Introduction to genetic analysis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Freeman
2008
|
| Ausgabe: | 9. ed., 1. print. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XXIII, 838 S. Ill., graph. Darst. |
| ISBN: | 9780716768876 9780716799023 0716768879 |
Internformat
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| 245 | 1 | 0 | |a Introduction to genetic analysis |c Anthony J. F. Griffiths .... |
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Datensatz im Suchindex
| _version_ | 1804136422219710464 |
|---|---|
| adam_text | Contents in Brief
Contents
Preface
1
PART I JRANSMISSION^GENETICS
2
3
4
Recombination
5
Viruses
6
7 DNA:
8
9
10
Bacteria and Their Viruses
11
in Eukaryotes
12
13
PART III MUTATION, VARIATION,
xiii
31
89
129
181
221
265
295
319
351
385
415
453
14
15
16
17
18
19
PART IV TECHNIQUES
20
715
A Brief Guide to Model Organisms
Appendix A: Genetic Nomenclature
Appendix B: Bioinformatics Resources
for Genetics and Genomics
Glossary
Answers to Selected Problems
Index
Preface
1
1.1
1.2
Specifying the
Gene regulation
1.3
The necessity of variation
Starting with variation: Forward genetics
Starting with
1.4
An Overview
Detecting specific molecules of
and protein
1.5
Lessons from the first model organisms
The need for a variety of model organisms
1.6
Organism
Model I: Genetic determination
Model II: Environmental determination
Model III: Genotype-environment interaction
The use of genotype and phenotype
Developmental noise
Three levels of development
PART I TRANSMISSION GENETICS
2
2.1
2.2
Mendel s law of equal segregation
2.3
Inheritance Patterns
Single-gene inheritance in haploids
The molecular basis of single-gene segregation
and expression
31
VI
Contents
2.4
Segregation Ratios
Discovering a gene active in the development
of flower color
Discovering a gene for wing development
Discovering a gene for spore production
The results of gene discovery
Forward genetics
Predicting progeny proportions or parental genotypes by
applying the principles of single-gene influence
2.5
Sex chromosomes
Sex-linked patterns of inheritance
Model Organism Box
Х
2.6
Autosomal recessive disorders
Autosomal dominant disorders
Autosomal polymorphisms
Х
Х
Y-linked inheritance
Calculating risks in pedigree analysis
3
3.1
3.2
Predicting progeny ratios
Using the chi-square test on
and dihybrid ratios
Synthesizing pure lines
Hybrid vigor
3.3
Assortment
Independent assortment in diploid organisms
Independent assortment in haploid organisms
Independent assortment of combinations of autosomal
and
Recombination
Model Organism Box
3.4
3.5 Organelle
of the Nucleus
Patterns of inheritance in organelles
Cytoplasmic segregation
Cytoplasmic mutations in humans
4
by Recombination
4.1
Using
How crossovers produce
genes
Linkage symbolism and terminology
Evidence that crossing over is a breakage-and-rejoining
process
Evidence that crossing over takes place at the four-
chromatid stage
Multiple crossovers can include more than two
chromatids
4.2
Map units
Three-point testcross
Deducing gene order by inspection
Interference
Using ratios as diagnostics
4.3
Single nucleotide polymorphisms
Mapping by using
Simple sequence length polymorphisms
4.4
Tetrads
4.5
Analysis
4.6
Pedigrees
4.7
A mapping function
The Perkins formula
Contents
VII
4.8
with Physical Maps
5
Viruses
5.1
5.2
Discovery of conjugation
Model Organism Box Escherichia
Discovery of the fertility factor (F)
Hf
Mapping of bacterial chromosomes
F
Rplasmids
5.3
Chromosome mapping using transformation
5.4
Infection of bacteria by phages
Mapping phage chromosomes by using
phage crosses
5.5
Discovery of transduction
Generalized transduction
Specialized transduction
Mechanism of specialized transduction
5.6
Compared
6
6.1
Variations on Dominance
Complete dominance and recessiveness
Incomplete dominance
Codominance
Recessive lethal
Model Organism Box Mouse
6.2
Biosynthetic pathways in
Gene interaction in other types of pathways
6.3
Defining the set of genes by using the
complementation test
Analyzing double mutants of random mutations
6.4
PARTII
X
7.1 DNA:
Discovery of transformation
Hershey-Chase experiment
7.2
DNA
The double helix
7.3
Meselson-Stahl experiment
The replication fork
DNA
7.4
7.5
Machine
Unwinding the double helix
Assembling the replisome: Replication initiation
7.6
The eukaryotic replisome
Eukaryotic origins of replication
DNA
Replication origins in higher eukaryotes
7.7
Termination
Telomeres, cancer, and aging
B RNA:
8.1
Early experiments suggest an
Properties of
Classes of
8.2
Overview:
Stages of transcription
8.3
Transcription initiation in eukaryotes
Elongation, termination, and pre-mRNA processing
in eukaryotes
VIII
Contents
8.4
Small nuclear RNAs (snRNAs):The mechanism of exon
splicing
Self-splicing
Small interfering RNAs (siRNAs)
9
9.1
9.2
9.3
Overlapping versus
Number of letters in the codon
Use of suppressors to demonstrate a triplet code
Degeneracy of the genetic code
Cracking the code
Stop
9.4
Codon translation by tRNA
Degeneracy revisited
9.5
Ribosome features
Translation initiation, elongation, and
termination
Nonsense suppressor mutations
9.6
Alternative splicing generates protein isoforms
Posttranslational events
10
and Their Viruses
10.1
The basics of prokaryotic transcriptional regulation:
Genetic switches
A first look at the lac regulatory circuit
10.2
Genes controlled together
Genetic evidence for the operator and
Genetic evidence for allostery
Genetic analysis of the lac promoter
Molecular characterization of the Lac
and the lac operator
Polar mutations
10.3
Positive Control
The basics of catabolite repression of the lac operon:
Choosing the best sugar to metabolize
The structures of target
A summary of the lac operon
10.4
The
10.5
of Regulation: Attenuation
Transcription of the
two steps
10.6
Complex
Molecular anatomy of the genetic switch
Sequence-specific binding of regulatory proteins
to
10.7
of Genes
11
Eukaryotes
11.1
An Overview
Model Organism Box Yeast
11.2
Gal4 regulates multiple genes through upstream
activation sequences
The Gal4 protein has separable DNA-binding and
activation domains
Gal4 activity is physiologically regulated
Gal4 functions in most eukaryotes
Activators recruit the transcriptional machinery
11.3
Regulation
Chromatm-remodeling proteins and gene
activation
Histones and chromatin remodeling
11.4
The
The control of yeast mating type: Combinatorial
interactions
DNA-binding proteins combinatorialiy
expression of cell-type-specific genes
Contents
IX
Enhancer-blocking
11.5 Genomic
But what about Dolly and other cloned mammals?
П.6
Mating-type switching and gene silencing
Heterochromatin and euchromatin compared
Position-effect variegation in
genomic neighborhoods
Genetic analysis of PEV reveals proteins necessary for
heterochromatin formation
Silencing an entire chromosome: X-chromosome
inactivation
The inheritance of epigenetic marks and chromatin
structure
12
12.1
Model Organism Box
12.2
Development
Classification of genes by developmental function
Homeotic genes and
Organization and expression of Hox genes
The homeobox
Clusters of Hox genes control development in most
animals
12.3
The anteroposterior and dorsoventral axes
Expression of toolkit genes
12.4
Development
Maternal gradients and gene activation
Drawing stripes: Integration of gap-protein inputs
Making segments different: Integration of Hox
inputs
12.5
in Development
RNA
Drosophila
Regulation of rnRNA translation and cell lineage in
C. elegans
Translational control in the early embryo
Model Organism Box Caenorhabditis
elegans
miRNA control of developmental timing in
and other species
12.6
From flies to fingers, feathers, and floor plates
12.7
Polydactyly
Holoprosencephaly
Cancer as a developmental disease
13
13.1
13.2
Turning sequence reads into a sequence
map
Establishing a genomic library of clones
Sequencing a simple genome by using the whole-
genome shotgun approach
Using the whole-genome shotgun approach to
create a draft sequence of a complex genome
Using the ordered-clone approach to sequence a
complex genome
Filling sequence gaps
13.3
Sequence
The nature of the information content of
Deducing the protein-encoding genes from
genomic sequence
13 4
13.5
Ofmice
Comparative genomics of chimpanzees and
humans
Conserved and uitraconserved noncoding
elements
Comparative genomics of non-pathogenic and
pathogenic
136
Ome,
Reverse genetics
Contents
PART III MUTATION, VARIATION,
ANJ^EVOLUTION
14
14.1
McClintock s experiments: the Ds element
Model Organism Box Maize
Autonomous and nonautomous elements
Transposable elements: Only in maize?
14.2
Bacterial insertion sequences
Prokaryotic
Mechanism of transposition
14.3
Class I: Retrotransposons
DNA
Utility of
14.4
Elements Than Ever Imagined
Large genomes are largely transposable elements
Transposable elements in the human genome
The grasses: LTR retrotransposons thrive in large
genomes
Safe havens
15
15.1
Types of point mutation
The molecular consequences of point mutations in a
coding region
The molecular consequences of point mutations in a
noncoding region
15.2
Mutations
Luria and Delbriick fluctuation test
Mechanisms of spontaneous mutations
Spontaneous mutations in humans:
Trinucleotide repeat diseases
153
Mechanisms of mutagenesis
The Ames test: Evaluating
environment
15.4
Direct reversal of damaged
Base-excision repair
Nucleotide-excision repair
Postreplication repair: Mismatch repair
Error-prone repair:
Repair of double-strand breaks
15.5
Programmed double-strand breaks initiate meiotic
recombination
Genetic analyses of tetrads provide clues to the
mechanism of recombination
The double-strand break model for meiotic
recombination
15.6
of Mutations
How cancer cells differ from normal cells
Mutations in cancer cells
16
16.1
Aberrant euploidy
Aneuploidy
The concept of gene balance
16.2
Deletions
Duplications
Inversions
Reciprocal
Robertsonian
Applications of inversions and
Rearrangements and cancer
Identifying chromosome mutations by genomics
16.3
Mutations
17
17.1
Observations of variation
Protein polymorphisms
DNA
Contents
ΧΙ
17.2
Meiotic segregation and genetic equilibrium
Heterozygosity
Random mating
Inbreeding and assortative mating
17.3
Variation from mutation
Variation from recombination
Variation from migration
17.4
Two forms of selection
Measuring fitness differences
How selection works
Rate of change in gene frequency
17.5
Overdominance and underdominance
Balance between mutation and selection
17.6
18
18.1
18.2
Statistical distributions
Statistical measures
18.3
The critical difference between quantitative
and Mendelian traits
Gene number and quantitative traits
18.4
Distribution
18.5
Domesticated plants and animals
Studies of natural populations
Results of norm-of-reaction studies
18.6
Familialityandheritability
Phenotypic similarity between relatives
18.7
Methods of estimating Hz
The meaning of
Narrow heritability
Estimating the components of genetic variance
Artificial selection
The use of h2 in breeding
18.8
Marker-gene segregation
Quantitative linkage analysis
Statistical Appendix
Measures of central tendency
Measures of dispersion: The variance
Measures of relation
19
19.1
19.2
of Populations
19.3
Exploration of adaptive peaks
19.4
Heritability of variation
Variation within and between populations
19.5
The signature of purifying selection on
19.6
Protein Evolution
The signature of positive selection on
sequences
Morphological evolution
Gene inactivation
19.7
Regulatory evolution in humans
19.8
Polyploidy
Duplications
Imported
19.9
in Evolution
Comparing the proteomes among distant species
Comparing the proteomes among near neighbors:
Human-mouse comparative genomics
19.10
Genetics of species isolation
XII
Contents
PART IV TECHNIQUES
20
20.1
Type of donor
Cutting genomic
Attaching donor and vector
Amplification inside a bacterial cell
Entry of
bacterial cell
Recovery of amplified
Making genomic and cDNA libraries
Finding a specific clone of interest
20.2 DNA
Chain Reaction
20.3
Segment
20.4
Cloning
A forward analysis to identify a human
disease gene
A forward analysis to identify a gene important to corn
domestication
20.5
Molecular Genetic Diagnostics
20.6
Genetic engineering in Saccharomyces cerevisiae
Genetic engineering in plants
Genetic engineering in animals
Human gene therapy
A Brief Guide to Model Organisms
Appendix A: Genetic Nomenclature
Appendix B: Bioinformatics Resources for Genetics
and Genomics
Glossary
Answers to Selected Problems
Index
About the Cover
Variation in wing patterns of the butterfly Morpho didius. The male (top left)
and female (top right) have strikingly different wing patterns, governed by sex
determination genes. Here, a rare genetic event during development produced
two gynandromorphs (bottom), butterflies in which part of the wing tissue
shows a pattern more typical of the opposite sex. Photographs courtesy
of Nipam
New to This Edition
The ninth edition of introduction to Genetic Analysis has been thoroughly
revised to showcase how genetics is practiced today.
This new edition features
Enhanced Emphasis on:
•
•
Expanded Coverage of:
•
•
•
Θ
while providing increased portability and flexibility. Students study
important genetic processes and concepts at their convenience by downloading
the animations to their MP3 players.
|
| adam_txt |
Contents in Brief
Contents
Preface
1
PART I JRANSMISSION^GENETICS
2
3
4
Recombination
5
Viruses
6
7 DNA:
8
9
10
Bacteria and Their Viruses
11
in Eukaryotes
12
13
PART III MUTATION, VARIATION,
xiii
31
89
129
181
221
265
295
319
351
385
415
453
14
15
16
17
18
19
PART IV TECHNIQUES
20
715
A Brief Guide to Model Organisms
Appendix A: Genetic Nomenclature
Appendix B: Bioinformatics Resources
for Genetics and Genomics
Glossary
Answers to Selected Problems
Index
Preface
1
1.1
1.2
Specifying the
Gene regulation
1.3
The necessity of variation
Starting with variation: Forward genetics
Starting with
1.4
An Overview
Detecting specific molecules of
and protein
1.5
Lessons from the first model organisms
The need for a variety of model organisms
1.6
Organism
Model I: Genetic determination
Model II: Environmental determination
Model III: Genotype-environment interaction
The use of genotype and phenotype
Developmental noise
Three levels of development
PART I TRANSMISSION GENETICS
2
2.1
2.2
Mendel's law of equal segregation
2.3
Inheritance Patterns
Single-gene inheritance in haploids
The molecular basis of single-gene segregation
and expression
31
VI
Contents
2.4
Segregation Ratios
Discovering a gene active in the development
of flower color
Discovering a gene for wing development
Discovering a gene for spore production
The results of gene discovery
Forward genetics
Predicting progeny proportions or parental genotypes by
applying the principles of single-gene influence
2.5
Sex chromosomes
Sex-linked patterns of inheritance
Model Organism Box
Х
2.6
Autosomal recessive disorders
Autosomal dominant disorders
Autosomal polymorphisms
Х
Х
Y-linked inheritance
Calculating risks in pedigree analysis
3
3.1
3.2
Predicting progeny ratios
Using the chi-square test on
and dihybrid ratios
Synthesizing pure lines
Hybrid vigor
3.3
Assortment
Independent assortment in diploid organisms
Independent assortment in haploid organisms
Independent assortment of combinations of autosomal
and
Recombination
Model Organism Box
3.4
3.5 Organelle
of the Nucleus
Patterns of inheritance in organelles
Cytoplasmic segregation
Cytoplasmic mutations in humans
4
by Recombination
4.1
Using
How crossovers produce
genes
Linkage symbolism and terminology
Evidence that crossing over is a breakage-and-rejoining
process
Evidence that crossing over takes place at the four-
chromatid stage
Multiple crossovers can include more than two
chromatids
4.2
Map units
Three-point testcross
Deducing gene order by inspection
Interference
Using ratios as diagnostics
4.3
Single nucleotide polymorphisms
Mapping by using
Simple sequence length polymorphisms
4.4
Tetrads
4.5
Analysis
4.6
Pedigrees
4.7
A mapping function
The Perkins formula
Contents
VII
4.8
with Physical Maps
5
Viruses
5.1
5.2
Discovery of conjugation
Model Organism Box Escherichia
Discovery of the fertility factor (F)
Hf
Mapping of bacterial chromosomes
F
Rplasmids
5.3
Chromosome mapping using transformation
5.4
Infection of bacteria by phages
Mapping phage chromosomes by using
phage crosses
5.5
Discovery of transduction
Generalized transduction
Specialized transduction
Mechanism of specialized transduction
5.6
Compared
6
6.1
Variations on Dominance
Complete dominance and recessiveness
Incomplete dominance
Codominance
Recessive lethal
Model Organism Box Mouse
6.2
Biosynthetic pathways in
Gene interaction in other types of pathways
6.3
Defining the set of genes by using the
complementation test
Analyzing double mutants of random mutations
6.4
PARTII
X
7.1 DNA:
Discovery of transformation
Hershey-Chase experiment
7.2
DNA
The double helix
7.3
Meselson-Stahl experiment
The replication fork
DNA
7.4
7.5
Machine
Unwinding the double helix
Assembling the replisome: Replication initiation
7.6
The eukaryotic replisome
Eukaryotic origins of replication
DNA
Replication origins in higher eukaryotes
7.7
Termination
Telomeres, cancer, and aging
B RNA:
8.1
Early experiments suggest an
Properties of
Classes of
8.2
Overview:
Stages of transcription
8.3
Transcription initiation in eukaryotes
Elongation, termination, and pre-mRNA processing
in eukaryotes
VIII
Contents
8.4
Small nuclear RNAs (snRNAs):The mechanism of exon
splicing
Self-splicing
Small interfering RNAs (siRNAs)
9
9.1
9.2
9.3
Overlapping versus
Number of letters in the codon
Use of suppressors to demonstrate a triplet code
Degeneracy of the genetic code
Cracking the code
Stop
9.4
Codon translation by tRNA
Degeneracy revisited
9.5
Ribosome features
Translation initiation, elongation, and
termination
Nonsense suppressor mutations
9.6
Alternative splicing generates protein isoforms
Posttranslational events
10
and Their Viruses
10.1
The basics of prokaryotic transcriptional regulation:
Genetic switches
A first look at the lac regulatory circuit
10.2
Genes controlled together
Genetic evidence for the operator and
Genetic evidence for allostery
Genetic analysis of the lac promoter
Molecular characterization of the Lac
and the lac operator
Polar mutations
10.3
Positive Control
The basics of catabolite repression of the lac operon:
Choosing the best sugar to metabolize
The structures of target
A summary of the lac operon
10.4
The
10.5
of Regulation: Attenuation
Transcription of the
two steps
10.6
Complex
Molecular anatomy of the genetic switch
Sequence-specific binding of regulatory proteins
to
10.7
of Genes
11
Eukaryotes
11.1
An Overview
Model Organism Box Yeast
11.2
Gal4 regulates multiple genes through upstream
activation sequences
The Gal4 protein has separable DNA-binding and
activation domains
Gal4 activity is physiologically regulated
Gal4 functions in most eukaryotes
Activators recruit the transcriptional machinery
11.3
Regulation
Chromatm-remodeling proteins and gene
activation
Histones and chromatin remodeling
11.4
The
The control of yeast mating type: Combinatorial
interactions
DNA-binding proteins combinatorialiy
expression of cell-type-specific genes
Contents
IX
Enhancer-blocking
11.5 Genomic
But what about Dolly and other cloned mammals?
П.6
Mating-type switching and gene silencing
Heterochromatin and euchromatin compared
Position-effect variegation in
genomic neighborhoods
Genetic analysis of PEV reveals proteins necessary for
heterochromatin formation
Silencing an entire chromosome: X-chromosome
inactivation
The inheritance of epigenetic marks and chromatin
structure
12
12.1
Model Organism Box
12.2
Development
Classification of genes by developmental function
Homeotic genes and
Organization and expression of Hox genes
The homeobox
Clusters of Hox genes control development in most
animals
12.3
The anteroposterior and dorsoventral axes
Expression of toolkit genes
12.4
Development
Maternal gradients and gene activation
Drawing stripes: Integration of gap-protein inputs
Making segments different: Integration of Hox
inputs
12.5
in Development
RNA
Drosophila
Regulation of rnRNA translation and cell lineage in
C. elegans
Translational control in the early embryo
Model Organism Box Caenorhabditis
elegans
miRNA control of developmental timing in
and other species
12.6
From flies to fingers, feathers, and floor plates
12.7
Polydactyly
Holoprosencephaly
Cancer as a developmental disease
13
13.1
13.2
Turning sequence reads into a sequence
map
Establishing a genomic library of clones
Sequencing a simple genome by using the whole-
genome shotgun approach
Using the whole-genome shotgun approach to
create a draft sequence of a complex genome
Using the ordered-clone approach to sequence a
complex genome
Filling sequence gaps
13.3
Sequence
The nature of the information content of
Deducing the protein-encoding genes from
genomic sequence
13 4
13.5
Ofmice
Comparative genomics of chimpanzees and
humans
Conserved and uitraconserved noncoding
elements
Comparative genomics of non-pathogenic and
pathogenic
136
Ome,
Reverse genetics
Contents
PART III MUTATION, VARIATION,
ANJ^EVOLUTION
14
14.1
McClintock's experiments: the Ds element
Model Organism Box Maize
Autonomous and nonautomous elements
Transposable elements: Only in maize?
14.2
Bacterial insertion sequences
Prokaryotic
Mechanism of transposition
14.3
Class I: Retrotransposons
DNA
Utility of
14.4
Elements Than Ever Imagined
Large genomes are largely transposable elements
Transposable elements in the human genome
The grasses: LTR retrotransposons thrive in large
genomes
Safe havens
15
15.1
Types of point mutation
The molecular consequences of point mutations in a
coding region
The molecular consequences of point mutations in a
noncoding region
15.2
Mutations
Luria and Delbriick fluctuation test
Mechanisms of spontaneous mutations
Spontaneous mutations in humans:
Trinucleotide repeat diseases
153
Mechanisms of mutagenesis
The Ames test: Evaluating
environment
15.4
Direct reversal of damaged
Base-excision repair
Nucleotide-excision repair
Postreplication repair: Mismatch repair
Error-prone repair:
Repair of double-strand breaks
15.5
Programmed double-strand breaks initiate meiotic
recombination
Genetic analyses of tetrads provide clues to the
mechanism of recombination
The double-strand break model for meiotic
recombination
15.6
of Mutations
How cancer cells differ from normal cells
Mutations in cancer cells
16
16.1
Aberrant euploidy
Aneuploidy
The concept of gene balance
16.2
Deletions
Duplications
Inversions
Reciprocal
Robertsonian
Applications of inversions and
Rearrangements and cancer
Identifying chromosome mutations by genomics
16.3
Mutations
17
17.1
Observations of variation
Protein polymorphisms
DNA
Contents
ΧΙ
17.2
Meiotic segregation and genetic equilibrium
Heterozygosity
Random mating
Inbreeding and assortative mating
17.3
Variation from mutation
Variation from recombination
Variation from migration
17.4
Two forms of selection
Measuring fitness differences
How selection works
Rate of change in gene frequency
17.5
Overdominance and underdominance
Balance between mutation and selection
17.6
18
18.1
18.2
Statistical distributions
Statistical measures
18.3
The critical difference between quantitative
and Mendelian traits
Gene number and quantitative traits
18.4
Distribution
18.5
Domesticated plants and animals
Studies of natural populations
Results of norm-of-reaction studies
18.6
Familialityandheritability
Phenotypic similarity between relatives
18.7
Methods of estimating Hz
The meaning of
Narrow heritability
Estimating the components of genetic variance
Artificial selection
The use of h2 in breeding
18.8
Marker-gene segregation
Quantitative linkage analysis
Statistical Appendix
Measures of central tendency
Measures of dispersion: The variance
Measures of relation
19
19.1
19.2
of Populations
19.3
Exploration of adaptive peaks
19.4
Heritability of variation
Variation within and between populations
19.5
The signature of purifying selection on
19.6
Protein Evolution
The signature of positive selection on
sequences
Morphological evolution
Gene inactivation
19.7
Regulatory evolution in humans
19.8
Polyploidy
Duplications
Imported
19.9
in Evolution
Comparing the proteomes among distant species
Comparing the proteomes among near neighbors:
Human-mouse comparative genomics
19.10
Genetics of species isolation
XII
Contents
PART IV TECHNIQUES
20
20.1
Type of donor
Cutting genomic
Attaching donor and vector
Amplification inside a bacterial cell
Entry of
bacterial cell
Recovery of amplified
Making genomic and cDNA libraries
Finding a specific clone of interest
20.2 DNA
Chain Reaction
20.3
Segment
20.4
Cloning
A forward analysis to identify a human
disease gene
A forward analysis to identify a gene important to corn
domestication
20.5
Molecular Genetic Diagnostics
20.6
Genetic engineering in Saccharomyces cerevisiae
Genetic engineering in plants
Genetic engineering in animals
Human gene therapy
A Brief Guide to Model Organisms
Appendix A: Genetic Nomenclature
Appendix B: Bioinformatics Resources for Genetics
and Genomics
Glossary
Answers to Selected Problems
Index
About the Cover
Variation in wing patterns of the butterfly Morpho didius. The male (top left)
and female (top right) have strikingly different wing patterns, governed by sex
determination genes. Here, a rare genetic event during development produced
two "gynandromorphs" (bottom), butterflies in which part of the wing tissue
shows a pattern more typical of the opposite sex. Photographs courtesy
of Nipam
New to This Edition
The ninth edition of introduction to Genetic Analysis has been thoroughly
revised to showcase how genetics is practiced today.
This new edition features
Enhanced Emphasis on:
•
•
Expanded Coverage of:
•
•
•
Θ
while providing increased portability and flexibility. Students study
important genetic processes and concepts at their convenience by downloading
the animations to their MP3 players. |
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| edition | 9. ed., 1. print. |
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| index_date | 2024-07-02T17:06:40Z |
| indexdate | 2024-07-09T20:56:09Z |
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| language | English |
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| spelling | Introduction to genetic analysis Anthony J. F. Griffiths .... 9. ed., 1. print. New York, NY Freeman 2008 XXIII, 838 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biotechnologie ram Genetik Génétique Génétique - Méthodologie Génétique - analyse Génétique ram Genetics Genetik (DE-588)4071711-2 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf CD-ROM (DE-588)4139307-7 gnd rswk-swf 1\p (DE-588)4151278-9 Einführung gnd-content 2\p (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s Methode (DE-588)4038971-6 s 3\p DE-604 CD-ROM (DE-588)4139307-7 s 4\p DE-604 Griffiths, Anthony J. F. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015579206&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015579206&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 4\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Introduction to genetic analysis Biotechnologie ram Genetik Génétique Génétique - Méthodologie Génétique - analyse Génétique ram Genetics Genetik (DE-588)4071711-2 gnd Methode (DE-588)4038971-6 gnd CD-ROM (DE-588)4139307-7 gnd |
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| title | Introduction to genetic analysis |
| title_auth | Introduction to genetic analysis |
| title_exact_search | Introduction to genetic analysis |
| title_exact_search_txtP | Introduction to genetic analysis |
| title_full | Introduction to genetic analysis Anthony J. F. Griffiths .... |
| title_fullStr | Introduction to genetic analysis Anthony J. F. Griffiths .... |
| title_full_unstemmed | Introduction to genetic analysis Anthony J. F. Griffiths .... |
| title_short | Introduction to genetic analysis |
| title_sort | introduction to genetic analysis |
| topic | Biotechnologie ram Genetik Génétique Génétique - Méthodologie Génétique - analyse Génétique ram Genetics Genetik (DE-588)4071711-2 gnd Methode (DE-588)4038971-6 gnd CD-ROM (DE-588)4139307-7 gnd |
| topic_facet | Biotechnologie Genetik Génétique Génétique - Méthodologie Génétique - analyse Genetics Methode CD-ROM Einführung Lehrbuch |
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