Alzheimer's disease: advances in genetics, molecular and cellular biology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2007
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis Klappentext |
| Beschreibung: | IX, 286 S. Ill., graph. Darst. |
| ISBN: | 9780387351346 0387351345 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Table
Introduction
Chapter
Lars Bertram
Chapter
Gopal Thinakaran and Edward H. Koo
Chapter
Tomoko Wakabayashi, Takeshi Iwatsubo and Bart
Chapter
Fiona M. Laird,
Alena
Chapter
of Alzheimer s Disease
Karen H. Ashe
Chapter
Henri J. Huttunen and Dora M.
Chapter
Charles
Chapter
Neuronal
Carl W. Cotman and Jorge Busciglio
Chapter
Roberto Malinow, Helen Hsieh and Wei Wei
vi
Chapter
Malcolm Leissring and Takaomi C. Saido
Chapter
and Treatment of Alzheimer s Disease
David M. Holtzman and Berislav Zlokovic
Chapter
Matthew J. Winton, John Q.
Chapter
Karen Duff, Pavan Krishnamurthy, Emmanuel
and Michael Hutton
Chapter
E.-M. Mandelkow, E. Thies and E. Mandelkow
Chapter
A. H. Nagahara andM. H. Tuszynski
Index
Alzheimer
Advances in Genetics, Molecular and Cellular Biology
Edited by
Alzheimer s Disease: Advances in Genetics, Molecular and Cellular Biology provides
exciting, comprehensive and up-to-date summaries of the most important recent
advances in the genetic, molecular, biochemical, and cell biological studies of AD. The
studies and advances described in this volume will help to accelerate the process of
rational drug discovery and soon serve to extend and enhance the mental health and
lifespan of our burgeoning elderly population.
In
female admitted to the local asylum who presented with early memory impairments,
psychoses, hallucinations and morbid jealousy. Dr. Alzheimer would argue that specific
lesions that were present in and around neurons were responsible for dementia. In the
ensuing decades, studies of the disorder that affected
Alzheimer s disease (AD), were largely limited to descriptive neuropathological and
psychological assessments of this disease, but with little understanding of the molecular
and cellular mechanisms underlying neurodegeneration and dementia.
This would change in the
neuropathological hallmarks of the disease, senile plaques (and cerebral blood vessel
amyloid) and neurofibrillary tangles were first determined. The identification of the
amyloid protein
of plaques and tangles, respectively, would pave the way for the molecular genetic era of
AD research. By the late-
(APP) and
autosoma!
dementia (FTD). respectively.
In the eariy
be associated with increased risk for late-onset AD. APP mutations increased the
generation and subsequent deposition of the neurotoxic
APOE-S4 affected aggregation of
genes encoding presenilin
МАРТ
molecular studies of age-related dementias with APP, presenilin
playing the major roles.
The vast majority of studies addressing the molecular mechanisms underlying dementia
would continue to focus on characterizing the five genes already firmly implicated in the
etiology and pathogenesis of these dementing disorders, and these efforts have provided
a firm foundation for transnational studies that will hopefully serve to take these findings
from the bench top to the bedside designing and developing novel ways to diagnose,
treat, and prevent these diseases.
|
| adam_txt |
Table
Introduction
Chapter
Lars Bertram
Chapter
Gopal Thinakaran and Edward H. Koo
Chapter
Tomoko Wakabayashi, Takeshi Iwatsubo and Bart
Chapter
Fiona M. Laird,
Alena
Chapter
of Alzheimer's Disease
Karen H. Ashe
Chapter
Henri J. Huttunen and Dora M.
Chapter
Charles
Chapter
Neuronal
Carl W. Cotman and Jorge Busciglio
Chapter
Roberto Malinow, Helen Hsieh and Wei Wei
vi
Chapter
Malcolm Leissring and Takaomi C. Saido
Chapter
and Treatment of Alzheimer's Disease
David M. Holtzman and Berislav Zlokovic
Chapter
Matthew J. Winton, John Q.
Chapter
Karen Duff, Pavan Krishnamurthy, Emmanuel
and Michael Hutton
Chapter
E.-M. Mandelkow, E. Thies and E. Mandelkow
Chapter
A. H. Nagahara andM. H. Tuszynski
Index
Alzheimer
Advances in Genetics, Molecular and Cellular Biology
Edited by
Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology provides
exciting, comprehensive and up-to-date summaries of the most important recent
advances in the genetic, molecular, biochemical, and cell biological studies of AD. The
studies and advances described in this volume will help to accelerate the process of
rational drug discovery and soon serve to extend and enhance the mental health and
lifespan of our burgeoning elderly population.
In
female admitted to the local asylum who presented with early memory impairments,
psychoses, hallucinations and morbid jealousy. Dr. Alzheimer would argue that specific
lesions that were present in and around neurons were responsible for dementia. In the
ensuing decades, studies of the disorder that affected
Alzheimer's disease (AD), were largely limited to descriptive neuropathological and
psychological assessments of this disease, but with little understanding of the molecular
and cellular mechanisms underlying neurodegeneration and dementia.
This would change in the
neuropathological hallmarks of the disease, senile plaques (and cerebral blood vessel
amyloid) and neurofibrillary tangles were first determined. The identification of the
amyloid protein
of plaques and tangles, respectively, would pave the way for the molecular genetic era of
AD research. By the late-
(APP) and
autosoma!
dementia (FTD). respectively.
In the eariy
be associated with increased risk for late-onset AD. APP mutations increased the
generation and subsequent deposition of the neurotoxic
APOE-S4 affected aggregation of
genes encoding presenilin
МАРТ
molecular studies of age-related dementias with APP, presenilin
playing the major roles.
The vast majority of studies addressing the molecular mechanisms underlying dementia
would continue to focus on characterizing the five genes already firmly implicated in the
etiology and pathogenesis of these dementing disorders, and these efforts have provided
a firm foundation for transnational studies that will hopefully serve to take these findings
from the bench top to the bedside designing and developing novel ways to diagnose,
treat, and prevent these diseases. |
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| spelling | Alzheimer's disease advances in genetics, molecular and cellular biology ed. by Sangram S. Sisodia ... New York, NY Springer 2007 IX, 286 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Alzheimer Disease physiopathology Alzheimer's disease Genetic aspects Alzheimer's disease Molecular aspects Alzheimer's disease Pathophysiology Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 s b DE-604 Sisodia, Sangram S. Sonstige (DE-588)173911668 oth text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2809718&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015492718&sequence=000005&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015492718&sequence=000006&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Alzheimer's disease advances in genetics, molecular and cellular biology Alzheimer Disease physiopathology Alzheimer's disease Genetic aspects Alzheimer's disease Molecular aspects Alzheimer's disease Pathophysiology Alzheimerkrankheit (DE-588)4112510-1 gnd |
| subject_GND | (DE-588)4112510-1 |
| title | Alzheimer's disease advances in genetics, molecular and cellular biology |
| title_auth | Alzheimer's disease advances in genetics, molecular and cellular biology |
| title_exact_search | Alzheimer's disease advances in genetics, molecular and cellular biology |
| title_exact_search_txtP | Alzheimer's disease advances in genetics, molecular and cellular biology |
| title_full | Alzheimer's disease advances in genetics, molecular and cellular biology ed. by Sangram S. Sisodia ... |
| title_fullStr | Alzheimer's disease advances in genetics, molecular and cellular biology ed. by Sangram S. Sisodia ... |
| title_full_unstemmed | Alzheimer's disease advances in genetics, molecular and cellular biology ed. by Sangram S. Sisodia ... |
| title_short | Alzheimer's disease |
| title_sort | alzheimer s disease advances in genetics molecular and cellular biology |
| title_sub | advances in genetics, molecular and cellular biology |
| topic | Alzheimer Disease physiopathology Alzheimer's disease Genetic aspects Alzheimer's disease Molecular aspects Alzheimer's disease Pathophysiology Alzheimerkrankheit (DE-588)4112510-1 gnd |
| topic_facet | Alzheimer Disease physiopathology Alzheimer's disease Genetic aspects Alzheimer's disease Molecular aspects Alzheimer's disease Pathophysiology Alzheimerkrankheit |
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