Bioinformatics for geneticists: a bioinformatics primer for the analysis of genetic data
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2007
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XXII, 554 S. Ill., graph. Darst. cm |
| ISBN: | 0470026200 9780470026205 0470026197 9780470026199 |
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| 245 | 1 | 0 | |a Bioinformatics for geneticists |b a bioinformatics primer for the analysis of genetic data |c [ed. by] Michael R. Barnes |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Chichester |b Wiley |c 2007 | |
| 300 | |a XXII, 554 S. |b Ill., graph. Darst. |c cm | ||
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| 500 | |a Includes bibliographical references and index | ||
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| 650 | 7 | |a genetics |2 cabt | |
| 650 | 4 | |a Genética - Procesamiento electrónico de datos | |
| 650 | 4 | |a Datenverarbeitung | |
| 650 | 4 | |a Genetics |x Data processing | |
| 650 | 4 | |a Bioinformatics | |
| 650 | 4 | |a Computational Biology |x methods | |
| 650 | 4 | |a Genomics |x methods | |
| 650 | 4 | |a Databases, Genetic | |
| 650 | 4 | |a Software | |
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Datensatz im Suchindex
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| adam_text | PREFACE GLOSSARY XI XV XVII XIX I 1 1 CHALLENQES FOR GENETICIST 3
MICHAEL R. BORNES 1.1 INTRODUCTION 1.2 THE ROLE OF BIOINFORMATICS IN
GENETICS RESEARCH 1.3 GENETICS IN THE POST-GENOME ERA 1.4 CONCLUSIONS
REFERENCES 2 MANIPULATING GENETIC DATA KARL VV. BROMAN AND SIMON C.
HEATH 2.1 INTRODUCTION 2.2 BASIC PRINCIPLES 2.3 DATA ENTRY AND STORAGE
2.4 DATA MANIPULATION 2.5 EXAMPLES OF CODE 2.6 RESOURCES 2.7 SUMMARY
REFERENCES 3 4 5 12 15 17 17 18 20 21 22 30 31 31 VI SECTION CONTENTS D
33 3 THE HAPMAP - A HAPLOTYPE MAP OF ELLEN M. BROWN ANDBRYAN J. BARRATT
3.1 INTRODUCTION 3.2 ACCESSI NG THE DATA 3.3 APPLICATION OF HAPMAP DATA
IN ASSOCIATION STUDIES 3.4 FUTURE PERSPECTIVES REFERENCES 4 ASSEMBLING A
VIEW OF THE HUMAN GENOME COLIN A. M. SEMPLE 4.1 INTRODUCTION 4.2 GENOMIC
SEQUENCE ASSEMBLY 4.3 ANNOTATION FROM A DISTANCE: THE GENERALITIES 4.4
ANNOTATION UP CLOSE AND PERSONAL: THE SPECIFICS 4.5 ANNOTATION: THE
NEXTGENERATION REFERENCES GENOME 35 35 38 42 54 54 59 59 60 64 70 78 80
5 FINDING, DELINEATING AND ANALYSING GENES CHRISTOPHER SOUTHAN
ANDMICHAEL R. BORNES 5.1 INTRODUCTION 5.2 WHY LEARN TO PREDICT AND
ANALYSE GENESIN THE COMPLETE GENOME ERA? 5.3 THE EVIDENCE CASCADE FOR
GENE PRODUCTS 5.4 DEALING WITH THE COMPLEXITIES OF GENE MODELS 5.5
LOCATING KNOWN GENES IN THE HUMAN GENOME 5.6 GENOME PORTALINSPECTION 5.7
ANALYSING NOVEL GENES 5.8 CONCLUSIONS AND PROSPECTS REFERENCES 6
COMPARATIVE GENOMICS MARTIN S. TAYLOR ONDRICHARD R. COPLEY 6.1
INTRODUCTION 6.2 THE GENOMIC LANDSCAPE 6.3 CONCEPTS 6.4 PRACTICALITIES
6.5 TECHNOLOGY 6.6 APPLICATIONS 6.7 CHALLENGES AND FUTURE DIRECTIONS 6.8
CONCLUSION REFERENCES 85 85 86 88 95 97 100 101 102 103 105 105 106 109
113 118 132 137 138 139 CONTENTS VIT 7 MUTATIONS SINGLE DISORDERS 147
DAVID P. KELSELL, DIANA BLAYDON AND CHARLES A. MEIN 7.1 INTRODUETION 147
7.2 CLINIEAL ASEERTAINMENT 147 7.3 GENOME-WIDE MAPPING OF MONOGENIE
DISEASES 148 7.4 THE NATURE OF MUTATION IN MONOGENIE DISEASES 152 7.5
CONSIDERING EPIGENETIE EFFEETS IN MENDELIAN TRAITS 160 7.6 SUMMARY 162
REFERENEES 162 8 FROM GENOME SCAN TO GENE 165 ION C. GRAY 8.1
INTRODUCTION 165 8.2 THEORETIEAL AND PRAETIEAL EONSIDERATIONS 166 8.3
ASTEPWISE APPROACH TO LOCUS REFINEMENT AND CANDIDATE GENE IDENTIFIEATION
176 8.4 CONELUSION 180 8.5 A LIST OF THE SOFTWARE TOOLS AND WEB LINKS
MENTIONED IN THIS EHAPTER 181 REFERENEES 182 9 INTEGRATING GENETICS,
GENOMICS AND EPIGENOMICS TO IDENTIFY DISESSE GENES 185 MICHAEL R. BORNES
9.1 INTRODUETION 9.2 DEALING WITH THE (DRAFT) HUMAN GENOME SEQUENEE 9.3
PROGRESSING LOEI OF INTEREST WITH GENOMIC INFORMATION 9.4 IN SILICO
EHARAETERIZATION OF THE IB05 LOEUS - A EASE STUDY 9.5 DRAWING TOGETHER
BIOLOGIEAL RATIONALE - HYPOTHESIS BUILDING 9.6 IDENTIFIEATION OF
POTENTIALLY FUNCTIONAL POLYMORPHISMS 9.7 CONELUSIONS REFERENEES 10 TOOLS
STATISTICAL GENETICS ARUNA BONSAI, CHARLOTTE VIGNAL AND RALPH MCGINNIS
10.1 INTRODUCTION 10.2 LINKAGE ANALYSIS 10.3 ASSOEIATION ANALYSIS 10.4
LINKAGE DISEQUILIBRIUM 10.5 QUANTITATIVE TRAIT LOCUS (QTL) MAPPING IN
EXPERIMENTAL CROSSES 10.6 CLOSING REMARKS REFERENEES 185 186 187 191 209
211 212 213 217 217 217 223 229 235 239 241 VIII CONTENTS 11 PREDICTIVE
FUNCTIONAL ANALYSIS OF POLYMORPHISMS: AN 249 MARY PLUMPTON AND MICHAEL
R. BORNES 11.1 INTRODUCTION 249 11.2 PRINCIPLES OF PREDICTIVE FUNCTIONAL
ANALYSIS OF POLYMORPHISMS 252 11.3 THE ANATOMY OF PROMOTER REGIONS AND
REGULATORY ELEMENTS 256 11.4 THE ANATOMY OF GENES 258 11.5 PSEUDOGENES
AND REGULATORY MRNA 266 11.6 ANALYSIS OF NOVEL REGULATORY ELEMENTS AND
MOTIFS IN NUCLEOTIDE SEQUENCES 266 11.7 FUNCTIONAL ANALYSIS OF
NON-SYNONYMOUS CODING POLYMORPHISMS 268 11.8 INTEGRATED TOOLS FOR
FUNCTIONAL ANALYSIS OF GENETIC VARIATION 273 11.9 ANOTE OF CAUTION ON
THE PRIORITIZATION OF IN SILICO PREDICTIONS FOR FURTHER LABORATORY
INVESTIGATION 275 11.10 CONCLUSIONS 275 REFERENCES 276 12 FUNCTIONAT IN
SIIICO ANALYSIS OF GENE REGULATORY POLYMORPHISM 281 CHAOLIN ZHONG,
XIOOYUE ZHAO, MICHAEL Q. ZHANG 12.1 INTRODUCTION 281 12.2 PREDICTING
REGULATORY REGIONS 282 12.3 MODELLING AND PREDICTING TRANSCRIPTION
FACTOR-BINDING SITES 288 12.4 PREDICTING REGULATORY ELEMENTS FOR
SPLICING REGULATION 295 12.5 EVALUATING THE FUNCTIONAL IMPORTANCE OF
REGULATORY POLYMORPHISMS 300 REFERENCES 302 13 AMINO-ACID PROPERTIES AND
CONSEQUENCES OF SUBSTITUTIONS 311 FVLATTHEW J. BETTS ANDROBERT B.
RUSSELL 13.1 INTRODUCTION 311 13.2 PROTEIN FEATURES RELEVANT TO
AMINO-ACID BEHAVIOUR 312 13.3 AMINO-ACID CLASSIFICATIONS 316 13.4
PROPERTIES OF THE AMINO ACIDS 318 13.5 AMINO-ACID QUICK REFERENCE 321
13.6 STUDIES OF HOW MUTATIONS AFFECT FUNCTION 334 13.7 ASUMMARY OF THE
THOUGHT PROCESS 339 REFERENCES 340 14 NON-CODING RNA BIOINFORMATICS 343
JAMES R. BROWN, STEVE DEHARO, BARRY DANCIS. MICHAEL R. BORNES AND
PHILIPPE SONSEAU 14.1 INTRODUCTION 343 14.2 THE NON-CODING (NC) RNA
UNIVERSE 344 14.3 COMPUTATIONAL ANALYSIS OF NCRNA 349 CONTENTS 14.4
NCRNA VARIATION IN DISAASE 14.5 ASSESSING THE IMPACT OF VARIATION IN
NCRNA 14.6 DATA RESOURCES TO SUPPORT SMALL NCRNA ANALYSIS 14.7
CONCLUSIONS REFERENCES IX 356 362 363 363 364 V 15 ARE
RN ILRTF IF ~ V~ I1~ CATBETINE A. BALL AND GAVIN SHERLOCK 15.1
INTRODUCTION 15.2 PRINCIPLES OF THE APPLICATION OF MICROARRAY TECHNOLOGY
15.3 COMPLEMENTARY APPROACHES TO MICROARRAY ANALYSIS 15.4 DIFFERENCES
BETWEEN DATA REPOSITORY AND RESEARCH DATABASE 15.5 DESCRIPTIONS OF
FREELY AVAILABLE RESEARCH DATABASE PACKAGES REFERENCES 371 371 373 377
377 377 385 16 389 17 ELISSA J. CHESTER 16.1 INTRODUCTION: THE GENETIC
REGULATION OF ENDOPHENOTYPES 389 16.2 TRANSCRIPT ABUNDANCE AS A COMPLEX
PHENOTYPE 390 16.3 SCALING UP GENETIC ANALYSIS AND MAPPING MODELS FOR
MICROARRAYS 394 16.4 GENETIC CORRELATION ANALYSIS 397 16.5 SYSTEMS
GENETIC ANALYSIS 400 16.6 USING EXPRESSION QTLS TO IDENTIFY CANDIDATE
GENES FOR THE REGULATION OF CAMPLEX PHENOTYPES 403 16.7 CONCLUSIONS 408
REFERENCES 408 JOEL GRESHOCK 17.1 INTRODUCTION 17.2 CA NCER GENOMES 17.3
APPROACHES TO STUDYING CANCER GENETICS 17.4 GENERAL RESOURCES FOR CANCER
GENETICS 17.5 CANCER GENES AND MUTATIONS 17.6 COPY NUMBER ALTERATIONS IN
CANCER 17.7 LASS OF HETEROZYGOSITY IN CANCER 17.8 GENE-EXPRESSION DATA
IN CANCER 17.9 MULTIPLATFORM GENE TARGET IDENTIFICATION 17.10 THE
EPIGENETICS OF CANCER 17.11 TUMOUR MODELLING 17.12 CONCLUSIONS
REFERENCES 413 414 415 418 420 425 431 432 435 438 438 439 439 X
CONTENTS 18 NEEDLE IN A HAYSTACK? DEALING 500 000 SNP GENOME SCANS 447
MICHAEL R. BORNES AND PAUL S. DERWENT 18.1 INTRODUCTION 447 18.2 GENOME
SCAN ANALYSIS ISSUES 449 18.3 ULTRA-HIGH-DENSITY GENOME-SCANNING
TECHNOLOGIES 459 18.4 BIOINFORMATICS FUER GENOME SCAN ANALYSIS 469 18.5
CONCLUSIONS 489 REFERENCES 490 19 A BIOINFORMATICS PERSPECTIVE ON
GENETICS IN DRUG DISCOVERY AND DEVELOPMENT 495 CHRISTOPHER SOUTHON.
MAGNUS ULVSBAECK AND MICHAEL R. BORNES 19.1 INTRODUCTION 495 19.2 TARGET
GENETICS 498 19.3 PHARMACOGENETICS (PGX) 508 19.4 CONCLUSIONS: TOWARD
PERSONALIZED MEDICINE 525 REFERENCES 525 APPENDIX I APPENDIX II INDEX
529 531 537
|
| adam_txt |
PREFACE GLOSSARY XI XV XVII XIX I 1 1 CHALLENQES FOR GENETICIST 3
MICHAEL R. BORNES 1.1 INTRODUCTION 1.2 THE ROLE OF BIOINFORMATICS IN
GENETICS RESEARCH 1.3 GENETICS IN THE POST-GENOME ERA 1.4 CONCLUSIONS
REFERENCES 2 MANIPULATING GENETIC DATA KARL VV. BROMAN AND SIMON C.
HEATH 2.1 INTRODUCTION 2.2 BASIC PRINCIPLES 2.3 DATA ENTRY AND STORAGE
2.4 DATA MANIPULATION 2.5 EXAMPLES OF CODE 2.6 RESOURCES 2.7 SUMMARY
REFERENCES 3 4 5 12 15 17 17 18 20 21 22 30 31 31 VI SECTION CONTENTS D
33 3 THE HAPMAP - A HAPLOTYPE MAP OF ELLEN M. BROWN ANDBRYAN J. BARRATT
3.1 INTRODUCTION 3.2 ACCESSI NG THE DATA 3.3 APPLICATION OF HAPMAP DATA
IN ASSOCIATION STUDIES 3.4 FUTURE PERSPECTIVES REFERENCES 4 ASSEMBLING A
VIEW OF THE HUMAN GENOME COLIN A. M. SEMPLE 4.1 INTRODUCTION 4.2 GENOMIC
SEQUENCE ASSEMBLY 4.3 ANNOTATION FROM A DISTANCE: THE GENERALITIES 4.4
ANNOTATION UP CLOSE AND PERSONAL: THE SPECIFICS 4.5 ANNOTATION: THE
NEXTGENERATION REFERENCES GENOME 35 35 38 42 54 54 59 59 60 64 70 78 80
5 FINDING, DELINEATING AND ANALYSING GENES CHRISTOPHER SOUTHAN
ANDMICHAEL R. BORNES 5.1 INTRODUCTION 5.2 WHY LEARN TO PREDICT AND
ANALYSE GENESIN THE COMPLETE GENOME ERA? 5.3 THE EVIDENCE CASCADE FOR
GENE PRODUCTS 5.4 DEALING WITH THE COMPLEXITIES OF GENE MODELS 5.5
LOCATING KNOWN GENES IN THE HUMAN GENOME 5.6 GENOME PORTALINSPECTION 5.7
ANALYSING NOVEL GENES 5.8 CONCLUSIONS AND PROSPECTS REFERENCES 6
COMPARATIVE GENOMICS MARTIN S. TAYLOR ONDRICHARD R. COPLEY 6.1
INTRODUCTION 6.2 THE GENOMIC LANDSCAPE 6.3 CONCEPTS 6.4 PRACTICALITIES
6.5 TECHNOLOGY 6.6 APPLICATIONS 6.7 CHALLENGES AND FUTURE DIRECTIONS 6.8
CONCLUSION REFERENCES 85 85 86 88 95 97 100 101 102 103 105 105 106 109
113 118 132 137 138 139 CONTENTS VIT 7 MUTATIONS SINGLE DISORDERS 147
DAVID P. KELSELL, DIANA BLAYDON AND CHARLES A. MEIN 7.1 INTRODUETION 147
7.2 CLINIEAL ASEERTAINMENT 147 7.3 GENOME-WIDE MAPPING OF MONOGENIE
DISEASES 148 7.4 THE NATURE OF MUTATION IN MONOGENIE DISEASES 152 7.5
CONSIDERING EPIGENETIE EFFEETS IN MENDELIAN TRAITS 160 7.6 SUMMARY 162
REFERENEES 162 8 FROM GENOME SCAN TO GENE 165 ION C. GRAY 8.1
INTRODUCTION 165 8.2 THEORETIEAL AND PRAETIEAL EONSIDERATIONS 166 8.3
ASTEPWISE APPROACH TO LOCUS REFINEMENT AND CANDIDATE GENE IDENTIFIEATION
176 8.4 CONELUSION 180 8.5 A LIST OF THE SOFTWARE TOOLS AND WEB LINKS
MENTIONED IN THIS EHAPTER 181 REFERENEES 182 9 INTEGRATING GENETICS,
GENOMICS AND EPIGENOMICS TO IDENTIFY DISESSE GENES 185 MICHAEL R. BORNES
9.1 INTRODUETION 9.2 DEALING WITH THE (DRAFT) HUMAN GENOME SEQUENEE 9.3
PROGRESSING LOEI OF INTEREST WITH GENOMIC INFORMATION 9.4 IN SILICO
EHARAETERIZATION OF THE IB05 LOEUS - A EASE STUDY 9.5 DRAWING TOGETHER
BIOLOGIEAL RATIONALE - HYPOTHESIS BUILDING 9.6 IDENTIFIEATION OF
POTENTIALLY FUNCTIONAL POLYMORPHISMS 9.7 CONELUSIONS REFERENEES 10 TOOLS
STATISTICAL GENETICS ARUNA BONSAI, CHARLOTTE VIGNAL AND RALPH MCGINNIS
10.1 INTRODUCTION 10.2 LINKAGE ANALYSIS 10.3 ASSOEIATION ANALYSIS 10.4
LINKAGE DISEQUILIBRIUM 10.5 QUANTITATIVE TRAIT LOCUS (QTL) MAPPING IN
EXPERIMENTAL CROSSES 10.6 CLOSING REMARKS REFERENEES 185 186 187 191 209
211 212 213 217 217 217 223 229 235 239 241 VIII CONTENTS 11 PREDICTIVE
FUNCTIONAL ANALYSIS OF POLYMORPHISMS: AN 249 MARY PLUMPTON AND MICHAEL
R. BORNES 11.1 INTRODUCTION 249 11.2 PRINCIPLES OF PREDICTIVE FUNCTIONAL
ANALYSIS OF POLYMORPHISMS 252 11.3 THE ANATOMY OF PROMOTER REGIONS AND
REGULATORY ELEMENTS 256 11.4 THE ANATOMY OF GENES 258 11.5 PSEUDOGENES
AND REGULATORY MRNA 266 11.6 ANALYSIS OF NOVEL REGULATORY ELEMENTS AND
MOTIFS IN NUCLEOTIDE SEQUENCES 266 11.7 FUNCTIONAL ANALYSIS OF
NON-SYNONYMOUS CODING POLYMORPHISMS 268 11.8 INTEGRATED TOOLS FOR
FUNCTIONAL ANALYSIS OF GENETIC VARIATION 273 11.9 ANOTE OF CAUTION ON
THE PRIORITIZATION OF IN SILICO PREDICTIONS FOR FURTHER LABORATORY
INVESTIGATION 275 11.10 CONCLUSIONS 275 REFERENCES 276 12 FUNCTIONAT IN
SIIICO ANALYSIS OF GENE REGULATORY POLYMORPHISM 281 CHAOLIN ZHONG,
XIOOYUE ZHAO, MICHAEL Q. ZHANG 12.1 INTRODUCTION 281 12.2 PREDICTING
REGULATORY REGIONS 282 12.3 MODELLING AND PREDICTING TRANSCRIPTION
FACTOR-BINDING SITES 288 12.4 PREDICTING REGULATORY ELEMENTS FOR
SPLICING REGULATION 295 12.5 EVALUATING THE FUNCTIONAL IMPORTANCE OF
REGULATORY POLYMORPHISMS 300 REFERENCES 302 13 AMINO-ACID PROPERTIES AND
CONSEQUENCES OF SUBSTITUTIONS 311 FVLATTHEW J. BETTS ANDROBERT B.
RUSSELL 13.1 INTRODUCTION 311 13.2 PROTEIN FEATURES RELEVANT TO
AMINO-ACID BEHAVIOUR 312 13.3 AMINO-ACID CLASSIFICATIONS 316 13.4
PROPERTIES OF THE AMINO ACIDS 318 13.5 AMINO-ACID QUICK REFERENCE 321
13.6 STUDIES OF HOW MUTATIONS AFFECT FUNCTION 334 13.7 ASUMMARY OF THE
THOUGHT PROCESS 339 REFERENCES 340 14 NON-CODING RNA BIOINFORMATICS 343
JAMES R. BROWN, STEVE DEHARO, BARRY DANCIS. MICHAEL R. BORNES AND
PHILIPPE SONSEAU 14.1 INTRODUCTION 343 14.2 THE NON-CODING (NC) RNA
UNIVERSE 344 14.3 COMPUTATIONAL ANALYSIS OF NCRNA 349 CONTENTS 14.4
NCRNA VARIATION IN DISAASE 14.5 ASSESSING THE IMPACT OF VARIATION IN
NCRNA 14.6 DATA RESOURCES TO SUPPORT SMALL NCRNA ANALYSIS 14.7
CONCLUSIONS REFERENCES IX 356 362 363 363 364 V 15 ARE
RN"'ILRTF'IF'\~""V~'I1~ CATBETINE A. BALL AND GAVIN SHERLOCK 15.1
INTRODUCTION 15.2 PRINCIPLES OF THE APPLICATION OF MICROARRAY TECHNOLOGY
15.3 COMPLEMENTARY APPROACHES TO MICROARRAY ANALYSIS 15.4 DIFFERENCES
BETWEEN DATA REPOSITORY AND RESEARCH DATABASE 15.5 DESCRIPTIONS OF
FREELY AVAILABLE RESEARCH DATABASE PACKAGES REFERENCES 371 371 373 377
377 377 385 16 389 17 ELISSA J. CHESTER 16.1 INTRODUCTION: THE GENETIC
REGULATION OF ENDOPHENOTYPES 389 16.2 TRANSCRIPT ABUNDANCE AS A COMPLEX
PHENOTYPE 390 16.3 SCALING UP GENETIC ANALYSIS AND MAPPING MODELS FOR
MICROARRAYS 394 16.4 GENETIC CORRELATION ANALYSIS 397 16.5 SYSTEMS
GENETIC ANALYSIS 400 16.6 USING EXPRESSION QTLS TO IDENTIFY CANDIDATE
GENES FOR THE REGULATION OF CAMPLEX PHENOTYPES 403 16.7 CONCLUSIONS 408
REFERENCES 408 JOEL GRESHOCK 17.1 INTRODUCTION 17.2 CA NCER GENOMES 17.3
APPROACHES TO STUDYING CANCER GENETICS 17.4 GENERAL RESOURCES FOR CANCER
GENETICS 17.5 CANCER GENES AND MUTATIONS 17.6 COPY NUMBER ALTERATIONS IN
CANCER 17.7 LASS OF HETEROZYGOSITY IN CANCER 17.8 GENE-EXPRESSION DATA
IN CANCER 17.9 MULTIPLATFORM GENE TARGET IDENTIFICATION 17.10 THE
EPIGENETICS OF CANCER 17.11 TUMOUR MODELLING 17.12 CONCLUSIONS
REFERENCES 413 414 415 418 420 425 431 432 435 438 438 439 439 X
CONTENTS 18 NEEDLE IN A HAYSTACK? DEALING 500 000 SNP GENOME SCANS 447
MICHAEL R. BORNES AND PAUL S. DERWENT 18.1 INTRODUCTION 447 18.2 GENOME
SCAN ANALYSIS ISSUES 449 18.3 ULTRA-HIGH-DENSITY GENOME-SCANNING
TECHNOLOGIES 459 18.4 BIOINFORMATICS FUER GENOME SCAN ANALYSIS 469 18.5
CONCLUSIONS 489 REFERENCES 490 19 A BIOINFORMATICS PERSPECTIVE ON
GENETICS IN DRUG DISCOVERY AND DEVELOPMENT 495 CHRISTOPHER SOUTHON.
MAGNUS ULVSBAECK AND MICHAEL R. BORNES 19.1 INTRODUCTION 495 19.2 TARGET
GENETICS 498 19.3 PHARMACOGENETICS (PGX) 508 19.4 CONCLUSIONS: TOWARD
'PERSONALIZED MEDICINE' 525 REFERENCES 525 APPENDIX I APPENDIX II INDEX
529 531 537 |
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| format | Book |
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| id | DE-604.BV021828103 |
| illustrated | Illustrated |
| index_date | 2024-07-02T15:56:22Z |
| indexdate | 2024-07-09T20:45:34Z |
| institution | BVB |
| isbn | 0470026200 9780470026205 0470026197 9780470026199 |
| language | English |
| lccn | 2006036197 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015040140 |
| oclc_num | 74941752 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-29T DE-20 DE-19 DE-BY-UBM DE-29 DE-11 DE-188 DE-1028 |
| owner_facet | DE-M49 DE-BY-TUM DE-29T DE-20 DE-19 DE-BY-UBM DE-29 DE-11 DE-188 DE-1028 |
| physical | XXII, 554 S. Ill., graph. Darst. cm |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Wiley |
| record_format | marc |
| spelling | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data [ed. by] Michael R. Barnes 2. ed. Chichester Wiley 2007 XXII, 554 S. Ill., graph. Darst. cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index bioinformatics cabt genetics cabt Genética - Procesamiento electrónico de datos Datenverarbeitung Genetics Data processing Bioinformatics Computational Biology methods Genomics methods Databases, Genetic Software Molekulare Bioinformatik (DE-588)4531334-9 gnd rswk-swf Bioinformatik (DE-588)4611085-9 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Molekulare Bioinformatik (DE-588)4531334-9 s DE-604 Molekulargenetik (DE-588)4039987-4 s Bioinformatik (DE-588)4611085-9 s Barnes, Michael R. Sonstige oth OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015040140&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data bioinformatics cabt genetics cabt Genética - Procesamiento electrónico de datos Datenverarbeitung Genetics Data processing Bioinformatics Computational Biology methods Genomics methods Databases, Genetic Software Molekulare Bioinformatik (DE-588)4531334-9 gnd Bioinformatik (DE-588)4611085-9 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| subject_GND | (DE-588)4531334-9 (DE-588)4611085-9 (DE-588)4039987-4 |
| title | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data |
| title_auth | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data |
| title_exact_search | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data |
| title_exact_search_txtP | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data |
| title_full | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data [ed. by] Michael R. Barnes |
| title_fullStr | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data [ed. by] Michael R. Barnes |
| title_full_unstemmed | Bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data [ed. by] Michael R. Barnes |
| title_short | Bioinformatics for geneticists |
| title_sort | bioinformatics for geneticists a bioinformatics primer for the analysis of genetic data |
| title_sub | a bioinformatics primer for the analysis of genetic data |
| topic | bioinformatics cabt genetics cabt Genética - Procesamiento electrónico de datos Datenverarbeitung Genetics Data processing Bioinformatics Computational Biology methods Genomics methods Databases, Genetic Software Molekulare Bioinformatik (DE-588)4531334-9 gnd Bioinformatik (DE-588)4611085-9 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| topic_facet | bioinformatics genetics Genética - Procesamiento electrónico de datos Datenverarbeitung Genetics Data processing Bioinformatics Computational Biology methods Genomics methods Databases, Genetic Software Molekulare Bioinformatik Bioinformatik Molekulargenetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015040140&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT barnesmichaelr bioinformaticsforgeneticistsabioinformaticsprimerfortheanalysisofgeneticdata |