Organic synthetic methods:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge, UK
Royal Soc. of Chemistry
2002
|
| Series: | Tutorial chemistry texts
12 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VII, 175 S. Ill. |
| ISBN: | 0854046828 |
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Record in the Search Index
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| adam_text | Contents
1 Introduction 1
1.1 Synthetic Strategies 1
1.2 Steric Factors 3
1.3 Criteria for Evaluating Synthetic Routes 3
1.4 Some Synthetic Terms 6
1.5 Learning to Apply Synthetic Methods 6
2 Organometallic and Ylide Methods of 9
Carbon-Carbon Bond Formation
2.1 Introduction 9
2.2 Reactions of Organometallic Compounds 11
2.3 Acetylides and Nitriles 20
2.4 Ylide Reactions 22
2.5 Silicon and Boron in C-C Bond Formation 26
3 Carbonyl Activation and Enolate Chemistry 32
in Carbon-Carbon Bond Formation
3.1 Introduction 32
3.2 Alkylation Reactions 36
3.3 Enolate Anions in Carbonyl Addition Reactions 39
3.4 The Stereochemistry of Condensation Reactions 48
4 Carbocations in Synthesis 54
4.1 Introduction 54
4.2 Alkyl Carbocations: the Friedel-Crafts Alkylation 55
4.3 Carbocations Derived from Aldehydes and Ketones 56
4.4 Acylium Carbocations: the Friedel-Crafts Acylation 57
4.5 Acid-catalysed Rearrangement Reactions 58
5 Free Radical and Pericyclic Reactions in the 64
Formation of Carbon-Carbon Bonds
5.1 Carbon Radical Reactions 64
5.2 Radical Addition Reactions 68
5.3 Carbenes 69
5.4 Alkene Metathesis 70
•5.5 The Diels-Alder Reaction 71
5.6 The Ene Reaction 73
5.7 The Cope and Claisen Rearrangements 73
6 Methods of Making Carbon-Nitrogen Bonds 78
6.1 Introduction 78
6.2 Electrophilic Methods of Making C-N Bonds 79
6.3 Nucleophilic Methods of Making C-N Bonds 80
6.4 Rearrangement Methods 84
6.5 The Synthesis of Amino Acids 85
6.6 The Synthesis of Heterocyclic Compounds 87
7 Functional Group Transformations 96
7.1 Oxidation 96
7.2 Reduction 103
7.3 Halogenation 111
8 Protecting Groups 126
8.1 Protection of Functional Groups 126
8.2 Peptide Synthesis 133
8.3 Combinatorial Synthesis 136
9 Some Examples of Total Syntheses 142
9.1 Introduction 142
9.2 p-Eudesmol 143
9.3 Griseofulvin 144
9.4 Thiamine (Vitamin Bj) 147
9.5 Prostaglandins 150
Further Reading 153
Answers to Problems 157
Subject Index 173
|
| adam_txt |
Contents
1 Introduction 1
1.1 Synthetic Strategies 1
1.2 Steric Factors 3
1.3 Criteria for Evaluating Synthetic Routes 3
1.4 Some Synthetic Terms 6
1.5 Learning to Apply Synthetic Methods 6
2 Organometallic and Ylide Methods of 9
Carbon-Carbon Bond Formation
2.1 Introduction 9
2.2 Reactions of Organometallic Compounds 11
2.3 Acetylides and Nitriles 20
2.4 Ylide Reactions 22
2.5 Silicon and Boron in C-C Bond Formation 26
3 Carbonyl Activation and Enolate Chemistry 32
in Carbon-Carbon Bond Formation
3.1 Introduction 32
3.2 Alkylation Reactions 36
3.3 Enolate Anions in Carbonyl Addition Reactions 39
3.4 The Stereochemistry of Condensation Reactions 48
4 Carbocations in Synthesis 54
4.1 Introduction 54
4.2 Alkyl Carbocations: the Friedel-Crafts Alkylation 55
4.3 Carbocations Derived from Aldehydes and Ketones 56
4.4 Acylium Carbocations: the Friedel-Crafts Acylation 57
4.5 Acid-catalysed Rearrangement Reactions 58
5 Free Radical and Pericyclic Reactions in the 64
Formation of Carbon-Carbon Bonds
5.1 Carbon Radical Reactions 64
5.2 Radical Addition Reactions 68
5.3 Carbenes 69
5.4 Alkene Metathesis 70
•5.5 The Diels-Alder Reaction 71
5.6 The Ene Reaction 73
5.7 The Cope and Claisen Rearrangements 73
6 Methods of Making Carbon-Nitrogen Bonds 78
6.1 Introduction 78
6.2 Electrophilic Methods of Making C-N Bonds 79
6.3 Nucleophilic Methods of Making C-N Bonds 80
6.4 Rearrangement Methods 84
6.5 The Synthesis of Amino Acids 85
6.6 The Synthesis of Heterocyclic Compounds 87
7 Functional Group Transformations 96
7.1 Oxidation 96
7.2 Reduction 103
7.3 Halogenation 111
8 Protecting Groups 126
8.1 Protection of Functional Groups 126
8.2 Peptide Synthesis 133
8.3 Combinatorial Synthesis 136
9 Some Examples of Total Syntheses 142
9.1 Introduction 142
9.2 p-Eudesmol 143
9.3 Griseofulvin 144
9.4 Thiamine (Vitamin Bj) 147
9.5 Prostaglandins 150
Further Reading 153
Answers to Problems 157
Subject Index 173 |
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| spelling | Hanson, James R. Verfasser aut Organic synthetic methods James R. Hanson Cambridge, UK Royal Soc. of Chemistry 2002 VII, 175 S. Ill. txt rdacontent n rdamedia nc rdacarrier Tutorial chemistry texts 12 Organic compounds Synthesis Organic compounds Synthesis Problems, exercises, etc Organische Synthese (DE-588)4075695-6 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Organische Synthese (DE-588)4075695-6 s DE-604 Tutorial chemistry texts 12 (DE-604)BV035419963 12 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014906236&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hanson, James R. Organic synthetic methods Tutorial chemistry texts Organic compounds Synthesis Organic compounds Synthesis Problems, exercises, etc Organische Synthese (DE-588)4075695-6 gnd |
| subject_GND | (DE-588)4075695-6 (DE-588)4123623-3 |
| title | Organic synthetic methods |
| title_auth | Organic synthetic methods |
| title_exact_search | Organic synthetic methods |
| title_exact_search_txtP | Organic synthetic methods |
| title_full | Organic synthetic methods James R. Hanson |
| title_fullStr | Organic synthetic methods James R. Hanson |
| title_full_unstemmed | Organic synthetic methods James R. Hanson |
| title_short | Organic synthetic methods |
| title_sort | organic synthetic methods |
| topic | Organic compounds Synthesis Organic compounds Synthesis Problems, exercises, etc Organische Synthese (DE-588)4075695-6 gnd |
| topic_facet | Organic compounds Synthesis Organic compounds Synthesis Problems, exercises, etc Organische Synthese Lehrbuch |
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