Tetrachloroethene:
Tetrachloroethene is used mainly in the dry cleaning of textiles, as a chemical intermediate and in metal degreasing. This report evaluates the available scientific literature on the health and environmental effects of tetrachloroethene based on selected national and regional evaluations. Of key int...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | French Spanish English |
| Veröffentlicht: |
Geneva
World Health Organization
2006
|
| Schriftenreihe: | Concise international chemical assessment document
68 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | Tetrachloroethene is used mainly in the dry cleaning of textiles, as a chemical intermediate and in metal degreasing. This report evaluates the available scientific literature on the health and environmental effects of tetrachloroethene based on selected national and regional evaluations. Of key interest is the relevance of several types of tumors included by tetrachloroethene in rats and mice. The report goes on to establish the criteria for setting tolerable intakes and concentrations taking into consideration the potential carcinogenicity, neurotoxicity, kidney, liver and reproductive/developmental toxicity and cancer. Environmental effects are assessed for terrestrial and aquatic organisms , sediment-dwelling organisms and micro-organisms in sewerage treatment processes. In addition the risks of harm to plants from air emissions of tetrachloroethene are discussed. Uncertainties in the risk assessment are set out for both human health and the environment.--Publisher's decription. |
| Beschreibung: | 115 S. |
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| 490 | 1 | |a Concise international chemical assessment document |v 68 | |
| 520 | 3 | |a Tetrachloroethene is used mainly in the dry cleaning of textiles, as a chemical intermediate and in metal degreasing. This report evaluates the available scientific literature on the health and environmental effects of tetrachloroethene based on selected national and regional evaluations. Of key interest is the relevance of several types of tumors included by tetrachloroethene in rats and mice. The report goes on to establish the criteria for setting tolerable intakes and concentrations taking into consideration the potential carcinogenicity, neurotoxicity, kidney, liver and reproductive/developmental toxicity and cancer. Environmental effects are assessed for terrestrial and aquatic organisms , sediment-dwelling organisms and micro-organisms in sewerage treatment processes. In addition the risks of harm to plants from air emissions of tetrachloroethene are discussed. Uncertainties in the risk assessment are set out for both human health and the environment.--Publisher's decription. | |
| 650 | 7 | |a Arbeidshygiëne |2 gtt | |
| 650 | 7 | |a Blootstelling |2 gtt | |
| 650 | 7 | |a Farmacologia |2 larpcal | |
| 650 | 7 | |a Gezondheidseffecten |2 gtt | |
| 650 | 4 | |a Solvants - Aspect de l'environnement | |
| 650 | 7 | |a Tetrachloorethyleen |2 gtt | |
| 650 | 7 | |a Tetracloroetileno - Aspectos ambientales |2 renib | |
| 650 | 7 | |a Tetracloroetileno - Efectos fisiológicos |2 renib | |
| 650 | 7 | |a Tetracloroetileno - Toxicología |2 renib | |
| 650 | 7 | |a Toxiciteit |2 gtt | |
| 650 | 4 | |a Tétrachloroéthylène | |
| 650 | 7 | |a Veiligheid |2 gtt | |
| 650 | 4 | |a Umwelt | |
| 650 | 4 | |a Environmental Exposure |x adverse effects | |
| 650 | 4 | |a Risk Assessment | |
| 650 | 4 | |a Solvents |x Environmental aspects | |
| 650 | 4 | |a Tetrachloroethylene |x Environmental aspects | |
| 650 | 4 | |a Tetrachloroethylene |x Physiological effect | |
| 650 | 4 | |a Tetrachloroethylene |x adverse effects | |
| 650 | 4 | |a Tetrachloroethylene |x toxicity | |
| 700 | 1 | |a Watts, Peter |e Sonstige |4 oth | |
| 710 | 2 | |a International Programme on Chemical Safety |e Sonstige |0 (DE-588)308058-4 |4 oth | |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6
3. ANALYTICAL METHODS 7
3.1 Environmental monitoring 7
3.2 Biological monitoring 8
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 9
4.1 Natural sources 9
4.2 Anthropogenic sources 9
4.3 Production and use 9
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 9
5.1 Environmental releases 9
5.2 Environmental partitioning 10
5.3 Bioaccumulation 11
5.4 Environmental degradation 12
5.4.1 Atmospheric degradation 12
5.4.2 Aquatic degradation and biodegradation 13
5.5 Contribution to photochemical ozone production and ozone depletion 16
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 16
6.1 Environmental levels 16
6.1.1 Ambient air 16
6.1.2 Indoor air 17
6.1.3 Drinking water 17
6.1.4 Surface water 17
6.1.5 Groundwater 18
6.1.6 Sediment and soil 18
6.1.7 Sewage and municipal wastewater 18
6.1.8 Food 18
6.2 Human exposure: environmental 19
6.3 Human exposure: occupational 19
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 20
7.1 Absorption 20
7.2 Distribution 21
7.3 Biotransformation 22
7.4 Excretion 25
7.5 Biological monitoring 26
7.6 Physiologically based pharmacokinetic models 26
iii
Concise International Chemical Assessment Document 68
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 27
8.1 Single exposure 27
8.1.1 Inhalation 27
8.1.2 Oral 28
8.1.3 Dermal 28
8.2 Short term and medium term exposure 28
8.2.1 Inhalation 28
8.2.2 Oral 32
8.3 Long term exposure and carcinogenicity 34
8.3.1 Inhalation 34
8.3.2 Oral 35
8.3.3 Dermal 36
8.3.4 Injection 36
8.3.5 Initiation/promotion studies 36
8.4 Genotoxicity and related end points 37
8.4.1 In vivo studies 37
8.4.2 In vitro studies 37
8.5 Reproductive toxicity 38
8.5.1 Effects on fertility 38
8.5.2 Developmental toxicity 39
8.6 Other toxicity 40
8.7 Mode of action 40
9. EFFECTS ON HUMANS 42
9.1 Local effects (irritation and sensitization) 42
9.2 General systemic effects 42
9.3 Carcinogenicity 43
9.4 Genotoxicity 51
9.5 Reproductive and developmental toxicity 51
9.6 Nephrotoxicity 53
9.7 Hepatotoxicity 54
9.8 Neurotoxicity 55
9.8.1 Studies on volunteers 55
9.8.2 Studies on occupational and residential exposure 56
9.9 Cardiotoxicity 59
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 59
10.1 Aquatic environment 59
10.1.1 Aquatic microorganisms 59
10.1.2 Aquatic plants (algae) 60
10.1.3 Aquatic invertebrates 60
10.1.4 Field study data 60
10.1.5 Fish 60
10.2 Terrestrial environment 61
10.2.1 Terrestrial mammals 61
10.2.2 Terrestrial invertebrates 61
10.2.3 Soil dwelling bacteria 62
10.2.4 Terrestrial plants 62
11. EFFECTS EVALUATION 64
11.1 Evaluation of health effects 64
iv
Tetrachloroethene
11.1.1 Hazard identification and dose response assessment 65
11.1.2 Criteria for setting tolerable intakes and concentrations 68
11.1.3 Sample risk characterization 69
11.1.4 Uncertainties in the evaluation of health risks 69
11.2 Evaluation of environmental effects 70
11.2.1 Assessment end points 70
11.2.2 Sample environmental risk characterization 70
11.2.3 Uncertainties in the environmental risk assessment 74
12. PREVIOUS EVALUATIONS BY IOMC BODIES 74
REFERENCES 75
APPENDIX 1 — ACRONYMS AND ABBREVIATIONS 93
APPENDIX 2 — SOURCE DOCUMENTS 94
APPENDIX 3 — CICAD PEER REVIEW 97
APPENDIX 4 — 12TH CICAD FINAL REVIEW BOARD 98
APPENDIX 5 — CONSULTATIVE GROUP 99
APPENDIX 6 — 13TH CICAD FINAL REVIEW BOARD 99
APPENDIX 7 — CALCULATION OF BMC AND BMCL 100
APPENDIX 8 — DERIVATION OF AN ORAL DOSE EQUIVALENT TO INHALATION TOLERABLE
CONCENTRATION BY PBPK MODELLING 104
INTERNATIONAL CHEMICAL SAFETY CARD 106
RESUME D ORIENTATION 108
RESUMEN DE ORIENTACION 112
v
|
| adam_txt |
TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6
3. ANALYTICAL METHODS 7
3.1 Environmental monitoring 7
3.2 Biological monitoring 8
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 9
4.1 Natural sources 9
4.2 Anthropogenic sources 9
4.3 Production and use 9
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 9
5.1 Environmental releases 9
5.2 Environmental partitioning 10
5.3 Bioaccumulation 11
5.4 Environmental degradation 12
5.4.1 Atmospheric degradation 12
5.4.2 Aquatic degradation and biodegradation 13
5.5 Contribution to photochemical ozone production and ozone depletion 16
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 16
6.1 Environmental levels 16
6.1.1 Ambient air 16
6.1.2 Indoor air 17
6.1.3 Drinking water 17
6.1.4 Surface water 17
6.1.5 Groundwater 18
6.1.6 Sediment and soil 18
6.1.7 Sewage and municipal wastewater 18
6.1.8 Food 18
6.2 Human exposure: environmental 19
6.3 Human exposure: occupational 19
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 20
7.1 Absorption 20
7.2 Distribution 21
7.3 Biotransformation 22
7.4 Excretion 25
7.5 Biological monitoring 26
7.6 Physiologically based pharmacokinetic models 26
iii
Concise International Chemical Assessment Document 68
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 27
8.1 Single exposure 27
8.1.1 Inhalation 27
8.1.2 Oral 28
8.1.3 Dermal 28
8.2 Short term and medium term exposure 28
8.2.1 Inhalation 28
8.2.2 Oral 32
8.3 Long term exposure and carcinogenicity 34
8.3.1 Inhalation 34
8.3.2 Oral 35
8.3.3 Dermal 36
8.3.4 Injection 36
8.3.5 Initiation/promotion studies 36
8.4 Genotoxicity and related end points 37
8.4.1 In vivo studies 37
8.4.2 In vitro studies 37
8.5 Reproductive toxicity 38
8.5.1 Effects on fertility 38
8.5.2 Developmental toxicity 39
8.6 Other toxicity 40
8.7 Mode of action 40
9. EFFECTS ON HUMANS 42
9.1 Local effects (irritation and sensitization) 42
9.2 General systemic effects 42
9.3 Carcinogenicity 43
9.4 Genotoxicity 51
9.5 Reproductive and developmental toxicity 51
9.6 Nephrotoxicity 53
9.7 Hepatotoxicity 54
9.8 Neurotoxicity 55
9.8.1 Studies on volunteers 55
9.8.2 Studies on occupational and residential exposure 56
9.9 Cardiotoxicity 59
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 59
10.1 Aquatic environment 59
10.1.1 Aquatic microorganisms 59
10.1.2 Aquatic plants (algae) 60
10.1.3 Aquatic invertebrates 60
10.1.4 Field study data 60
10.1.5 Fish 60
10.2 Terrestrial environment 61
10.2.1 Terrestrial mammals 61
10.2.2 Terrestrial invertebrates 61
10.2.3 Soil dwelling bacteria 62
10.2.4 Terrestrial plants 62
11. EFFECTS EVALUATION 64
11.1 Evaluation of health effects 64
iv
Tetrachloroethene
11.1.1 Hazard identification and dose response assessment 65
11.1.2 Criteria for setting tolerable intakes and concentrations 68
11.1.3 Sample risk characterization 69
11.1.4 Uncertainties in the evaluation of health risks 69
11.2 Evaluation of environmental effects 70
11.2.1 Assessment end points 70
11.2.2 Sample environmental risk characterization 70
11.2.3 Uncertainties in the environmental risk assessment 74
12. PREVIOUS EVALUATIONS BY IOMC BODIES 74
REFERENCES 75
APPENDIX 1 — ACRONYMS AND ABBREVIATIONS 93
APPENDIX 2 — SOURCE DOCUMENTS 94
APPENDIX 3 — CICAD PEER REVIEW 97
APPENDIX 4 — 12TH CICAD FINAL REVIEW BOARD 98
APPENDIX 5 — CONSULTATIVE GROUP 99
APPENDIX 6 — 13TH CICAD FINAL REVIEW BOARD 99
APPENDIX 7 — CALCULATION OF BMC AND BMCL 100
APPENDIX 8 — DERIVATION OF AN ORAL DOSE EQUIVALENT TO INHALATION TOLERABLE
CONCENTRATION BY PBPK MODELLING 104
INTERNATIONAL CHEMICAL SAFETY CARD 106
RESUME D'ORIENTATION 108
RESUMEN DE ORIENTACION 112
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| id | DE-604.BV022215858 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T16:27:19Z |
| indexdate | 2024-07-09T20:52:34Z |
| institution | BVB |
| institution_GND | (DE-588)308058-4 |
| language | French Spanish English |
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| physical | 115 S. |
| publishDate | 2006 |
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| publishDateSort | 2006 |
| publisher | World Health Organization |
| record_format | marc |
| series | Concise international chemical assessment document |
| series2 | Concise international chemical assessment document |
| spelling | Tetrachloroethene 1. draft prepared by Peter Watts ... Geneva World Health Organization 2006 115 S. txt rdacontent n rdamedia nc rdacarrier Concise international chemical assessment document 68 Tetrachloroethene is used mainly in the dry cleaning of textiles, as a chemical intermediate and in metal degreasing. This report evaluates the available scientific literature on the health and environmental effects of tetrachloroethene based on selected national and regional evaluations. Of key interest is the relevance of several types of tumors included by tetrachloroethene in rats and mice. The report goes on to establish the criteria for setting tolerable intakes and concentrations taking into consideration the potential carcinogenicity, neurotoxicity, kidney, liver and reproductive/developmental toxicity and cancer. Environmental effects are assessed for terrestrial and aquatic organisms , sediment-dwelling organisms and micro-organisms in sewerage treatment processes. In addition the risks of harm to plants from air emissions of tetrachloroethene are discussed. Uncertainties in the risk assessment are set out for both human health and the environment.--Publisher's decription. Arbeidshygiëne gtt Blootstelling gtt Farmacologia larpcal Gezondheidseffecten gtt Solvants - Aspect de l'environnement Tetrachloorethyleen gtt Tetracloroetileno - Aspectos ambientales renib Tetracloroetileno - Efectos fisiológicos renib Tetracloroetileno - Toxicología renib Toxiciteit gtt Tétrachloroéthylène Veiligheid gtt Umwelt Environmental Exposure adverse effects Risk Assessment Solvents Environmental aspects Tetrachloroethylene Environmental aspects Tetrachloroethylene Physiological effect Tetrachloroethylene adverse effects Tetrachloroethylene toxicity Watts, Peter Sonstige oth International Programme on Chemical Safety Sonstige (DE-588)308058-4 oth Concise international chemical assessment document 68 (DE-604)BV021595306 68 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015427150&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tetrachloroethene Concise international chemical assessment document Arbeidshygiëne gtt Blootstelling gtt Farmacologia larpcal Gezondheidseffecten gtt Solvants - Aspect de l'environnement Tetrachloorethyleen gtt Tetracloroetileno - Aspectos ambientales renib Tetracloroetileno - Efectos fisiológicos renib Tetracloroetileno - Toxicología renib Toxiciteit gtt Tétrachloroéthylène Veiligheid gtt Umwelt Environmental Exposure adverse effects Risk Assessment Solvents Environmental aspects Tetrachloroethylene Environmental aspects Tetrachloroethylene Physiological effect Tetrachloroethylene adverse effects Tetrachloroethylene toxicity |
| title | Tetrachloroethene |
| title_auth | Tetrachloroethene |
| title_exact_search | Tetrachloroethene |
| title_exact_search_txtP | Tetrachloroethene |
| title_full | Tetrachloroethene 1. draft prepared by Peter Watts ... |
| title_fullStr | Tetrachloroethene 1. draft prepared by Peter Watts ... |
| title_full_unstemmed | Tetrachloroethene 1. draft prepared by Peter Watts ... |
| title_short | Tetrachloroethene |
| title_sort | tetrachloroethene |
| topic | Arbeidshygiëne gtt Blootstelling gtt Farmacologia larpcal Gezondheidseffecten gtt Solvants - Aspect de l'environnement Tetrachloorethyleen gtt Tetracloroetileno - Aspectos ambientales renib Tetracloroetileno - Efectos fisiológicos renib Tetracloroetileno - Toxicología renib Toxiciteit gtt Tétrachloroéthylène Veiligheid gtt Umwelt Environmental Exposure adverse effects Risk Assessment Solvents Environmental aspects Tetrachloroethylene Environmental aspects Tetrachloroethylene Physiological effect Tetrachloroethylene adverse effects Tetrachloroethylene toxicity |
| topic_facet | Arbeidshygiëne Blootstelling Farmacologia Gezondheidseffecten Solvants - Aspect de l'environnement Tetrachloorethyleen Tetracloroetileno - Aspectos ambientales Tetracloroetileno - Efectos fisiológicos Tetracloroetileno - Toxicología Toxiciteit Tétrachloroéthylène Veiligheid Umwelt Environmental Exposure adverse effects Risk Assessment Solvents Environmental aspects Tetrachloroethylene Environmental aspects Tetrachloroethylene Physiological effect Tetrachloroethylene adverse effects Tetrachloroethylene toxicity |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015427150&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV021595306 |
| work_keys_str_mv | AT wattspeter tetrachloroethene AT internationalprogrammeonchemicalsafety tetrachloroethene |