Analyzing T cell responses: how to analyze cellular immune responses against tumor associated antigens
This book reviews, describes, categorizes and provides a critical assessment of all assays that have been used for the monitoring of antigen-specific immune responses. In particular, it emphasizes a global approach to the analysis of T cell mediated target/host interactions at the systemic and the p...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer
2005
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Zusammenfassung: | This book reviews, describes, categorizes and provides a critical assessment of all assays that have been used for the monitoring of antigen-specific immune responses. In particular, it emphasizes a global approach to the analysis of T cell mediated target/host interactions at the systemic and the peripheral level when such interactions are supposed to occur. The book, therefore, targets a specialized audience of clinical investigators interested in the strategic planning of monitoring aspects of clinical protocols. In addition, the tools described here could be utilized for the search of surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome that are of interest to the biotechnology industry. Biomarker discovery, validation and utilization for class prediction can only be rationally achieved through a comprehensive review of available technologies and the understanding of their unique advantages and limitations. In detail, this book provides an overview of antigen-specific immune biology in human models of tumor and viral disease, discusses modulation of such responses through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine production using ELISPOT, intracellular staining or cytometric assessment, detection of antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers, T cell receptor analysis, assessment of T cell receptor/HLA interactions using peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular assays including quantitative real-time PCR and gene profiling for evaluation of systemic and peripheral immune responses. All chapters were prepared by individuals who pioneered the utilization of such assays and, therefore, provide an in depth overview of the potential of each individual assay. |
| Beschreibung: | XII, 313 S. Ill., graph. Darst. |
| ISBN: | 1402036221 9781402036224 |
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| 520 | 3 | |a This book reviews, describes, categorizes and provides a critical assessment of all assays that have been used for the monitoring of antigen-specific immune responses. In particular, it emphasizes a global approach to the analysis of T cell mediated target/host interactions at the systemic and the peripheral level when such interactions are supposed to occur. The book, therefore, targets a specialized audience of clinical investigators interested in the strategic planning of monitoring aspects of clinical protocols. In addition, the tools described here could be utilized for the search of surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome that are of interest to the biotechnology industry. Biomarker discovery, validation and utilization for class prediction can only be rationally achieved through a comprehensive review of available technologies and the understanding of their unique advantages and limitations. In detail, this book provides an overview of antigen-specific immune biology in human models of tumor and viral disease, discusses modulation of such responses through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine production using ELISPOT, intracellular staining or cytometric assessment, detection of antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers, T cell receptor analysis, assessment of T cell receptor/HLA interactions using peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular assays including quantitative real-time PCR and gene profiling for evaluation of systemic and peripheral immune responses. All chapters were prepared by individuals who pioneered the utilization of such assays and, therefore, provide an in depth overview of the potential of each individual assay. | |
| 650 | 4 | |a Antigènes tumoraux | |
| 650 | 4 | |a Immunité cellulaire | |
| 650 | 4 | |a Lymphocytes T - Immunologie | |
| 650 | 4 | |a Antigens, Neoplasm |x analysis | |
| 650 | 4 | |a Antigens, Neoplasm |x immunology | |
| 650 | 4 | |a Cellular immunity | |
| 650 | 4 | |a Immunity, Cellular | |
| 650 | 4 | |a T cells |x Immunology | |
| 650 | 4 | |a T-Cell Antigen Receptor Specificity | |
| 650 | 4 | |a T-Lymphocytes |x immunology | |
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Datensatz im Suchindex
| _version_ | 1804135343236055040 |
|---|---|
| adam_text | TABLE OF CONTENTS
List of Contributors ix
Chapter
MONITORING ANTIGEN-SPECIFIC T CELL
RESPONSES
Dirk Nagorsen, Francesco M.
Chapter
TUMOR ASSOCIATED ANTIGENS
Paul F. Robbins
Chapter
IMMUNE ESCAPE
Tumor induced immune suppression and immune escape:
Mechanisms and Possible Solutions
Theresa L. Whiteside, Michael Campoli, Soldano Ferrone
Chapter
VIRUS SPECIFIC T-CELL RESPONSES
Victor Appay
Chapter
CYTOTOXICITY ASSAYS
Killer Lymphocytes in Cancer
Gideon Berke
vi
Chapter
MONITORING T CELL PROLIFERATION
Philip D. Hodgkin, Edwin D. Hawkins, Jhaguaral Hasbold,
Amanda V. Gett, Elissa K. Deenick, Hilary F. Todd
Hommel
Chapter
ELISPOT ASSAY
Assessment of Cellular Immune Responses to Anti-Cancer
Vaccines
Theresa L. Whiteside
Chapter
MODIFIED ELISPOT
Modifications of the Elispot Assay for T Cell Monitoring in
Cancer Vaccine Trials
Anatoli Malyguine
Chapter
INTRACELLULAR CYTOKINE STAINING
Cytokine flow cytometry for characterization of tumor-specific T
cell responses
Carmen Scheibenbogen, Anne Letsch, Anne Marie Asemissen,
Alexander Schmittel,
Chapter
CYTOMETRIC CYTOKINE
Detection and Isolation of Antigen-Specific T Cells
Mario
Chapter
PEPTIDE/MHC TETRAMER ANALYSIS
Peter P. Lee
Chapter
IN SITU MHC TETRAMER STAINING
In situ tetramers
Pamela J. Skinner
Table of Contents
Chapter
MHC-IG DIMERIC MOLECULES
Dimers
specific T cell responses
Tim F. Greten
Chapter
TCR ANALYSES
T-cell receptor CDR3 analysis: Molecular fingerprinting of the
T-cell receptor repertoire
Markus J.
Chapter
PEPTIDE/HLA-GFP COMPLEXES
Detection of Antigen-Specific T Cells by Acquisition of
Peptide/Hla-Gfp Complexes
Utano Tomaru, Yoshihisa Yamano
Chapter
QRT-PCR
Quantitative RT-PCR for the Analysis of T cell Responses in
Immunized Cancer Patients
Udai S. Kammula
Chapter
MICROARRAYS
Gene expression profiling approaches for the monitoring of anti-
cancer immune responses
Ena Wang
CONCLUDING REMARK
Dirk Nagorsen
COLOR PLATES
INDEX
Analyzing T Cell Responses
How to analyze cellular immune responses
against tumor associated antigens
Edited by Dirk Nagorsen and F.M.
This book reviews, describes, categorizes and provides a critical assessment of all
assays that have been used for the monitoring of antigen-specific immune responses. In
particular, it emphasizes a global approach to the analysis of T cell mediated target/host
interactions at the systemic and the peripheral level when such interactions are
supposed to occur. The book, therefore, targets a specialized audience of clinical
investigators interested in the strategic planning of monitoring aspects of clinical
protocols. In addition, the tools described here could be utilized for the search of
surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome
that are of interest to the biotechnology industry. Biomarker discovery, validation and
utilization for class prediction can only be rationally achieved through a comprehensive
review of available technologies and the understanding of their unique advantages and
limitations. In detail, this book provides an overview of antigen-specific immune biology
in human models of tumor and viral disease, discusses modulation of such responses
through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine
production using EUSPOX ¡ntracellular staining or cytometric assessment detection of
antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers,
T cell receptor analysis, assessment of T cell receptor/HLA interactions using
peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular
assays including quantitative real-time PCR and gene profiling for evaluation of
systemic and peripheral immune responses. All chapters were prepared by individuals
who pioneered the utilization of such assays and, therefore, provide an in-depth
overview of the potential of each individual assay.
|
| adam_txt |
TABLE OF CONTENTS
List of Contributors ix
Chapter
MONITORING ANTIGEN-SPECIFIC T CELL
RESPONSES
Dirk Nagorsen, Francesco M.
Chapter
TUMOR ASSOCIATED ANTIGENS
Paul F. Robbins
Chapter
IMMUNE ESCAPE
Tumor induced immune suppression and immune escape:
Mechanisms and Possible Solutions
Theresa L. Whiteside, Michael Campoli, Soldano Ferrone
Chapter
VIRUS SPECIFIC T-CELL RESPONSES
Victor Appay
Chapter
CYTOTOXICITY ASSAYS
Killer Lymphocytes in Cancer
Gideon Berke
vi
Chapter
MONITORING T CELL PROLIFERATION
Philip D. Hodgkin, Edwin D. Hawkins, Jhaguaral Hasbold,
Amanda V. Gett, Elissa K. Deenick, Hilary F. Todd
Hommel
Chapter
ELISPOT ASSAY
Assessment of Cellular Immune Responses to Anti-Cancer
Vaccines
Theresa L. Whiteside
Chapter
MODIFIED ELISPOT
Modifications of the Elispot Assay for T Cell Monitoring in
Cancer Vaccine Trials
Anatoli Malyguine
Chapter
INTRACELLULAR CYTOKINE STAINING
Cytokine flow cytometry for characterization of tumor-specific T
cell responses
Carmen Scheibenbogen, Anne Letsch, Anne Marie Asemissen,
Alexander Schmittel,
Chapter
CYTOMETRIC CYTOKINE
Detection and Isolation of Antigen-Specific T Cells
Mario
Chapter
PEPTIDE/MHC TETRAMER ANALYSIS
Peter P. Lee
Chapter
IN SITU MHC TETRAMER STAINING
In situ tetramers
Pamela J. Skinner
Table of Contents
Chapter
MHC-IG DIMERIC MOLECULES
Dimers
specific T cell responses
Tim F. Greten
Chapter
TCR ANALYSES
T-cell receptor CDR3 analysis: Molecular fingerprinting of the
T-cell receptor repertoire
Markus J.
Chapter
PEPTIDE/HLA-GFP COMPLEXES
Detection of Antigen-Specific T Cells by Acquisition of
Peptide/Hla-Gfp Complexes
Utano Tomaru, Yoshihisa Yamano
Chapter
QRT-PCR
Quantitative RT-PCR for the Analysis of T cell Responses in
Immunized Cancer Patients
Udai S. Kammula
Chapter
MICROARRAYS
Gene expression profiling approaches for the monitoring of anti-
cancer immune responses
Ena Wang
CONCLUDING REMARK
Dirk Nagorsen
COLOR PLATES
INDEX
Analyzing T Cell Responses
How to analyze cellular immune responses
against tumor associated antigens
Edited by Dirk Nagorsen and F.M.
This book reviews, describes, categorizes and provides a critical assessment of all
assays that have been used for the monitoring of antigen-specific immune responses. In
particular, it emphasizes a global approach to the analysis of T cell mediated target/host
interactions at the systemic and the peripheral level when such interactions are
supposed to occur. The book, therefore, targets a specialized audience of clinical
investigators interested in the strategic planning of monitoring aspects of clinical
protocols. In addition, the tools described here could be utilized for the search of
surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome
that are of interest to the biotechnology industry. Biomarker discovery, validation and
utilization for class prediction can only be rationally achieved through a comprehensive
review of available technologies and the understanding of their unique advantages and
limitations. In detail, this book provides an overview of antigen-specific immune biology
in human models of tumor and viral disease, discusses modulation of such responses
through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine
production using EUSPOX ¡ntracellular staining or cytometric assessment detection of
antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers,
T cell receptor analysis, assessment of T cell receptor/HLA interactions using
peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular
assays including quantitative real-time PCR and gene profiling for evaluation of
systemic and peripheral immune responses. All chapters were prepared by individuals
who pioneered the utilization of such assays and, therefore, provide an in-depth
overview of the potential of each individual assay. |
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| index_date | 2024-07-02T14:39:40Z |
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| language | English |
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| spelling | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens ed. by Dirk Nagorsen ... Dordrecht Springer 2005 XII, 313 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier This book reviews, describes, categorizes and provides a critical assessment of all assays that have been used for the monitoring of antigen-specific immune responses. In particular, it emphasizes a global approach to the analysis of T cell mediated target/host interactions at the systemic and the peripheral level when such interactions are supposed to occur. The book, therefore, targets a specialized audience of clinical investigators interested in the strategic planning of monitoring aspects of clinical protocols. In addition, the tools described here could be utilized for the search of surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome that are of interest to the biotechnology industry. Biomarker discovery, validation and utilization for class prediction can only be rationally achieved through a comprehensive review of available technologies and the understanding of their unique advantages and limitations. In detail, this book provides an overview of antigen-specific immune biology in human models of tumor and viral disease, discusses modulation of such responses through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine production using ELISPOT, intracellular staining or cytometric assessment, detection of antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers, T cell receptor analysis, assessment of T cell receptor/HLA interactions using peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular assays including quantitative real-time PCR and gene profiling for evaluation of systemic and peripheral immune responses. All chapters were prepared by individuals who pioneered the utilization of such assays and, therefore, provide an in depth overview of the potential of each individual assay. Antigènes tumoraux Immunité cellulaire Lymphocytes T - Immunologie Antigens, Neoplasm analysis Antigens, Neoplasm immunology Cellular immunity Immunity, Cellular T cells Immunology T-Cell Antigen Receptor Specificity T-Lymphocytes immunology Tumor antigens Tumorantigen (DE-588)4186425-6 gnd rswk-swf T-Lymphozyt (DE-588)4127387-4 gnd rswk-swf Tumorantigen (DE-588)4186425-6 s T-Lymphozyt (DE-588)4127387-4 s b DE-604 Nagorsen, Dirk 1974- Sonstige (DE-588)12152471X oth Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014790607&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014790607&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
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| title | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens |
| title_auth | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens |
| title_exact_search | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens |
| title_exact_search_txtP | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens |
| title_full | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens ed. by Dirk Nagorsen ... |
| title_fullStr | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens ed. by Dirk Nagorsen ... |
| title_full_unstemmed | Analyzing T cell responses how to analyze cellular immune responses against tumor associated antigens ed. by Dirk Nagorsen ... |
| title_short | Analyzing T cell responses |
| title_sort | analyzing t cell responses how to analyze cellular immune responses against tumor associated antigens |
| title_sub | how to analyze cellular immune responses against tumor associated antigens |
| topic | Antigènes tumoraux Immunité cellulaire Lymphocytes T - Immunologie Antigens, Neoplasm analysis Antigens, Neoplasm immunology Cellular immunity Immunity, Cellular T cells Immunology T-Cell Antigen Receptor Specificity T-Lymphocytes immunology Tumor antigens Tumorantigen (DE-588)4186425-6 gnd T-Lymphozyt (DE-588)4127387-4 gnd |
| topic_facet | Antigènes tumoraux Immunité cellulaire Lymphocytes T - Immunologie Antigens, Neoplasm analysis Antigens, Neoplasm immunology Cellular immunity Immunity, Cellular T cells Immunology T-Cell Antigen Receptor Specificity T-Lymphocytes immunology Tumor antigens Tumorantigen T-Lymphozyt |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014790607&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014790607&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nagorsendirk analyzingtcellresponseshowtoanalyzecellularimmuneresponsesagainsttumorassociatedantigens |