Introduction to genomics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2007
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 419 S. zahlr. Ill., graph. Darst. |
| ISBN: | 0199296952 9780199296958 |
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| adam_text | TABLE
Preface vii
Acknowledgements
part
1
The human genome
4
Haemoglobin
5
Expression of the human haemoglobin
9
Haemoglobinopathies
haemoglobins
13
Control of
14
Classical genetics as background
15
Discovery of the structure of
17
Development of the Human Genome Project
21
Ethical, legal, and social issues
24
A/laps and tour guides
27
Genetic maps
27
Linkage
29
Linkage disequilibrium
31
Chromosome banding pattern maps
32
High-resolution maps, based directly on
35
Restriction maps
37
Single-nucleotide polymorphisms and haplotypes
38
Bioinformatics and computational biology
43
Contents and organization of genomes
46
Chromosomes,
46
Genes
47
Dynamic components of genomes
51
Regulation of gene expression
53
More than a genome: phenotype
+
57
The human genome and medicine
58
Contents
2
Introduction
72
Unity and diversity of life
72
Sizes and organization of genomes
79
Genome sizes
79
Viral genomes
82
Influenza: a past and current threat
85
Genome organization in prokaryotes
88
Genome organization in eukaryotes
92
How genomes differ
95
Variation at the level of individual nucleotides
95
Duplications
95
Comparisons at the chromosome level: synteny
105
What makes us human?
105
Genes and minds: neurogenomics
108
Genomes of chimpanzees and humans
112
Genomes of mice and rats
113
Flies and worms are model organisms for the study of
human diseases
115
Genome sequencing projects
119
partii
3
Evolution is exploration
Species
Biological systematics
Biological nomenclature
Measurement of biological similarities and differences
Phylogeny
Phylogenetic trees
Clustering methods
Cladistic methods
The problem of varying rates of evolution
Evolution and phylogenetic relationships in prokaryotes
Major types of prokaryote
Do we know the root of the tree of life?
Contents
Archaea 156
The genome of
Life at extreme temperatures
Comparative genomics of hyperthermophilic archaea: Thermococcus
kodakarensis and Pyrococci
Bacteria
Metagenomics: the collection of genomes in a coherent
environmental sample
Marine cyanobacteria
Evolution and phylogenetic relationships in eukaryotes
The evolution of plants
The domestication of maize
The dog genome
Genomics in anthropology: ancient populations and migrations
Genomics and languages
4
DNA
Frederick
The Maxam-Gilbert chemical cleavage method
Automated
DNA
Organizing a large-scale sequencing project
Bring on the clones: hierarchical
Whole-genome shotgun sequencing
Resequencing
Sequence databanking and annotation
Genomics in personal identification
Annotation of protein-encoding genes
Evolution of protein sequences, structures, and functions
Pattern matching
Computers and computer science
Sequence alignment
Defining the optimum alignment
Approximate methods for quick screening of databases
Pattern matching in three-dimensional structures
Classification and assignment of protein function
Development of databanks in molecular biology
Nucleic acid sequence databases
Genome browsers
Contents
Protein
Databases of genetic diseases
Databases of structures
Classifications of protein structures
Specialized or boutique databases
Expression and proteomics databases
Databases of metabolic pathways
Bibliographic databases
Surveys of molecular biology databases and servers
part
5
Introduction
Analysis of microarray data
Expression patterns in different physiological states
The diauxic shift in Saccharomyces cerevisiae
Sleep in rats and fruit flies
Expression pattern changes in development
Variation of expression patterns during the life cycle of
melanogaster
Flower formation in roses
Gene expression patterns in learning and memory:
long-term potentiation
Evolutionary changes in expression patterns
Applications of microarrays in medicine
Development of antibiotic resistance in bacteria
Childhood leukaemias
6
Introduction
Protein nature and types
Protein structure
The chemical structure of proteins
Conformation of the polypeptide chain
Protein folding patterns
Post-translational modifications
Why is there a common genetic code with
Contents
Separation
317
Polyacrylamide gel electrophoresis (PAGE)
318
Mass spectrometry
319
Classification of Protein Structures
322
SCOP
324
Changes in folding patterns in protein evolution
325
Many proteins change conformation as part of the mechanism of
their function
327
Conformational change during enzymatic catalysis
327
Motor proteins
330
Allosteric regulation of protein function
331
Conformational states of
335
Protein structure prediction and modelling
337
Homology modelling
339
Methods specialized to particular types of structure
343
Available protocols
344
Structural genomics
345
Directed evolution and protein design
346
Directed evolution of subtilisin
347
Enzyme design
348
Protein complexes and aggregates
349
Properties of protein-protein complexes
350
Multisubunit proteins
352
7
Introduction
Pictures of networks as graphs
Dynamics, stability, and robustness
Sources of ideas for systems biology
Shannon s definition of entropy
Randomness of sequences
Static and dynamic complexity
Computational complexity
Metabolic networks
Methionine synthesis in Escherichia
Dynamic modelling
Protein interaction networks
Structural biology of regulatory networks
Contents
Protein-DNA interactions
Structural themes in protein-DNA binding and sequence recognition
An album of transcription regulators
Protein-protein and protein-nucleic acid interactions
Regulation of the lactose
Regulatory networks
Signal transduction and transcriptional control
Structures of regulatory networks
The genetic regulatory network of Saccharomyces cerevisiae
Adaptability of the yeast regulatory network
Epilogue
Index
|
| adam_txt |
TABLE
Preface vii
Acknowledgements
part
1
The human genome
4
Haemoglobin
5
Expression of the human haemoglobin
9
Haemoglobinopathies
haemoglobins
13
Control of
14
Classical genetics as background
15
Discovery of the structure of
17
Development of the Human Genome Project
21
Ethical, legal, and social issues
24
A/laps and tour guides
27
Genetic maps
27
Linkage
29
Linkage disequilibrium
31
Chromosome banding pattern maps
32
High-resolution maps, based directly on
35
Restriction maps
37
Single-nucleotide polymorphisms and haplotypes
38
Bioinformatics and computational biology
43
Contents and organization of genomes
46
Chromosomes,
46
Genes
47
Dynamic components of genomes
51
Regulation of gene expression
53
More than a genome: phenotype
+
57
The human genome and medicine
58
Contents
2
Introduction
72
Unity and diversity of life
72
Sizes and organization of genomes
79
Genome sizes
79
Viral genomes
82
Influenza: a past and current threat
85
Genome organization in prokaryotes
88
Genome organization in eukaryotes
92
How genomes differ
95
Variation at the level of individual nucleotides
95
Duplications
95
Comparisons at the chromosome level: synteny
105
What makes us human?
105
Genes and minds: neurogenomics
108
Genomes of chimpanzees and humans
112
Genomes of mice and rats
113
Flies and worms are model organisms for the study of
human diseases
115
Genome sequencing projects
119
partii
3
Evolution is exploration
Species
Biological systematics
Biological nomenclature
Measurement of biological similarities and differences
Phylogeny
Phylogenetic trees
Clustering methods
Cladistic methods
The problem of varying rates of evolution
Evolution and phylogenetic relationships in prokaryotes
Major types of prokaryote
Do we know the root of the tree of life?
Contents
Archaea 156
The genome of
Life at extreme temperatures
Comparative genomics of hyperthermophilic archaea: Thermococcus
kodakarensis and Pyrococci
Bacteria
Metagenomics: the collection of genomes in a coherent
environmental sample
Marine cyanobacteria
Evolution and phylogenetic relationships in eukaryotes
The evolution of plants
The domestication of maize
The dog genome
Genomics in anthropology: ancient populations and migrations
Genomics and languages
4
DNA
Frederick
The Maxam-Gilbert chemical cleavage method
Automated
DNA
Organizing a large-scale sequencing project
Bring on the clones: hierarchical
Whole-genome shotgun sequencing
Resequencing
Sequence databanking and annotation
Genomics in personal identification
Annotation of protein-encoding genes
Evolution of protein sequences, structures, and functions
Pattern matching
Computers and computer science
Sequence alignment
Defining the optimum alignment
Approximate methods for quick screening of databases
Pattern matching in three-dimensional structures
Classification and assignment of protein function
Development of databanks in molecular biology
Nucleic acid sequence databases
Genome browsers
Contents
Protein
Databases of genetic diseases
Databases of structures
Classifications of protein structures
Specialized or 'boutique' databases
Expression and proteomics databases
Databases of metabolic pathways
Bibliographic databases
Surveys of molecular biology databases and servers
part
5
Introduction
Analysis of microarray data
Expression patterns in different physiological states
The diauxic shift in Saccharomyces cerevisiae
Sleep in rats and fruit flies
Expression pattern changes in development
Variation of expression patterns during the life cycle of
melanogaster
Flower formation in roses
Gene expression patterns in learning and memory:
long-term potentiation
Evolutionary changes in expression patterns
Applications of microarrays in medicine
Development of antibiotic resistance in bacteria
Childhood leukaemias
6
Introduction
Protein nature and types
Protein structure
The chemical structure of proteins
Conformation of the polypeptide chain
Protein folding patterns
Post-translational modifications
Why is there a common genetic code with
Contents
Separation
317
Polyacrylamide gel electrophoresis (PAGE)
318
Mass spectrometry
319
Classification of Protein Structures
322
SCOP
324
Changes in folding patterns in protein evolution
325
Many proteins change conformation as part of the mechanism of
their function
327
Conformational change during enzymatic catalysis
327
Motor proteins
330
Allosteric regulation of protein function
331
Conformational states of
335
Protein structure prediction and modelling
337
Homology modelling
339
Methods specialized to particular types of structure
343
Available protocols
344
Structural genomics
345
Directed evolution and protein design
346
Directed evolution of subtilisin
347
Enzyme design
348
Protein complexes and aggregates
349
Properties of protein-protein complexes
350
Multisubunit proteins
352
7
Introduction
Pictures of networks as graphs
Dynamics, stability, and robustness
Sources of ideas for systems biology
Shannon's definition of entropy
Randomness of sequences
Static and dynamic complexity
Computational complexity
Metabolic networks
Methionine synthesis in Escherichia
Dynamic modelling
Protein interaction networks
Structural biology of regulatory networks
Contents
Protein-DNA interactions
Structural themes in protein-DNA binding and sequence recognition
An album of transcription regulators
Protein-protein and protein-nucleic acid interactions
Regulation of the lactose
Regulatory networks
Signal transduction and transcriptional control
Structures of regulatory networks
The genetic regulatory network of Saccharomyces cerevisiae
Adaptability of the yeast regulatory network
Epilogue
Index |
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| spellingShingle | Lesk, Arthur M. Introduction to genomics Genómica Génomique Genomics Evolution (DE-588)4071050-6 gnd Genanalyse (DE-588)4200230-8 gnd Genomik (DE-588)4776397-8 gnd |
| subject_GND | (DE-588)4071050-6 (DE-588)4200230-8 (DE-588)4776397-8 (DE-588)4123623-3 |
| title | Introduction to genomics |
| title_auth | Introduction to genomics |
| title_exact_search | Introduction to genomics |
| title_exact_search_txtP | Introduction to genomics |
| title_full | Introduction to genomics Arthur M. Lesk |
| title_fullStr | Introduction to genomics Arthur M. Lesk |
| title_full_unstemmed | Introduction to genomics Arthur M. Lesk |
| title_short | Introduction to genomics |
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| topic_facet | Genómica Génomique Genomics Evolution Genanalyse Genomik Lehrbuch |
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