Asphalt (Bitumen):
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
2004
|
| Schriftenreihe: | Concise international chemical assessment document
59 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IV, 50 S. |
| ISBN: | 9241530596 |
Internformat
MARC
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| 100 | 1 | |a Wess, Joann A. |e Verfasser |4 aut | |
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| 264 | 1 | |a Geneva |b World Health Organization |c 2004 | |
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| 700 | 1 | |a Olsen, Larry D. |e Verfasser |4 aut | |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6
2.1 Definitions and terminology 6
2.2 Production of asphalt and some asphalt products 8
3. ANALYTICAL METHODS 11
3.1 Chemical analysis 11
3.2 Biological analysis 11
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 12
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 12
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 12
6.1 Environmental levels 12
6.2 Human exposure 13
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 14
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 15
8.1 Irritation 15
8.2 Genotoxicity 16
8.2.1 Mutagenic effects 16
8.2.2 Micronuclei formation and chromosomal aberrations 16
8.2.3 DNA adduct formation 16
8.2.4 Intercellular communication 17
8.3 Toxic responses and CYP1A1 17
8.4 Carcinogenicity 17
9. EFFECTS ON HUMANS 20
9.1 Acute effects 20
9.1.1 Respiratory effects 21
9.1.2 Other acute effects 22
9.1.3 Burns 22
9.2 Chronic effects 23
9.2.1 Lung cancer among pavers 23
9.2.2 Lung cancer among roofers and asphalt roofing materials production workers 23
9.2.3 The IARC study of asphalt workers 23
9.2.4 Other asphalt exposures and cancers 26
9.3 Other effects 29
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND HELD 29
11. EFFECTS EVALUATION 29
11.1 Evaluation of health effects 29
11.1.1 Hazard identification and dose—response assessment 29
Concise International Chemical Assessment Document 59 11.1.2 Criteria for setting tolerable intakes/concentrations for asphalt 30
11.1.3 Sample risk characterization 30
11.1.4 Uncertainties in the hazard characterization 30
11.1.4.1 Chemistry 31
11.1.4.2 Animal studies 31
11.1.4.3 Human studies 31
11.1.4.4 Potential for exposure 31
11.1.4.5 Conclusion 32
11.2 Evaluation of environmental effects 32
12. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 32
REFERENCES 33
APPENDIX 1 — SOURCE DOCUMENT 38
APPENDIX 2 —CICAD PEER REVIEW 39
APPENDIX 3 — CICAD FINAL REVIEW BOARD 40
APPENDIX 4 — ABBREVIATIONS AND ACRONYMS 41
INTERNATIONAL CHEMICAL SAFETY CARD 42
RESUME D ORIENTATION 44
RESUMEN DE ORIENTACION 47
|
| adam_txt |
TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6
2.1 Definitions and terminology 6
2.2 Production of asphalt and some asphalt products 8
3. ANALYTICAL METHODS 11
3.1 Chemical analysis 11
3.2 Biological analysis 11
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 12
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 12
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 12
6.1 Environmental levels 12
6.2 Human exposure 13
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 14
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 15
8.1 Irritation 15
8.2 Genotoxicity 16
8.2.1 Mutagenic effects 16
8.2.2 Micronuclei formation and chromosomal aberrations 16
8.2.3 DNA adduct formation 16
8.2.4 Intercellular communication 17
8.3 Toxic responses and CYP1A1 17
8.4 Carcinogenicity 17
9. EFFECTS ON HUMANS 20
9.1 Acute effects 20
9.1.1 Respiratory effects 21
9.1.2 Other acute effects 22
9.1.3 Burns 22
9.2 Chronic effects 23
9.2.1 Lung cancer among pavers 23
9.2.2 Lung cancer among roofers and asphalt roofing materials production workers 23
9.2.3 The IARC study of asphalt workers 23
9.2.4 Other asphalt exposures and cancers 26
9.3 Other effects 29
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND HELD 29
11. EFFECTS EVALUATION 29
11.1 Evaluation of health effects 29
11.1.1 Hazard identification and dose—response assessment 29
Concise International Chemical Assessment Document 59 11.1.2 Criteria for setting tolerable intakes/concentrations for asphalt 30
11.1.3 Sample risk characterization 30
11.1.4 Uncertainties in the hazard characterization 30
11.1.4.1 Chemistry 31
11.1.4.2 Animal studies 31
11.1.4.3 Human studies 31
11.1.4.4 Potential for exposure 31
11.1.4.5 Conclusion 32
11.2 Evaluation of environmental effects 32
12. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 32
REFERENCES 33
APPENDIX 1 — SOURCE DOCUMENT 38
APPENDIX 2 —CICAD PEER REVIEW 39
APPENDIX 3 — CICAD FINAL REVIEW BOARD 40
APPENDIX 4 — ABBREVIATIONS AND ACRONYMS 41
INTERNATIONAL CHEMICAL SAFETY CARD 42
RESUME D'ORIENTATION 44
RESUMEN DE ORIENTACION 47 |
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| index_date | 2024-07-02T14:46:33Z |
| indexdate | 2024-07-09T20:39:32Z |
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| isbn | 9241530596 |
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| publishDate | 2004 |
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| series | Concise international chemical assessment document |
| series2 | Concise international chemical assessment document |
| spelling | Wess, Joann A. Verfasser aut Asphalt (Bitumen) 1. draft prepared Joann A. Wess, Larry D. Olsen, and Marie Haring Sweeney Geneva World Health Organization 2004 IV, 50 S. txt rdacontent n rdamedia nc rdacarrier Concise international chemical assessment document 59 Olsen, Larry D. Verfasser aut Sweeney, Marie H. Verfasser aut Concise international chemical assessment document 59 (DE-604)BV021595306 59 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014812785&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wess, Joann A. Olsen, Larry D. Sweeney, Marie H. Asphalt (Bitumen) Concise international chemical assessment document |
| title | Asphalt (Bitumen) |
| title_auth | Asphalt (Bitumen) |
| title_exact_search | Asphalt (Bitumen) |
| title_exact_search_txtP | Asphalt (Bitumen) |
| title_full | Asphalt (Bitumen) 1. draft prepared Joann A. Wess, Larry D. Olsen, and Marie Haring Sweeney |
| title_fullStr | Asphalt (Bitumen) 1. draft prepared Joann A. Wess, Larry D. Olsen, and Marie Haring Sweeney |
| title_full_unstemmed | Asphalt (Bitumen) 1. draft prepared Joann A. Wess, Larry D. Olsen, and Marie Haring Sweeney |
| title_short | Asphalt (Bitumen) |
| title_sort | asphalt bitumen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014812785&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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