Integrating the neurobiology of schizophrenia:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier [u.a.]
2007
|
| Schriftenreihe: | International review of neurobiology
78 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | XVI, 459 S. Ill., graph. Darst. |
| ISBN: | 9780123737373 0123737370 |
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| 650 | 4 | |a Schizophrenia |x Chemotherapy | |
| 650 | 4 | |a Schizophrenia |x Physiological aspects | |
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Datensatz im Suchindex
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| adam_text | CONTENTS
Contributors xi
Preface xiii
Neurobiology of Dopamine in Schizophrenia
Olivier Guillin, Anissa Abi Dargham, and Marc Laruelle
I. Introduction 1
II. Dopaminergic System in the Brain 3
III. Evidence Supporting Alterations of DA Systems in Schizophrenia 9
IV. Conclusions 25
References 26
The Dopamine System and the Pathophysiology of Schizophrenia:
A Basic Science Perspective
Yukiori Goto and Anthony A. Grace
I. Introduction 42
II. Neuroanatomy of DA Systems 42
III. DA Neuron Activity and Release 45
IV. Cellular Actions of DA 49
V. Roles of DA on Cognitive and Affective Functions 51
VI. Development and Maturation of the DA System 53
VII. DA Deficits in Schizophrenia 55
VIII. Conclusions 58
References 58
Glutamate and Schizophrenia: Phencyclidine,
N Methyl D Aspartate Receptors, and
Dopamine Glutamate Interactions
Daniel C. Javitt
I. Introduction 70
II. Glutamatergic Physiology 71
III. Glutamatergic Models of Schizophrenia 75
IV. Clinical Studies with NMDA Agonists 81
v
vi CONTENTS
V. Potential Causes of Glutamatergic Dysfunction in Schizophrenia 90
VI. Future Research and Treatment Implications 96
References 96
Deciphering the Disease Process of Schizophrenia:
The Contribution of Cortical GABA Neurons
David A. Lewis and Takanori Hashimoto
I. Working Memory Impairments: A Core
Feature of Schizophrenia 109
II. Working Memory Impairments and Altered
GABA Neurotransmission in the DLPFC 110
III. Potential Pathogenetic Mechanisms for Cell
Type Specific Alterations in GABA Neurons 118
IV. Connecting Alterations in PV Positive Neurons to Working
Memory Impairments: Decreased Gamma
Band Synchrony in Schizophrenia 122
V. Treatment Implications 123
References 124
Alterations of Serotonin Transmission in Schizophrenia
Anissa Abi Dargham
I. Introduction 133
II. Alteration of 5 HT Receptors in Schizophrenia 134
III. Pharmacological Manipulation of 5 HT Transmission
in Schizophrenia 141
IV. 5 HT DA Interactions Relevant to Schizophrenia 149
V. Discussions 151
References 153
Serotonin and Dopamine Interactions in Rodents and Primates:
Implications for Psychosis and Antipsychotic
Drug Development
Gerard J. Marek
I. Introduction 166
II. Dopamine and 5 HT Receptors 167
III. Psychomotor Stimulants: A Dopamine—Serotonin Interaction
Case Study 168
IV. Monoaminergic Nuclei Interactions 170
V. Serotonin and Dopamine in the Thalamus 172
VI. Dopamine and Serotonin in the Striatum 174
VII. Dopamine and Serotonin in the Hippocampal Formation 176
VIII. Dopamine and Serotonin in the Prefrontal Cortex/Neocortex 177
IX. Animal Models 181
CONTENTS vii
X. Conclusions 183
References 183
Cholinergic Circuits and Signaling in the
Pathophysiology of Schizophrenia
Joshua A. Berman, David A. Talmage, and Lorna W. Role
I. Introduction 194
II. ACh in Brain Regions Implicated in Schizophrenia 195
HI. Physiology of ACh Circuits and Signaling in Brain Regions
Implicated in Schizophrenia Pathology 198
IV. Developmental and Genetic Deficits in Schizophrenia That May
Influence Function and Assembly of Cholinergic Systems 203
V. Clinical and Preclinical Evidence for Deficits in Components of
Brain Cholinergic Systems in Schizophrenia 206
VI. Evidence for Cholinergic Contributions to Schizophrenia
Pathophysiology from Clinical and
Preclinical Psychopharmacology 208
VII. Conclusions 213
References 214
Schizophrenia and the oJ Nicotinic Acetylcholine Receptor
Laura F. Martin and Robert Freedman
I. Introduction 226
II. Neurobiological and Neurogenetic Evidence for a Link Between
the ccl Nicotinic Acetylcholine Receptor and Schizophrenia 226
III. The Prototypic q7 Nicotinic Agonist, Nicotine, and Schizophrenia... 228
IV. The Search for an al Nicotinic Acetylcholine Receptor Agonist 233
V. The Phase 1 Study of DMXBA in Schizophrenia 234
References 237
Histamine and Schizophrenia
Jean Michel Arrang
I. Introduction 248
II. The Histaminergic Neuronal System 249
III. Changes in the Histaminergic System in Schizophrenia 264
viii CONTENTS
IV. Interactions of Antipsychotic Drugs with the Histaminergic System ... 267
V. Role of Histaminergic Neurons in Schizophrenia 269
VI. Conclusions 272
References 272
Cannabinoids and Psychosis
Deepak Cyril D Souza
I. Introduction 290
II. Ancedotal Reports 291
III. Epidemiological Studies 297
IV. Pharmacological Studies 303
V. Cannabis and Psychosis: Causality 312
VI. Cannabinoid Receptor Dysfunction and Psychotic Disorders 314
VII. Summary and Conclusions 317
References 318
Involvement of Neuropeptide Systems in
Schizophrenia: Human Studies
Ricardo Caceda, Becky Kinkead, and Charles B. Nemeroff
I. Introduction 328
II. Cholecystokinin 329
III. Corticotropin Releasing Factor 337
IV. Interleukins 344
V. Neurotensin 346
VT. Neuropeptide Y 348
VII. Opioid Peptides 349
VIII. Secretin 351
IX. Somatostatin 351
X. Vasoactive Intestinal Peptide 352
XI. Tachykinins 352
XII. Thyrotropin Releasing Hormone 353
XIII. Other Peptides 354
XIV. Conclusions 356
References 357
Brain Derived Neurotrophic Factor in Schizophrenia
and Its Relation with Dopamine
Olivier Guillin, Caroline Demily, and Florence Thibaut
I. Introduction 377
II. Genetic Studies 379
III. BDNF in the Serum of Patients with Schizophrenia 382
IV. BDNF and TrkB Receptor in the Brain of
Patients with Schizophrenia 382
CONTENTS ix
V. Dopamine BDNF Interactions 385
VI. Conclusions 388
References 389
Schizophrenia Susceptibility Genes: In Search of
a Molecular Logic and Novel Drug Targets for
a Devastating Disorder
Joseph A. Gogos
I. The Genetic Component of Schizophrenia 398
II. Genes Identified Through Systematic
Follow Up of Linkage Signals 399
III. Other Candidate Genes 406
IV. Areas of Caution in the Interpretation and
Generalization of Genetic Findings 408
V. Future Directions of the Genetic Research: Advancing
Our Understanding of How the Specific Genetic Factors
Contribute Biologically to the Disease Process 409
References 414
Index 423
Contents of Recent Volumes 439
|
| adam_txt |
CONTENTS
Contributors xi
Preface xiii
Neurobiology of Dopamine in Schizophrenia
Olivier Guillin, Anissa Abi Dargham, and Marc Laruelle
I. Introduction 1
II. Dopaminergic System in the Brain 3
III. Evidence Supporting Alterations of DA Systems in Schizophrenia 9
IV. Conclusions 25
References 26
The Dopamine System and the Pathophysiology of Schizophrenia:
A Basic Science Perspective
Yukiori Goto and Anthony A. Grace
I. Introduction 42
II. Neuroanatomy of DA Systems 42
III. DA Neuron Activity and Release 45
IV. Cellular Actions of DA 49
V. Roles of DA on Cognitive and Affective Functions 51
VI. Development and Maturation of the DA System 53
VII. DA Deficits in Schizophrenia 55
VIII. Conclusions 58
References 58
Glutamate and Schizophrenia: Phencyclidine,
N Methyl D Aspartate Receptors, and
Dopamine Glutamate Interactions
Daniel C. Javitt
I. Introduction 70
II. Glutamatergic Physiology 71
III. Glutamatergic Models of Schizophrenia 75
IV. Clinical Studies with NMDA Agonists 81
v
vi CONTENTS
V. Potential Causes of Glutamatergic Dysfunction in Schizophrenia 90
VI. Future Research and Treatment Implications 96
References 96
Deciphering the Disease Process of Schizophrenia:
The Contribution of Cortical GABA Neurons
David A. Lewis and Takanori Hashimoto
I. Working Memory Impairments: A Core
Feature of Schizophrenia 109
II. Working Memory Impairments and Altered
GABA Neurotransmission in the DLPFC 110
III. Potential Pathogenetic Mechanisms for Cell
Type Specific Alterations in GABA Neurons 118
IV. Connecting Alterations in PV Positive Neurons to Working
Memory Impairments: Decreased Gamma
Band Synchrony in Schizophrenia 122
V. Treatment Implications 123
References 124
Alterations of Serotonin Transmission in Schizophrenia
Anissa Abi Dargham
I. Introduction 133
II. Alteration of 5 HT Receptors in Schizophrenia 134
III. Pharmacological Manipulation of 5 HT Transmission
in Schizophrenia 141
IV. 5 HT DA Interactions Relevant to Schizophrenia 149
V. Discussions 151
References 153
Serotonin and Dopamine Interactions in Rodents and Primates:
Implications for Psychosis and Antipsychotic
Drug Development
Gerard J. Marek
I. Introduction 166
II. Dopamine and 5 HT Receptors 167
III. Psychomotor Stimulants: A Dopamine—Serotonin Interaction
"Case Study" 168
IV. Monoaminergic Nuclei Interactions 170
V. Serotonin and Dopamine in the Thalamus 172
VI. Dopamine and Serotonin in the Striatum 174
VII. Dopamine and Serotonin in the Hippocampal Formation 176
VIII. Dopamine and Serotonin in the Prefrontal Cortex/Neocortex 177
IX. Animal Models 181
CONTENTS vii
X. Conclusions 183
References 183
Cholinergic Circuits and Signaling in the
Pathophysiology of Schizophrenia
Joshua A. Berman, David A. Talmage, and Lorna W. Role
I. Introduction 194
II. ACh in Brain Regions Implicated in Schizophrenia 195
HI. Physiology of ACh Circuits and Signaling in Brain Regions
Implicated in Schizophrenia Pathology 198
IV. Developmental and Genetic Deficits in Schizophrenia That May
Influence Function and Assembly of Cholinergic Systems 203
V. Clinical and Preclinical Evidence for Deficits in Components of
Brain Cholinergic Systems in Schizophrenia 206
VI. Evidence for Cholinergic Contributions to Schizophrenia
Pathophysiology from Clinical and
Preclinical Psychopharmacology 208
VII. Conclusions 213
References 214
Schizophrenia and the oJ Nicotinic Acetylcholine Receptor
Laura F. Martin and Robert Freedman
I. Introduction 226
II. Neurobiological and Neurogenetic Evidence for a Link Between
the ccl Nicotinic Acetylcholine Receptor and Schizophrenia 226
III. The Prototypic q7 Nicotinic Agonist, Nicotine, and Schizophrenia. 228
IV. The Search for an al Nicotinic Acetylcholine Receptor Agonist 233
V. The Phase 1 Study of DMXBA in Schizophrenia 234
References 237
Histamine and Schizophrenia
Jean Michel Arrang
I. Introduction 248
II. The Histaminergic Neuronal System 249
III. Changes in the Histaminergic System in Schizophrenia 264
viii CONTENTS
IV. Interactions of Antipsychotic Drugs with the Histaminergic System . 267
V. Role of Histaminergic Neurons in Schizophrenia 269
VI. Conclusions 272
References 272
Cannabinoids and Psychosis
Deepak Cyril D'Souza
I. Introduction 290
II. Ancedotal Reports 291
III. Epidemiological Studies 297
IV. Pharmacological Studies 303
V. Cannabis and Psychosis: Causality 312
VI. Cannabinoid Receptor Dysfunction and Psychotic Disorders 314
VII. Summary and Conclusions 317
References 318
Involvement of Neuropeptide Systems in
Schizophrenia: Human Studies
Ricardo Caceda, Becky Kinkead, and Charles B. Nemeroff
I. Introduction 328
II. Cholecystokinin 329
III. Corticotropin Releasing Factor 337
IV. Interleukins 344
V. Neurotensin 346
VT. Neuropeptide Y 348
VII. Opioid Peptides 349
VIII. Secretin 351
IX. Somatostatin 351
X. Vasoactive Intestinal Peptide 352
XI. Tachykinins 352
XII. Thyrotropin Releasing Hormone 353
XIII. Other Peptides 354
XIV. Conclusions 356
References 357
Brain Derived Neurotrophic Factor in Schizophrenia
and Its Relation with Dopamine
Olivier Guillin, Caroline Demily, and Florence Thibaut
I. Introduction 377
II. Genetic Studies 379
III. BDNF in the Serum of Patients with Schizophrenia 382
IV. BDNF and TrkB Receptor in the Brain of
Patients with Schizophrenia 382
CONTENTS ix
V. Dopamine BDNF Interactions 385
VI. Conclusions 388
References 389
Schizophrenia Susceptibility Genes: In Search of
a Molecular Logic and Novel Drug Targets for
a Devastating Disorder
Joseph A. Gogos
I. The Genetic Component of Schizophrenia 398
II. Genes Identified Through Systematic
Follow Up of Linkage Signals 399
III. Other Candidate Genes 406
IV. Areas of Caution in the Interpretation and
Generalization of Genetic Findings 408
V. Future Directions of the Genetic Research: Advancing
Our Understanding of How the Specific Genetic Factors
Contribute Biologically to the Disease Process 409
References 414
Index 423
Contents of Recent Volumes 439 |
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| spelling | Integrating the neurobiology of schizophrenia ed. by Anissa Abi-Dargham ... Amsterdam [u.a.] Elsevier [u.a.] 2007 XVI, 459 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier International review of neurobiology 78 Einzelaufnahme eines Zeitschr.-Bd. Schizophrénie - Aspect physiologique Schizophrénie - Chimiothérapie Schizophrenia Chemotherapy Schizophrenia Physiological aspects Schizophrenia drug therapy Schizophrenia physiopathology Schizophrenie (DE-588)4052527-2 gnd rswk-swf Neurophysiologie (DE-588)4041897-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Schizophrenie (DE-588)4052527-2 s Neurophysiologie (DE-588)4041897-2 s b DE-604 Abi-Dargham, Anissa Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015515676&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Integrating the neurobiology of schizophrenia Schizophrénie - Aspect physiologique Schizophrénie - Chimiothérapie Schizophrenia Chemotherapy Schizophrenia Physiological aspects Schizophrenia drug therapy Schizophrenia physiopathology Schizophrenie (DE-588)4052527-2 gnd Neurophysiologie (DE-588)4041897-2 gnd |
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| title | Integrating the neurobiology of schizophrenia |
| title_auth | Integrating the neurobiology of schizophrenia |
| title_exact_search | Integrating the neurobiology of schizophrenia |
| title_exact_search_txtP | Integrating the neurobiology of schizophrenia |
| title_full | Integrating the neurobiology of schizophrenia ed. by Anissa Abi-Dargham ... |
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| title_full_unstemmed | Integrating the neurobiology of schizophrenia ed. by Anissa Abi-Dargham ... |
| title_short | Integrating the neurobiology of schizophrenia |
| title_sort | integrating the neurobiology of schizophrenia |
| topic | Schizophrénie - Aspect physiologique Schizophrénie - Chimiothérapie Schizophrenia Chemotherapy Schizophrenia Physiological aspects Schizophrenia drug therapy Schizophrenia physiopathology Schizophrenie (DE-588)4052527-2 gnd Neurophysiologie (DE-588)4041897-2 gnd |
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