Genetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Alpha Science
2005
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXV, 903 S. Ill., graph. Darst. |
| ISBN: | 1842652109 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV021551732 | ||
| 003 | DE-604 | ||
| 005 | 20060517 | ||
| 007 | t | ||
| 008 | 060418s2005 ad|| |||| 00||| eng d | ||
| 020 | |a 1842652109 |9 1-84265-210-9 | ||
| 035 | |a (OCoLC)62120658 | ||
| 035 | |a (DE-599)BVBBV021551732 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-M49 | ||
| 050 | 0 | |a QH430 | |
| 082 | 0 | |a 576.5 |2 22 | |
| 084 | |a BIO 180f |2 stub | ||
| 100 | 1 | |a Sambamurty, A. V. S. S. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Genetics |c A. V. S. S. Sambamurty |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Oxford |b Alpha Science |c 2005 | |
| 300 | |a XXV, 903 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Molecular genetics | |
| 650 | 4 | |a Plant breeding | |
| 650 | 0 | 7 | |a Genetik |0 (DE-588)4071711-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Genetik |0 (DE-588)4071711-2 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014767786&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-014767786 | ||
Datensatz im Suchindex
| _version_ | 1804135308152799232 |
|---|---|
| adam_text | GENETICS
A Conceptual Approach
Second Edition
Benjamin A Pierce
Baylor University
IS W H Freeman and Company • New York
* — ^ Contents in Brief J
Chapter 1 Introduction to Genetics 1
Chapter 2 Chromosomes and Cellular Reproduction 17
Chapter 3 Basic Principles of Heredity 47
Chapter 4 Sex Determination and Sex-Linked Characteristics 75
Chapter 5 Extensions and Modifications of Basic Principles 101
Chapter 6 Pedigree Analysis and Applications 132
I INTEGRATIVE CASE STUDY [ Phenylketonuria: Part I 156
Chapter 7 Linkage Recombination, and Eukaryotic Gene Mapping 160
Chapter 8 Bacterial and Viral Genetic Systems 197
Chapter 9 Chromosome Variation 235
Chapter 10 DNA - The Chemical Nature of the Gene 266
Chapter 11 Chromosome Structure and Transposable Elements 287
Chapter 12 DNA Replication and Recombination 318
Chapter 13 Transcription 348
Chapter 14 RNA Molecules and RNA Processing 372
Chapter 15 The Genetic Code~and Translation 402
Chapter 16 Control of Gene Expression 433
Chapter 17 Gene Mutations and DNA Repair 473
INTEGRATIVE CASE STUDY [ Phenylketonuria: Part II 506
Chapter 18 Recombinant DNA Technology 509
Chapter 19 Genomics 552
Chapter 20 Organelle DNA 587
Chapter 21 Advanced Topics in Genetics: Developmental Genetics
Immunogenetics, and Cancer Genetics 607
Chapter 22 Quantitative Genetics 642
Chapter 23 Population and Evolutionary Genetics 676
1 INTEGRATIVE CASE STUDY] Phenylketonuria: Part III 716
Contents
Preface xv
Chapter 1 Introduction to Genetics 1
Royal Hemophilia and Romanov DNA
The Importance of Genetics
The Role of Genetics in Biology 5
Genetic Diversity and Evolution 5
Divisions of Genetics 6
Model Genetic Organisms 6
A Brief History of Genetics
Prehistory 8
Early Written Records 8
The Rise of Genetics 10
Modern Genetics 11
The Future of Genetics 11
Basic Concepts in Genetics
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Choosing the Sex of Your Child by Ron Green
Chapter 2 Chromosomes and Cellular
Reproduction 17
The Blind Men s Riddle ~ — _____
Basic Cell Types: Structure and Evolutionary
Relationships
Cell Reproduction
Prokaryotic Cell Reproduction 21
Eukaryotic Cell Reproduction 21
The Cell Cycle and Mitosis 23
The Movement of Chromosomes in Mitosis 27
Genetic Consequences of the Cell Cycle 27
Control of the Cell Cycle 28
Connecting Concepts Counting Chromosomes and
DNA Molecules
Sexual Reproduction and Genetic Variation
Meiosis 30
Consequences of Meiosis 32
Connecting Concepts Comparison of Mitosis and
Meiosis
Separation of Sister Chromatids and Homologous
Chromosomes 37
Meiosis in the Life Cycles of Plants and Animals 38
Chapter 3 Basic Principles
of Heredity 47
Black Urine and First Cousins 47
Mendel: The Father of Genetics 48
Mendel s Success 49
Genetic Terminology 49
Monohybrid Crosses 50
What Monohybrid Crosses Reveal 51
Connecting Concepts Relating Genetic Crosses
to Meiosis S3
Predicting the Outcomes of Genetic Crosses 53
The Testcross 58
Incomplete Dominance 58
Genetic Symbols 59
(£• Connecting Concepts Ratios in Simple Crosses 60
Multiple-Loci Crosses 61
Dihybrid Crosses 61
The Principle of Independent Assortment 61
The Relation of the Principle of Independent
Assortment to Meiosis 62
Applying Probability and the Branch Diagram to
Dihybrid Crosses 62
The Dihybrid Testcross 63
Observed and Expected Ratios 65
The Goodness-of-Fit Chi-Square Test 65
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Rest in Peace Mr Lincoln? by Arthur L Caplan and Ron Green 68
Chapter 4 Sex Determination and Sex-
Linked Characteristics 75
Sex Wars in Isopods 75
Sex Determination 77
Chromosomal Sex-Determining Systems 77
Genetic Sex-Determining Systems 79
Environmental Sex Determination 80
Sex Determination in Drosophila melanogaster 80
Sex Determination in Humans 81
Sex-Linked Characteristics 83
X-Linked White Eyes in Drosophila 84
Nondisjunction and the Chromosome Theory of
Inheritance 85
Contents
^ Model Organism: The Fruit Fly Drosophila
melanogaster 86
X-Linked Color Blindness in Humans 88
Symbols for X-Linked Genes 89
Dosage Compensation 90
Z-Linked Characteristics 92
Y-Linked Characteristics 92
Connecting Concepts Recognizing Sex-Linked
inheritance 94
Chapter 5 Extensions and Modifications
of Basic Principles 101
Birth Weight and Genomic Imprinting 101
Dominance Revisited 102
Penetrance and Expressivity 104
Lethal Alleles 105
Multiple Alleles 105
Duck-Feather Patterns 105
The ABO Blood Group 106
Gene Interaction 107
Gene Interaction That Produces Novel Phenotypes 107
Gene Interaction with Epistasis 108
(01 Connecting Concepts Interpreting Ratios Produced
by Gene Interaction 111
The Complex Genetics of Coat Color in Dogs 112
Complementation: Determining Whether Mutations
Are at the Same or Different Loci 115
Interaction-Betvyeen Sex and Heredity 115
Sex-Influenced and SePLimited Characteristics 115
Cytoplasmic Inheritance 117
Genetic Maternal Effect 119
Genomic Imprinting 120
Anticipation 122
Interaction Between Genes and Environment 122
Environmental Effects on Gene Expression 122
The Inheritance of Continuous Characteristics 123
Chapter 6 Pedigree Analysis and
Applications 132
Lou Gehrig and Superoxide Free Radicals 132
The Study of Human Genetic Characteristics 133
Analyzing Pedigrees 134
Autosomal Recessive Traits 135
Autosomal Dominant Traits 136
X-Linked Recessive Traits 137
X-Linked Dominant Traits 139
Y-Linked Traits 139
Twin Studies 141
Concordance 141
Twin Studies and Obesity 142
Adoption Studies 143
Adoption Studies and Obesity 144
Adoption Studies and Alcoholism 145
Genetic Counseling 145
Genetic Testing 146
Prenatal Genetic Testing 147
Postnatal Genetic Testing 149
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Lifesaving Sibling or Designer Baby? by Ron Green 150
I INTEGRATIVE CASE STUDY 1 Phenylketonuria: Part I 156
PKU and Dominance 156
Multiple Alleles at the PAH Locus 157
PKU As a Multifactorial Trait 157
The Treatment of PKU 157
PKU As a Genetic Maternal Effect 158
Newborn Screening for PKU 158
Genetic Risk and Genetic Counseling for PKU 159
Chapter 7 Linkage, Recombination, and
Eukaryotic Gene Mapping 160
Alfred Sturtevant and the First Genetic Map 160
Genes That Assort Independently and
Those That Don t 161
Linkage and Recombination Between
Two Genes 163
Notation for Crosses with Linkage 163
Complete Linkage Compared with Independent
Assortment 164
Crossing Over with Linked Genes 164
Calculating Recombination Frequency 167
Coupling and Repulsion 167
Connecting Concepts Relating Independent
Assortment, Linkage, and Crossing Over 169
Evidence for the Physical Basis of Recombination 169
Predicting the Outcome of Crosses with Linked
Genes 170
Testing for Independent Assortment 171
Gene Mapping with Recombination Frequencies 173
Constructing a Genetic Map with Two-Point
Testcrosses 174
Linkage and Recombination Between
Three Genes 175
Constructing a Genetic Map with the Three-Point
Testcross 176
(01 Connecting Concepts Stepping Through the
Three-Point Cross 181
Mapping Human Genes 182
Mapping with Molecular Markers 184
Physical Chromosome Mapping 184
Deletion Mapping 184
Somatic-Cell Hybridization 185
In Situ Hybridization 186
Mapping by DNA Sequencing 186
Chapter 8 Bacterial and Viral
Genetic Systems 197
Gutsy Travelers 197
Bacterial Genetics 199
Techniques for the Study of Bacteria 199
The Bacterial Genome 201
Plasmids 201
Gene Transfer in Bacteria 202
Conjugation 204
Natural Gene Transfer and Antibiotic Resistance
Transformation in Bacteria 211
Bacterial Genome Sequences 212
63 Model Organism: The Bacterium Escherichia coli
Viral Genetics
Techniques for the Study of Bacteriophages 216
Gene Mapping in Phages 217
Transduction: Using Phages to Map Bacterial
Genes 218 -
@ Connecting Concepts Three Methods
for Mapping Bacterial Genes
Fine-Structure Analysis of Bacteriophage Genes
Overlapping Genes 225
RNA Viruses 226
Prions: Pathogens Without Genes 228
Aneuploidy 247
Types of Aneuploidy 248
Effects of Aneuploidy 249
Aneuploidy in Humans 249
Uniparental Disomy 253
Mosaicism 253
Polyploidy 254
Autopolyploidy 254
Allopolyploidy 255
The Significance of Polyploidy 256
Chromosome Mutations and Cancer 257
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
A Duty to Warn? by Ron Green 260
Chapter 10 DNA: The Chemical
Nature of the Gene 266
The Elegantly Stable Double Helix:
Ice Man s DNA 266
Characteristics of Genetic Material 267
The Molecular Basis of Heredity 268
Early Studies of DNA 268
DNA As the Source of Genetic Information 269
Watson and Crick s Discovery of the Three-
Dimensional Structure of DNA 273
RNA As Genetic Material 274
The Structure of DNA 275
The Primary Structure of DNA 275
Secondary Structures of DNA 277
Connecting Concepts Genetic Implications
of DNA Structure
Special Structures in DNA and RNA
DNA Methylation 282
Bends in DNA 282
Chapter 9 Chromosome Variation 235
Once in a Blue Moon 235
Chromosome Variation 236
Chromosome Morphology 236
Types of Chromosome Mutations 238
Chromosome Rearrangements 238
Duplications 238
Deletions 240
Inversions 242
Translocations 244
Fragile Sites 247
Chapter 11 Chromosome Structure and
Transposable Elements 287
How Much DNA Does It Take to Make an
Organism? 287
Packing DNA into Small Spaces 288
The Bacterial Chromosome 290
The Eukaryotic Chromosome 290
Chromatin Structure 290
Centromere Structure 295
Telomere Structure 296
Artificial Chromosomes 297
Contents
Variation in Eukaryotic DNA Sequences 298
The Denaturation and Renaturation of DNA 298
Types of DNA Sequence in Eukaryotes 298
The Nature of Transposable Elements 299
General Characteristics of Transposable Elements 299
Transposition 300
The Mechanisms of Transposition 300
The Mutagenic Effects of Transposition 303
The Regulation of Transposition 303
The Structure of Transposable Elements 304
Transposable Elements in Bacteria 304
Transposable Elements in Eukaryotes 306
Connecting Concepts Classes of Transposable
Elements
The Evolution of Transposable Elements
Chapter 12 DNA Replication and
Recombination
RNA in the Primeval World
RNA Molecules
The Structure of RNA 349
Classes of RNA 350
Transcription: Synthesizing RNA from
a DNA Template
The Template 351
The Substrate for Transcription 354
The Transcription Apparatus 355
Preventing Train Wrecks in Replication 318
The Central Problem of Replication 319
Semiconservative Replication 320
Meselson and Stahl s Experiment 321
Modes of Replication 321
Requirements of Replication 325
Direction of Replication 325
The Mechanism of Replication 327
Bacterial DNA Replication 328
Connecting Cdncepts-IheJJasic Rules of
Replication 334
Eukaryotic DNA Replication 334
Replication in Archaea 339
Molecular Basis of Recombination 339
Models of Recombination 340
Enzymes Required for Recombination 341
Chapter 13 Transcription 348
The Process of Bacterial Transcription 356
Initiation 356
Elongation 359
Termination 359
(fl® Connecting Concepts The Basic Rules of
Transcription 361
The Process of Eukaryotic Transcription 361
Transcription and Nucleosome Structure 361
Transcription Initiation 361
RNA Polymerase II Promoters 362
RNA Polymerase I and III Promoters 364
(ft® Connecting Concepts Characteristics of Eukaryotic
Promoters and Transcription Factors 364
Elongation 365
Termination 365
The Process of Transcription in Archaea 366
Chapter 14 RNA Molecules and
RNA Processing 372
The Immense Dystrophin Gene 372
Gene Structure 373
Gene Organization 373
Introns 375
The Concept of the Gene Revisited 376
Messenger RNA 376
The Structure of Messenger RNA 376
Pre-mRNA Processing 377
The Addition of the 5 Cap 378
The Addition of the Poly(A) Tail 379
RNA Splicing 380
Alternative Processing Pathways 385
RNA Editing 386
Connecting Concepts Eukaryotic Gene Structure
and Pre-mRNA Processing 387
Transfer RNA 389
The Structure of Transfer RNA 389
Transfer RNA Gene Structure and Processing 390
Ribosomal RNA 391
The Structure of the Ribosome 392
Ribosomal RNA Gene Structure and Processing 392
Small Interfering RNAs and MicroRNAs 393
RNA Interference 393
Q Model Organism: The Nematode Worm
Caenorhabditis elegans 394
Contents
Chapter 15 The Genetic Code and
Translation 402
The Deadly Diphtheria Toxin
The Molecular Relation Between
Genotype and Phenotype
The One Gene, One Enzyme Hypothesis 403
The Structure and Function of Proteins 407
The Genetic Code 409
Breaking the Genetic Code 410
The Degeneracy of the Code 412
The Reading Frame and Initiation Codons 413
Termination Codons 414
The Universality of th£ Code 414
@ Connecting Concepts Characteristics of the
Genetic Code 414
The Process of Translation 414
The Binding of Amino Acids to Transfer RNAs 415
The Initiation of Translation 416
Elongation 418
Termination 420
Connecting Concepts A Comparison of Bacterial
and Eukaryotic Translation 421
Further Considerations of Protein Synthesis 422
The Three-Dimensional Structure
of the Ribosome 422
RNA-RNA Interactions in Translation 423
Polyribosomes 423
Messenger RNA Surveillance 424
The Posttranslational Modifications-of-Eroteins 425
Translation and Antibiotics 426
Nonstandard Protein Synthesis 426
Chapter 16 Control of Gene
Expression 433
Creating Giant Mice Through Gene Regulation 433
General Principles of Gene Regulation 434
Levels of Gene Control 435
Genes and Regulatory Elements 435
DNA-Binding Proteins 436
Gene Regulation in Bacterial Cells 436
Operon Structure 436
Negative and Positive Control: Inducible and
Repressible Operons 438
The lac Operon of E coli 441
lac Mutations 443
Positive Control and Catabolite Repression 446
The trp Operon of E coli 447
Attenuation: The Premature Termination of
Transcription 448
Antisense RNA in Gene Regulation 452
Riboswitches and RNA-Mediated Repression 452
Transcriptional Control in Bacteriophage Lambda 453
Eukaryotic Gene Regulation 454
Chromatin Structure and Gene Regulation 455
Transcriptional Control in Eukaryotic Cells 457
Gene Control Through Messenger
RNA Processing 460
Gene Control Through RNA Stability 462
RNA Silencing 462
Translational and Posttranslational Control 463
Connecting Concepts A Comparison of Bacterial
and Eukaryotic Gene Control 464
Model Organism: Arabidopsis thaliana 464
Chapter 17 Gene Mutations and
DNA Repair 473
The Genetic Legacy of Chernobyl 473
The Nature of Mutation 474
The Importance of Mutations 474
Categories of Mutations 475
Types of Gene Mutations 476
Mutation Rates 481
Causes of Mutations 483
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Seeking a Disabled Child by Ron Green 484
Spontaneous Replication Errors 484
Spontaneous Chemical Changes 486
Chemically Induced Mutations 488
Radiation 490
The Study of Mutations 492
The Analysis of Reverse Mutations 492
Detecting Mutations with the Ames Test 492
Radiation Exposure in Humans 494
DNA Repair 495
Mismatch Repair 495
Direct Repair 496
Base-Excision Repair 497
Nucleotide-Excision Repair 497
Other Types of DNA Repair 498
Connecting Concepts The Basic Pathway
of DNA Repair 498
Genetic Diseases and Faulty DNA Repair 499
i Contents
I INTEGRATIVE CASE STUDY 1 Phenylketonuria: Part II 506
The PAH Locus 506
Regulatory Sequences 506
Mutations at the PAH Locus 507
Complicating Factors 507
Other Loci 508
Chapter 18 Recombinant DNA
Technology 509
Feeding the Future Population of the World 509
Basic Concepts of Recombinant DNA Technology 510
The Impact of Recombinant DNA Technology 511
Working at the Molecular Level 511
Recombinant DNA Techniques 512
Cutting and Joining DNA Fragments 512
Viewing DNA Fragments 514
Locating DNA Fragments with Southern
Blotting and Probes 516
Cloning Genes 517
Finding Genes 523
Connecting Concepts Cloning Strategies 529
Using the Polymerase Chain Reaction
to Amplify DNA 530
Analyzing DNA Sequences 532
Q Model Organism: The Mouse Mus musculus 536
Applications of Recombinant DNA Technology 538
Pharmaceuticals 538
Specialized Bacteria 538
Agricultural Products 538
Oligonucleotide Drugs 539
Genetic Testing 540
Gene Therapy 541
Gene Mapping 542
DNA Fingerprinting 543
Concerns About Recombinant DNA Technology 545
Chapter 19 Genomics 552
The Decaying Genome of Mycobacterium
leprae 552
Structural Genomics 554
Genetic Maps 554
Physical Maps 555
DNA-Sequencing Methods 557
Sequencing an Entire Genome 560
The Human Genome Project 563
Single-Nucleotide Polymorphisms 564
The New Genetics ETHICS • SCIENCE TECHNOLOGY
The Human Genome Project: Book of Life or Pandora s Box?
by Ron Green 565
Expressed-Sequence Tags 566
Bioinformatics 566
Functional Genomics
Predicting Function from Sequence 566
Gene Expression and Microarrays 569
Gene Expression and Reporter Sequences 571
Genomewide Mutagenesis 572
Comparative Genomics 573
Prokaryotic Genomes 573
Eukaryotic Genomes 575
The Future of Genomics 579
587 Chapter 20 Organelle DNA
The Donkey: A Wild Ass or a Half Ass? 587
The Biology of Mitochondria and Chloroplasts 589
Mitochondrion and Chloroplast Structure 589
The Genetics of Organelle-Encoded Traits 590
The Endosymbiotic Theory 591
Mitochondrial DNA 592
The Gene Structure and Organization of mtDNA 593
Nonuniversal Codons in mtDNA 595
The Replication, Transcription, and Translation
of mtDNA 595
The Evolution of mtDNA 596
HJ Model Organism: The Yeast Saccharomyces
cerevisiae 596
Chloroplast DNA 598
The Gene Structure and Organization of cpDNA 598
The Replication, Transcription, and Translation
of cpDNA 599
The Evolution of cpDNA 600
(^ Connecting Concepts Genome Comparisons 600
The Intergenomic Exchange of Genetic
Information 601
Mitochondrial DNA and Aging in Humans 601
Chapter 21 Advanced Topics in Genetics-
Developmental Genetics
Immunogenetics and
Cancer Genetics 607
Flies with Extra Eyes
Developmental Genetics
Cloning Experiments 608
The Genetics of Pattern Formation in Drosophila 609
Homeobox Genes in Other Organisms 616
Connecting Concepts The Control of Development 616
The Genetics of Flower Development in
Arabidopsis 617
Contents
Programmed Cell Death in Development 618
Evo-Devo: The Study of Evolution and
Development 619
Immunogenetics 620
The Organization of the Immune System 620
Immunoglobulin Structure 621
The Generation of Antibody Diversity 623
T-Cell-Receptor Diversity 625
Major Histocompatibility Complex Genes 626
Genes and Organ Transplants 627
Cancer Genetics 627
The Nature of Cancer 627
Cancer As a Genetic Disease 627
Genetic Changes That Contribute to Cancer 630
The Molecular Genetics of Colorectal Cancer 635
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
TV Commercials for Genetic Tests by Ron Green 637
Chapter 22 Quantitative Genetics 642
Porkier Pigs Through Quantitative Genetics 642
Quantitative Characteristics 643
The Relation Between Genotype and Phenotype 644
Types of Quantitative Characteristics 645
Polygenic Inheritance 646
Kernel Color in Wheat 646
Determining Gene Number for a Polygenic
Characteristic 648
Statistical Methods for Analyzing Quantitative
Characteristics ~ — 648
Distributions 649
Samples and Populations 649
The Mean 650
The Variance and Standard Deviation 650
Correlation 652
Regression 653
Applying Statistics to the Study of a Polygenic
Characteristic 655
Heritability
Phenotypic Variance 656
Types of Heritability 657
Calculating Heritability 658
The Limitations of Heritability 660
Locating Genes That Affect Quantitative
Characteristics 662
Response to Selection
Predicting the Response to Selection 664
Limits to Selection Response 665
Correlated Responses 666
Chapter 23 Population and
Evolutionary Genetics 676
The Genetic History of Tristan da Cuna 676
Genetic Variation 677
Calculating Genotypic Frequencies 678
Calculating Allelic Frequencies 678
The Hardy-Weinberg Law 680
Closer Examination of the Assumptions
of the Hardy-Weinberg Law 681
Implications of the Hardy-Weinberg Law 681
Extensions of the Hardy-Weinberg Law 682
Testing for Hardy-Weinberg Proportions 682
Estimating Allelic Frequencies with the
Hardy-Weinberg Law 683
Nonrandom Mating 683
Changes in Allelic Frequencies 686
Mutation 686
Migration 687
Genetic Drift 689
Natural Selection 692
Connecting Concepts The General Effects
of Evolutionary Forces 696
Molecular Evolution 697
Protein Variation 698
DNA Sequence Variation 700
Molecular Phylogenies 703
Rates of Molecular Evolution 706
The Molecular Clock 707
Genome Evolution 708
1 INTEGRATIVE CASE STUDY 1 Phenylketonuria: Part III 716
Incidence of PKU in Human Populations 716
PAH Mutations in Human Populations 716
PAH Mutations and Haplotypes 716
The Origin and Spread of PAH Mutations
in European Populations 717
Calculating Allelic and Genotypic Frequencies at the
PAH Locus 718
The Balance Between Mutation and Natural Selection
for PKU Mutations 719
Other Possible Causes of the High Frequency of PKU
in European Populations 719
Glossary
Suggested Readings
Answers to Selected Questions
and Problems
Index
G-l
S-l
A-l
1-1
|
| adam_txt |
GENETICS
A Conceptual Approach
Second Edition
Benjamin A Pierce
Baylor University
IS W H Freeman and Company • New York
* — ^ Contents in Brief J
Chapter 1 Introduction to Genetics 1
Chapter 2 Chromosomes and Cellular Reproduction 17
Chapter 3 Basic Principles of Heredity 47
Chapter 4 Sex Determination and Sex-Linked Characteristics 75
Chapter 5 Extensions and Modifications of Basic Principles 101
Chapter 6 Pedigree Analysis and Applications 132
I INTEGRATIVE CASE STUDY [ Phenylketonuria: Part I 156
Chapter 7 Linkage Recombination, and Eukaryotic Gene Mapping 160
Chapter 8 Bacterial and Viral Genetic Systems 197
Chapter 9 Chromosome Variation 235
Chapter 10 DNA - The Chemical Nature of the Gene 266
Chapter 11 Chromosome Structure and Transposable Elements 287
Chapter 12 DNA Replication and Recombination 318
Chapter 13 Transcription 348
Chapter 14 RNA Molecules and RNA Processing 372
Chapter 15 The Genetic Code~and Translation 402
Chapter 16 Control of Gene Expression 433
Chapter 17 Gene Mutations and DNA Repair 473
INTEGRATIVE CASE STUDY [ Phenylketonuria: Part II 506
Chapter 18 Recombinant DNA Technology 509
Chapter 19 Genomics 552
Chapter 20 Organelle DNA 587
Chapter 21 Advanced Topics in Genetics: Developmental Genetics
Immunogenetics, and Cancer Genetics 607
Chapter 22 Quantitative Genetics 642
Chapter 23 Population and Evolutionary Genetics 676
1 INTEGRATIVE CASE STUDY] Phenylketonuria: Part III 716
Contents
Preface xv
Chapter 1 Introduction to Genetics 1
Royal Hemophilia and Romanov DNA
The Importance of Genetics
The Role of Genetics in Biology 5
Genetic Diversity and Evolution 5
Divisions of Genetics 6
Model Genetic Organisms 6
A Brief History of Genetics
Prehistory 8
Early Written Records 8
The Rise of Genetics 10
Modern Genetics 11
The Future of Genetics 11
Basic Concepts in Genetics
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Choosing the Sex of Your Child by Ron Green
Chapter 2 Chromosomes and Cellular
Reproduction 17
The Blind Men's Riddle ~ — _
Basic Cell Types: Structure and Evolutionary
Relationships
Cell Reproduction
Prokaryotic Cell Reproduction 21
Eukaryotic Cell Reproduction 21
The Cell Cycle and Mitosis 23
The Movement of Chromosomes in Mitosis 27
Genetic Consequences of the Cell Cycle 27
Control of the Cell Cycle 28
Connecting Concepts Counting Chromosomes and
DNA Molecules
Sexual Reproduction and Genetic Variation
Meiosis 30
Consequences of Meiosis 32
Connecting Concepts Comparison of Mitosis and
Meiosis
Separation of Sister Chromatids and Homologous
Chromosomes 37
Meiosis in the Life Cycles of Plants and Animals 38
Chapter 3 Basic Principles
of Heredity 47
Black Urine and First Cousins 47
Mendel: The Father of Genetics 48
Mendel's Success 49
Genetic Terminology 49
Monohybrid Crosses 50
What Monohybrid Crosses Reveal 51
Connecting Concepts Relating Genetic Crosses
to Meiosis S3
Predicting the Outcomes of Genetic Crosses 53
The Testcross 58
Incomplete Dominance 58
Genetic Symbols 59
(£• Connecting Concepts Ratios in Simple Crosses 60
Multiple-Loci Crosses 61
Dihybrid Crosses 61
The Principle of Independent Assortment 61
The Relation of the Principle of Independent
Assortment to Meiosis 62
Applying Probability and the Branch Diagram to
Dihybrid Crosses 62
The Dihybrid Testcross 63
Observed and Expected Ratios 65
The Goodness-of-Fit Chi-Square Test 65
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Rest in Peace Mr Lincoln? by Arthur L Caplan and Ron Green 68
Chapter 4 Sex Determination and Sex-
Linked Characteristics 75
Sex Wars in Isopods 75
Sex Determination 77
Chromosomal Sex-Determining Systems 77
Genetic Sex-Determining Systems 79
Environmental Sex Determination 80
Sex Determination in Drosophila melanogaster 80
Sex Determination in Humans 81
Sex-Linked Characteristics 83
X-Linked White Eyes in Drosophila 84
Nondisjunction and the Chromosome Theory of
Inheritance 85
Contents
^ Model Organism: The Fruit Fly Drosophila
melanogaster 86
X-Linked Color Blindness in Humans 88
Symbols for X-Linked Genes 89
Dosage Compensation 90
Z-Linked Characteristics 92
Y-Linked Characteristics 92
Connecting Concepts Recognizing Sex-Linked
inheritance 94
Chapter 5 Extensions and Modifications
of Basic Principles 101
Birth Weight and Genomic Imprinting 101
Dominance Revisited 102
Penetrance and Expressivity 104
Lethal Alleles 105
Multiple Alleles 105
Duck-Feather Patterns 105
The ABO Blood Group 106
Gene Interaction 107
Gene Interaction That Produces Novel Phenotypes 107
Gene Interaction with Epistasis 108
(01 Connecting Concepts Interpreting Ratios Produced
by Gene Interaction 111
The Complex Genetics of Coat Color in Dogs 112
Complementation: Determining Whether Mutations
Are at the Same or Different Loci 115
Interaction-Betvyeen Sex and Heredity 115
Sex-Influenced and SePLimited Characteristics 115
Cytoplasmic Inheritance 117
Genetic Maternal Effect 119
Genomic Imprinting 120
Anticipation 122
Interaction Between Genes and Environment 122
Environmental Effects on Gene Expression 122
The Inheritance of Continuous Characteristics 123
Chapter 6 Pedigree Analysis and
Applications 132
Lou Gehrig and Superoxide Free Radicals 132
The Study of Human Genetic Characteristics 133
Analyzing Pedigrees 134
Autosomal Recessive Traits 135
Autosomal Dominant Traits 136
X-Linked Recessive Traits 137
X-Linked Dominant Traits 139
Y-Linked Traits 139
Twin Studies 141
Concordance 141
Twin Studies and Obesity 142
Adoption Studies 143
Adoption Studies and Obesity 144
Adoption Studies and Alcoholism 145
Genetic Counseling 145
Genetic Testing 146
Prenatal Genetic Testing 147
Postnatal Genetic Testing 149
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Lifesaving Sibling or Designer Baby? by Ron Green 150
I INTEGRATIVE CASE STUDY 1 Phenylketonuria: Part I 156
PKU and Dominance 156
Multiple Alleles at the PAH Locus 157
PKU As a Multifactorial Trait 157
The Treatment of PKU 157
PKU As a Genetic Maternal Effect 158
Newborn Screening for PKU 158
Genetic Risk and Genetic Counseling for PKU 159
Chapter 7 Linkage, Recombination, and
Eukaryotic Gene Mapping 160
Alfred Sturtevant and the First Genetic Map 160
Genes That Assort Independently and
Those That Don't 161
Linkage and Recombination Between
Two Genes 163
Notation for Crosses with Linkage 163
Complete Linkage Compared with Independent
Assortment 164
Crossing Over with Linked Genes 164
Calculating Recombination Frequency 167
Coupling and Repulsion 167
Connecting Concepts Relating Independent
Assortment, Linkage, and Crossing Over 169
Evidence for the Physical Basis of Recombination 169
Predicting the Outcome of Crosses with Linked
Genes 170
Testing for Independent Assortment 171
Gene Mapping with Recombination Frequencies 173
Constructing a Genetic Map with Two-Point
Testcrosses 174
Linkage and Recombination Between
Three Genes 175
Constructing a Genetic Map with the Three-Point
Testcross 176
(01 Connecting Concepts Stepping Through the
Three-Point Cross 181
Mapping Human Genes 182
Mapping with Molecular Markers 184
Physical Chromosome Mapping 184
Deletion Mapping 184
Somatic-Cell Hybridization 185
In Situ Hybridization 186
Mapping by DNA Sequencing 186
Chapter 8 Bacterial and Viral
Genetic Systems 197
Gutsy Travelers 197
Bacterial Genetics 199
Techniques for the Study of Bacteria 199
The Bacterial Genome 201
Plasmids 201
Gene Transfer in Bacteria 202
Conjugation 204
Natural Gene Transfer and Antibiotic Resistance
Transformation in Bacteria 211
Bacterial Genome Sequences 212
63 Model Organism: The Bacterium Escherichia coli
Viral Genetics
Techniques for the Study of Bacteriophages 216
Gene Mapping in Phages 217
Transduction: Using Phages to Map Bacterial
Genes 218 -
@ Connecting Concepts Three Methods
for Mapping Bacterial Genes
Fine-Structure Analysis of Bacteriophage Genes
Overlapping Genes 225
RNA Viruses 226
Prions: Pathogens Without Genes 228
Aneuploidy 247
Types of Aneuploidy 248
Effects of Aneuploidy 249
Aneuploidy in Humans 249
Uniparental Disomy 253
Mosaicism 253
Polyploidy 254
Autopolyploidy 254
Allopolyploidy 255
The Significance of Polyploidy 256
Chromosome Mutations and Cancer 257
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
A Duty to Warn? by Ron Green 260
Chapter 10 DNA: The Chemical
Nature of the Gene 266
The Elegantly Stable Double Helix:
Ice Man's DNA 266
Characteristics of Genetic Material 267
The Molecular Basis of Heredity 268
Early Studies of DNA 268
DNA As the Source of Genetic Information 269
Watson and Crick's Discovery of the Three-
Dimensional Structure of DNA 273
RNA As Genetic Material 274
The Structure of DNA 275
The Primary Structure of DNA 275
Secondary Structures of DNA 277
Connecting Concepts Genetic Implications
of DNA Structure
Special Structures in DNA and RNA
DNA Methylation 282
Bends in DNA 282
Chapter 9 Chromosome Variation 235
Once in a Blue Moon 235
Chromosome Variation 236
Chromosome Morphology 236
Types of Chromosome Mutations 238
Chromosome Rearrangements 238
Duplications 238
Deletions 240
Inversions 242
Translocations 244
Fragile Sites 247
Chapter 11 Chromosome Structure and
Transposable Elements 287
How Much DNA Does It Take to Make an
Organism? 287
Packing DNA into Small Spaces 288
The Bacterial Chromosome 290
The Eukaryotic Chromosome 290
Chromatin Structure 290
Centromere Structure 295
Telomere Structure 296
Artificial Chromosomes 297
Contents
Variation in Eukaryotic DNA Sequences 298
The Denaturation and Renaturation of DNA 298
Types of DNA Sequence in Eukaryotes 298
The Nature of Transposable Elements 299
General Characteristics of Transposable Elements 299
Transposition 300
The Mechanisms of Transposition 300
The Mutagenic Effects of Transposition 303
The Regulation of Transposition 303
The Structure of Transposable Elements 304
Transposable Elements in Bacteria 304
Transposable Elements in Eukaryotes 306
Connecting Concepts Classes of Transposable
Elements
The Evolution of Transposable Elements
Chapter 12 DNA Replication and
Recombination
RNA in the Primeval World
RNA Molecules
The Structure of RNA 349
Classes of RNA 350
Transcription: Synthesizing RNA from
a DNA Template
The Template 351
The Substrate for Transcription 354
The Transcription Apparatus 355
Preventing Train Wrecks in Replication 318
The Central Problem of Replication 319
Semiconservative Replication 320
Meselson and Stahl's Experiment 321
Modes of Replication 321
Requirements of Replication 325
Direction of Replication 325
The Mechanism of Replication 327
Bacterial DNA Replication 328
Connecting Cdncepts-IheJJasic Rules of
Replication 334
Eukaryotic DNA Replication 334
Replication in Archaea 339
Molecular Basis of Recombination 339
Models of Recombination 340
Enzymes Required for Recombination 341
Chapter 13 Transcription 348
The Process of Bacterial Transcription 356
Initiation 356
Elongation 359
Termination 359
(fl® Connecting Concepts The Basic Rules of
Transcription 361
The Process of Eukaryotic Transcription 361
Transcription and Nucleosome Structure 361
Transcription Initiation 361
RNA Polymerase II Promoters 362
RNA Polymerase I and III Promoters 364
(ft® Connecting Concepts Characteristics of Eukaryotic
Promoters and Transcription Factors 364
Elongation 365
Termination 365
The Process of Transcription in Archaea 366
Chapter 14 RNA Molecules and
RNA Processing 372
The Immense Dystrophin Gene 372
Gene Structure 373
Gene Organization 373
Introns 375
The Concept of the Gene Revisited 376
Messenger RNA 376
The Structure of Messenger RNA 376
Pre-mRNA Processing 377
The Addition of the 5' Cap 378
The Addition of the Poly(A) Tail 379
RNA Splicing 380
Alternative Processing Pathways 385
RNA Editing 386
Connecting Concepts Eukaryotic Gene Structure
and Pre-mRNA Processing 387
Transfer RNA 389
The Structure of Transfer RNA 389
Transfer RNA Gene Structure and Processing 390
Ribosomal RNA 391
The Structure of the Ribosome 392
Ribosomal RNA Gene Structure and Processing 392
Small Interfering RNAs and MicroRNAs 393
RNA Interference 393
Q Model Organism: The Nematode Worm
Caenorhabditis elegans 394
Contents
Chapter 15 The Genetic Code and
Translation 402
The Deadly Diphtheria Toxin
The Molecular Relation Between
Genotype and Phenotype
The One Gene, One Enzyme Hypothesis 403
The Structure and Function of Proteins 407
The Genetic Code 409
Breaking the Genetic Code 410
The Degeneracy of the Code 412
The Reading Frame and Initiation Codons 413
Termination Codons 414
The Universality of th£ Code 414
@ Connecting Concepts Characteristics of the
Genetic Code 414
The Process of Translation 414
The Binding of Amino Acids to Transfer RNAs 415
The Initiation of Translation 416
Elongation 418
Termination 420
Connecting Concepts A Comparison of Bacterial
and Eukaryotic Translation 421
Further Considerations of Protein Synthesis 422
The Three-Dimensional Structure
of the Ribosome 422
RNA-RNA Interactions in Translation 423
Polyribosomes 423
Messenger RNA Surveillance 424
The Posttranslational Modifications-of-Eroteins 425
Translation and Antibiotics 426
Nonstandard Protein Synthesis 426
Chapter 16 Control of Gene
Expression 433
Creating Giant Mice Through Gene Regulation 433
General Principles of Gene Regulation 434
Levels of Gene Control 435
Genes and Regulatory Elements 435
DNA-Binding Proteins 436
Gene Regulation in Bacterial Cells 436
Operon Structure 436
Negative and Positive Control: Inducible and
Repressible Operons 438
The lac Operon of E coli 441
lac Mutations 443
Positive Control and Catabolite Repression 446
The trp Operon of E coli 447
Attenuation: The Premature Termination of
Transcription 448
Antisense RNA in Gene Regulation 452
Riboswitches and RNA-Mediated Repression 452
Transcriptional Control in Bacteriophage Lambda 453
Eukaryotic Gene Regulation 454
Chromatin Structure and Gene Regulation 455
Transcriptional Control in Eukaryotic Cells 457
Gene Control Through Messenger
RNA Processing 460
Gene Control Through RNA Stability 462
RNA Silencing 462
Translational and Posttranslational Control 463
Connecting Concepts A Comparison of Bacterial
and Eukaryotic Gene Control 464
Model Organism: Arabidopsis thaliana 464
Chapter 17 Gene Mutations and
DNA Repair 473
The Genetic Legacy of Chernobyl 473
The Nature of Mutation 474
The Importance of Mutations 474
Categories of Mutations 475
Types of Gene Mutations 476
Mutation Rates 481
Causes of Mutations 483
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
Seeking a Disabled Child by Ron Green 484
Spontaneous Replication Errors 484
Spontaneous Chemical Changes 486
Chemically Induced Mutations 488
Radiation 490
The Study of Mutations 492
The Analysis of Reverse Mutations 492
Detecting Mutations with the Ames Test 492
Radiation Exposure in Humans 494
DNA Repair 495
Mismatch Repair 495
Direct Repair 496
Base-Excision Repair 497
Nucleotide-Excision Repair 497
Other Types of DNA Repair 498
Connecting Concepts The Basic Pathway
of DNA Repair 498
Genetic Diseases and Faulty DNA Repair 499
i Contents
I INTEGRATIVE CASE STUDY 1 Phenylketonuria: Part II 506
The PAH Locus 506
Regulatory Sequences 506
Mutations at the PAH Locus 507
Complicating Factors 507
Other Loci 508
Chapter 18 Recombinant DNA
Technology 509
Feeding the Future Population of the World 509
Basic Concepts of Recombinant DNA Technology 510
The Impact of Recombinant DNA Technology 511
Working at the Molecular Level 511
Recombinant DNA Techniques 512
Cutting and Joining DNA Fragments 512
Viewing DNA Fragments 514
Locating DNA Fragments with Southern
Blotting and Probes 516
Cloning Genes 517
Finding Genes 523
Connecting Concepts Cloning Strategies 529
Using the Polymerase Chain Reaction
to Amplify DNA 530
Analyzing DNA Sequences 532
Q Model Organism: The Mouse Mus musculus 536
Applications of Recombinant DNA Technology 538
Pharmaceuticals 538
Specialized Bacteria 538
Agricultural Products 538
Oligonucleotide Drugs 539
Genetic Testing 540
Gene Therapy 541
Gene Mapping 542
DNA Fingerprinting 543
Concerns About Recombinant DNA Technology 545
Chapter 19 Genomics 552
The Decaying Genome of Mycobacterium
leprae 552
Structural Genomics 554
Genetic Maps 554
Physical Maps 555
DNA-Sequencing Methods 557
Sequencing an Entire Genome 560
The Human Genome Project 563
Single-Nucleotide Polymorphisms 564
The New Genetics ETHICS • SCIENCE TECHNOLOGY
The Human Genome Project: Book of Life or Pandora's Box?
by Ron Green 565
Expressed-Sequence Tags 566
Bioinformatics 566
Functional Genomics
Predicting Function from Sequence 566
Gene Expression and Microarrays 569
Gene Expression and Reporter Sequences 571
Genomewide Mutagenesis 572
Comparative Genomics 573
Prokaryotic Genomes 573
Eukaryotic Genomes 575
The Future of Genomics 579
587 Chapter 20 Organelle DNA
The Donkey: A Wild Ass or a Half Ass? 587
The Biology of Mitochondria and Chloroplasts 589
Mitochondrion and Chloroplast Structure 589
The Genetics of Organelle-Encoded Traits 590
The Endosymbiotic Theory 591
Mitochondrial DNA 592
The Gene Structure and Organization of mtDNA 593
Nonuniversal Codons in mtDNA 595
The Replication, Transcription, and Translation
of mtDNA 595
The Evolution of mtDNA 596
HJ Model Organism: The Yeast Saccharomyces
cerevisiae 596
Chloroplast DNA 598
The Gene Structure and Organization of cpDNA 598
The Replication, Transcription, and Translation
of cpDNA 599
The Evolution of cpDNA 600
(^ Connecting Concepts Genome Comparisons 600
The Intergenomic Exchange of Genetic
Information 601
Mitochondrial DNA and Aging in Humans 601
Chapter 21 Advanced Topics in Genetics-
Developmental Genetics
Immunogenetics and
Cancer Genetics 607
Flies with Extra Eyes
Developmental Genetics
Cloning Experiments 608
The Genetics of Pattern Formation in Drosophila 609
Homeobox Genes in Other Organisms 616
Connecting Concepts The Control of Development 616
The Genetics of Flower Development in
Arabidopsis 617
Contents
Programmed Cell Death in Development 618
Evo-Devo: The Study of Evolution and
Development 619
Immunogenetics 620
The Organization of the Immune System 620
Immunoglobulin Structure 621
The Generation of Antibody Diversity 623
T-Cell-Receptor Diversity 625
Major Histocompatibility Complex Genes 626
Genes and Organ Transplants 627
Cancer Genetics 627
The Nature of Cancer 627
Cancer As a Genetic Disease 627
Genetic Changes That Contribute to Cancer 630
The Molecular Genetics of Colorectal Cancer 635
The New Genetics ETHICS • SCIENCE • TECHNOLOGY
TV Commercials for Genetic Tests by Ron Green 637
Chapter 22 Quantitative Genetics 642
Porkier Pigs Through Quantitative Genetics 642
Quantitative Characteristics 643
The Relation Between Genotype and Phenotype 644
Types of Quantitative Characteristics 645
Polygenic Inheritance 646
Kernel Color in Wheat 646
Determining Gene Number for a Polygenic
Characteristic 648
Statistical Methods for Analyzing Quantitative
Characteristics ~ — 648
Distributions 649
Samples and Populations 649
The Mean 650
The Variance and Standard Deviation 650
Correlation 652
Regression 653
Applying Statistics to the Study of a Polygenic
Characteristic 655
Heritability
Phenotypic Variance 656
Types of Heritability 657
Calculating Heritability 658
The Limitations of Heritability 660
Locating Genes That Affect Quantitative
Characteristics 662
Response to Selection
Predicting the Response to Selection 664
Limits to Selection Response 665
Correlated Responses 666
Chapter 23 Population and
Evolutionary Genetics 676
The Genetic History of Tristan da Cuna 676
Genetic Variation 677
Calculating Genotypic Frequencies 678
Calculating Allelic Frequencies 678
The Hardy-Weinberg Law 680
Closer Examination of the Assumptions
of the Hardy-Weinberg Law 681
Implications of the Hardy-Weinberg Law 681
Extensions of the Hardy-Weinberg Law 682
Testing for Hardy-Weinberg Proportions 682
Estimating Allelic Frequencies with the
Hardy-Weinberg Law 683
Nonrandom Mating 683
Changes in Allelic Frequencies 686
Mutation 686
Migration 687
Genetic Drift 689
Natural Selection 692
Connecting Concepts The General Effects
of Evolutionary Forces 696
Molecular Evolution 697
Protein Variation 698
DNA Sequence Variation 700
Molecular Phylogenies 703
Rates of Molecular Evolution 706
The Molecular Clock 707
Genome Evolution 708
1 INTEGRATIVE CASE STUDY 1 Phenylketonuria: Part III 716
Incidence of PKU in Human Populations 716
PAH Mutations in Human Populations 716
PAH Mutations and Haplotypes 716
The Origin and Spread of PAH Mutations
in European Populations 717
Calculating Allelic and Genotypic Frequencies at the
PAH Locus 718
The Balance Between Mutation and Natural Selection
for PKU Mutations 719
Other Possible Causes of the High Frequency of PKU
in European Populations 719
Glossary
Suggested Readings
Answers to Selected Questions
and Problems
Index
G-l
S-l
A-l
1-1 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Sambamurty, A. V. S. S. |
| author_facet | Sambamurty, A. V. S. S. |
| author_role | aut |
| author_sort | Sambamurty, A. V. S. S. |
| author_variant | a v s s s avss avsss |
| building | Verbundindex |
| bvnumber | BV021551732 |
| callnumber-first | Q - Science |
| callnumber-label | QH430 |
| callnumber-raw | QH430 |
| callnumber-search | QH430 |
| callnumber-sort | QH 3430 |
| callnumber-subject | QH - Natural History and Biology |
| classification_tum | BIO 180f |
| ctrlnum | (OCoLC)62120658 (DE-599)BVBBV021551732 |
| dewey-full | 576.5 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 576 - Genetics and evolution |
| dewey-raw | 576.5 |
| dewey-search | 576.5 |
| dewey-sort | 3576.5 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| edition | 2. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01268nam a2200385 c 4500</leader><controlfield tag="001">BV021551732</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20060517 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">060418s2005 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1842652109</subfield><subfield code="9">1-84265-210-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)62120658</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV021551732</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-M49</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH430</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">576.5</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 180f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sambamurty, A. V. S. S.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetics</subfield><subfield code="c">A. V. S. S. Sambamurty</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">2. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford</subfield><subfield code="b">Alpha Science</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXV, 903 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plant breeding</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014767786&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-014767786</subfield></datafield></record></collection> |
| id | DE-604.BV021551732 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:31:55Z |
| indexdate | 2024-07-09T20:38:26Z |
| institution | BVB |
| isbn | 1842652109 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014767786 |
| oclc_num | 62120658 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM |
| owner_facet | DE-M49 DE-BY-TUM |
| physical | XXV, 903 S. Ill., graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Alpha Science |
| record_format | marc |
| spelling | Sambamurty, A. V. S. S. Verfasser aut Genetics A. V. S. S. Sambamurty 2. ed. Oxford Alpha Science 2005 XXV, 903 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetics Molecular genetics Plant breeding Genetik (DE-588)4071711-2 gnd rswk-swf Genetik (DE-588)4071711-2 s b DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014767786&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sambamurty, A. V. S. S. Genetics Genetics Molecular genetics Plant breeding Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4071711-2 |
| title | Genetics |
| title_auth | Genetics |
| title_exact_search | Genetics |
| title_exact_search_txtP | Genetics |
| title_full | Genetics A. V. S. S. Sambamurty |
| title_fullStr | Genetics A. V. S. S. Sambamurty |
| title_full_unstemmed | Genetics A. V. S. S. Sambamurty |
| title_short | Genetics |
| title_sort | genetics |
| topic | Genetics Molecular genetics Plant breeding Genetik (DE-588)4071711-2 gnd |
| topic_facet | Genetics Molecular genetics Plant breeding Genetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014767786&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sambamurtyavss genetics |