Introduction to glycobiology:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2006
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis Inhaltsverzeichnis Klappentext |
| Beschreibung: | XIX, 255 S. Ill., graph. Darst. |
| ISBN: | 9780199282784 0199282781 |
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| 100 | 1 | |a Taylor, Maureen E. |e Verfasser |0 (DE-588)1028028660 |4 aut | |
| 245 | 1 | 0 | |a Introduction to glycobiology |c Maureen E. Taylor ; Kurt Drickamer |
| 246 | 1 | 3 | |a Glycobiology |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2006 | |
| 300 | |a XIX, 255 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Fysiologische aspecten |2 gtt | |
| 650 | 7 | |a Glycoconjugaten |2 gtt | |
| 650 | 7 | |a Koolhydraten |2 gtt | |
| 650 | 4 | |a Carbohydrates |x chemistry | |
| 650 | 4 | |a Carbohydrates |x physiology | |
| 650 | 4 | |a Glycoconjugates |x Physiological effect | |
| 650 | 0 | 7 | |a Glykoproteine |0 (DE-588)4071905-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Glykolipide |0 (DE-588)4157740-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Glykolipide |0 (DE-588)4157740-1 |D s |
| 689 | 0 | 1 | |a Glykoproteine |0 (DE-588)4071905-4 |D s |
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Datensatz im Suchindex
| _version_ | 1804135251738361856 |
|---|---|
| adam_text | INTRODUCTION TO GLYCOBIOLOGY / TAYLOR, MAUREEN E. : C2006
TABLE OF CONTENTS / INHALTSVERZEICHNIS
CONCEPTS OF GLYCOBIOLOGY
CONFORMATIONS OF OLIGOSACCHARIDES
N-LINKED GLYCOSYLATION
O-LINKED GLYCOSYLATION
GLYCOLIPIDS AND MEMBRANE PROTEIN GLYCOSYLATION
GLYCOMICS AND ANALYSIS OF GLYCAN STRUCTURES
EFFECTS OF GLYCOSYLATION ON PROTEIN STRUCTURE AND FUNCTION
CARBOHYDRATE RECOGNITION IN CELL ADHESION AND SIGNALLING
GLYCOPROTEIN TRAFFICKING IN CELLS AND ORGANISMS
GLYCOBIOLOGY OF PLANTS, BACTERIA, AND VIRUSES
GLYCOBIOLOGY AND DEVELOPMENT
GLYCOSYLATION AND DISEASE
THE FUTURE OF GLYCOBIOLOGY.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
part I Structures and biosynthesis of glycans
1
1.1
of sugars attached to proteins and liplds
1.2
1.3
chemical structures
1.4
multiple configurations
1.5
catalysed by specific enzymes
1.6
glycans can be more difficult than for other classes of biopolymer
1.7
Summary
Key references
Questions
2
2.1
are called conformations
2.2
2.3
2.4
conformations of glycosidic linkages
2.5
interactions between hexoses that are distant from
each other in the covalent structure
2.6
oiigosaccharides
2.7
2.8
conformations of polysaccharides
2.9
of cell walls
xiv Contents
2.10
have been analysed by X-ray crystallography and
nuclear magnetic resonance
Summary 31
Key references
Questions
3
3.1
3.2
3.3
assembled on the lipid dolichol
3.4
transferred to asparagine residues of polypeptides
3.5
glycosidases and glycosyltransferases
3.6
common variations of the core oiigosaccharide
3.7
different terminal sugars on giycans of red blood cells
3.8
diverse N-linked giycans
3.9
are usually heterogeneous
3.10
giycoprotein is determined by the protein
and the cell in which it is expressed
3.11
but the glycosylation machinery has evolved to produce
complex glycans in higher organisms
3.12
of multiceliuiar organisms
Summary
Key references
Questions
4
4.1
4.2
4.3
clusters of O-linked sugars
4.4
addition of monosaccharides to proteins in the Golgi apparatus
4.5
give strength to the extracellular matrix 56
4.6
enzymes in addition to glycosyltransferases
Contents
4.7
4.8
of O-linked N-acetylglucosamine
4.9
system that is affected in diabetes
Box
N-acetylglucosamine are linked to Alzheimer s disease
Summary
Key references
Questions
5
5.1
5.2
5.3
5.4
5.5
through glycolipid anchors
Box
inhibitors of glycolipid synthesis can be used to
treat storage diseases
5.6
endoplasmic reticulum
5.7
the plasma membrane
Box
glycolipid anchor biosynthesis may provide a way to
treat African sleeping sickness
5.8
caused by a glycolipid anchor deficiency
Summary
Key references
Questions
6
6.1
oligosaccharide structures
6.2
of N-linked glycans
6.3
complex mixtures containing small amounts of glycans
6.4
cells and tissues and is used to study receptors
that bind glycans
6.5
6.6
analysed using lectins
xvi Contents
6.7
6.8
of oligosaccharides
Box
are used to control blood clotting
6.9
sugars to proteins or lipids
Summary
Key references
Questions
PART
7
7.1
of glycosylation
7.2
molecule CD2
7.3
surface glycoproteins of trypanosomes
7.4
7.5
7.6
by oligosaccharides
7.7
against proteolysis
Box
of prion proteins may be linked to the conformational
changes leading to CJD and related diseases
Summary
Key references
Questions
8
8.1
8.2
initiates the lectin pathway of complement activation
8.3
from both monsoaccharide-binding specificity and
oligomer geometry
8.4
internalize pathogens
8.5
8.6
through extended binding sites on the C-type CRDs
8.7
Contents xvü
8.8 C-Type lectins
antigen
8.9
Box
HIV infections mimic recognition by DC-SIGN
8.10
8.11
in the immune system
8.12
and cell signalling
8.13
survival by triggering or inhibiting apoptosis
Summary
Key references
Questions
9
9.1
9.2
endoplasmic reticulum
9.3
9.4
reticulum to the Golgi
9.5
enzymes to iysosomes
9.6
lysosomal enzyme targeting
9.7
glycoproteins into the liver
9.8
glycoproteins from circulation
9.9
sulphated hormones
Box
glycoproteins must be controlled carefully to ensure correct targeting
9.10
Summary
Key references
Questions
10
10.1
seen in mammals
10.2
10.3
10.4
10.5
xviii Contents
10.6
Box
stomach ulcers use blood-group glycans as receptors
10.7
10.8
functions in higher organisms 1
Summary 192
Key references
Questions 193
11
11.1
proteoglycans serve as co-receptors for growth factors
11.2
proteoglycans in mammalian development
11.3
reveals multiple roles for heparan sulphate proteoglycans
Box
from aberrant proteoglycan biosynthesis
11.4
11.5
signalling during development in vertebrates
and invertebrates
11.6
the nervous system
11.7
of the central and peripheral nervous systems
11.8
cell adhesion during development
11.9
the immune system
Box
facilitates regeneration in the central nervous system
11.10
initial binding of sperm
Summary
Key references
Questions
12
12.1
congenital disorders of glycosylation
12.2
blood-clotting defect
12.3
12.4
12.5
can cause muscular dystrophy
Contents xix
12.6 IgG glycosylation
12.7
12.8
detection and treatment
Box
on tumour cells may be useful in treating cancer
Summary
Key references
Questions
13
13.1
combined to define roles of giycans
13.2
have an impact on our understanding of glycobiology
13.3
presents enormous technical challenges
13.4
insights into glycobiology
13.5
to human genetics to understand giycans and their receptors
13.6
further elucidation of structure-function relationships
13.7
applied to practical issues
Summary
Glossary
Index
TtLtA on neresourcecentre
www.oxfondtextbooks.co.uW
orc/tayloße/
The Online Resource Centre includes:
For lecturers:
-
the book, available to download
•
developments in the field, provided
on a six-monthly basis, to maintain
the currency of the resource
For students:
•
literature articles cited in the book,
and full articles from appropriate
OOP Journals, to
to these additional resources
•
problems, to support self-
directed [earning
|
| adam_txt |
INTRODUCTION TO GLYCOBIOLOGY / TAYLOR, MAUREEN E. : C2006
TABLE OF CONTENTS / INHALTSVERZEICHNIS
CONCEPTS OF GLYCOBIOLOGY
CONFORMATIONS OF OLIGOSACCHARIDES
N-LINKED GLYCOSYLATION
O-LINKED GLYCOSYLATION
GLYCOLIPIDS AND MEMBRANE PROTEIN GLYCOSYLATION
GLYCOMICS AND ANALYSIS OF GLYCAN STRUCTURES
EFFECTS OF GLYCOSYLATION ON PROTEIN STRUCTURE AND FUNCTION
CARBOHYDRATE RECOGNITION IN CELL ADHESION AND SIGNALLING
GLYCOPROTEIN TRAFFICKING IN CELLS AND ORGANISMS
GLYCOBIOLOGY OF PLANTS, BACTERIA, AND VIRUSES
GLYCOBIOLOGY AND DEVELOPMENT
GLYCOSYLATION AND DISEASE
THE FUTURE OF GLYCOBIOLOGY.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
part I Structures and biosynthesis of glycans
1
1.1
of sugars attached to proteins and liplds
1.2
1.3
chemical structures
1.4
multiple configurations
1.5
catalysed by specific enzymes
1.6
glycans can be more difficult than for other classes of biopolymer
1.7
Summary
Key references
Questions
2
2.1
are called conformations
2.2
2.3
2.4
conformations of glycosidic linkages
2.5
interactions between hexoses that are distant from
each other in the covalent structure
2.6
oiigosaccharides
2.7
2.8
conformations of polysaccharides
2.9
of cell walls
xiv Contents
2.10
have been analysed by X-ray crystallography and
nuclear magnetic resonance
Summary 31
Key references
Questions
3
3.1
3.2
3.3
assembled on the lipid dolichol
3.4
transferred to asparagine residues of polypeptides
3.5
glycosidases and glycosyltransferases
3.6
common variations of the core oiigosaccharide
3.7
different terminal sugars on giycans of red blood cells
3.8
diverse N-linked giycans
3.9
are usually heterogeneous
3.10
giycoprotein is determined by the protein
and the cell in which it is expressed
3.11
but the glycosylation machinery has evolved to produce
complex glycans in higher organisms
3.12
of multiceliuiar organisms
Summary
Key references
Questions
4
4.1
4.2
4.3
clusters of O-linked sugars
4.4
addition of monosaccharides to proteins in the Golgi apparatus
4.5
give strength to the extracellular matrix 56
4.6
enzymes in addition to glycosyltransferases
Contents
4.7
4.8
of O-linked N-acetylglucosamine
4.9
system that is affected in diabetes
Box
N-acetylglucosamine are linked to Alzheimer's disease
Summary
Key references
Questions
5
5.1
5.2
5.3
5.4
5.5
through glycolipid anchors
Box
inhibitors of glycolipid synthesis can be used to
treat storage diseases
5.6
endoplasmic reticulum
5.7
the plasma membrane
Box
glycolipid anchor biosynthesis may provide a way to
treat African sleeping sickness
5.8
caused by a glycolipid anchor deficiency
Summary
Key references
Questions
6
6.1
oligosaccharide structures
6.2
of N-linked glycans
6.3
complex mixtures containing small amounts of glycans
6.4
cells and tissues and is used to study receptors
that bind glycans
6.5
6.6
analysed using lectins
xvi Contents
6.7
6.8
of oligosaccharides
Box
are used to control blood clotting
6.9
sugars to proteins or lipids
Summary
Key references
Questions
PART
7
7.1
of glycosylation
7.2
molecule CD2
7.3
surface glycoproteins of trypanosomes
7.4
7.5
7.6
by oligosaccharides
7.7
against proteolysis
Box
of prion proteins may be linked to the conformational
changes leading to CJD and related diseases
Summary
Key references
Questions
8
8.1
8.2
initiates the lectin pathway of complement activation
8.3
from both monsoaccharide-binding specificity and
oligomer geometry
8.4
internalize pathogens
8.5
8.6
through extended binding sites on the C-type CRDs
8.7
Contents xvü
8.8 C-Type lectins
antigen
8.9
Box
HIV infections mimic recognition by DC-SIGN
8.10
8.11
in the immune system
8.12
and cell signalling
8.13
survival by triggering or inhibiting apoptosis
Summary
Key references
Questions
9
9.1
9.2
endoplasmic reticulum
9.3
9.4
reticulum to the Golgi
9.5
enzymes to iysosomes
9.6
lysosomal enzyme targeting
9.7
glycoproteins into the liver
9.8
glycoproteins from circulation
9.9
sulphated hormones
Box
glycoproteins must be controlled carefully to ensure correct targeting
9.10
Summary
Key references
Questions
10
10.1
seen in mammals
10.2
10.3
10.4
10.5
xviii Contents
10.6
Box
stomach ulcers use blood-group glycans as receptors
10.7
10.8
functions in higher organisms 1
Summary 192
Key references
Questions 193
11
11.1
proteoglycans serve as co-receptors for growth factors
11.2
proteoglycans in mammalian development
11.3
reveals multiple roles for heparan sulphate proteoglycans
Box
from aberrant proteoglycan biosynthesis
11.4
11.5
signalling during development in vertebrates
and invertebrates
11.6
the nervous system
11.7
of the central and peripheral nervous systems
11.8
cell adhesion during development
11.9
the immune system
Box
facilitates regeneration in the central nervous system
11.10
initial binding of sperm
Summary
Key references
Questions
12
12.1
congenital disorders of glycosylation
12.2
blood-clotting defect
12.3
12.4
12.5
can cause muscular dystrophy
Contents xix
12.6 IgG glycosylation
12.7
12.8
detection and treatment
Box
on tumour cells may be useful in treating cancer
Summary
Key references
Questions
13
13.1
combined to define roles of giycans
13.2
have an impact on our understanding of glycobiology
13.3
presents enormous technical challenges
13.4
insights into glycobiology
13.5
to human genetics to understand giycans and their receptors
13.6
further elucidation of structure-function relationships
13.7
applied to practical issues
Summary
Glossary
Index
TtLtA on''neresourcecentre
www.oxfondtextbooks.co.uW
orc/tayloße/
The Online Resource Centre includes:
For lecturers:
-
the book, available to download
•
developments in the field, provided
on a six-monthly basis, to maintain
the currency of the resource
For students:
•
literature articles cited in the book,
and full articles from appropriate
OOP Journals, to
to these additional resources
•
problems, to support self-
directed [earning |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Taylor, Maureen E. Drickamer, Kurt |
| author_GND | (DE-588)1028028660 |
| author_facet | Taylor, Maureen E. Drickamer, Kurt |
| author_role | aut aut |
| author_sort | Taylor, Maureen E. |
| author_variant | m e t me met k d kd |
| building | Verbundindex |
| bvnumber | BV021513920 |
| callnumber-first | Q - Science |
| callnumber-label | QP702 |
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| callnumber-search | QP702.G577 |
| callnumber-sort | QP 3702 G577 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 5650 |
| classification_tum | BIO 210f CHE 670f |
| ctrlnum | (OCoLC)62307306 (DE-599)BVBBV021513920 |
| dewey-full | 572/.567 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572/.567 |
| dewey-search | 572/.567 |
| dewey-sort | 3572 3567 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie |
| discipline_str_mv | Biologie Chemie |
| edition | 2. ed. |
| format | Book |
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| id | DE-604.BV021513920 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:19:48Z |
| indexdate | 2024-07-09T20:37:32Z |
| institution | BVB |
| isbn | 9780199282784 0199282781 |
| language | English |
| lccn | 2005034575 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014730500 |
| oclc_num | 62307306 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-20 DE-526 |
| owner_facet | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-20 DE-526 |
| physical | XIX, 255 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | Taylor, Maureen E. Verfasser (DE-588)1028028660 aut Introduction to glycobiology Maureen E. Taylor ; Kurt Drickamer Glycobiology 2. ed. Oxford [u.a.] Oxford Univ. Press 2006 XIX, 255 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Fysiologische aspecten gtt Glycoconjugaten gtt Koolhydraten gtt Carbohydrates chemistry Carbohydrates physiology Glycoconjugates Physiological effect Glykoproteine (DE-588)4071905-4 gnd rswk-swf Glykolipide (DE-588)4157740-1 gnd rswk-swf Glykolipide (DE-588)4157740-1 s Glykoproteine (DE-588)4071905-4 s b DE-604 Drickamer, Kurt Verfasser aut http://www.loc.gov/catdir/toc/ecip064/2005034575.html Table of contents LoC Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014730500&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014730500&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014730500&sequence=000004&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Taylor, Maureen E. Drickamer, Kurt Introduction to glycobiology Fysiologische aspecten gtt Glycoconjugaten gtt Koolhydraten gtt Carbohydrates chemistry Carbohydrates physiology Glycoconjugates Physiological effect Glykoproteine (DE-588)4071905-4 gnd Glykolipide (DE-588)4157740-1 gnd |
| subject_GND | (DE-588)4071905-4 (DE-588)4157740-1 |
| title | Introduction to glycobiology |
| title_alt | Glycobiology |
| title_auth | Introduction to glycobiology |
| title_exact_search | Introduction to glycobiology |
| title_exact_search_txtP | Introduction to glycobiology |
| title_full | Introduction to glycobiology Maureen E. Taylor ; Kurt Drickamer |
| title_fullStr | Introduction to glycobiology Maureen E. Taylor ; Kurt Drickamer |
| title_full_unstemmed | Introduction to glycobiology Maureen E. Taylor ; Kurt Drickamer |
| title_short | Introduction to glycobiology |
| title_sort | introduction to glycobiology |
| topic | Fysiologische aspecten gtt Glycoconjugaten gtt Koolhydraten gtt Carbohydrates chemistry Carbohydrates physiology Glycoconjugates Physiological effect Glykoproteine (DE-588)4071905-4 gnd Glykolipide (DE-588)4157740-1 gnd |
| topic_facet | Fysiologische aspecten Glycoconjugaten Koolhydraten Carbohydrates chemistry Carbohydrates physiology Glycoconjugates Physiological effect Glykoproteine Glykolipide |
| url | http://www.loc.gov/catdir/toc/ecip064/2005034575.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014730500&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014730500&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014730500&sequence=000004&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT taylormaureene introductiontoglycobiology AT drickamerkurt introductiontoglycobiology AT taylormaureene glycobiology AT drickamerkurt glycobiology |
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