Radioionidation reactions for radiopharmaceuticals: compendium for effective synthesis strategies
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer
2006
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Druckfehler im Sachtitel: Radioionidation reactions for radiopharmaceuticals |
| Beschreibung: | XI, 101 S. graph. Darst. |
| ISBN: | 1402045603 9781402045608 |
Internformat
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Datensatz im Suchindex
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| adam_text | RADIOIONIDATION REACTIONS FOR RADIOPHARMACEUTICALS COMPENDIUM FOR
EFFECTIVE SYNTHESIS STRATEGIES BY HEINZ H. COENEN INSTITUTE OF NUCLEAR
CHEMISTRY, RESEARCH CENTRE JIILICH (FZJ), JTILICH JOHN MERTENS BEFY/NUGE
- RADIOPHARMACEUTICAL CHEMISTRY, BRUXELLES AND BERNARD MAZIERE CEA/DRIPP
- DEPARTEMENT DE BIOLOGIE SERVICE HOSPITALLER FREDERIC-JOLIOT, ORSAY
WITH CONTRIBUTIONS FROM PETER BLAUENSTEIN, PATRIK EMOND, YVES FRANGIN,
DENIS GUILLOTEAU, MARIELLE GYSEMANS, MARCUS HOLSCHBACH, CHRISTIAN LOC H,
AUGUST P. SCHUBIGER AND SYED M. QAIM 4Y SPRINGER TABLE OF CONTENTS 1
INTRODUCTION 1 1.1 AUTHENTIC LABELLING 2 1.2 LABELLING WITH METALLIC
RADIOISOTOPES 2 1.3 LABELLING METHODS FOR RADIOIODINE 2 2 IODINE
RADIONUCLIDES 5 2.1 PHYSICAL PROPERTIES AND AREAS OF APPLICATION 5 2.2
RADIOCHEMICAL AND RADIONUCLIDIC PURITY 5 2.3 SPECIFIC RADIOACTIVITY 7
2.4 PRODUCTION OF IODINE RADIONUCLIDES 8 2.4.1 PRODUCTION OF L20 I 8
2.4.2 PRODUCTION OF 122 I 9 2.4.3 PRODUCTION OF I23 I 9 2.4.4 PRODUCTION
OF 124 I 12 2.4.5 PRODUCTION OF I25 I 13 2.4.6 PRODUCTION OF I31 I 14
2.5 REFERENCES 15 3 IODINATED RADIOPHARMACEUTICALS 17 3.1
PHYSICO-CHEMICAL PROPERTIES 17 3.1.1 CARBON-IODINE BOND 17 3.1.2
LIPOPHILICITY 20 3.2 PHARMACEUTICAL PROPERTIES 23 3.2.1 CHEMICAL AND
RADIOCHEMICAL PURITY 23 3.2.2 STABILITY IN VITRO AND SHELF-LIFE 24 TABLE
OF CONTENTS 3.2.3 PHARMACOLOGICAL CHARACTERISTICS 25 3.2.4
PHARMACEUTICAL CONSIDERATIONS 26 3.3 REFERENCES 26 METHODS OF
RADIOIODINATION 29 4.1 NUCLEOPHILIC SUBSTITUTION 30 4.1.1 GENERAL 30
4.1.2 HALOGEN EXCHANGE IN ALIPHATIC COMPOUNDS 30 4.1.3 HALOGEN EXCHANGE
IN AROMATIC COMPOUNDS 32 4.1.4 COPPER-ASSISTED HALOGEN EXCHANGE 34 4.1.5
RADIOIODO-DEDIAZONISATION 37 4.1.6 REFERENCES 38 4.2 ELECTROPHILIC
SUBSTITUTION 45 4.2.1 GENERAL CONSIDERATIONS 45 4.2.2 OXIDISING REAGENTS
46 4.2.3 DIRECT ELECTROPHILIC RADIOIODINATION (RADIOIODO-DEPROTONATION)
50 4.2.4 DEMETALLATION TECHNIQUES (RADIOIODO-DEMETALLATION) 51 4.2.5
REFERENCES 57 4.3 MACROMOLECULE LABELLING 62 4.3.1 PROTEIN
RADIOIODINATION 62 4.3.2 OLIGONUCLEOTIDE RADIOIODINATION 68 4.3.3
REFERENCES 69 IODINATED RADIOPHARMACEUTICALS 73 5.1 EXAMPLES OF
NUCLEOPHILIC LABELLING 73 5.1.1 INTERHALOGEN EXCHANGE 73 5.1.2 OTHER
METHODS 76 5.2 EXAMPLES OF ELECTROPHILIC LABELLING 77 5.2.1 DIRECT
IODINATION 77 5.2.2 RADIOIODO-DEMETALLATION 80 5.3 REFERENCES 84 EXPERT
SYSTEM 87 6.1 GENERAL CONSIDERATIONS 87 6.2 ACTIVATING EFFECTS OF
AROMATIC SUBSTITUENTS 88 6.2.1 AROMATIC NUCLEOPHILIC SUBSTITUTION (SN AR
) 88 6.2.2 AROMATIC ELECTROPHILIC SUBSTITUTION (SE AR ) 89 TABLE OF
CONTENTS XI 7 GUIDELINES FOR RADIOIODINATION 93 7.1 INTRODUCTION 93
7.1.1 REACTIVITY OF THE AROMATIC RING 93 7.2 EXAMPLES 94 7.2.1 COMPOUND:
R91150 94 7.2.2 COMPOUND: IBZM 96 7.3 BLANK CHECKLIST 98
|
| adam_txt |
RADIOIONIDATION REACTIONS FOR RADIOPHARMACEUTICALS COMPENDIUM FOR
EFFECTIVE SYNTHESIS STRATEGIES BY HEINZ H. COENEN INSTITUTE OF NUCLEAR
CHEMISTRY, RESEARCH CENTRE JIILICH (FZJ), JTILICH JOHN MERTENS BEFY/NUGE
- RADIOPHARMACEUTICAL CHEMISTRY, BRUXELLES AND BERNARD MAZIERE CEA/DRIPP
- DEPARTEMENT DE BIOLOGIE SERVICE HOSPITALLER FREDERIC-JOLIOT, ORSAY
WITH CONTRIBUTIONS FROM PETER BLAUENSTEIN, PATRIK EMOND, YVES FRANGIN,
DENIS GUILLOTEAU, MARIELLE GYSEMANS, MARCUS HOLSCHBACH, CHRISTIAN LOC'H,
AUGUST P. SCHUBIGER AND SYED M. QAIM 4Y SPRINGER TABLE OF CONTENTS 1
INTRODUCTION 1 1.1 AUTHENTIC LABELLING 2 1.2 LABELLING WITH METALLIC
RADIOISOTOPES 2 1.3 LABELLING METHODS FOR RADIOIODINE 2 2 IODINE
RADIONUCLIDES 5 2.1 PHYSICAL PROPERTIES AND AREAS OF APPLICATION 5 2.2
RADIOCHEMICAL AND RADIONUCLIDIC PURITY 5 2.3 SPECIFIC RADIOACTIVITY 7
2.4 PRODUCTION OF IODINE RADIONUCLIDES 8 2.4.1 PRODUCTION OF L20 I 8
2.4.2 PRODUCTION OF 122 I 9 2.4.3 PRODUCTION OF I23 I 9 2.4.4 PRODUCTION
OF 124 I 12 2.4.5 PRODUCTION OF I25 I 13 2.4.6 PRODUCTION OF I31 I 14
2.5 REFERENCES 15 3 IODINATED RADIOPHARMACEUTICALS 17 3.1
PHYSICO-CHEMICAL PROPERTIES 17 3.1.1 CARBON-IODINE BOND 17 3.1.2
LIPOPHILICITY 20 3.2 PHARMACEUTICAL PROPERTIES 23 3.2.1 CHEMICAL AND
RADIOCHEMICAL PURITY 23 3.2.2 STABILITY IN VITRO AND SHELF-LIFE 24 TABLE
OF CONTENTS 3.2.3 PHARMACOLOGICAL CHARACTERISTICS 25 3.2.4
PHARMACEUTICAL CONSIDERATIONS 26 3.3 REFERENCES 26 METHODS OF
RADIOIODINATION 29 4.1 NUCLEOPHILIC SUBSTITUTION 30 4.1.1 GENERAL 30
4.1.2 HALOGEN EXCHANGE IN ALIPHATIC COMPOUNDS 30 4.1.3 HALOGEN EXCHANGE
IN AROMATIC COMPOUNDS 32 4.1.4 COPPER-ASSISTED HALOGEN EXCHANGE 34 4.1.5
RADIOIODO-DEDIAZONISATION 37 4.1.6 REFERENCES 38 4.2 ELECTROPHILIC
SUBSTITUTION 45 4.2.1 GENERAL CONSIDERATIONS 45 4.2.2 OXIDISING REAGENTS
46 4.2.3 DIRECT ELECTROPHILIC RADIOIODINATION (RADIOIODO-DEPROTONATION)
50 4.2.4 DEMETALLATION TECHNIQUES (RADIOIODO-DEMETALLATION) 51 4.2.5
REFERENCES 57 4.3 MACROMOLECULE LABELLING 62 4.3.1 PROTEIN
RADIOIODINATION 62 4.3.2 OLIGONUCLEOTIDE RADIOIODINATION 68 4.3.3
REFERENCES 69 IODINATED RADIOPHARMACEUTICALS 73 5.1 EXAMPLES OF
NUCLEOPHILIC LABELLING 73 5.1.1 INTERHALOGEN EXCHANGE 73 5.1.2 OTHER
METHODS 76 5.2 EXAMPLES OF ELECTROPHILIC LABELLING 77 5.2.1 DIRECT
IODINATION 77 5.2.2 RADIOIODO-DEMETALLATION 80 5.3 REFERENCES 84 EXPERT
SYSTEM 87 6.1 GENERAL CONSIDERATIONS 87 6.2 ACTIVATING EFFECTS OF
AROMATIC SUBSTITUENTS 88 6.2.1 AROMATIC NUCLEOPHILIC SUBSTITUTION (SN AR
) 88 6.2.2 AROMATIC ELECTROPHILIC SUBSTITUTION (SE AR ) 89 TABLE OF
CONTENTS XI 7 GUIDELINES FOR RADIOIODINATION 93 7.1 INTRODUCTION 93
7.1.1 REACTIVITY OF THE AROMATIC RING 93 7.2 EXAMPLES 94 7.2.1 COMPOUND:
R91150 94 7.2.2 COMPOUND: IBZM 96 7.3 BLANK CHECKLIST 98 |
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| spellingShingle | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies Drugs Effectiveness Handbooks, manuals, etc Iodine Radioisotopes chemistry Iodine Radioisotopes therapeutic use Radioactive Tracers Radiopharmaceuticals Synthesis Handbooks, manuals, etc Radiopharmaceuticals radiation effects Tomography, Emission-Computed, Single-Photon Arzneimittel (DE-588)4003115-9 gnd Radiopharmakon (DE-588)4048223-6 gnd Radioiodierung (DE-588)4176832-2 gnd Iodisotop (DE-588)4162277-7 gnd |
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| title | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies |
| title_alt | Radioiodination reactions for radiopharmaceuticals |
| title_auth | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies |
| title_exact_search | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies |
| title_exact_search_txtP | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies |
| title_full | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies by Heinz H. Coenen ... |
| title_fullStr | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies by Heinz H. Coenen ... |
| title_full_unstemmed | Radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies by Heinz H. Coenen ... |
| title_short | Radioionidation reactions for radiopharmaceuticals |
| title_sort | radioionidation reactions for radiopharmaceuticals compendium for effective synthesis strategies |
| title_sub | compendium for effective synthesis strategies |
| topic | Drugs Effectiveness Handbooks, manuals, etc Iodine Radioisotopes chemistry Iodine Radioisotopes therapeutic use Radioactive Tracers Radiopharmaceuticals Synthesis Handbooks, manuals, etc Radiopharmaceuticals radiation effects Tomography, Emission-Computed, Single-Photon Arzneimittel (DE-588)4003115-9 gnd Radiopharmakon (DE-588)4048223-6 gnd Radioiodierung (DE-588)4176832-2 gnd Iodisotop (DE-588)4162277-7 gnd |
| topic_facet | Drugs Effectiveness Handbooks, manuals, etc Iodine Radioisotopes chemistry Iodine Radioisotopes therapeutic use Radioactive Tracers Radiopharmaceuticals Synthesis Handbooks, manuals, etc Radiopharmaceuticals radiation effects Tomography, Emission-Computed, Single-Photon Arzneimittel Radiopharmakon Radioiodierung Iodisotop Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2805850&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014944394&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT coenenheinzh radioionidationreactionsforradiopharmaceuticalscompendiumforeffectivesynthesisstrategies AT coenenheinzh radioiodinationreactionsforradiopharmaceuticals |