine (DE-588)4076388-2 gnd Evolution (DE-588)4071050-6 gnd Genregulation (DE-588)4122166-7 gnd |
| topic_facet | Cristallin Crystallines Evolutie Genen Genexpressie Homologie Protéines - Évolution Régulation génétique Taxonomie Œil - Aspect moléculaire Genetic regulation Proteins Evolution Eye Molecular aspects Crystalline lens Genexpression Augenlinse Molekulare Evolution Auge Proteine Evolution Genregulation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015606902&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT piatigorskyjoram genesharingandevolutionthediversityofproteinfunctions |