Hedgehog-Gli signaling in human disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Georgetown, Tex.
Landes Bioscience [u.a.]
2006
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | 228 S. Ill., graph. Darst. |
| ISBN: | 0387257845 9780387257846 |
Internformat
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| 245 | 1 | 0 | |a Hedgehog-Gli signaling in human disease |c Ariel Ruiz i Altalba [ed.] |
| 264 | 1 | |a Georgetown, Tex. |b Landes Bioscience [u.a.] |c 2006 | |
| 300 | |a 228 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 0 | |a Molecular biology intelligence unit | |
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Oncogene Proteins |x metabolism | |
| 650 | 4 | |a Oncogenes | |
| 650 | 4 | |a Signal Transduction |x physiology | |
| 650 | 4 | |a Transcription Factors |x metabolism | |
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Datensatz im Suchindex
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CONTENTS
Preface
.
1.
Interference with HEDGEHOG-GLI Signaling
as Anti-Cancer Therapy?
Ariel Ruiz
2.
Signaling Pathway
Luis Quijada, Ainhoa Callejo,
The Hedgehog Signaling Pathway
Sequence and Functional Analysis of Ptc
Hedgehog
Reception of Hh
Hh Internalization and Signal Transduction
Smo
Ptc and Human Disease
3.
Henk Roelink
Displ, A Molecule Dedicated to the Export of Shh
Is Shh Handed Over from Cell to Cell Using
an Active Mechanism?
4.
by Hedgehog Signaling
Anthony
The Hair Follicle Cycle
Interfollicular Epithelial Cells Are Competent to Induce Shh
Target Genes
Outcomes of Shh Target Gene Induction in die Skin
Regulation of Shh Induction in
Regulation of Shh Signal Reception
Maintenance of Shh Signaling during Tissue Morphogenesis
Future Perspectives
5.
Insights ficom Mutant Ptchl Mice
Heidi
Is Loss of Both PTCHl/Ptchl
for Tumor Formation?
What Are the Modifiers of
Tumorigenesis?
6.
and die
Ervin
Rhabdomyosarcomas
Medulloblastomas
BCCs
7.
and Disease
Fritz Aberger and
GLI
Human Epidermis and die Origin of BCC
GLII
The Oncogenic Nature of
Regulation of
Unresolved Problems and Future Perspectives
8.
Functions during Epidermal Development and Disease
Pleasantine Mill and Chi-Chung
The
Molecular Mechanisms of Embryonic
and Adult Hair Development
Shh: Stem Cells, Cell Cycle and Cancer
9.
PaulM. Fitch,
William A.H. Walhce and Sarah EM. Howie
The Hedgehog Pathway
Hedgehog Signalling in Normal Pulmonary Tissues
Hedgehog Signalling in Injury and Disease
Shh in the Immune System
Hedgehogs and Pulmonary Progenitor Cells
Shh and Type II Epithelial Cells
10.
Leslie G. Biesecker
The Delineation of the Greig Cephalopolysyndactyly
Syndrome (GCPS)
The Molecular Basis of GCPS
The Clinical Delineation of Pallister-Hall Syndrome (PHS)
Animal Models of GLI3 Phenotypes
11.
Role of Shh and Gli3 in Limb Morphogenesis
Chin Chiang
Shh Expression and the Specification of Digit Identity
Congenital Limb Malformations Associated
with Shh Misregulation
Shh Activity in Limb Patterning Is Mediated by Gli3
Congenital Limb Malformations Are Associated
with Gli3 Mutations
12.
M. Elizabeth McCready and Dennis
Brachydactyly Type
Acrocapitofemoral Dysplasia (ACFD)
Comparison of Human IHH Disorders
IHH Animal Model
13.
Dwight
The Face in Myth and Reality
The Craniofacial Consequences of Disrupting SHH Signaling:
The Human Experience
Models to Study Craniofacial Development
Craniofacial Consequences of Shh Perturbation:
The Model Experience
Embryologie
An Introduction
Future Directions
14.
during the Dorsal-Ventral Patterning of the Telencephalon
Jun
Shh Signaling and Dorsal-Ventral Patterning
of the Telencephalon
Gli3
Gli3 as a Suppressor of Ventral Cell Type
Importance of the Balance between Gli3 and Shh
Future Perspectives
15.
Signaling in CNS Development and Tumorigenesis
Anna Marie Kenney and David H. Rowitch
Mitogenic Signaling in the Developing CNS
SHH Signaling Is Required for Growth of Cerebellar Granule
Neuron Precursors and Is
N-MYC as a Key Component of HH Signaling
16.
Frederic
Identification of Small Molecule Hedgehog (Hh) Antagonists
Identification of Hh Small Molecule Hh Agonists
17.
Marina
The Hedgehog Signaling Pathway
Hedgehog Signaling in Gastrointestinal Tumors of the Pancreas
and Colon
Index
CONTENTS
Preface
.
1.
Interference with HEDGEHOG-GLI Signaling
as Anti-Cancer Therapy?
Ariel Ruiz
2.
Signaling Pathway
Luis Quijada, Ainhoa Callejo,
The Hedgehog Signaling Pathway
Sequence and Functional Analysis of Ptc
Hedgehog
Reception of Hh
Hh Internalization and Signal Transduction
Smo
Ptc and Human Disease
3.
Henk Roelink
Displ, A Molecule Dedicated to the Export of Shh
Is Shh Handed Over from Cell to Cell Using
an Active Mechanism?
4.
by Hedgehog Signaling
Anthony
The Hair Follicle Cycle
Interfollicular Epithelial Cells Are Competent to Induce Shh
Target Genes
Outcomes of Shh Target Gene Induction in die Skin
Regulation of Shh Induction in
Regulation of Shh Signal Reception
Maintenance of Shh Signaling during Tissue Morphogenesis
Future Perspectives
5.
Insights ficom Mutant Ptchl Mice
Heidi
Is Loss of Both PTCHl/Ptchl
for Tumor Formation?
What Are the Modifiers of
Tumorigenesis?
6.
and die
Ervin
Rhabdomyosarcomas
Medulloblastomas
BCCs
7.
and Disease
Fritz Aberger and
GLI
Human Epidermis and die Origin of BCC
GLII
The Oncogenic Nature of
Regulation of
Unresolved Problems and Future Perspectives
8.
Functions during Epidermal Development and Disease
Pleasantine Mill and Chi-Chung
The
Molecular Mechanisms of Embryonic
and Adult Hair Development
Shh: Stem Cells, Cell Cycle and Cancer
9.
PaulM. Fitch,
William A.H. Walhce and Sarah EM. Howie
The Hedgehog Pathway
Hedgehog Signalling in Normal Pulmonary Tissues
Hedgehog Signalling in Injury and Disease
Shh in the Immune System
Hedgehogs and Pulmonary Progenitor Cells
Shh and Type II Epithelial Cells
10.
Leslie G. Biesecker
The Delineation of the Greig Cephalopolysyndactyly
Syndrome (GCPS)
The Molecular Basis of GCPS
The Clinical Delineation of Pallister-Hall Syndrome (PHS)
Animal Models of GLI3 Phenotypes
11.
Role of Shh and Gli3 in Limb Morphogenesis
Chin Chiang
Shh Expression and the Specification of Digit Identity
Congenital Limb Malformations Associated
with Shh Misregulation
Shh Activity in Limb Patterning Is Mediated by Gli3
Congenital Limb Malformations Are Associated
with Gli3 Mutations
12.
M. Elizabeth McCready and Dennis
Brachydactyly Type
Acrocapitofemoral Dysplasia (ACFD)
Comparison of Human IHH Disorders
IHH Animal Model
13.
Dwight
The Face in Myth and Reality
The Craniofacial Consequences of Disrupting SHH Signaling:
The Human Experience
Models to Study Craniofacial Development
Craniofacial Consequences of Shh Perturbation:
The Model Experience
Embryologie
An Introduction
Future Directions
14.
during the Dorsal-Ventral Patterning of the Telencephalon
Jun
Shh Signaling and Dorsal-Ventral Patterning
of the Telencephalon
Gli3
Gli3 as a Suppressor of Ventral Cell Type
Importance of the Balance between Gli3 and Shh
Future Perspectives
15.
Signaling in CNS Development and Tumorigenesis
Anna Marie Kenney and David H. Rowitch
Mitogenic Signaling in the Developing CNS
SHH Signaling Is Required for Growth of Cerebellar Granule
Neuron Precursors and Is
N-MYC as a Key Component of HH Signaling
16.
Frederic
Identification of Small Molecule Hedgehog (Hh) Antagonists
Identification of Hh Small Molecule Hh Agonists
17.
Marina
The Hedgehog Signaling Pathway
Hedgehog Signaling in Gastrointestinal Tumors of the Pancreas
and Colon
Index |
| adam_txt |
CONTENTS
Preface
.
1.
Interference with HEDGEHOG-GLI Signaling
as Anti-Cancer Therapy?
Ariel Ruiz
2.
Signaling Pathway
Luis Quijada, Ainhoa Callejo,
The Hedgehog Signaling Pathway
Sequence and Functional Analysis of Ptc
Hedgehog
Reception of Hh
Hh Internalization and Signal Transduction
Smo
Ptc and Human Disease
3.
Henk Roelink
Displ, A Molecule Dedicated to the Export of Shh
Is Shh Handed Over from Cell to Cell Using
an Active Mechanism?
4.
by Hedgehog Signaling
Anthony
The Hair Follicle Cycle
Interfollicular Epithelial Cells Are Competent to Induce Shh
Target Genes
Outcomes of Shh Target Gene Induction in die Skin
Regulation of Shh Induction in
Regulation of Shh Signal Reception
Maintenance of Shh Signaling during Tissue Morphogenesis
Future Perspectives
5.
Insights ficom Mutant Ptchl Mice
Heidi
Is Loss of Both PTCHl/Ptchl
for Tumor Formation?
What Are the Modifiers of
Tumorigenesis?
6.
and die
Ervin
Rhabdomyosarcomas
Medulloblastomas
BCCs
7.
and Disease
Fritz Aberger and
GLI
Human Epidermis and die Origin of BCC
GLII
The Oncogenic Nature of
Regulation of
Unresolved Problems and Future Perspectives
8.
Functions during Epidermal Development and Disease
Pleasantine Mill and Chi-Chung
The
Molecular Mechanisms of Embryonic
and Adult Hair Development
Shh: Stem Cells, Cell Cycle and Cancer
9.
PaulM. Fitch,
William A.H. Walhce and Sarah EM. Howie
The Hedgehog Pathway
Hedgehog Signalling in Normal Pulmonary Tissues
Hedgehog Signalling in Injury and Disease
Shh in the Immune System
Hedgehogs and Pulmonary Progenitor Cells
Shh and Type II Epithelial Cells
10.
Leslie G. Biesecker
The Delineation of the Greig Cephalopolysyndactyly
Syndrome (GCPS)
The Molecular Basis of GCPS
The Clinical Delineation of Pallister-Hall Syndrome (PHS)
Animal Models of GLI3 Phenotypes
11.
Role of Shh and Gli3 in Limb Morphogenesis
Chin Chiang
Shh Expression and the Specification of Digit Identity
Congenital Limb Malformations Associated
with Shh Misregulation
Shh Activity in Limb Patterning Is Mediated by Gli3
Congenital Limb Malformations Are Associated
with Gli3 Mutations
12.
M. Elizabeth McCready and Dennis
Brachydactyly Type
Acrocapitofemoral Dysplasia (ACFD)
Comparison of Human IHH Disorders
IHH Animal Model
13.
Dwight
The Face in Myth and Reality
The Craniofacial Consequences of Disrupting SHH Signaling:
The Human Experience
Models to Study Craniofacial Development
Craniofacial Consequences of Shh Perturbation:
The Model Experience
Embryologie
An Introduction
Future Directions
14.
during the Dorsal-Ventral Patterning of the Telencephalon
Jun
Shh Signaling and Dorsal-Ventral Patterning
of the Telencephalon
Gli3
Gli3 as a Suppressor of Ventral Cell Type
Importance of the Balance between Gli3 and Shh
Future Perspectives
15.
Signaling in CNS Development and Tumorigenesis
Anna Marie Kenney and David H. Rowitch
Mitogenic Signaling in the Developing CNS
SHH Signaling Is Required for Growth of Cerebellar Granule
Neuron Precursors and Is
N-MYC as a Key Component of HH Signaling
16.
Frederic
Identification of Small Molecule Hedgehog (Hh) Antagonists
Identification of Hh Small Molecule Hh Agonists
17.
Marina
The Hedgehog Signaling Pathway
Hedgehog Signaling in Gastrointestinal Tumors of the Pancreas
and Colon
Index
CONTENTS
Preface
.
1.
Interference with HEDGEHOG-GLI Signaling
as Anti-Cancer Therapy?
Ariel Ruiz
2.
Signaling Pathway
Luis Quijada, Ainhoa Callejo,
The Hedgehog Signaling Pathway
Sequence and Functional Analysis of Ptc
Hedgehog
Reception of Hh
Hh Internalization and Signal Transduction
Smo
Ptc and Human Disease
3.
Henk Roelink
Displ, A Molecule Dedicated to the Export of Shh
Is Shh Handed Over from Cell to Cell Using
an Active Mechanism?
4.
by Hedgehog Signaling
Anthony
The Hair Follicle Cycle
Interfollicular Epithelial Cells Are Competent to Induce Shh
Target Genes
Outcomes of Shh Target Gene Induction in die Skin
Regulation of Shh Induction in
Regulation of Shh Signal Reception
Maintenance of Shh Signaling during Tissue Morphogenesis
Future Perspectives
5.
Insights ficom Mutant Ptchl Mice
Heidi
Is Loss of Both PTCHl/Ptchl
for Tumor Formation?
What Are the Modifiers of
Tumorigenesis?
6.
and die
Ervin
Rhabdomyosarcomas
Medulloblastomas
BCCs
7.
and Disease
Fritz Aberger and
GLI
Human Epidermis and die Origin of BCC
GLII
The Oncogenic Nature of
Regulation of
Unresolved Problems and Future Perspectives
8.
Functions during Epidermal Development and Disease
Pleasantine Mill and Chi-Chung
The
Molecular Mechanisms of Embryonic
and Adult Hair Development
Shh: Stem Cells, Cell Cycle and Cancer
9.
PaulM. Fitch,
William A.H. Walhce and Sarah EM. Howie
The Hedgehog Pathway
Hedgehog Signalling in Normal Pulmonary Tissues
Hedgehog Signalling in Injury and Disease
Shh in the Immune System
Hedgehogs and Pulmonary Progenitor Cells
Shh and Type II Epithelial Cells
10.
Leslie G. Biesecker
The Delineation of the Greig Cephalopolysyndactyly
Syndrome (GCPS)
The Molecular Basis of GCPS
The Clinical Delineation of Pallister-Hall Syndrome (PHS)
Animal Models of GLI3 Phenotypes
11.
Role of Shh and Gli3 in Limb Morphogenesis
Chin Chiang
Shh Expression and the Specification of Digit Identity
Congenital Limb Malformations Associated
with Shh Misregulation
Shh Activity in Limb Patterning Is Mediated by Gli3
Congenital Limb Malformations Are Associated
with Gli3 Mutations
12.
M. Elizabeth McCready and Dennis
Brachydactyly Type
Acrocapitofemoral Dysplasia (ACFD)
Comparison of Human IHH Disorders
IHH Animal Model
13.
Dwight
The Face in Myth and Reality
The Craniofacial Consequences of Disrupting SHH Signaling:
The Human Experience
Models to Study Craniofacial Development
Craniofacial Consequences of Shh Perturbation:
The Model Experience
Embryologie
An Introduction
Future Directions
14.
during the Dorsal-Ventral Patterning of the Telencephalon
Jun
Shh Signaling and Dorsal-Ventral Patterning
of the Telencephalon
Gli3
Gli3 as a Suppressor of Ventral Cell Type
Importance of the Balance between Gli3 and Shh
Future Perspectives
15.
Signaling in CNS Development and Tumorigenesis
Anna Marie Kenney and David H. Rowitch
Mitogenic Signaling in the Developing CNS
SHH Signaling Is Required for Growth of Cerebellar Granule
Neuron Precursors and Is
N-MYC as a Key Component of HH Signaling
16.
Frederic
Identification of Small Molecule Hedgehog (Hh) Antagonists
Identification of Hh Small Molecule Hh Agonists
17.
Marina
The Hedgehog Signaling Pathway
Hedgehog Signaling in Gastrointestinal Tumors of the Pancreas
and Colon
Index |
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| id | DE-604.BV022296058 |
| illustrated | Illustrated |
| index_date | 2024-07-02T16:53:27Z |
| indexdate | 2024-08-14T00:51:54Z |
| institution | BVB |
| isbn | 0387257845 9780387257846 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015506133 |
| oclc_num | 61860815 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 228 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Landes Bioscience [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Hedgehog-Gli signaling in human disease Ariel Ruiz i Altalba [ed.] Georgetown, Tex. Landes Bioscience [u.a.] 2006 228 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Cellular signal transduction Oncogene Proteins metabolism Oncogenes Signal Transduction physiology Transcription Factors metabolism Tumor proteins Krankheit (DE-588)4032844-2 gnd rswk-swf Hedgehog Gen (DE-588)4671692-0 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Hedgehog Gen (DE-588)4671692-0 s Signaltransduktion (DE-588)4318717-1 s Krankheit (DE-588)4032844-2 s b DE-604 Ruiz i Altaba, Ariel 1962 Sonstige (DE-588)12989107X oth text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2739530&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015506133&sequence=000005&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hedgehog-Gli signaling in human disease Cellular signal transduction Oncogene Proteins metabolism Oncogenes Signal Transduction physiology Transcription Factors metabolism Tumor proteins Krankheit (DE-588)4032844-2 gnd Hedgehog Gen (DE-588)4671692-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4032844-2 (DE-588)4671692-0 (DE-588)4318717-1 |
| title | Hedgehog-Gli signaling in human disease |
| title_auth | Hedgehog-Gli signaling in human disease |
| title_exact_search | Hedgehog-Gli signaling in human disease |
| title_exact_search_txtP | Hedgehog-Gli signaling in human disease |
| title_full | Hedgehog-Gli signaling in human disease Ariel Ruiz i Altalba [ed.] |
| title_fullStr | Hedgehog-Gli signaling in human disease Ariel Ruiz i Altalba [ed.] |
| title_full_unstemmed | Hedgehog-Gli signaling in human disease Ariel Ruiz i Altalba [ed.] |
| title_short | Hedgehog-Gli signaling in human disease |
| title_sort | hedgehog gli signaling in human disease |
| topic | Cellular signal transduction Oncogene Proteins metabolism Oncogenes Signal Transduction physiology Transcription Factors metabolism Tumor proteins Krankheit (DE-588)4032844-2 gnd Hedgehog Gen (DE-588)4671692-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Cellular signal transduction Oncogene Proteins metabolism Oncogenes Signal Transduction physiology Transcription Factors metabolism Tumor proteins Krankheit Hedgehog Gen Signaltransduktion |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2739530&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015506133&sequence=000005&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ruizialtabaariel hedgehogglisignalinginhumandisease |