Nickel and its surprising impact in nature:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2007
|
| Schriftenreihe: | Metal ions in life sciences
2 |
| Schlagworte: | |
| Online-Zugang: | Table of contents only Inhaltsverzeichnis |
| Beschreibung: | XXVI, 702 S. Ill., graph. Darst. |
| ISBN: | 047001671X 9780470016718 |
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| 245 | 1 | 0 | |a Nickel and its surprising impact in nature |c ed. by Astrid Sigel ... |
| 264 | 1 | |a Chichester |b Wiley |c 2007 | |
| 300 | |a XXVI, 702 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Metal ions in life sciences |v 2 | |
| 650 | 4 | |a Nickel in the body | |
| 650 | 4 | |a Nickel enzymes | |
| 650 | 4 | |a Organonickel compounds | |
| 650 | 4 | |a Nickel |x metabolism | |
| 650 | 4 | |a Environmental Exposure | |
| 650 | 4 | |a Nickel |x adverse effects | |
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| 650 | 0 | 7 | |a Stoffwechsel |0 (DE-588)4057699-1 |2 gnd |9 rswk-swf |
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| 830 | 0 | |a Metal ions in life sciences |v 2 |w (DE-604)BV022275400 |9 2 | |
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Datensatz im Suchindex
| _version_ | 1804135747130753024 |
|---|---|
| adam_text | Contents
HISTORICAL DEVELOPMENT AND PERSPECTIVES
OF THE SERIES v
PREFACE TO VOLUME 2 vi i
CONTRIBUTORS TO VOLUME 2 xvii
TITLES OF VOLUMES 1 44 IN THE
METAL IONS IN BIOLOGICAL SYSTEMS SERIES xxi
CONTENTS OF VOLUMES IN THE
METAL IONS IN LIFE SCIENCES SERIES xxiii
1 BIOGEOCHEMISTRY OF NICKEL AND
ITS RELEASE INTO THE ENVIRONMENT 1
Tiina M. Nieminen, Liisa Ukonmaanaho, Nicole Rausch,
and William Shotyk
1. Introduction 2
2. Chemistry of Nickel 2
3. Ancient and Modern Uses of Nickel 6
4. Sources of Atmospheric Nickel 6
5. Deposition and Fate of Atmospheric Nickel 7
6. Historical Records of Nickel Deposition 14
7. Bioavailability and Mobility of Nickel in Soils 17
8. Summary and Conclusions 21
Abbreviations 21
References 22
x CONTENTS
2 NICKEL IN THE ENVIRONMENT AND ITS ROLE
IN THE METABOLISM OF PLANTS
AND CYANOBACTERIA 31
Hendrik Ktipper and Peter M. H. Kroneck
1. Introduction 32
2. Nickel as a Micronutrient for Plants and Cyanobacteria 37
3. Nickel as an Environmental Pollutant and Its Effects on Plants 40
4. Nickel Hyperaccumulation 48
5. Outlook 53
Acknowledgments 54
Abbreviations 54
References 55
3 NICKEL ION COMPLEXES OF AMINO ACIDS
AND PEPTIDES 63
Teresa Kowalik Jankowska, Henryk Kozlowski, Etelka Farkas,
and Imre Sovdgo
1. Introduction 64
2. Complexes of Amino Acids and Derivatives 66
3. Complexes of Peptides and Related Ligands 76
4. Formation of Nickel(II) Complexes under Biological
Conditions: Model Calculations in Multicomponent Systems 94
5. Conclusions 96
Abbreviations 97
References 98
4 COMPLEX FORMATION OF NICKEL(II) AND RELATED
METAL IONS WITH SUGAR RESIDUES, NUCLEOBASES,
PHOSPHATES, NUCLEOTIDES, AND NUCLEIC ACIDS 109
Roland K. O. Sigel and Helmut Sigel
1. Introduction 110
2. Nickel(II) Sugar Interactions 112
3. Interactions of Nickel(II) with Nucleobase Residues 118
4. Complexes of Nickel(II) with Phosphates 128
5. Nickel(II) Complexes of Nucleotides 131
6. Complexes of Some Less Common Nucleotides 144
7. Complexes of Some Nucleotide Derivatives and Analogs 149
8. Mixed Ligand Complexes Containing a Nucleotide 159
9. Nickel(II) Binding in Nucleic Acids 165
10. Concluding Remarks 168
CONTENTS Xi
Acknowledgments 169
Abbreviations and Definitions 169
References 172
5 SYNTHETIC MODELS FOR THE ACTIVE SITES
OF NICKEL CONTAINING ENZYMES 181
Jarl Ivar van der Vlugt and Franc Meyer
1. Introduction 181
2. Models for Cofactor F430 182
3. Models for Sulfur Rich Nickel Sites 191
4. Models for the Urease Active Site 214
5. Models for Acireductone Reductase 229
6. Concluding Remarks 230
Acknowledgments 230
Abbreviations 230
References 232
6 UREASE: RECENT INSIGHTS ON THE ROLE OF NICKEL 241
Stefano Ciurli
1. Introduction: Urease and Its Biological Significance 242
2. The Biochemistry of Urease 243
3. Structural Studies on Bacterial Ureases 244
4. The Structure Based Mechanism of Urease 267
5. Conclusions 273
Acknowledgments 273
Abbreviations 273
References 274
7 NICKEL IRON HYDROGENASES 279
Wolfgang Lubitz, Maurice van Gastel, and Wolfgang Gartner
1. Introduction to Hydrogenases 280
2. Biochemistry and Molecular Biology 283
3. Crystallization and X Ray Structure Analysis 291
4. Spectroscopic Investigations 295
5. Electrochemistry 306
6. Hydrogenase Function and the Catalytic Cycle 309
7. Conclusions and Outlook 312
Acknowledgments 314
Abbreviations 314
References 315
xii CONTENTS
8 METHYL COENZYME M REDUCTASE
AND ITS NICKEL CORPHIN COENZYME F430
IN METHANOGENIC ARCHAEA 323
Bernhard Jaun and Rudolf K. Thauer
1. Introduction 324
2. Structure and Properties of Coenzyme F430 328
3. Molecular Properties of Methyl Coenzyme M Reductase 335
4. Catalytic Properties of Methyl Coenzyme M Reductase 345
Acknowledgments 350
Abbreviations 350
References 351
9 ACETYL COENZYME A SYNTHASES
AND NICKEL CONTAINING CARBON MONOXIDE
DEHYDROGENASES 357
Paul A. Lindahl and David E. Graham
1. Introduction 358
2. Structure and Function of Carbon Monoxide Dehydrogenases 361
3. Sequence Analysis and Phylogeny of Carbon Monoxide
Dehydrogenases 369
4. Acetyl Coenzyme A Synthases/Carbon Monoxide
Dehydrogenases 373
5. Sequence Analysis and Phylogeny of the a Subunit 381
6. Corrinoid Iron Sulfur Proteins 382
7. Acetyl Coenzyme A Decarbonylase/Synthases 384
8. Physiological Roles and Evolution of Acetyl Coenzyme A
Synthase/Carbon Monoxide Dehydrogenase Proteins 386
9. Origins and Evolution of ACDS, ACS/CODH,
and CODH Complexes 392
Acknowledgments 393
Abbreviations 394
Appendices 395
References 411
10 NICKEL SUPEROXIDE DISMUTASE 417
Peter A. Bryngelson and Michael J. Maroney
1. Introduction 418
2. Molecular Biology 422
3. Structural Biology 426
4. Mechanism 429
CONTENTS xiii
5. Conclusions 438
Acknowledgments 438
Abbreviations and Definitions 439
References 439
11 BIOCHEMISTRY OF THE NICKEL DEPENDENT
GLYOXALASE I ENZYMES 445
Nicole Sukdeo, Elisabeth Daub, and John F. Honek
1. Introduction 446
2. Biochemical Investigations of Glyoxalase I 450
3. Biophysical and Mechanistic Studies of Glyoxalase I 453
4. Glyoxalase I Genes and Protein Sequence Comparisons 460
5. Glyoxalase I as a Member of the pappp Superfamily
of Proteins 463
6. Other Aspects of Glyoxalase I 464
7. Conclusions 465
Acknowledgments 466
Abbreviations 466
References 467
12 NICKEL IN ACIREDUCTONE DIOXYGENASE 473
Thomas C. Pochapsky, Tingling Ju, Marina Dang, Rachel Beaulieu,
Gina M. Pagani, and Bo OuYang
1. Introduction 474
2. The Methionine Salvage Pathway 475
3. One Protein, Two Enzymes: Acireductone Dioxygenase from
Klebsiella oxytoca All
4. Homologs of Acireductone Dioxygenase from
Other Organisms 481
5. Known Acireductone Dioxygenase Structures 483
6. Spectroscopic Probes of Acireductone Dioxygenase Enzyme
Active Sites 486
7. Enzymatic Studies of Acireductone Dioxygenase 489
8. Mechanistic Considerations: What is the Role of Ni(II) in
Acireductone Dioxygenase Activity? 490
9. Structurally and Functionally Related Enzymes 493
10. Future Directions 495
Acknowledgments 497
Abbreviations 497
References 498
xiv CONTENTS
13 THE NICKEL REGULATED PEPTIDYL PROLYL
CIS/TRANS ISOMERASE SlyD 501
Frank Erdmann and Gunter Fischer
1. Introduction 502
2. SlyD Belongs to the Peptidyl Prolyl cisltrans Isomerases 503
3. Insights into the Biological Role of SlyD 513
4. Conclusions 515
Abbreviations and Definitions 515
References 516
14 CHAPERONES OF NICKEL METABOLISM 519
Soledad Quiroz, Jong K. Kim, Scott B. Mulrooney,
and Robert P. Hausinger
1. Introduction to Nickel Metabolism 520
2. Nickel Metallochaperones 530
3. Molecular Chaperones Involved in Nickel Metabolism 534
4. Conclusions and Remaining Questions 538
Acknowledgments 539
Abbreviations 539
References 540
15 THE ROLE OF NICKEL IN ENVIRONMENTAL
ADAPTATION OF THE GASTRIC PATHOGEN
HELICOBACTER PYLORI 545
Florian D. Ernst, Arnoud H. M. van Vliet, Manfred Kist, Johannes
G. Kusters, and Stefan Bereswill
1. Introduction 546
2. Nickel Enzymes and Environmental Adaptation 554
3. Nickel Uptake Systems 560
4. Mechanisms of Nickel Regulation 562
5. Protection of Nickel Metabolism 566
6. Metal Metabolism as Drug Target: Therapeutic Considerations 568
7. Conclusions 570
Abbreviations 570
References 571
16 NICKEL DEPENDENT GENE EXPRESSION 581
Konstantin Salnikow and Kazimierz S. Kasprzak
1. Introduction 582
2. Genetic and Epigenetic Changes in Nickel Exposed Cells 585
CONTENTS xv
3. Alteration of Gene Expression Following Nickel Induced
Lung Injury 587
4. Nickel Induced Allergy and Gene Expression 592
5. Nickel Induced Expression of Erythropoietin 592
6. Alteration of Transcription Factors and Signaling Pathways 593
7. Changes in Gene Expression and Nickel Carcinogenesis 607
8. Conclusions 608
Acknowledgments 609
Abbreviations 609
References 610
17 NICKEL TOXICITY AND CARCINOGENESIS 619
Kazimierz S. Kasprzak and Konstantin Salnikow
1. Introduction 621
2. An Overview of Nickel Toxicity 621
3. Nickel Induced Carcinogenesis 638
4. Conclusion 645
Acknowledgments 647
Abbreviations 647
References 647
SUBJECT INDEX 661
|
| adam_txt |
Contents
HISTORICAL DEVELOPMENT AND PERSPECTIVES
OF THE SERIES v
PREFACE TO VOLUME 2 vi i
CONTRIBUTORS TO VOLUME 2 xvii
TITLES OF VOLUMES 1 44 IN THE
METAL IONS IN BIOLOGICAL SYSTEMS SERIES xxi
CONTENTS OF VOLUMES IN THE
METAL IONS IN LIFE SCIENCES SERIES xxiii
1 BIOGEOCHEMISTRY OF NICKEL AND
ITS RELEASE INTO THE ENVIRONMENT 1
Tiina M. Nieminen, Liisa Ukonmaanaho, Nicole Rausch,
and William Shotyk
1. Introduction 2
2. Chemistry of Nickel 2
3. Ancient and Modern Uses of Nickel 6
4. Sources of Atmospheric Nickel 6
5. Deposition and Fate of Atmospheric Nickel 7
6. Historical Records of Nickel Deposition 14
7. Bioavailability and Mobility of Nickel in Soils 17
8. Summary and Conclusions 21
Abbreviations 21
References 22
x CONTENTS
2 NICKEL IN THE ENVIRONMENT AND ITS ROLE
IN THE METABOLISM OF PLANTS
AND CYANOBACTERIA 31
Hendrik Ktipper and Peter M. H. Kroneck
1. Introduction 32
2. Nickel as a Micronutrient for Plants and Cyanobacteria 37
3. Nickel as an Environmental Pollutant and Its Effects on Plants 40
4. Nickel Hyperaccumulation 48
5. Outlook 53
Acknowledgments 54
Abbreviations 54
References 55
3 NICKEL ION COMPLEXES OF AMINO ACIDS
AND PEPTIDES 63
Teresa Kowalik Jankowska, Henryk Kozlowski, Etelka Farkas,
and Imre Sovdgo
1. Introduction 64
2. Complexes of Amino Acids and Derivatives 66
3. Complexes of Peptides and Related Ligands 76
4. Formation of Nickel(II) Complexes under Biological
Conditions: Model Calculations in Multicomponent Systems 94
5. Conclusions 96
Abbreviations 97
References 98
4 COMPLEX FORMATION OF NICKEL(II) AND RELATED
METAL IONS WITH SUGAR RESIDUES, NUCLEOBASES,
PHOSPHATES, NUCLEOTIDES, AND NUCLEIC ACIDS 109
Roland K. O. Sigel and Helmut Sigel
1. Introduction 110
2. Nickel(II) Sugar Interactions 112
3. Interactions of Nickel(II) with Nucleobase Residues 118
4. Complexes of Nickel(II) with Phosphates 128
5. Nickel(II) Complexes of Nucleotides 131
6. Complexes of Some Less Common Nucleotides 144
7. Complexes of Some Nucleotide Derivatives and Analogs 149
8. Mixed Ligand Complexes Containing a Nucleotide 159
9. Nickel(II) Binding in Nucleic Acids 165
10. Concluding Remarks 168
CONTENTS Xi
Acknowledgments 169
Abbreviations and Definitions 169
References 172
5 SYNTHETIC MODELS FOR THE ACTIVE SITES
OF NICKEL CONTAINING ENZYMES 181
Jarl Ivar van der Vlugt and Franc Meyer
1. Introduction 181
2. Models for Cofactor F430 182
3. Models for Sulfur Rich Nickel Sites 191
4. Models for the Urease Active Site 214
5. Models for Acireductone Reductase 229
6. Concluding Remarks 230
Acknowledgments 230
Abbreviations 230
References 232
6 UREASE: RECENT INSIGHTS ON THE ROLE OF NICKEL 241
Stefano Ciurli
1. Introduction: Urease and Its Biological Significance 242
2. The Biochemistry of Urease 243
3. Structural Studies on Bacterial Ureases 244
4. The Structure Based Mechanism of Urease 267
5. Conclusions 273
Acknowledgments 273
Abbreviations 273
References 274
7 NICKEL IRON HYDROGENASES 279
Wolfgang Lubitz, Maurice van Gastel, and Wolfgang Gartner
1. Introduction to Hydrogenases 280
2. Biochemistry and Molecular Biology 283
3. Crystallization and X Ray Structure Analysis 291
4. Spectroscopic Investigations 295
5. Electrochemistry 306
6. Hydrogenase Function and the Catalytic Cycle 309
7. Conclusions and Outlook 312
Acknowledgments 314
Abbreviations 314
References 315
xii CONTENTS
8 METHYL COENZYME M REDUCTASE
AND ITS NICKEL CORPHIN COENZYME F430
IN METHANOGENIC ARCHAEA 323
Bernhard Jaun and Rudolf K. Thauer
1. Introduction 324
2. Structure and Properties of Coenzyme F430 328
3. Molecular Properties of Methyl Coenzyme M Reductase 335
4. Catalytic Properties of Methyl Coenzyme M Reductase 345
Acknowledgments 350
Abbreviations 350
References 351
9 ACETYL COENZYME A SYNTHASES
AND NICKEL CONTAINING CARBON MONOXIDE
DEHYDROGENASES 357
Paul A. Lindahl and David E. Graham
1. Introduction 358
2. Structure and Function of Carbon Monoxide Dehydrogenases 361
3. Sequence Analysis and Phylogeny of Carbon Monoxide
Dehydrogenases 369
4. Acetyl Coenzyme A Synthases/Carbon Monoxide
Dehydrogenases 373
5. Sequence Analysis and Phylogeny of the a Subunit 381
6. Corrinoid Iron Sulfur Proteins 382
7. Acetyl Coenzyme A Decarbonylase/Synthases 384
8. Physiological Roles and Evolution of Acetyl Coenzyme A
Synthase/Carbon Monoxide Dehydrogenase Proteins 386
9. Origins and Evolution of ACDS, ACS/CODH,
and CODH Complexes 392
Acknowledgments 393
Abbreviations 394
Appendices 395
References 411
10 NICKEL SUPEROXIDE DISMUTASE 417
Peter A. Bryngelson and Michael J. Maroney
1. Introduction 418
2. Molecular Biology 422
3. Structural Biology 426
4. Mechanism 429
CONTENTS xiii
5. Conclusions 438
Acknowledgments 438
Abbreviations and Definitions 439
References 439
11 BIOCHEMISTRY OF THE NICKEL DEPENDENT
GLYOXALASE I ENZYMES 445
Nicole Sukdeo, Elisabeth Daub, and John F. Honek
1. Introduction 446
2. Biochemical Investigations of Glyoxalase I 450
3. Biophysical and Mechanistic Studies of Glyoxalase I 453
4. Glyoxalase I Genes and Protein Sequence Comparisons 460
5. Glyoxalase I as a Member of the pappp Superfamily
of Proteins 463
6. Other Aspects of Glyoxalase I 464
7. Conclusions 465
Acknowledgments 466
Abbreviations 466
References 467
12 NICKEL IN ACIREDUCTONE DIOXYGENASE 473
Thomas C. Pochapsky, Tingling Ju, Marina Dang, Rachel Beaulieu,
Gina M. Pagani, and Bo OuYang
1. Introduction 474
2. The Methionine Salvage Pathway 475
3. One Protein, Two Enzymes: Acireductone Dioxygenase from
Klebsiella oxytoca All
4. Homologs of Acireductone Dioxygenase from
Other Organisms 481
5. Known Acireductone Dioxygenase Structures 483
6. Spectroscopic Probes of Acireductone Dioxygenase Enzyme
Active Sites 486
7. Enzymatic Studies of Acireductone Dioxygenase 489
8. Mechanistic Considerations: What is the Role of Ni(II) in
Acireductone Dioxygenase Activity? 490
9. Structurally and Functionally Related Enzymes 493
10. Future Directions 495
Acknowledgments 497
Abbreviations 497
References 498
xiv CONTENTS
13 THE NICKEL REGULATED PEPTIDYL PROLYL
CIS/TRANS ISOMERASE SlyD 501
Frank Erdmann and Gunter Fischer
1. Introduction 502
2. SlyD Belongs to the Peptidyl Prolyl cisltrans Isomerases 503
3. Insights into the Biological Role of SlyD 513
4. Conclusions 515
Abbreviations and Definitions 515
References 516
14 CHAPERONES OF NICKEL METABOLISM 519
Soledad Quiroz, Jong K. Kim, Scott B. Mulrooney,
and Robert P. Hausinger
1. Introduction to Nickel Metabolism 520
2. Nickel Metallochaperones 530
3. Molecular Chaperones Involved in Nickel Metabolism 534
4. Conclusions and Remaining Questions 538
Acknowledgments 539
Abbreviations 539
References 540
15 THE ROLE OF NICKEL IN ENVIRONMENTAL
ADAPTATION OF THE GASTRIC PATHOGEN
HELICOBACTER PYLORI 545
Florian D. Ernst, Arnoud H. M. van Vliet, Manfred Kist, Johannes
G. Kusters, and Stefan Bereswill
1. Introduction 546
2. Nickel Enzymes and Environmental Adaptation 554
3. Nickel Uptake Systems 560
4. Mechanisms of Nickel Regulation 562
5. Protection of Nickel Metabolism 566
6. Metal Metabolism as Drug Target: Therapeutic Considerations 568
7. Conclusions 570
Abbreviations 570
References 571
16 NICKEL DEPENDENT GENE EXPRESSION 581
Konstantin Salnikow and Kazimierz S. Kasprzak
1. Introduction 582
2. Genetic and Epigenetic Changes in Nickel Exposed Cells 585
CONTENTS xv
3. Alteration of Gene Expression Following Nickel Induced
Lung Injury 587
4. Nickel Induced Allergy and Gene Expression 592
5. Nickel Induced Expression of Erythropoietin 592
6. Alteration of Transcription Factors and Signaling Pathways 593
7. Changes in Gene Expression and Nickel Carcinogenesis 607
8. Conclusions 608
Acknowledgments 609
Abbreviations 609
References 610
17 NICKEL TOXICITY AND CARCINOGENESIS 619
Kazimierz S. Kasprzak and Konstantin Salnikow
1. Introduction 621
2. An Overview of Nickel Toxicity 621
3. Nickel Induced Carcinogenesis 638
4. Conclusion 645
Acknowledgments 647
Abbreviations 647
References 647
SUBJECT INDEX 661 |
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| id | DE-604.BV021821486 |
| illustrated | Illustrated |
| index_date | 2024-07-02T15:54:25Z |
| indexdate | 2024-07-09T20:45:25Z |
| institution | BVB |
| isbn | 047001671X 9780470016718 |
| language | English |
| lccn | 2006022828 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015033622 |
| oclc_num | 70660028 |
| open_access_boolean | |
| owner | DE-703 DE-19 DE-BY-UBM DE-83 DE-11 |
| owner_facet | DE-703 DE-19 DE-BY-UBM DE-83 DE-11 |
| physical | XXVI, 702 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Wiley |
| record_format | marc |
| series | Metal ions in life sciences |
| series2 | Metal ions in life sciences |
| spelling | Nickel and its surprising impact in nature ed. by Astrid Sigel ... Chichester Wiley 2007 XXVI, 702 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Metal ions in life sciences 2 Nickel in the body Nickel enzymes Organonickel compounds Nickel metabolism Environmental Exposure Nickel adverse effects Nickel (DE-588)4042133-8 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Nickel (DE-588)4042133-8 s Stoffwechsel (DE-588)4057699-1 s DE-604 Sigel, Astrid Sonstige (DE-588)103367866X oth Metal ions in life sciences 2 (DE-604)BV022275400 2 http://www.loc.gov/catdir/toc/ecip0617/2006022828.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015033622&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nickel and its surprising impact in nature Metal ions in life sciences Nickel in the body Nickel enzymes Organonickel compounds Nickel metabolism Environmental Exposure Nickel adverse effects Nickel (DE-588)4042133-8 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| subject_GND | (DE-588)4042133-8 (DE-588)4057699-1 |
| title | Nickel and its surprising impact in nature |
| title_auth | Nickel and its surprising impact in nature |
| title_exact_search | Nickel and its surprising impact in nature |
| title_exact_search_txtP | Nickel and its surprising impact in nature |
| title_full | Nickel and its surprising impact in nature ed. by Astrid Sigel ... |
| title_fullStr | Nickel and its surprising impact in nature ed. by Astrid Sigel ... |
| title_full_unstemmed | Nickel and its surprising impact in nature ed. by Astrid Sigel ... |
| title_short | Nickel and its surprising impact in nature |
| title_sort | nickel and its surprising impact in nature |
| topic | Nickel in the body Nickel enzymes Organonickel compounds Nickel metabolism Environmental Exposure Nickel adverse effects Nickel (DE-588)4042133-8 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| topic_facet | Nickel in the body Nickel enzymes Organonickel compounds Nickel metabolism Environmental Exposure Nickel adverse effects Nickel Stoffwechsel |
| url | http://www.loc.gov/catdir/toc/ecip0617/2006022828.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015033622&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV022275400 |
| work_keys_str_mv | AT sigelastrid nickelanditssurprisingimpactinnature |