Expression and function of midkine and pleiotrophin in meningiomas:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Mikrofilm Buch |
| Sprache: | English |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Kiel, Univ., Diss., 2006 |
| Beschreibung: | 57 Bl. Ill., graph. Darst. |
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Datensatz im Suchindex
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| adam_text | Titel: Expression and function of midkine and pleiotrophin in meningiomas
Autor: Tong, Ying
Jahr: 2006
Contents
1 Introduction I
1.1 Origination, epidemiology and prognosis of meningiomas I
1.2 Genetic aspects of meningiomas I
1.3 Heparin-binding growth factor family 2
1.4 Protein structure and genomical organization 2
1.5 Expression of midkine and pleiotrophin .1
1.6 Receptors and signal pathways 4
1.7 Cancer-related biological activity 5
1.8 Application 6
1.9 Aim of study 7
2 Materials and Methods 8
2.1 Clinical material 8
2.2 Cell culture X
2.3 Immunohistochemistry 9
2.4 RNA isolation 9
2.5 cDNA synthesis 10
2.6 Real-time RT-PCR 10
2.7 RT-PCR 11
2.8 Enzyme-linked immunosorbent assay ( Midkine-ELISA) 11
2.9 Western blot 12
2.10 Proliferation assay 13
2.11 Antiapoptotic assay 13
2.12 Statistical analysis 14
3 Result 15
3.1 Midkine and pleiotrophin mRNA expression in meningioma tissues 15
3.2 Expression of truncated form of midkine 18
3.3 Midkine protein expression in meningioma tissues 19
3.3.1 Immunohistochemistry 19
3.3.2 Midkine ELISA 20
3.4 Expression of midkine receptors
3.5 Signal transduction pathways of midkine in meningiomas
3.6 Biological effects of midkine in meningiomas
4 Discussion -
4.1 Introduction 30
4.2 Expression levels of midkine and pleiotrophin in meningiomas 31
4.3 Expression of truncated form of midkine 33
4.4 Expression of midkine receptors 34
4.5 Possible signal transduction pathway 35
4.6 Biological effects of midkine in meningioma cells 37
5 Summary 39
6 References 41
7 Appendix 51
8 Acknowledgements 56
9 Curriculum Vitae 57
|
| adam_txt |
Titel: Expression and function of midkine and pleiotrophin in meningiomas
Autor: Tong, Ying
Jahr: 2006
Contents
1 Introduction I
1.1 Origination, epidemiology and prognosis of meningiomas I
1.2 Genetic aspects of meningiomas I
1.3 Heparin-binding growth factor family 2
1.4 Protein structure and genomical organization 2
1.5 Expression of midkine and pleiotrophin .1
1.6 Receptors and signal pathways 4
1.7 Cancer-related biological activity 5
1.8 Application 6
1.9 Aim of study 7
2 Materials and Methods 8
2.1 Clinical material 8
2.2 Cell culture X
2.3 Immunohistochemistry 9
2.4 RNA isolation 9
2.5 cDNA synthesis 10
2.6 Real-time RT-PCR 10
2.7 RT-PCR 11
2.8 Enzyme-linked immunosorbent assay ( Midkine-ELISA) 11
2.9 Western blot 12
2.10 Proliferation assay 13
2.11 Antiapoptotic assay 13
2.12 Statistical analysis 14
3 Result 15
3.1 Midkine and pleiotrophin mRNA expression in meningioma tissues 15
3.2 Expression of truncated form of midkine 18
3.3 Midkine protein expression in meningioma tissues 19
3.3.1 Immunohistochemistry 19
3.3.2 Midkine ELISA 20
3.4 Expression of midkine receptors
3.5 Signal transduction pathways of midkine in meningiomas
3.6 Biological effects of midkine in meningiomas
4 Discussion -
4.1 Introduction 30
4.2 Expression levels of midkine and pleiotrophin in meningiomas 31
4.3 Expression of truncated form of midkine 33
4.4 Expression of midkine receptors 34
4.5 Possible signal transduction pathway 35
4.6 Biological effects of midkine in meningioma cells 37
5 Summary 39
6 References 41
7 Appendix 51
8 Acknowledgements 56
9 Curriculum Vitae 57 |
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| index_date | 2024-07-02T16:27:47Z |
| indexdate | 2024-07-09T20:52:36Z |
| institution | BVB |
| language | English |
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| physical | 57 Bl. Ill., graph. Darst. |
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| spelling | Tong, Ying 1971- Verfasser (DE-588)131920235 aut Expression and function of midkine and pleiotrophin in meningiomas vorgelegt von Ying Tong 2006 57 Bl. Ill., graph. Darst. txt rdacontent h rdamedia he rdacarrier Kiel, Univ., Diss., 2006 Mikroform-Ausgabe 2006 1 Mikrofiche : 24x Mikrofiche-Ausg.: [Mikrofiche-Ausg.] Signatur des reproduzierten Kulturobjekts: L_x001C_2006 MF 728 s2006 Genexpression Hochschulschrift Meningeom Nervenwachstumsfaktor (DE-588)4113937-9 Hochschulschrift gnd-content Reproduktion von Tong, Ying, 1971- Expression and function of midkine and pleiotrophin in meningiomas 2006 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015428419&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tong, Ying 1971- Expression and function of midkine and pleiotrophin in meningiomas Genexpression Hochschulschrift Meningeom Nervenwachstumsfaktor |
| subject_GND | (DE-588)4113937-9 |
| title | Expression and function of midkine and pleiotrophin in meningiomas |
| title_auth | Expression and function of midkine and pleiotrophin in meningiomas |
| title_exact_search | Expression and function of midkine and pleiotrophin in meningiomas |
| title_exact_search_txtP | Expression and function of midkine and pleiotrophin in meningiomas |
| title_full | Expression and function of midkine and pleiotrophin in meningiomas vorgelegt von Ying Tong |
| title_fullStr | Expression and function of midkine and pleiotrophin in meningiomas vorgelegt von Ying Tong |
| title_full_unstemmed | Expression and function of midkine and pleiotrophin in meningiomas vorgelegt von Ying Tong |
| title_short | Expression and function of midkine and pleiotrophin in meningiomas |
| title_sort | expression and function of midkine and pleiotrophin in meningiomas |
| topic | Genexpression Hochschulschrift Meningeom Nervenwachstumsfaktor |
| topic_facet | Genexpression Hochschulschrift Meningeom Nervenwachstumsfaktor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015428419&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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