Understanding carcinogenesis: an introduction to the molecular basis of cancer
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2006
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XIV, 236 S. Ill., graph. Darst. |
| ISBN: | 3527314865 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Foreword
Preface IX
Part I Basic Aspects
1
Clonal Evolution and Autonomy versus Non-autonomy of Cancer Cells
2
Part II Genes Involved in Carcinogenesis
3
4
5
6
7
Role of the Tumor Stroma
8
9
10
VI
Partili
11
or Oncogenic Function of Certain
12
13
14
15
16
Part IV Unifying the Concepts
17
for the Development of Fully Fledged Malignancy
18
to Generate Genetically Modified Animals
19
Molecular Epidemiology and the Colon Cancer Model
Part V Future Perspectives
20
Index
Cancer, the second leading cause of death in the industrialized world,
is a heterogeneous group of many different diseases. It is characterized
by disordered and deregulated cellular and stromal proliferation accom¬
panied by reduced cell death. At the molecular level, cancer is a genetic
disease that develops due to the accumulation of mutations over time in
somatic cells.
This book is a concise, up-to-date introduction to the molecular basis
of carcinogenesis. The author manages to present both the basic and
the clinical areas while retaining a simple and concise style.
Following an introduction to fundamental concepts related to the
donality of the tumors and the hypermutability of the cancer cells,
he continues with a description of genes involved in the process of car¬
cinogenesis and concludes with more complex phenomena of tumor
biology, such as the role of the tumor stroma and the metastatic process.
A whole section on specific topics includes pharmacogenomics and
viral carcinogenesis. In addition, he describes human and animal mod¬
els of the disease, emphasizing their advantages and their limitations,
rounding off with unifying concepts, as well as ongoing and future
perspectives. The book makes good use of simple graphs to underline
the notions described in the text, a feature that particularly aids
comprehension.
With a foreword by Nobel Laureate Andrew V. Schally.
Hippokratis Kieris studied biology at the University of Athens.
Afier graduate studies at the National Hellenic Research Foun¬
dation, Athens, and the Medical School, University of Crete,
he joined the Molecular Genetics and Oncology Croup at the
University of Liverpool. From
research instructor at Tulane University Medical School In the
group of Nobel Laureate Andrew Schally. In
a position at the MCH Cancer Center, Harvard Medical
School, before returning to the University of Athens in
His current research focuses on the elucidation of the mo¬
lecular events that contribute to breast cancer development,
and to the mechanistic aspects oftumor-stroma interactions.
|
| adam_txt |
Contents
Foreword
Preface IX
Part I Basic Aspects
1
Clonal Evolution and Autonomy versus Non-autonomy of Cancer Cells
2
Part II Genes Involved in Carcinogenesis
3
4
5
6
7
Role of the Tumor Stroma
8
9
10
VI
Partili
11
or Oncogenic Function of Certain
12
13
14
15
16
Part IV Unifying the Concepts
17
for the Development of Fully Fledged Malignancy
18
to Generate Genetically Modified Animals
19
Molecular Epidemiology and the Colon Cancer Model
Part V Future Perspectives
20
Index
Cancer, the second leading cause of death in the industrialized world,
is a heterogeneous group of many different diseases. It is characterized
by disordered and deregulated cellular and stromal proliferation accom¬
panied by reduced cell death. At the molecular level, cancer is a genetic
disease that develops due to the accumulation of mutations over time in
somatic cells.
This book is a concise, up-to-date introduction to the molecular basis
of carcinogenesis. The author manages to present both the basic and
the clinical areas while retaining a simple and concise style.
Following an introduction to fundamental concepts related to the
donality of the tumors and the hypermutability of the cancer cells,
he continues with a description of genes involved in the process of car¬
cinogenesis and concludes with more complex phenomena of tumor
biology, such as the role of the tumor stroma and the metastatic process.
A whole section on specific topics includes pharmacogenomics and
viral carcinogenesis. In addition, he describes human and animal mod¬
els of the disease, emphasizing their advantages and their limitations,
rounding off with unifying concepts, as well as ongoing and future
perspectives. The book makes good use of simple graphs to underline
the notions described in the text, a feature that particularly aids
comprehension.
With a foreword by Nobel Laureate Andrew V. Schally.
Hippokratis Kieris studied biology at the University of Athens.
Afier graduate studies at the National Hellenic Research Foun¬
dation, Athens, and the Medical School, University of Crete,
he joined the Molecular Genetics and Oncology Croup at the
University of Liverpool. From
research instructor at Tulane University Medical School In the
group of Nobel Laureate Andrew Schally. In
a position at the MCH Cancer Center, Harvard Medical
School, before returning to the University of Athens in
His current research focuses on the elucidation of the mo¬
lecular events that contribute to breast cancer development,
and to the mechanistic aspects oftumor-stroma interactions. |
| any_adam_object | 1 |
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| id | DE-604.BV021556054 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:33:06Z |
| indexdate | 2024-07-09T20:38:32Z |
| institution | BVB |
| isbn | 3527314865 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014772061 |
| oclc_num | 181513464 |
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| physical | XIV, 236 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley-VCH |
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| spelling | Kiaris, Hippokratis ca. 20./21. Jh. Verfasser (DE-588)131693247 aut Understanding carcinogenesis an introduction to the molecular basis of cancer Hippokratis Kiaris Weinheim Wiley-VCH 2006 XIV, 236 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Carcinogenese (DE-588)4069853-1 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Carcinogenese (DE-588)4069853-1 s Molekularbiologie (DE-588)4039983-7 s DE-604 Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014772061&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014772061&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Kiaris, Hippokratis ca. 20./21. Jh Understanding carcinogenesis an introduction to the molecular basis of cancer Carcinogenese (DE-588)4069853-1 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4069853-1 (DE-588)4039983-7 |
| title | Understanding carcinogenesis an introduction to the molecular basis of cancer |
| title_auth | Understanding carcinogenesis an introduction to the molecular basis of cancer |
| title_exact_search | Understanding carcinogenesis an introduction to the molecular basis of cancer |
| title_exact_search_txtP | Understanding carcinogenesis an introduction to the molecular basis of cancer |
| title_full | Understanding carcinogenesis an introduction to the molecular basis of cancer Hippokratis Kiaris |
| title_fullStr | Understanding carcinogenesis an introduction to the molecular basis of cancer Hippokratis Kiaris |
| title_full_unstemmed | Understanding carcinogenesis an introduction to the molecular basis of cancer Hippokratis Kiaris |
| title_short | Understanding carcinogenesis |
| title_sort | understanding carcinogenesis an introduction to the molecular basis of cancer |
| title_sub | an introduction to the molecular basis of cancer |
| topic | Carcinogenese (DE-588)4069853-1 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Carcinogenese Molekularbiologie |
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