Understanding nicotine and tobacco addiction: [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2006
|
| Schriftenreihe: | Novartis Foundation symposium
275 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VIII, 275 S. Ill., graph. Darst. |
| ISBN: | 9780470016572 0470016574 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation,
London,
17-19
May
2005
Editors: Gregory Bock (Organiser) and Jamie
Goode
This symposium is based on a proposal made by Robert West and Gino van Heeke
William
A. Corrigall Chair s introduction
1
Richard
Peto
and Richard Doll The hazards of smoking and the benefits of
stopping
3
Discussion
15
Ian Stolerman Animal models for nicotine dependence
17
Discussion
28
Robert West Defining and assessing nicotine dependence in humans
36
Discussion
52
General discussion I
59
Uwe Maskos,
Sylvie Granon,
Philippe
Faure
and Jean-Pierre Changeux
Nicotinic acetylcholine receptor functions in the CNS investigated with a novel
method of stereotaxic gene re-expression in knockout mice
64
Discussion
79
Marina R.
Picciotto
Nicotine-mediated activation of signal transduction
pathways
83
Discussion
90
David Balfour Complementary roles for the accumbal shell and core in
nicotine dependence
96
Discussion
105
CONTENTS
Christian Heidbreder The dopamine D3
system:
new opportunities for
dopamine-based reward
116
Discussion
123
Athina
Markou
Pathways and systems involved in nicotine
dependence
132
Discussion
145
Arthur
L. Brody
Localizing tobacco dependence pathways with functional
brain imaging
153
Discussion
166
Caryn Lerman Pharmacogenetic approach to nicotine dependence
treatment
171
Discussion
178
Robert Walton Pharmacogenomics and smoking cessation
184
Discussion
194
General discussion II Power in studies
197
Receptor desensitization
199
Peter
Hajek
What Hmits the efficacy of current nicotine replacement
therapies?
204
Discussion
213
Saul Shiftman, Stuart Ferguson and Deborah
Scharf
Exploring
behavioural mechanisms of nicotine replacement therapy for smoking
cessation
219
Discussion
231
Rachel F. Tyndale and Edward M. Sellers Modifying the metabolism of
nicotine as a therapeutic strategy
235
Discussion
244
William A. Corrigall Challenges in discovery and development of
pharmacotherapies for tobacco addiction
249
Discussion
259
Final discussion Nicotine comorbidity
262
Animal models
264
Index of contributors
266
Subject index
268
UNDERSTANDING NICOTINE
AND TOBACCO ADDICTION
Chair: William A. Corrigall
Cigarette smoking is estimated to lead to
4.9
million premature deaths per year worldwide.
This is predicted to rise to
10
million by
2020.
In western countries it kills half of all smokers
who fail to stop.
The prevailing model for tobacco addiction is that nicotine from cigarettes rewards smoking
and punishes abstinence, tapping into a motivational system of
operant
conditioning that
requires no conscious awareness. However, there are also accounts which involve cognitive
biases and the effect of nicotine on impulse control. The brain pathways involved have been
studied extensively, but the role of different nicotine receptor subtypes and other
neurotransmitter
systems is still subject to debate.
In western countries, cigarette smoking as an adult has a heritability of
30-50%
and candidate
genes have been identified that may contribute in part to addiction susceptibility. Many
socio¬
cultural
correlates of cigarette smoking have been established, but a comprehensive model
that accounts for these and links them with the psychobiological aspects of nicotine addiction
has not been forthcoming. Structured behavioural support programmes aid cessation
attempts, as do a number of pharmacotherapies, most notably nicotine replacement
treatments and bupropion, but the underlying mechanisms are unclear.
This book deals with the problems involved in understanding and treating nicotine and tobacco
addiction. Topics covered include the nature of the worldwide health problem posed by
cigarette smoking, the psychodynamics of cigarette addiction, and the basic pharmacology
and biochemistry of nicotine and its effect on the brain. Further chapters analyse the genetic
basis of susceptibility to nicotine addiction. Finally, the contributors address approaches to
therapy. A continuing theme in the discussions throughout the book is how best to treat
nicotine addiction, given that many smokers would like to stop smoking but are unable to do
so because of their addiction.
This book will be of great value to all psychologists and psychiatrists working on addiction,
specifically to nicotine but also to other compounds and behaviours. It will also be of interest
to neuroscientists and pharmacologists working on nicotine receptors and the brain pathways
involved in dependence, as well as to biochemists, molecular biologists and to public
health officials.
|
| adam_txt |
Contents
Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation,
London,
17-19
May
2005
Editors: Gregory Bock (Organiser) and Jamie
Goode
This symposium is based on a proposal made by Robert West and Gino van Heeke
William
A. Corrigall Chair's introduction
1
Richard
Peto
and Richard Doll The hazards of smoking and the benefits of
stopping
3
Discussion
15
Ian Stolerman Animal models for nicotine dependence
17
Discussion
28
Robert West Defining and assessing nicotine dependence in humans
36
Discussion
52
General discussion I
59
Uwe Maskos,
Sylvie Granon,
Philippe
Faure
and Jean-Pierre Changeux
Nicotinic acetylcholine receptor functions in the CNS investigated with a novel
method of stereotaxic gene re-expression in knockout mice
64
Discussion
79
Marina R.
Picciotto
Nicotine-mediated activation of signal transduction
pathways
83
Discussion
90
David Balfour Complementary roles for the accumbal shell and core in
nicotine dependence
96
Discussion
105
CONTENTS
Christian Heidbreder The dopamine D3
system:
new opportunities for
dopamine-based reward
116
Discussion
123
Athina
Markou
Pathways and systems involved in nicotine
dependence
132
Discussion
145
Arthur
L. Brody
Localizing tobacco dependence pathways with functional
brain imaging
153
Discussion
166
Caryn Lerman Pharmacogenetic approach to nicotine dependence
treatment
171
Discussion
178
Robert Walton Pharmacogenomics and smoking cessation
184
Discussion
194
General discussion II Power in studies
197
Receptor desensitization
199
Peter
Hajek
What Hmits the efficacy of current nicotine replacement
therapies?
204
Discussion
213
Saul Shiftman, Stuart Ferguson and Deborah
Scharf
Exploring
behavioural mechanisms of nicotine replacement therapy for smoking
cessation
219
Discussion
231
Rachel F. Tyndale and Edward M. Sellers Modifying the metabolism of
nicotine as a therapeutic strategy
235
Discussion
244
William A. Corrigall Challenges in discovery and development of
pharmacotherapies for tobacco addiction
249
Discussion
259
Final discussion Nicotine comorbidity
262
Animal models
264
Index of contributors
266
Subject index
268
UNDERSTANDING NICOTINE
AND TOBACCO ADDICTION
Chair: William A. Corrigall
Cigarette smoking is estimated to lead to
4.9
million premature deaths per year worldwide.
This is predicted to rise to
10
million by
2020.
In western countries it kills half of all smokers
who fail to stop.
The prevailing model for tobacco addiction is that nicotine from cigarettes rewards smoking
and punishes abstinence, tapping into a motivational system of
operant
conditioning that
requires no conscious awareness. However, there are also accounts which involve cognitive
biases and the effect of nicotine on impulse control. The brain pathways involved have been
studied extensively, but the role of different nicotine receptor subtypes and other
neurotransmitter
systems is still subject to debate.
In western countries, cigarette smoking as an adult has a heritability of
30-50%
and candidate
genes have been identified that may contribute in part to addiction susceptibility. Many
socio¬
cultural
correlates of cigarette smoking have been established, but a comprehensive model
that accounts for these and links them with the psychobiological aspects of nicotine addiction
has not been forthcoming. Structured behavioural support programmes aid cessation
attempts, as do a number of pharmacotherapies, most notably nicotine replacement
treatments and bupropion, but the underlying mechanisms are unclear.
This book deals with the problems involved in understanding and treating nicotine and tobacco
addiction. Topics covered include the nature of the worldwide health problem posed by
cigarette smoking, the psychodynamics of cigarette addiction, and the basic pharmacology
and biochemistry of nicotine and its effect on the brain. Further chapters analyse the genetic
basis of susceptibility to nicotine addiction. Finally, the contributors address approaches to
therapy. A continuing theme in the discussions throughout the book is how best to treat
nicotine addiction, given that many smokers would like to stop smoking but are unable to do
so because of their addiction.
This book will be of great value to all psychologists and psychiatrists working on addiction,
specifically to nicotine but also to other compounds and behaviours. It will also be of interest
to neuroscientists and pharmacologists working on nicotine receptors and the brain pathways
involved in dependence, as well as to biochemists, molecular biologists and to public
health officials. |
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| spelling | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] [ed. by Gregory Bock ...] Chichester [u.a.] Wiley 2006 VIII, 275 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Novartis Foundation symposium 275 Neuropharmakologie (DE-588)4041896-0 gnd rswk-swf Substitutionstherapie (DE-588)4206768-6 gnd rswk-swf Nicotin (DE-588)4131089-5 gnd rswk-swf Raucherentwöhnung (DE-588)4048542-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2005 London gnd-content Nicotin (DE-588)4131089-5 s Neuropharmakologie (DE-588)4041896-0 s DE-604 Raucherentwöhnung (DE-588)4048542-0 s Substitutionstherapie (DE-588)4206768-6 s b DE-604 Bock, Gregory Sonstige oth Novartis Foundation symposium 275 (DE-604)BV011990857 275 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014809319&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014809319&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
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| title | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] |
| title_auth | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] |
| title_exact_search | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] |
| title_exact_search_txtP | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] |
| title_full | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] [ed. by Gregory Bock ...] |
| title_fullStr | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] [ed. by Gregory Bock ...] |
| title_full_unstemmed | Understanding nicotine and tobacco addiction [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] [ed. by Gregory Bock ...] |
| title_short | Understanding nicotine and tobacco addiction |
| title_sort | understanding nicotine and tobacco addiction symposium on understanding nicotine and tobacco addiction held at the novartis foundation london 17 19 may 2005 |
| title_sub | [Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17 - 19 May 2005] |
| topic | Neuropharmakologie (DE-588)4041896-0 gnd Substitutionstherapie (DE-588)4206768-6 gnd Nicotin (DE-588)4131089-5 gnd Raucherentwöhnung (DE-588)4048542-0 gnd |
| topic_facet | Neuropharmakologie Substitutionstherapie Nicotin Raucherentwöhnung Konferenzschrift 2005 London |
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