Internationalisation of pharmaceutical R&D into emerging markets: the case of India
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Format: | Abschlussarbeit Buch |
Sprache: | English |
Veröffentlicht: |
2006
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Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XII, 296 S. graph. Darst. |
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adam_text | I
I
[
Content i
j
LIST OF FIGURES VII i
i
LIST OF TABLES IX ]
ABBREVIATIONS X I
i
I. INTRODUCTION 1
1.1 Relevance of the Topic 1 ,
1.2 Objectives of the Dissertation 5 I
I
1.3 Structure of the Dissertation 7 j
II. THEORETICAL MOTIVATION AND RESEARCH METHODOLOGIES 10
II. 1 Theoretical Motivation of the Topic 10
11.1.1 Literature on R D Internationalization 11
11.1.2 Literature on Outsourcing 16
II. 1.3 Literature on Organisation of global R D 19
11.1.4 Conclusion of Literature Review 25
11.1.5 Costs of R D Decentralisation 28
11.2 Research Methodology 29
11.2.1 Literature Analysis 32
11.2.2 Case Study Approach 32
11.2.3 Interviews 34
11.2.4 Survey 37
11.2.5 Archival Data 38
11.3 Introduction of the Cases 39
11.3.1 AstraZeneca 41
11.3.2 GlaxoSmithKline (GSK) 42
11.3.3 ALTANA Pharma AG 43
III. PHARMACEUTICAL R D 46
III. 1 The Pharmaceutical Industry 46
///././ Particularities 46
III. 1.2 R D Process in the Pharmaceutical Industry 47
111.1.3 Developments in the Pharmaceutical Industry 5/
111.1.4 Innovation Problem 56
111.2 Pharmaceutical R D Internationalisation 59
///. 2.1 R D Internationalisation of Multinational Pharmaceutical Companies 59
III.2.2 Internationalisation and Performance of Pharmaceutical R D 62
111.3 Summary and Implications of Results So Far 73
11 T
IV. PHARMACEUTICAL R D IN INDIA 75
IV.l The Indian Pharmaceutical Industry 75
IV. I.I Historic Development of the Indian Pharmaceutical Industry 77
IV. 1.2 India s Pharmaceutical Industry Today 79
IV.l.3 Future Developments 83
IV.2 Pharmaceutical R D in India 84
IV.2.1 R D Activities of Indian Pharmaceutical Companies 84
IV.2.2 India as a Future Pharmaceutical R D Hub 86
IV.2.3 Development Paths of India as an R D Hub 91
IV.3 Implications of India s Development on the global Pharmaceutical
Industry 98
V. PHARMACEUTICAL R D OF MNCS IN INDIA 100
V.I R D Activities of MNCs in India 100
V. 1.1 Involvement of global Pharmaceutical Players in India 100
V.I.2 Involvement in R D Activities in India 103
V.I.3 Summary 116
V.2 Determinants of Pharmaceutical MNCs R D Activities in India 117
V.2.1 Motivations for Pharmaceutical R D in India 119
V.2.2 Barriers of Conducting Pharmaceutical R D in India 127
V.2.3 Case Studies 131
V.2.4 Quantitative Results from Motivations and Barriers 140
V.2.5 Implications on Theory 144
V.3 INTERNATIONALISATION STRATEGIES FOR INDIA 149
V.3.1 Local Product Assistance Strategy 151
V.3.2 Local Focussed Strategy 153
V.3.3 Global Specialised Strategy 155
V.3.4 Global Integrated Strategy 157
V.3.5 Future Trends 158
V.4 Location of Foreign Pharmaceutical R D in India 162
V.5 Implications of India on Pharmaceutical R D Performance 164
V.5.1 Knowledge 164
V.5.2 Time 168
V.5.3 Costs 171
V.5.4 Implications on Theory and Practice 174
V
VI. MANAGEMENT OF GLOBAL R D ACTIVITIES OF PHARMACEUTICAL
MNCS 179
VI. 1 Significance of R D Outsourcing for MNCs in India 179
VI. 1.1 Relation between Scale and R D Performance of Pharmaceutical MNCs. 180
VI. 1.2 Trend to R D Outsourcing in the Pharmaceutical Industry 184
VI. 1.3 Importance of External Linkages for Pharmaceutical MNCs in India 194
VI. 1.4 Strategic Implication on the global Pharmaceutical Industry 205
VI.2 Organisation 214
VI.2.1 The Significance of Organisation of R D Activities in MNCs 214
VI.2.2 Models of Development of R D Management 216
VI.2.3 New Demands on Pharmaceutical R D Organisations 218
VI.2.4 Gaps of existing Organisation Models on International R D in Academic
Research 233
VI.2.5 The GlocalR D Organisation 235
Vl.2.6 Conclusion for the Glocal R D Organisation 248
VI.2.7 Practical Implementation: Case Studies 250
VII. CONCLUSION 258
VII. 1 Research Contributions 258
VII.1.1 Implications on Academic Research 258
VII. 1.2 Implications for Practitioners 261
VII.2 Limitations 263
REFERENCES 266
INTERVIEWS 283
APPENDIX: QUESTIONNAIRE 287
List of Figures
Figure 1: Objectives of the Dissertation 6
Figure 2: Overview of the Topic of the Dissertation 8
Figure 3: Structure of the Dissertation 9
Figure 4: Literature Streams 10
Figure 5: Stages of Offshoring(McKinsey 2003) 15
Figure 6: Concepts of Organisational Design (Gassmann 1997) 22
Figure 7: Research Gaps 27
Figure 8: Research Questions 28
Figure 9: Research Methodology 31
Figure 10: Influences on the Pharmaceutical Industry (Dreger 2000) 52
Figure 11: R D Expenditures of Major Pharmaceutical Companies (PhRMA 2003b) 57
Figure 12: Characterisation of Pharmaceutical Firnis: R D Internationalisation and R D
Intensity (Gassmann and von Zedtwitz 1998 and von Zedtwitz et al. 2003) 60
Figure 13: Foreign R D Expenditures of US Pharmaceutical Companies 1970 2004
(based on data of PhRMA 2005a) 61
Figure 14: DOI and R D Performance 68
Figure 15: DOI and Performance of R D Diagram with U curve 71
Figure 16: Segmentation of the Asian Pharmaceutical Market (IMS Health 2003) 79
Figure 17: Number of Units in the Indian Pharmaceutical Industry (ICRA 2002) 80
Figure 18: SWOT Analysis for India as an R D Hub 91
Figure 19: Forces of the Indian Pharmaceutical Market 102
Figure 20: Activities of Pharmaceutical MNCs in India (based on survey data) 104
Figure 21: Motivations andBarriers of Pharmaceutical R D in India 132
Figure 22: Determinants of R D Internationalisation (Helble 2004) 145
Figure 23: Extended Concept of Determinants of R D Internationalisation 146
Figure 24: Internationalisation Strategies of Pharmaceutical MNCs concerning Extent
and Scopeof R D Activities 150
Figure 25: Typology of Pharmaceutical R D Internationalisation Strategies to
Emerging Markets 159
Figure 26: Advantages and Disadvantages of Pharmaceutical R D Activities in India
from the Perspective of Knowledge 166
Figure 27: Advantages and Disadvantages of Pharmaceutical R D Activities from
the Perspective of Time 169
Figure 28: Advantages and Disadvantages of Relocating Pharmaceutical R D
Activities from the Perspective of Costs 172
Figure 29: Newly established High tech R D Partnerships (1960 1998)
(Hagedoorn 2002) 176
Figure 30: Options of Sourcing Strategies 177
Figure 31: Relationship between Size and R D Performance of Pharmaceutical MNCs.. 184
Figure 32: Contract Research Market Size (OPPI2003) 186
Figure 33: Collaboration and Outsourcing Possibilities in the Pharmaceutical R D
Process 187
Figure 34: Global Pharmaceutical Outsourcing by Stage in 2001 (Reuters 2002) 188
Figure 35: Reliance on In licensing, 2001 versus 2007 (Reuters 2004) 191
Figure 36: Example of Developments in the Pharmaceutical Licensing Market
(BCG2004) 192
Figure 37: Organisation of R D in India 195
Figure 38: Classification of Collaborations of MNCs in India 196
Figure 39: Network of Astra Zeneca in India 205
Figure 40: Specialised Business Models (Heuskel 1999) 211
Figure 41: Five Concepts for R D Process Management 212
Figure 42: Benefits of early Integration of Pharmacoeconomics into R D
(Reuters 2004) 223
Figure 43: Four major Determinants for Organising R D in an Increasing Number of
R D Locations 239
Figure 44: Activities of a Glocal R D Organisation 240
Figure 45: Sourcing Strategies for R D Input Factors 241
Figure 46: Framework for International R D Organisation 242
Figure 47: Centralisation of Co ordination and Decision Making 244
Figure 48: Two step Location Decision Process of Glocal R D Organisations 245
Figure 49: Modes of Collaboration in R D (in accordance with Robert and Berry 1985) 247
Figure 50: Glocal R D Information System 248
Figure 51: Glocal R D Organisation 249
Figure 52: R D Organisation of Multinational Pharmaceutical Companies 251
Figure 53: GSK s R D Organisation (Hamilton 2005) 255
Figure 54: ALTANA s R D Organisation 257
List of Tables
Table 1: Most important Literature on R D Internationalisation 12
Table 2: Literature Overview: Organisation of R D Internationalisation 20
Table 3: Overview of Case Studies 40
Table 4: Pharmaceutical R D process Research and Preclinical Development 48
Table 5: Pharmaceutical R D Process Clinical Development 50
Table 6: Results of the Quadratic Regression 72
Table 7: R D Expenditures of selected Indian Pharmaceutical Companies (Source:
Companies financial statements) 85
Table 8: Development Paths 93
Table 9: R D Activities of MNCs in India 108
Table 10: Overview on the Determinants of R D Internationalisation to India of the
Case Study Companies 132
Table 11: Motivations of MNCs for Pharmaceutical R D in India 141
Table 12: Barriers of Pharmaceutical MNCs to locate R D Activities to India 143
Table 13: Four Typical Forms of international R D Organisations 151
Table 14: Linkage between Company Size and R D Performance 183
Table 15: Examples of In licensing of NCE from Indian Pharmaceutical Companies
(ICRA2002) 198
Table 16: Features of R D Collaboration of the Case Study Companies 202
Table 17: Global Challenges to Pharmaceutical R D Organisation 226
Table 18: Global Challenges to Pharmaceutical R D Organisation 231
|
adam_txt |
I
I
[
Content i
j
LIST OF FIGURES VII i
i
LIST OF TABLES IX ]
ABBREVIATIONS X I
i
I. INTRODUCTION 1
1.1 Relevance of the Topic 1 ',
1.2 Objectives of the Dissertation 5 I
I
1.3 Structure of the Dissertation 7 j
II. THEORETICAL MOTIVATION AND RESEARCH METHODOLOGIES 10
II. 1 Theoretical Motivation of the Topic 10
11.1.1 Literature on R D Internationalization 11
11.1.2 Literature on Outsourcing 16
II. 1.3 Literature on Organisation of global R D 19
11.1.4 Conclusion of Literature Review 25
11.1.5 Costs of R D Decentralisation 28
11.2 Research Methodology 29
11.2.1 Literature Analysis 32
11.2.2 Case Study Approach 32
11.2.3 Interviews 34 '
11.2.4 Survey 37
11.2.5 Archival Data 38
11.3 Introduction of the Cases 39
11.3.1 AstraZeneca 41
11.3.2 GlaxoSmithKline (GSK) 42
11.3.3 ALTANA Pharma AG 43
III. PHARMACEUTICAL R D 46
III. 1 The Pharmaceutical Industry 46
///././ Particularities 46
III. 1.2 R D Process in the Pharmaceutical Industry 47
111.1.3 Developments in the Pharmaceutical Industry 5/
111.1.4 Innovation Problem 56
111.2 Pharmaceutical R D Internationalisation 59
///. 2.1 R D Internationalisation of Multinational Pharmaceutical Companies 59
III.2.2 Internationalisation and Performance of Pharmaceutical R D 62
111.3 Summary and Implications of Results So Far 73
11 T
IV. PHARMACEUTICAL R D IN INDIA 75
IV.l The Indian Pharmaceutical Industry 75
IV. I.I Historic Development of the Indian Pharmaceutical Industry 77
IV. 1.2 India's Pharmaceutical Industry Today 79
IV.l.3 Future Developments 83
IV.2 Pharmaceutical R D in India 84
IV.2.1 R D Activities of Indian Pharmaceutical Companies 84
IV.2.2 India as a Future Pharmaceutical R D Hub 86
IV.2.3 Development Paths of India as an R D Hub 91
IV.3 Implications of India's Development on the global Pharmaceutical
Industry 98
V. PHARMACEUTICAL R D OF MNCS IN INDIA 100
V.I R D Activities of MNCs in India 100
V. 1.1 Involvement of global Pharmaceutical Players in India 100
V.I.2 Involvement in R D Activities in India 103
V.I.3 Summary 116
V.2 Determinants of Pharmaceutical MNCs R D Activities in India 117
V.2.1 Motivations for Pharmaceutical R D in India 119
V.2.2 Barriers of Conducting Pharmaceutical R D in India 127
V.2.3 Case Studies 131
V.2.4 Quantitative Results from Motivations and Barriers 140
V.2.5 Implications on Theory 144
V.3 INTERNATIONALISATION STRATEGIES FOR INDIA 149
V.3.1 Local Product Assistance Strategy 151
V.3.2 Local Focussed Strategy 153
V.3.3 Global Specialised Strategy 155
V.3.4 Global Integrated Strategy 157
V.3.5 Future Trends 158
V.4 Location of Foreign Pharmaceutical R D in India 162
V.5 Implications of India on Pharmaceutical R D Performance 164
V.5.1 Knowledge 164
V.5.2 Time 168
V.5.3 Costs 171
V.5.4 Implications on Theory and Practice 174
V
VI. MANAGEMENT OF GLOBAL R D ACTIVITIES OF PHARMACEUTICAL
MNCS 179
VI. 1 Significance of R D Outsourcing for MNCs in India 179
VI. 1.1 Relation between Scale and R D Performance of Pharmaceutical MNCs. 180
VI. 1.2 Trend to R D Outsourcing in the Pharmaceutical Industry 184
VI. 1.3 Importance of External Linkages for Pharmaceutical MNCs in India 194
VI. 1.4 Strategic Implication on the global Pharmaceutical Industry 205
VI.2 Organisation 214
VI.2.1 The Significance of Organisation of R D Activities in MNCs 214
VI.2.2 Models of Development of R D Management 216
VI.2.3 New Demands on Pharmaceutical R D Organisations 218
VI.2.4 Gaps of existing Organisation Models on International R D in Academic
Research 233
VI.2.5 The GlocalR D Organisation 235
Vl.2.6 Conclusion for the Glocal R D Organisation 248
VI.2.7 Practical Implementation: Case Studies 250
VII. CONCLUSION 258
VII. 1 Research Contributions 258
VII.1.1 Implications on Academic Research 258
VII. 1.2 Implications for Practitioners 261
VII.2 Limitations 263
REFERENCES 266
INTERVIEWS 283
APPENDIX: QUESTIONNAIRE 287
List of Figures
Figure 1: Objectives of the Dissertation 6
Figure 2: Overview of the Topic of the Dissertation 8
Figure 3: Structure of the Dissertation 9
Figure 4: Literature Streams 10
Figure 5: Stages of Offshoring(McKinsey 2003) 15
Figure 6: Concepts of Organisational Design (Gassmann 1997) 22
Figure 7: Research Gaps 27
Figure 8: Research Questions 28
Figure 9: Research Methodology 31
Figure 10: Influences on the Pharmaceutical Industry (Dreger 2000) 52
Figure 11: R D Expenditures of Major Pharmaceutical Companies (PhRMA 2003b) 57
Figure 12: Characterisation of Pharmaceutical Firnis: R D Internationalisation and R D
Intensity (Gassmann and von Zedtwitz 1998 and von Zedtwitz et al. 2003) 60
Figure 13: Foreign R D Expenditures of US Pharmaceutical Companies 1970 2004
(based on data of PhRMA 2005a) 61
Figure 14: DOI and R D Performance 68
Figure 15: DOI and Performance of R D Diagram with U curve 71
Figure 16: Segmentation of the Asian Pharmaceutical Market (IMS Health 2003) 79
Figure 17: Number of Units in the Indian Pharmaceutical Industry (ICRA 2002) 80
Figure 18: SWOT Analysis for India as an R D Hub 91
Figure 19: Forces of the Indian Pharmaceutical Market 102
Figure 20: Activities of Pharmaceutical MNCs in India (based on survey data) 104
Figure 21: Motivations andBarriers of Pharmaceutical R D in India 132
Figure 22: Determinants of R D Internationalisation (Helble 2004) 145
Figure 23: Extended Concept of Determinants of R D Internationalisation 146
Figure 24: Internationalisation Strategies of Pharmaceutical MNCs concerning Extent
and Scopeof R D Activities 150
Figure 25: Typology of Pharmaceutical R D Internationalisation Strategies to
Emerging Markets 159
Figure 26: Advantages and Disadvantages of Pharmaceutical R D Activities in India
from the Perspective of Knowledge 166
Figure 27: Advantages and Disadvantages of Pharmaceutical R D Activities from
the Perspective of Time 169
Figure 28: Advantages and Disadvantages of Relocating Pharmaceutical R D
Activities from the Perspective of Costs 172
Figure 29: Newly established High tech R D Partnerships (1960 1998)
(Hagedoorn 2002) 176
Figure 30: Options of Sourcing Strategies 177
Figure 31: Relationship between Size and R D Performance of Pharmaceutical MNCs. 184
Figure 32: Contract Research Market Size (OPPI2003) 186
Figure 33: Collaboration and Outsourcing Possibilities in the Pharmaceutical R D
Process 187
Figure 34: Global Pharmaceutical Outsourcing by Stage in 2001 (Reuters 2002) 188
Figure 35: Reliance on In licensing, 2001 versus 2007 (Reuters 2004) 191
Figure 36: Example of Developments in the Pharmaceutical Licensing Market
(BCG2004) 192
Figure 37: Organisation of R D in India 195
Figure 38: Classification of Collaborations of MNCs in India 196
Figure 39: Network of Astra Zeneca in India 205
Figure 40: Specialised Business Models (Heuskel 1999) 211
Figure 41: Five Concepts for R D Process Management 212
Figure 42: Benefits of early Integration of Pharmacoeconomics into R D
(Reuters 2004) 223
Figure 43: Four major Determinants for Organising R D in an Increasing Number of
R D Locations 239
Figure 44: Activities of a Glocal R D Organisation 240
Figure 45: Sourcing Strategies for R D Input Factors 241
Figure 46: Framework for International R D Organisation 242
Figure 47: Centralisation of Co ordination and Decision Making 244
Figure 48: Two step Location Decision Process of Glocal R D Organisations 245
Figure 49: Modes of Collaboration in R D (in accordance with Robert and Berry 1985) 247
Figure 50: Glocal R D Information System 248
Figure 51: Glocal R D Organisation 249
Figure 52: R D Organisation of Multinational Pharmaceutical Companies 251
Figure 53: GSK's R D Organisation (Hamilton 2005) 255
Figure 54: ALTANA's R D Organisation 257
List of Tables
Table 1: Most important Literature on R D Internationalisation 12
Table 2: Literature Overview: Organisation of R D Internationalisation 20
Table 3: Overview of Case Studies 40
Table 4: Pharmaceutical R D process Research and Preclinical Development 48
Table 5: Pharmaceutical R D Process Clinical Development 50
Table 6: Results of the Quadratic Regression 72
Table 7: R D Expenditures of selected Indian Pharmaceutical Companies (Source:
Companies' financial statements) 85
Table 8: Development Paths 93
Table 9: R D Activities of MNCs in India 108
Table 10: Overview on the Determinants of R D Internationalisation to India of the
Case Study Companies 132
Table 11: Motivations of MNCs for Pharmaceutical R D in India 141
Table 12: Barriers of Pharmaceutical MNCs to locate R D Activities to India 143
Table 13: Four Typical Forms of international R D Organisations 151
Table 14: Linkage between Company Size and R D Performance 183
Table 15: Examples of In licensing of NCE from Indian Pharmaceutical Companies
(ICRA2002) 198
Table 16: Features of R D Collaboration of the Case Study Companies 202
Table 17: Global Challenges to Pharmaceutical R D Organisation 226
Table 18: Global Challenges to Pharmaceutical R D Organisation 231 |
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format | Thesis Book |
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genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
genre_facet | Hochschulschrift |
geographic | Indien (DE-588)4026722-2 gnd |
geographic_facet | Indien |
id | DE-604.BV021569850 |
illustrated | Illustrated |
index_date | 2024-07-02T14:37:56Z |
indexdate | 2024-07-09T20:38:52Z |
institution | BVB |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014785680 |
oclc_num | 69663298 |
open_access_boolean | |
owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-83 DE-188 |
owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-83 DE-188 |
physical | XII, 296 S. graph. Darst. |
publishDate | 2006 |
publishDateSearch | 2006 |
publishDateSort | 2006 |
record_format | marc |
spelling | Fabian, Claudia Verfasser (DE-588)102842299 aut Internationalisation of pharmaceutical R&D into emerging markets the case of India Claudia Fabian 2006 XII, 296 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier St. Gallen, Univ., Diss., 2005 Pharmazeutische Industrie (DE-588)4045696-1 gnd rswk-swf Multinationales Unternehmen (DE-588)4075092-9 gnd rswk-swf Forschung und Entwicklung (DE-588)4017897-3 gnd rswk-swf Internationalisierung (DE-588)4162106-2 gnd rswk-swf Indien (DE-588)4026722-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Indien (DE-588)4026722-2 g Forschung und Entwicklung (DE-588)4017897-3 s Internationalisierung (DE-588)4162106-2 s Multinationales Unternehmen (DE-588)4075092-9 s Pharmazeutische Industrie (DE-588)4045696-1 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014785680&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Fabian, Claudia Internationalisation of pharmaceutical R&D into emerging markets the case of India Pharmazeutische Industrie (DE-588)4045696-1 gnd Multinationales Unternehmen (DE-588)4075092-9 gnd Forschung und Entwicklung (DE-588)4017897-3 gnd Internationalisierung (DE-588)4162106-2 gnd |
subject_GND | (DE-588)4045696-1 (DE-588)4075092-9 (DE-588)4017897-3 (DE-588)4162106-2 (DE-588)4026722-2 (DE-588)4113937-9 |
title | Internationalisation of pharmaceutical R&D into emerging markets the case of India |
title_auth | Internationalisation of pharmaceutical R&D into emerging markets the case of India |
title_exact_search | Internationalisation of pharmaceutical R&D into emerging markets the case of India |
title_exact_search_txtP | Internationalisation of pharmaceutical R&D into emerging markets the case of India |
title_full | Internationalisation of pharmaceutical R&D into emerging markets the case of India Claudia Fabian |
title_fullStr | Internationalisation of pharmaceutical R&D into emerging markets the case of India Claudia Fabian |
title_full_unstemmed | Internationalisation of pharmaceutical R&D into emerging markets the case of India Claudia Fabian |
title_short | Internationalisation of pharmaceutical R&D into emerging markets |
title_sort | internationalisation of pharmaceutical r d into emerging markets the case of india |
title_sub | the case of India |
topic | Pharmazeutische Industrie (DE-588)4045696-1 gnd Multinationales Unternehmen (DE-588)4075092-9 gnd Forschung und Entwicklung (DE-588)4017897-3 gnd Internationalisierung (DE-588)4162106-2 gnd |
topic_facet | Pharmazeutische Industrie Multinationales Unternehmen Forschung und Entwicklung Internationalisierung Indien Hochschulschrift |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014785680&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT fabianclaudia internationalisationofpharmaceuticalrdintoemergingmarketsthecaseofindia |