Metabolism in diabetes mellitus:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Washington
Carnegie Inst.
1910
|
| Series: | Carnegie Institution of Washington publication
Nr. 136 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VI, 234 S. |
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| 100 | 1 | |a Benedict, Francis Gano |d 1870-1957 |e Verfasser |0 (DE-588)116119977 |4 aut | |
| 245 | 1 | 0 | |a Metabolism in diabetes mellitus |c by Francis G[ano] Benedict and Elliott P[roctor] Joslin |
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| 490 | 1 | |a Carnegie Institution of Washington publication |v Nr. 136 | |
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| 650 | 4 | |a Metabolism | |
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Record in the Search Index
| _version_ | 1823947272253079553 |
|---|---|
| adam_text |
£•1 • Af
Metabolism in Diabetes Mellitus
BY
FRANCIS G BENEDICT and ELLIOTT P JOSLIN
Carnegie/Bucb
WASHINGTON, D C
PUBLISHED BY THE CARNEGIE INSTITUTION OF WASHINGTCI?®P®®^^®^
1910 I0HATIUS 001
VALKENB'I RQ
CONTENTS
PART I
Pagt
Introduction 3
Earlier investigations on gross metabolism in diabetes 3
Investigations made by the respiration chamber method 3
Investigations made with mouth-breathing appliances 12
Apparatus and methods used in the investigations here reported 15
Determination of the gaseous exchange with the respiration calorimeter 15
Determination of the gaseous exchange with the respiration apparatus,
^ using nosepieces 17
Method of determining the transformations of energy IS
Heat-production as compared with heat-elimination 19
Acetone in the breath 23
Supplementary apparatus 22
Stethoscope 22
Pneumograph 22
Significance of pneumograph curves 22
Urine analysis 24
Determination of total nitrogen 24
Determination of ammonia 24
Determination of diacetic acid 25
Determination of /3-oxybutyric acid 25
Determination * of sugar in 1-hour periods 26
Determination of sugar in 24-hour periods 28
PART II
Statistics of experiments on metabolism in diabetes 29
Classification of cases 29
Diet 29
Treatment 31
General clinical comparison of cases 33
Plan and details of experiments 35
Group I—Case A 36
Description of the case 36
Experiments with Case A 43
Metabolism experiments, A-l to A-16 44
Comparison of experiments with Case A 59
Group I—Case B 61
Group I—Case C 67
Group I—Case D 92
Group I—Case E 97
Group I—Case F 105
Group I—Case G Ill
Group I—Case H 118
Group I—Case I 126
Group I—Case J 131
Group II—Case K 139
Group II—Case L 144
Group III—Case M 152
III
IV CONTENTS
PART III
Page
Discussion of results and general conclusions 160
Pulse-rate 160
Respiration-rate 160
Body-temperature 161
Changes in body-weight: : 161
Body-surface 163
The gaseous exchange and energy transformations in periods without food 164
Significance of the calorific equivalent and the respiratory quotient 164
The gaseous exchange and energy transformations of normal indi
viduals 166
The gaseous exchange of normal individuals as determined with
the Zuntz-Geppert apparatus 167
The gaseous exchange of normal individuals during sleep in the
respiration calorimeter 168
Variations in metabolism during sleep due to variations in
physical characteristics 169
Comparison of the results obtained with the Zuntz-Geppert ap
paratus and with the respiration calorimeter during sleep 170
Gaseous exchange and energy transformations in recent control
experiments on normal individuals 171
Comparison of the metabolism of the same individual as deter
mined with three different types of apparatus 173
Comparison of metabolism measurements with three different
types of apparatus 174
The gaseous exchange and energy transformations in diabetes 176
Carbon-dioxide elimination • 176
Comparison with carbon-dioxide elimination in earlier experi
ments with diabetics 179
Oxygen absorption 181
* Comparison with oxygen absorption in earlier experiments
with diabetics 183
Comparison of the gaseous exchange of diabetics as determined
with three different types of apparatus 185
Carbon-dioxide elimination 185
Oxygen absorption 187
The energy transformations of diabetics 188
Indirect calorimetry 188
Direct calorimetry 189
Comparison of the metabolism in diabetes of different degrees of
severity 191
Comparison of the metabolism in diabetes with metabolism in
health 192
The nitrogen and sugar excretion of diabetics in periods without food 194
The nitrogen excretion 194
The dextrose-nitrogen ratio 197
The respiratory quotient in diabetes 203
The respiratory quotient as an index of the character of the katabolism 205
Vaporization of water from the lungs and skin in diabetes 207
Influence of the ingestion of food on metabolism in diabetes 208
Influence on the nitrogen and sugar excretion 208
Influence on the respiratory exchange and on the total katabolism 211
General conclusions regarding the influence of food in diabetes 215
Possible influence of the ingestion of cotfee 216
Influence of muscular work upon metabolism in diabetes 217
The calorific equivalents of carbon dioxide and oxygen 219
General considerations with regard to the increased metabolism of diabetics 223
Practical considerations 230
Investigations needed 232 |
| adam_txt |
£•1 • Af
Metabolism in Diabetes Mellitus
BY
FRANCIS G BENEDICT and ELLIOTT P JOSLIN
Carnegie/Bucb
WASHINGTON, D C
PUBLISHED BY THE CARNEGIE INSTITUTION OF WASHINGTCI?®P®®^^®^
1910 I0HATIUS 001
VALKENB'I RQ
CONTENTS
PART I
Pagt
Introduction 3
Earlier investigations on gross metabolism in diabetes 3
Investigations made by the respiration chamber method 3
Investigations made with mouth-breathing appliances 12
Apparatus and methods used in the investigations here reported 15
Determination of the gaseous exchange with the respiration calorimeter 15
Determination of the gaseous exchange with the respiration apparatus,
^ using nosepieces 17
Method of determining the transformations of energy IS
Heat-production as compared with heat-elimination 19
Acetone in the breath 23
Supplementary apparatus 22
Stethoscope 22
Pneumograph 22
Significance of pneumograph curves 22
Urine analysis 24
Determination of total nitrogen 24
Determination of ammonia 24
Determination of diacetic acid 25
Determination of /3-oxybutyric acid 25
Determination * of sugar in 1-hour periods 26
Determination of sugar in 24-hour periods 28
PART II
Statistics of experiments on metabolism in diabetes 29
Classification of cases 29
Diet 29
Treatment 31
General clinical comparison of cases 33
Plan and details of experiments 35
Group I—Case A 36
Description of the case 36
Experiments with Case A 43
Metabolism experiments, A-l to A-16 44
Comparison of experiments with Case A 59
Group I—Case B 61
Group I—Case C 67
Group I—Case D 92
Group I—Case E 97
Group I—Case F 105
Group I—Case G Ill
Group I—Case H 118
Group I—Case I 126
Group I—Case J 131
Group II—Case K 139
Group II—Case L 144
Group III—Case M 152
III
IV CONTENTS
PART III
Page
Discussion of results and general conclusions 160
Pulse-rate 160
Respiration-rate 160
Body-temperature 161
Changes in body-weight: : 161
Body-surface 163
The gaseous exchange and energy transformations in periods without food 164
Significance of the calorific equivalent and the respiratory quotient 164
The gaseous exchange and energy transformations of normal indi
viduals 166
The gaseous exchange of normal individuals as determined with
the Zuntz-Geppert apparatus 167
The gaseous exchange of normal individuals during sleep in the
respiration calorimeter 168
Variations in metabolism during sleep due to variations in
physical characteristics 169
Comparison of the results obtained with the Zuntz-Geppert ap
paratus and with the respiration calorimeter during sleep 170
Gaseous exchange and energy transformations in recent control
experiments on normal individuals 171
Comparison of the metabolism of the same individual as deter
mined with three different types of apparatus 173
Comparison of metabolism measurements with three different
types of apparatus 174
The gaseous exchange and energy transformations in diabetes 176
Carbon-dioxide elimination • 176
Comparison with carbon-dioxide elimination in earlier experi
ments with diabetics 179
Oxygen absorption 181
* Comparison with oxygen absorption in earlier experiments
with diabetics 183
Comparison of the gaseous exchange of diabetics as determined
with three different types of apparatus 185
Carbon-dioxide elimination 185
Oxygen absorption 187
The energy transformations of diabetics 188
Indirect calorimetry 188
Direct calorimetry 189
Comparison of the metabolism in diabetes of different degrees of
severity 191
Comparison of the metabolism in diabetes with metabolism in
health 192
The nitrogen and sugar excretion of diabetics in periods without food 194
The nitrogen excretion 194
The dextrose-nitrogen ratio 197
The respiratory quotient in diabetes 203
The respiratory quotient as an index of the character of the katabolism 205
Vaporization of water from the lungs and skin in diabetes 207
Influence of the ingestion of food on metabolism in diabetes 208
Influence on the nitrogen and sugar excretion 208
Influence on the respiratory exchange and on the total katabolism 211
General conclusions regarding the influence of food in diabetes 215
Possible influence of the ingestion of cotfee 216
Influence of muscular work upon metabolism in diabetes 217
The calorific equivalents of carbon dioxide and oxygen 219
General considerations with regard to the increased metabolism of diabetics 223
Practical considerations 230
Investigations needed 232 |
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| author | Benedict, Francis Gano 1870-1957 Joslin, Elliott P. 1869-1962 |
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| spelling | Benedict, Francis Gano 1870-1957 Verfasser (DE-588)116119977 aut Metabolism in diabetes mellitus by Francis G[ano] Benedict and Elliott P[roctor] Joslin Washington Carnegie Inst. 1910 VI, 234 S. txt rdacontent n rdamedia nc rdacarrier Carnegie Institution of Washington publication Nr. 136 Diabetes Metabolism Joslin, Elliott P. 1869-1962 Verfasser (DE-588)172172268 aut Carnegie Institution of Washington publication Nr. 136 (DE-604)BV035415500 136 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014947126&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Benedict, Francis Gano 1870-1957 Joslin, Elliott P. 1869-1962 Metabolism in diabetes mellitus Carnegie Institution of Washington publication Diabetes Metabolism |
| title | Metabolism in diabetes mellitus |
| title_auth | Metabolism in diabetes mellitus |
| title_exact_search | Metabolism in diabetes mellitus |
| title_exact_search_txtP | Metabolism in diabetes mellitus |
| title_full | Metabolism in diabetes mellitus by Francis G[ano] Benedict and Elliott P[roctor] Joslin |
| title_fullStr | Metabolism in diabetes mellitus by Francis G[ano] Benedict and Elliott P[roctor] Joslin |
| title_full_unstemmed | Metabolism in diabetes mellitus by Francis G[ano] Benedict and Elliott P[roctor] Joslin |
| title_short | Metabolism in diabetes mellitus |
| title_sort | metabolism in diabetes mellitus |
| topic | Diabetes Metabolism |
| topic_facet | Diabetes Metabolism |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014947126&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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