Oligonucleotide therapeutics: first annual meeting of the Oligonucleotide Therapeutics Society
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boston, Mass.
Blackwell
2006
|
| Schriftenreihe: | Annals of the New York Academy of Sciences
1082 |
| Schlagworte: | |
| Online-Zugang: | Table of contents only Inhaltsverzeichnis |
| Beschreibung: | XIII, 182 S. Ill., graph. Darst. |
| ISBN: | 9781573315876 1573315877 |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1082
October 2006
OLIGONUCLEOTIDE THERAPEUTICS
First Annual Meeting of the
Oligonucleotide Therapeutics Society
Editors
Thomas Tuschl and John Rossi
This volume is the result of a conference entitled First Meeting of the Oligonucleotide
Therapeutics Society held by the New York Academy of Sciences and the Oligonucleotide
Therapeutics Society on September 15 18, 2005 at Rockefeller University in New York
City.
CONTENTS
Preface and Overview. By Thomas Tuschl and John Rossi xi
Part I. Delivery
Surface Modified LPD Nanoparticles for Tumor Targeting. By
Shyh Dar Li and Leaf Huang 1
Atelocollagen Mediated Systemic DDS for Nucleic Acid Medicines. By
Koji Hanai, Fumitaka Takeshita, Kimi Honma, Shunji Nacjahara,
Miho Maeda, Yoshiko Minakuchi, Akihiko Sano,
and takahiro ochiya 9
Intracellular Delivery of Oligonucleotide Conjugates and Dendrimer
Complexes. By R.L. Juliano IS
Mechanism of PNA Transport to the Nuclear Compartment. By
Lenka Stankova, Amy J. Ziemba, Zhanna V. Zhilina,
and Scot W. Ebbinghaus 27
Part II. Identifying and Validating Targets and Systems
TLR9 and the Recognition of Self and Non Self Nucleic Acids. By
Marc S. Lamphier, Cherilyn M. Sirois, Anjali Verma,
Douglas T. Golenbock, and Eicke Latz 31
RNA Silencing in the Struggle against Disease. By Volker Patzel, Isabell
Dietrich, and Stefan H.E. Kaufmann 44
Cellular Dynamics of Antisense Oligonucleotides and Short Interfering
RNAs. By Li Kim Lee, Brandee M. Dunham, Zhuting Li,
and Charles M. Roth 47
Inhibition of Hepatitis C IRES Mediated Gene Expression by Small
Hairpin RNAs in Human Hepatocytes and Mice. By Heini Ilves,
Roger L. Kaspar, Qian Wang, Attila A. Seyhan,
Alexander V Vlassov, Christopher H. Contag, Devin Leake,
and Brian H. Johnston 52
SiRNA Mediated Selective Inhibition of Mutant Keratin mRNAs Responsible
for the Skin Disorder Pachyonychia Congenita. By Robyn P. Hickerson,
Frances J.D. Smith, W.H. Irwin McLean, Markus Landthaler,
Rudolf E. Leube, and Roger L. Kaspar 56
Multitargeted Approach Using Antisense Oligonucleotides for the Treatment
of Asthma. By Z. Aixakhverdi, M. Allam, A. Guimond, N. Ferrari,
K. Zemzoumi, R. Seguin, L. Paquet, and P.M. Renzi 62
Therapeutic Modulation of DMD Splicing by Blocking Exonic Splicing
Enhancer Sites with Antisense Oligonucleotides. By A. Aartsma Rus,
A.A.M. Janson, J.A. Heemskerk, C.L. De Winter, G. J.B. Van Ommen,
and J.C.T. Van Deutekom 74
Neuromuscular Therapeutics by RNA Targeted Suppression of ACHE Gene
Expression. By Amir Dori and Hermona Soreq 77
Characterization of Antisense Oligonucleotides Comprising
2 Deoxy 2 Fluoro P D Arabinonucleic Acid (FANA): Specificity,
Potency, and Duration of Activity. By Nicolay Ferrari,
Denis Bergeron, Anna Lisa Tedeschi, Maria M. Mangos,
Luc Paquet, Paolo M. Renzi, and Masad J. Damha 91
Anti HIV Activity of Steric Block Oligonucleotides. By Gabriela Ivanova,
Andrey A. Arzumanov, John J. Turner, Sandrine Reigadas,
Jean Jacques Toulme, Douglas E. Brown, Andrew M.L. Lever, and
Michael J. Gait 103
Selection of Thioaptamers for Diagnostics and Therapeutics. By
Xianbin Yang, He Wang, David W.C. Beasley, David E. Volk,
Xu Zhao, Bruce A. Luxon, Lee O. Lomas, Norbert K. Herzog,
Judith F. Aronson, Alan D.T. Barrett, James F. Leary,
and David G. Gorenstein 116
Modification of the Pig CFTR Gene Mediated by Small Fragment
Homologous Replacement. By Rosalie Maurisse, Judy Cheung,
Jonathan Widdicombe, and Dieter C. Gruenert 120
Part III. Clinical Studies
Nucleic Acid Therapeutics for Hematologic Malignancies—Theoretical
Considerations. By Joanna B. Opalinska, Anna Kalota,
Jyoti Chattopadhyaya, Masad Damha, and Alan M. Gewirtz 124
CpG Oligonucleotides Improve the Protective Immune Response Induced
by the Licensed Anthrax Vaccine. By Dennis M. Klinman, Hang Xie,
and Bruce E. Ivins 137
Anti VEGF Aptamer (Pegaptanib) Therapy for Ocular Vascular Diseases. By
Eugene W.M. Ng and Anthony P. Adamis 151
RNAi in Combination with a Ribozyme and TAR Decoy for Treatment of HIV
Infection in Hematopoietic Cell Gene Therapy. By Mingjie Li,
Haitang Li, and John J. Rossi 172
Index of Contributors 181
Financial assistance was received from:
Silver Sponsors
• Avecia
• Coley Pharmaceutical Group, Inc.
• Isis Pharmaceuticals
• Pfizer, Inc.
• National Institutes of Health/National Cancer Institute
Bronze Sponsors
• AInylam Pharmaceuticals
• ALTANA Pharma AG
• Avatar Pharmaceutical Services Inc.
• Calando Pharmaceuticals
• Dharmacon Inc.
• Dowpharma
• Dynavax Technologies
• Ercole Biotech Inc.
• Eurogentec
• Eyetech Pharmaceuticals
• GE Healthcare
• Genta
• Glen Research Corporation
• IDT
• Invitrogen
• Kinovate Life Sciences, Inc.
• Merck
• Monomer Sciences Inc.
• Pierce Nucleic Acid Technologies
• PrimeSyn Lab Inc.
• Promega
• Sigma Aldrich Corp.
• Topigen
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums.
|
| adam_txt |
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1082
October 2006
OLIGONUCLEOTIDE THERAPEUTICS
First Annual Meeting of the
Oligonucleotide Therapeutics Society
Editors
Thomas Tuschl and John Rossi
This volume is the result of a conference entitled First Meeting of the Oligonucleotide
Therapeutics Society held by the New York Academy of Sciences and the Oligonucleotide
Therapeutics Society on September 15 18, 2005 at Rockefeller University in New York
City.
CONTENTS
Preface and Overview. By Thomas Tuschl and John Rossi xi
Part I. Delivery
Surface Modified LPD Nanoparticles for Tumor Targeting. By
Shyh Dar Li and Leaf Huang 1
Atelocollagen Mediated Systemic DDS for Nucleic Acid Medicines. By
Koji Hanai, Fumitaka Takeshita, Kimi Honma, Shunji Nacjahara,
Miho Maeda, Yoshiko Minakuchi, Akihiko Sano,
and takahiro ochiya 9
Intracellular Delivery of Oligonucleotide Conjugates and Dendrimer
Complexes. By R.L. Juliano IS
Mechanism of PNA Transport to the Nuclear Compartment. By
Lenka Stankova, Amy J. Ziemba, Zhanna V. Zhilina,
and Scot W. Ebbinghaus 27
Part II. Identifying and Validating Targets and Systems
TLR9 and the Recognition of Self and Non Self Nucleic Acids. By
Marc S. Lamphier, Cherilyn M. Sirois, Anjali Verma,
Douglas T. Golenbock, and Eicke Latz 31
RNA Silencing in the Struggle against Disease. By Volker Patzel, Isabell
Dietrich, and Stefan H.E. Kaufmann 44
Cellular Dynamics of Antisense Oligonucleotides and Short Interfering
RNAs. By Li Kim Lee, Brandee M. Dunham, Zhuting Li,
and Charles M. Roth 47
Inhibition of Hepatitis C IRES Mediated Gene Expression by Small
Hairpin RNAs in Human Hepatocytes and Mice. By Heini Ilves,
Roger L. Kaspar, Qian Wang, Attila A. Seyhan,
Alexander V Vlassov, Christopher H. Contag, Devin Leake,
and Brian H. Johnston 52
SiRNA Mediated Selective Inhibition of Mutant Keratin mRNAs Responsible
for the Skin Disorder Pachyonychia Congenita. By Robyn P. Hickerson,
Frances J.D. Smith, W.H. Irwin McLean, Markus Landthaler,
Rudolf E. Leube, and Roger L. Kaspar 56
Multitargeted Approach Using Antisense Oligonucleotides for the Treatment
of Asthma. By Z. Aixakhverdi, M. Allam, A. Guimond, N. Ferrari,
K. Zemzoumi, R. Seguin, L. Paquet, and P.M. Renzi 62
Therapeutic Modulation of DMD Splicing by Blocking Exonic Splicing
Enhancer Sites with Antisense Oligonucleotides. By A. Aartsma Rus,
A.A.M. Janson, J.A. Heemskerk, C.L. De Winter, G. J.B. Van Ommen,
and J.C.T. Van Deutekom 74
Neuromuscular Therapeutics by RNA Targeted Suppression of ACHE Gene
Expression. By Amir Dori and Hermona Soreq 77
Characterization of Antisense Oligonucleotides Comprising
2' Deoxy 2' Fluoro P D Arabinonucleic Acid (FANA): Specificity,
Potency, and Duration of Activity. By Nicolay Ferrari,
Denis Bergeron, Anna Lisa Tedeschi, Maria M. Mangos,
Luc Paquet, Paolo M. Renzi, and Masad J. Damha 91
Anti HIV Activity of Steric Block Oligonucleotides. By Gabriela Ivanova,
Andrey A. Arzumanov, John J. Turner, Sandrine Reigadas,
Jean Jacques Toulme, Douglas E. Brown, Andrew M.L. Lever, and
Michael J. Gait 103
Selection of Thioaptamers for Diagnostics and Therapeutics. By
Xianbin Yang, He Wang, David W.C. Beasley, David E. Volk,
Xu Zhao, Bruce A. Luxon, Lee O. Lomas, Norbert K. Herzog,
Judith F. Aronson, Alan D.T. Barrett, James F. Leary,
and David G. Gorenstein 116
Modification of the Pig CFTR Gene Mediated by Small Fragment
Homologous Replacement. By Rosalie Maurisse, Judy Cheung,
Jonathan Widdicombe, and Dieter C. Gruenert 120
Part III. Clinical Studies
Nucleic Acid Therapeutics for Hematologic Malignancies—Theoretical
Considerations. By Joanna B. Opalinska, Anna Kalota,
Jyoti Chattopadhyaya, Masad Damha, and Alan M. Gewirtz 124
CpG Oligonucleotides Improve the Protective Immune Response Induced
by the Licensed Anthrax Vaccine. By Dennis M. Klinman, Hang Xie,
and Bruce E. Ivins 137
Anti VEGF Aptamer (Pegaptanib) Therapy for Ocular Vascular Diseases. By
Eugene W.M. Ng and Anthony P. Adamis 151
RNAi in Combination with a Ribozyme and TAR Decoy for Treatment of HIV
Infection in Hematopoietic Cell Gene Therapy. By Mingjie Li,
Haitang Li, and John J. Rossi 172
Index of Contributors 181
Financial assistance was received from:
Silver Sponsors
• Avecia
• Coley Pharmaceutical Group, Inc.
• Isis Pharmaceuticals
• Pfizer, Inc.
• National Institutes of Health/National Cancer Institute
Bronze Sponsors
• AInylam Pharmaceuticals
• ALTANA Pharma AG
• Avatar Pharmaceutical Services Inc.
• Calando Pharmaceuticals
• Dharmacon Inc.
• Dowpharma
• Dynavax Technologies
• Ercole Biotech Inc.
• Eurogentec
• Eyetech Pharmaceuticals
• GE Healthcare
• Genta
• Glen Research Corporation
• IDT
• Invitrogen
• Kinovate Life Sciences, Inc.
• Merck
• Monomer Sciences Inc.
• Pierce Nucleic Acid Technologies
• PrimeSyn Lab Inc.
• Promega
• Sigma Aldrich Corp.
• Topigen
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums. |
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| index_date | 2024-07-02T16:30:48Z |
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| spelling | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society ed. by Thomas Tuschl ... Boston, Mass. Blackwell 2006 XIII, 182 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 1082 Antisense RNA - Congresses - Therapeutic use Oligonucleotides - Congresses - Therapeutic use Oligonucleotides - Congresses - pharmacokinetics Oligonucleotides - Congresses - therapeutic use Oligonucleotides Therapeutic use Congresses Antisense RNA Therapeutic use Congresses Oligonucleotides therapeutic use Congresses Oligonucleotides pharmacokinetics Congresses Heilmittel (DE-588)4024069-1 gnd rswk-swf Oligonucleotide (DE-588)4133456-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2005 New York, NY gnd-content Oligonucleotide (DE-588)4133456-5 s Heilmittel (DE-588)4024069-1 s DE-604 Tuschl, Thomas 1966- Sonstige (DE-588)115043187 oth Annals of the New York Academy of Sciences 1082 (DE-604)BV002532608 1082 http://www.loc.gov/catdir/toc/ecip0618/2006024996.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015436644&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society Annals of the New York Academy of Sciences Antisense RNA - Congresses - Therapeutic use Oligonucleotides - Congresses - Therapeutic use Oligonucleotides - Congresses - pharmacokinetics Oligonucleotides - Congresses - therapeutic use Oligonucleotides Therapeutic use Congresses Antisense RNA Therapeutic use Congresses Oligonucleotides therapeutic use Congresses Oligonucleotides pharmacokinetics Congresses Heilmittel (DE-588)4024069-1 gnd Oligonucleotide (DE-588)4133456-5 gnd |
| subject_GND | (DE-588)4024069-1 (DE-588)4133456-5 (DE-588)1071861417 |
| title | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society |
| title_auth | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society |
| title_exact_search | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society |
| title_exact_search_txtP | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society |
| title_full | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society ed. by Thomas Tuschl ... |
| title_fullStr | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society ed. by Thomas Tuschl ... |
| title_full_unstemmed | Oligonucleotide therapeutics first annual meeting of the Oligonucleotide Therapeutics Society ed. by Thomas Tuschl ... |
| title_short | Oligonucleotide therapeutics |
| title_sort | oligonucleotide therapeutics first annual meeting of the oligonucleotide therapeutics society |
| title_sub | first annual meeting of the Oligonucleotide Therapeutics Society |
| topic | Antisense RNA - Congresses - Therapeutic use Oligonucleotides - Congresses - Therapeutic use Oligonucleotides - Congresses - pharmacokinetics Oligonucleotides - Congresses - therapeutic use Oligonucleotides Therapeutic use Congresses Antisense RNA Therapeutic use Congresses Oligonucleotides therapeutic use Congresses Oligonucleotides pharmacokinetics Congresses Heilmittel (DE-588)4024069-1 gnd Oligonucleotide (DE-588)4133456-5 gnd |
| topic_facet | Antisense RNA - Congresses - Therapeutic use Oligonucleotides - Congresses - Therapeutic use Oligonucleotides - Congresses - pharmacokinetics Oligonucleotides - Congresses - therapeutic use Oligonucleotides Therapeutic use Congresses Antisense RNA Therapeutic use Congresses Oligonucleotides therapeutic use Congresses Oligonucleotides pharmacokinetics Congresses Heilmittel Oligonucleotide Konferenzschrift 2005 New York, NY |
| url | http://www.loc.gov/catdir/toc/ecip0618/2006024996.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015436644&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT tuschlthomas oligonucleotidetherapeuticsfirstannualmeetingoftheoligonucleotidetherapeuticssociety |