The biological basis of cancer:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge [u.a.]
Cambridge University Press
2006
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XVII, 475 S. Ill., graph. Darst. |
| ISBN: | 0521844584 0521606330 |
Internformat
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV021443550 | ||
| 003 | DE-604 | ||
| 005 | 20061128 | ||
| 007 | t | ||
| 008 | 060217s2006 xxkad|| |||| 00||| eng d | ||
| 010 | |a 2005028814 | ||
| 020 | |a 0521844584 |c hardcover |9 0-521-84458-4 | ||
| 020 | |a 0521606330 |c pbk. |9 0-521-60633-0 | ||
| 035 | |a (OCoLC)61859804 | ||
| 035 | |a (DE-599)BVBBV021443550 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 044 | |a xxk |c GB | ||
| 049 | |a DE-29 |a DE-20 | ||
| 050 | 0 | |a RC261 | |
| 082 | 0 | |a 616.99/4 |2 22 | |
| 084 | |a XH 1500 |0 (DE-625)152870:12905 |2 rvk | ||
| 245 | 1 | 0 | |a The biological basis of cancer |c Robert G. McKinnell ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Cambridge [u.a.] |b Cambridge University Press |c 2006 | |
| 300 | |a XVII, 475 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Biologische aspecten |2 gtt | |
| 650 | 4 | |a Cancer | |
| 650 | 7 | |a Cancer |2 ram | |
| 650 | 4 | |a Cancérogenèse | |
| 650 | 7 | |a Cancérogenèse |2 ram | |
| 650 | 4 | |a Cellules cancéreuses | |
| 650 | 7 | |a Cellules cancéreuses |2 ram | |
| 650 | 7 | |a Etiologie (geneeskunde) |2 gtt | |
| 650 | 7 | |a Kanker |2 gtt | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Carcinogenesis | |
| 650 | 4 | |a Cancer cells | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Neoplastic Processes | |
| 650 | 0 | 7 | |a Carcinogenese |0 (DE-588)4069853-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Carcinogenese |0 (DE-588)4069853-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |D s |
| 689 | 1 | |8 1\p |5 DE-604 | |
| 700 | 1 | |a McKinnell, Robert Gilmore |d 1926- |e Sonstige |0 (DE-588)10981181X |4 oth | |
| 856 | 4 | |u http://www.loc.gov/catdir/toc/ecip061/2005028814.html |3 Table of contents | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014660564&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-014660564 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
Datensatz im Suchindex
| _version_ | 1804135157954772992 |
|---|---|
| adam_text | Contents
Preface page xv
Introduction: Letters illustrating clinical
aspects of cancer • G. Barry Pierce 1
Colon cancer 2
Breast cancer 4
Acute leukemia 5
Lung cancer 6
Kidney cancer 7
Squamous cell cancer 8
Testicular cancer 9
Stomach cancer 10
Melanoma 11
Neuroblastoma 12
Summary 13
1 The pathology of cancer • G. Barry Pierce
and Ivan Damjanov 14
1.1 Introduction 14
1.2 Benign versus malignant tumors 18
1.3 The diagnosis of benign and
malignant tumors 24
1.4 Tumor grading and staging 25
1.5 Classification and nomenclature 27
1.6 Metastasis 28
1.7 Tumor markers 30
1.8 How cancer kills 30
1.8a Organ failure 30
vii
viii CONTENTS
1.8b Obstruction of the gastrointestinal
tract, ducts, and hollow organs 31
1.8c Cachexia and infection 33
1.9 Spontaneous regression 34
1.10 Dormancy 35
1.11 Initiation 36
1.12 Latency 36
1.13 Progression to the autonomous
state 37
1.14 Selection and cellular heterogeneity 38
1.15 A developmental concept of cancer 40
1.16 Apoptosis 48
1.17 Summary 49
2 Invasion and metastasis • Robert G. McKinneh 51
2.1 Introduction 51
2.2 The metastatic cascade 54
2.2a Disruption of the basement membrane
and lytic activity in the extracellular
matrix 56
2.2b Cell detachment 59
2.2c Cell migration and motility 61
2.2d Invasion 64
2.2e Penetration of the vascular
system 65
2.2f Cancer cells in the circulation 67
2.2g Arrest of circulating cancer cells
(stasis) 67
2.2h Extravasation, growth of metastases,
and metastasis of metastases 68
2.3 A multiplicity of genes are
associated with metastasis 69
2.4 Soil and seed hypothesis of Paget 70
Box: Stephen Paget: No ploughman was he! 71
2.5 Is metastasis limited to malignant
cells? 72
2.6 How do we know a metastasis to
the liver is not a primary neoplasm
of the liver? 76
2.7 Why study metastasis? 77
2.8 Summary 78
CONTENTS ix
3 Carcinogenesis • Alan O. Perantoni 80
3.1 Introduction 80
3.2 What is a carcinogen? 81
3.3 Carcinogenesis as a multistage process 82
3.4 Chemical carcinogenesis 84
3.4a Organic compounds 92
3.4b Inorganic compounds and asbestos 95
3.4c Naturally occurring chemicals 98
3.5 Radiation 98
3.5a Ultraviolet radiation 98
3.5b Ionizing radiation 100
3.5c Endogenous ionizing radiation 103
3.6 Radon 103
3.7 Viral carcinogenesis 105
3.8 Endogenous carcinogenesis 107
3.9 Metabolism of xenobiotics 109
3.9a Host defenses 109
3.9b Inducibility of xenobiotic
metabolism 111
3.9c Metabolic activation of chemical
carcinogens 113
3.9d Inactivation of chemical
carcinogens 114
3.9e Systemic distribution of chemical
carcinogens 114
3.9f Mechanisms for carcinogen
suppression/chemoprevention 115
Box: Elizabeth Cavert Miller with
husband James 116
3.10 Modulation of carcinogenesis 117
3.11 Tumor promotion 120
3.12 Tumor progression 122
3.13 Alternative pathways for carcinogenesis? 123
3.14 Federal regulations 123
3.15 Summary 125
4 Genetics and heredity • Robert G. McKinnell 126
4.1 Introduction 126
4.2 Chromosomes and cancer 127
4.2a Aneuploidy 127
X CONTENTS
4.2b Euploidy does not preclude genetic
change 129
4.2c Cancers with chromosomal
aberrations 131
4.3 Chromosome damage, mutation,
and vulnerability to cancer 135
4.4 Hereditary cancers 136
4.4a Retinoblastoma 136
4.4b Wilms tumor 137
4.4c Hereditary conditions that increase
cancer risk 138
4.5 Familial cancer syndromes 139
4.5a Colon cancer 139
4.5b Breast cancer 141
4.5c Prostate cancer 142
4.5d Microarray technology as a way
of examining many genes
simultaneously 143
4.6 Summary 144
5 Cancer associated genes • Alan O. Perantoni 145
5.1 Introduction 145
5.2 What is an oncogene? 145
5.3 Proto oncogenes function in signal
transduction, cell cycle regulation,
differentiation, or programmed cell
death (apoptosis) 148
5.4 Genetic approaches to delineate
proto oncogene function 150
5.4a DNA microarray analysis global gene
expression or genomic profiling 154
5.5 Classification of proto oncogenes/
oncogenes 155
5.5a Growth factors and their receptors 156
5.5b Nonreceptor tyrosine kinases 161
5.5c GTP binding proteins: ras activation 162
5.5d Cytoplasmic serine/threonine kinases 163
5.5e Suppression of ras signaling 165
5.5f Nuclear signaling 165
5.5g Transcriptional activation 166
5.6 Regulation of DNA synthesis and
the cell cycle 168
CONTENTS xi
5.7 Other mechanisms for the
regulation of signaling 171
5.8 Mechanisms of oncogene
activation 173
5.9 Carcinogens and oncogene
activation 178
5.10 Oncogene cooperation 179
5.11 Normal cells suppress tumor
growth 180
5.12 Angiogenesis and tumor
development 180
5.13 Tumor Suppressor genes 181
5.13a The Rb locus 183
5.13b p53 suppressor gene 184
5.13c Other tumor suppressors 187
5.13d Apoptosis and its role in growth
regulation 188
5.13e Senescence 191
5.14 Where pathology meets molecular
biology 192
5.15 Summary 193
6 Cancer in nonhuman organisms • Robert G. McKinneu. 195
6.1 Introduction 196
6.2 Plant growths 197
6.3 Invertebrate animals 200
Box: Yoshio Masui 202
6.4 Cancer in selected ectothermic
(cold blooded) vertebrates 203
6.4a Fish 204
6.4b Amphibia 207
6.4c Reptiles 212
Box: John C. Harshbarger 214
6.5 Cancer in selected warm blooded
vertebrates 215
6.5a Birds 215
6.5b Mammals 216
6.6 Summary — But try anyway! 220
7 Epidemiology • Robert G. McKinneu 221
7.1 Introduction 221
xij CONTENTS
7.2 Cancer in fossil humans: A brief
digression concerning
paleopathology 226
7.3 Epidemiology of selected human
cancers 226
7.3a Lung cancer 227
Box: Alton Ochsner 229
Box: Richard Doll 231
7.3b Breast cancer 233
7.3c Skin cancer 236
7.3d Prostate cancer 239
7.3e Colorectal cancer 241
7.3f Cervical cancer: The Beginning
of the End 243
7.3g Hodgkin lymphoma 244
7.4 Occupational cancers 244
7.5 AIDS related Kaposi s sarcoma 245
7.6 What is next? 246
8 Lifestyle: Is there anything more
important? • Robert G. McKinnell 248
8.1 Introduction 248
8.2 Lung cancer is a preventable disease 249
8.3 Ultraviolet radiation and that
healthy tan 251
8.3a How to minimize risk for skin cancer 252
8.3b The peculiar status of protection by
sunscreens 253
8.4 Diet, nutrition, and cancer 253
8.4a Dietary fiber and colorectal cancer 255
Box: Denis Burkitt 256
8.4b Correlations between food substances
and cancer prevalence: Significance 258
8.4c Dietary fat and obesity 258
8.4d Vitamins and cancer 259
8.4e Selenium and calcium 260
8.4f Non nutrient organic compounds in
food that may protect against cancer 260
8.4g American Cancer Society (2002)
Guidelines on Diet, Nutrition, and
Cancer Prevention 262
8.5 Exercise as it relates to cancer 263
CONTENTS xiii
8.6 A special note about breast cancer 263
8.7 Other lifestyle hazards 264
8.8 Summary 264
9 The stem cell basis of cancer treatment: concepts
and clinical outcomes • Ralph E. Parchment 266
9.1 Introduction 266
9.1a Therapies remaining at the conceptual
level 266
9. lb Therapies being explored clinically:
Differentiation therapy and cytostatic
therapy 267
Box: Leland Hartwell, R. Timothy
Hunt, and Sir Paul Nurse 269
9.1c Eradicating cancer cells the aim
of current cancer therapy 271
9.2 Absolute versus fractional
cytoreduction 273
Box: Howard Skipper 275
9.3 The meaning of curing cancer
depends on whom you ask 279
9.4 The biological basis of multimodality
therapy as optimal cancer
treatment 282
9.5 Biological factors that contribute
to treatment success 289
Box: H. Rodney Withers 291
9.6 Biological factors that contribute
to treatment failure 293
9.7 Treatment of intermediate stage
breast cancer as a clinical science
success story 301
9.8 Summary 305
10 Oncology: The difficult task of eradicating
caricatures of normal tissue renewal
in the human patient • Ralph E. Parchment 307
10.1 Surgical oncology 308
10.2 Radiation oncology 311
10.3 Chemotherapy 314
10.3a Directly cytotoxic chemotherapy
drugs 314
XIV CONTENTS
10.3b Reactive chemicals as cytotoxic
anticancer drugs 315
10.3c Selective cytotoxicity as a screening tool
to discover more cytotoxic drugs 315
10.3d Indirect tumor cytotoxicity by nutrient
deprivation ( antimetabolite therapy ) 317
Box: George H. Hitchings, Jr.,
and Gertrude B. Elion 318
Box: Charles Brenton Huggins 329
10.3e Trophic factor therapy to treat
hematologic side effects of
chemotherapy 341
10.3f Therapy that exploits differentiation
processes in malignancies 342
10.4 Pharmacological issues arising from
tumor biology 349
10.5 Unknowns, the future, and the
emergence of molecular oncology 353
Appendix: Description of selected
tumors • G. Barry Pierce and Ivan Damjanov 355
A. 1 Adenocarcinoma of the breast 355
A.2 Adenocarcinoma of the prostate 358
A.3 Adenocarcinoma of the colon 359
A.4 Squamous cell carcinoma 361
A. 5 Teratocarcinomas 365
A.6 Liver cell carcinoma 370
A.7 Lung cancer 370
A. 8 Malignant melanoma 372
A. 9 Retinoblastoma 374
A. 10 Neuroblastoma 374
A. 11 Wilms tumor (nephroblastoma) 375
A. 12 Sarcomas 377
A. 13 Lymphoma and leukemia 378
Glossary 381
References 401
Index 469
|
| adam_txt |
Contents
Preface page xv
Introduction: Letters illustrating clinical
aspects of cancer • G. Barry Pierce 1
Colon cancer 2
Breast cancer 4
Acute leukemia 5
Lung cancer 6
Kidney cancer 7
Squamous cell cancer 8
Testicular cancer 9
Stomach cancer 10
Melanoma 11
Neuroblastoma 12
Summary 13
1 The pathology of cancer • G. Barry Pierce
and Ivan Damjanov 14
1.1 Introduction 14
1.2 Benign versus malignant tumors 18
1.3 The diagnosis of benign and
malignant tumors 24
1.4 Tumor grading and staging 25
1.5 Classification and nomenclature 27
1.6 Metastasis 28
1.7 Tumor markers 30
1.8 How cancer kills 30
1.8a Organ failure 30
vii
viii CONTENTS
1.8b Obstruction of the gastrointestinal
tract, ducts, and hollow organs 31
1.8c Cachexia and infection 33
1.9 Spontaneous regression 34
1.10 Dormancy 35
1.11 Initiation 36
1.12 Latency 36
1.13 Progression to the autonomous
state 37
1.14 Selection and cellular heterogeneity 38
1.15 A developmental concept of cancer 40
1.16 Apoptosis 48
1.17 Summary 49
2 Invasion and metastasis • Robert G. McKinneh 51
2.1 Introduction 51
2.2 The metastatic cascade 54
2.2a Disruption of the basement membrane
and lytic activity in the extracellular
matrix 56
2.2b Cell detachment 59
2.2c Cell migration and motility 61
2.2d Invasion 64
2.2e Penetration of the vascular
system 65
2.2f Cancer cells in the circulation 67
2.2g Arrest of circulating cancer cells
(stasis) 67
2.2h Extravasation, growth of metastases,
and metastasis of metastases 68
2.3 A multiplicity of genes are
associated with metastasis 69
2.4 Soil and seed hypothesis of Paget 70
Box: Stephen Paget: No "ploughman" was he! 71
2.5 Is metastasis limited to malignant
cells? 72
2.6 How do we know a metastasis to
the liver is not a primary neoplasm
of the liver? 76
2.7 Why study metastasis? 77
2.8 Summary 78
CONTENTS ix
3 Carcinogenesis • Alan O. Perantoni 80
3.1 Introduction 80
3.2 What is a carcinogen? 81
3.3 Carcinogenesis as a multistage process 82
3.4 Chemical carcinogenesis 84
3.4a Organic compounds 92
3.4b Inorganic compounds and asbestos 95
3.4c Naturally occurring chemicals 98
3.5 Radiation 98
3.5a Ultraviolet radiation 98
3.5b Ionizing radiation 100
3.5c Endogenous ionizing radiation 103
3.6 Radon 103
3.7 Viral carcinogenesis 105
3.8 Endogenous carcinogenesis 107
3.9 Metabolism of xenobiotics 109
3.9a Host defenses 109
3.9b Inducibility of xenobiotic
metabolism 111
3.9c Metabolic activation of chemical
carcinogens 113
3.9d Inactivation of chemical
carcinogens 114
3.9e Systemic distribution of chemical
carcinogens 114
3.9f Mechanisms for carcinogen
suppression/chemoprevention 115
Box: Elizabeth Cavert Miller with
husband James 116
3.10 Modulation of carcinogenesis 117
3.11 Tumor promotion 120
3.12 Tumor progression 122
3.13 Alternative pathways for carcinogenesis? 123
3.14 Federal regulations 123
3.15 Summary 125
4 Genetics and heredity • Robert G. McKinnell 126
4.1 Introduction 126
4.2 Chromosomes and cancer 127
4.2a Aneuploidy 127
X CONTENTS
4.2b Euploidy does not preclude genetic
change 129
4.2c Cancers with chromosomal
aberrations 131
4.3 Chromosome damage, mutation,
and vulnerability to cancer 135
4.4 Hereditary cancers 136
4.4a Retinoblastoma 136
4.4b Wilms tumor 137
4.4c Hereditary conditions that increase
cancer risk 138
4.5 Familial cancer syndromes 139
4.5a Colon cancer 139
4.5b Breast cancer 141
4.5c Prostate cancer 142
4.5d Microarray technology as a way
of examining many genes
simultaneously 143
4.6 Summary 144
5 Cancer associated genes • Alan O. Perantoni 145
5.1 Introduction 145
5.2 What is an oncogene? 145
5.3 Proto oncogenes function in signal
transduction, cell cycle regulation,
differentiation, or programmed cell
death (apoptosis) 148
5.4 Genetic approaches to delineate
proto oncogene function 150
5.4a DNA microarray analysis global gene
expression or genomic profiling 154
5.5 Classification of proto oncogenes/
oncogenes 155
5.5a Growth factors and their receptors 156
5.5b Nonreceptor tyrosine kinases 161
5.5c GTP binding proteins: ras activation 162
5.5d Cytoplasmic serine/threonine kinases 163
5.5e Suppression of ras signaling 165
5.5f Nuclear signaling 165
5.5g Transcriptional activation 166
5.6 Regulation of DNA synthesis and
the cell cycle 168
CONTENTS xi
5.7 Other mechanisms for the
regulation of signaling 171
5.8 Mechanisms of oncogene
activation 173
5.9 Carcinogens and oncogene
activation 178
5.10 Oncogene cooperation 179
5.11 Normal cells suppress tumor
growth 180
5.12 Angiogenesis and tumor
development 180
5.13 Tumor Suppressor genes 181
5.13a The Rb locus 183
5.13b p53 suppressor gene 184
5.13c Other tumor suppressors 187
5.13d Apoptosis and its role in growth
regulation 188
5.13e Senescence 191
5.14 Where pathology meets molecular
biology 192
5.15 Summary 193
6 Cancer in nonhuman organisms • Robert G. McKinneu. 195
6.1 Introduction 196
6.2 Plant growths 197
6.3 Invertebrate animals 200
Box: Yoshio Masui 202
6.4 Cancer in selected ectothermic
(cold blooded) vertebrates 203
6.4a Fish 204
6.4b Amphibia 207
6.4c Reptiles 212
Box: John C. Harshbarger 214
6.5 Cancer in selected warm blooded
vertebrates 215
6.5a Birds 215
6.5b Mammals 216
6.6 Summary — But try anyway! 220
7 Epidemiology • Robert G. McKinneu 221
7.1 Introduction 221
xij CONTENTS
7.2 Cancer in fossil humans: A brief
digression concerning
paleopathology 226
7.3 Epidemiology of selected human
cancers 226
7.3a Lung cancer 227
Box: Alton Ochsner 229
Box: Richard Doll 231
7.3b Breast cancer 233
7.3c Skin cancer 236
7.3d Prostate cancer 239
7.3e Colorectal cancer 241
7.3f Cervical cancer: "The Beginning
of the End" 243
7.3g Hodgkin lymphoma 244
7.4 Occupational cancers 244
7.5 AIDS related Kaposi's sarcoma 245
7.6 What is next? 246
8 Lifestyle: Is there anything more
important? • Robert G. McKinnell 248
8.1 Introduction 248
8.2 Lung cancer is a preventable disease 249
8.3 Ultraviolet radiation and that
"healthy tan" 251
8.3a How to minimize risk for skin cancer 252
8.3b The peculiar status of protection by
sunscreens 253
8.4 Diet, nutrition, and cancer 253
8.4a Dietary fiber and colorectal cancer 255
Box: Denis Burkitt 256
8.4b Correlations between food substances
and cancer prevalence: Significance 258
8.4c Dietary fat and obesity 258
8.4d Vitamins and cancer 259
8.4e Selenium and calcium 260
8.4f Non nutrient organic compounds in
food that may protect against cancer 260
8.4g American Cancer Society (2002)
Guidelines on Diet, Nutrition, and
Cancer Prevention 262
8.5 Exercise as it relates to cancer 263
CONTENTS xiii
8.6 A special note about breast cancer 263
8.7 Other lifestyle hazards 264
8.8 Summary 264
9 The stem cell basis of cancer treatment: concepts
and clinical outcomes • Ralph E. Parchment 266
9.1 Introduction 266
9.1a Therapies remaining at the conceptual
level 266
9. lb Therapies being explored clinically:
Differentiation therapy and cytostatic
therapy 267
Box: Leland Hartwell, R. Timothy
Hunt, and Sir Paul Nurse 269
9.1c Eradicating cancer cells the aim
of current cancer therapy 271
9.2 Absolute versus fractional
cytoreduction 273
Box: Howard Skipper 275
9.3 The meaning of "curing cancer"
depends on whom you ask 279
9.4 The biological basis of multimodality
therapy as optimal cancer
treatment 282
9.5 Biological factors that contribute
to treatment success 289
Box: H. Rodney Withers 291
9.6 Biological factors that contribute
to treatment failure 293
9.7 Treatment of intermediate stage
breast cancer as a clinical science
success story 301
9.8 Summary 305
10 Oncology: The difficult task of eradicating
caricatures of normal tissue renewal
in the human patient • Ralph E. Parchment 307
10.1 Surgical oncology 308
10.2 Radiation oncology 311
10.3 Chemotherapy 314
10.3a Directly cytotoxic chemotherapy
drugs 314
XIV CONTENTS
10.3b Reactive chemicals as cytotoxic
anticancer drugs 315
10.3c Selective cytotoxicity as a screening tool
to discover more cytotoxic drugs 315
10.3d Indirect tumor cytotoxicity by nutrient
deprivation ("antimetabolite therapy") 317
Box: George H. Hitchings, Jr.,
and Gertrude B. Elion 318
Box: Charles Brenton Huggins 329
10.3e Trophic factor therapy to treat
hematologic side effects of
chemotherapy 341
10.3f Therapy that exploits differentiation
processes in malignancies 342
10.4 Pharmacological issues arising from
tumor biology 349
10.5 Unknowns, the future, and the
emergence of molecular oncology 353
Appendix: Description of selected
tumors • G. Barry Pierce and Ivan Damjanov 355
A. 1 Adenocarcinoma of the breast 355
A.2 Adenocarcinoma of the prostate 358
A.3 Adenocarcinoma of the colon 359
A.4 Squamous cell carcinoma 361
A. 5 Teratocarcinomas 365
A.6 Liver cell carcinoma 370
A.7 Lung cancer 370
A. 8 Malignant melanoma 372
A. 9 Retinoblastoma 374
A. 10 Neuroblastoma 374
A. 11 Wilms tumor (nephroblastoma) 375
A. 12 Sarcomas 377
A. 13 Lymphoma and leukemia 378
Glossary 381
References 401
Index 469 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author_GND | (DE-588)10981181X |
| building | Verbundindex |
| bvnumber | BV021443550 |
| callnumber-first | R - Medicine |
| callnumber-label | RC261 |
| callnumber-raw | RC261 |
| callnumber-search | RC261 |
| callnumber-sort | RC 3261 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | XH 1500 |
| ctrlnum | (OCoLC)61859804 (DE-599)BVBBV021443550 |
| dewey-full | 616.99/4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/4 |
| dewey-search | 616.99/4 |
| dewey-sort | 3616.99 14 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | 2. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02245nam a2200625zc 4500</leader><controlfield tag="001">BV021443550</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20061128 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">060217s2006 xxkad|| |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2005028814</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0521844584</subfield><subfield code="c">hardcover</subfield><subfield code="9">0-521-84458-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0521606330</subfield><subfield code="c">pbk.</subfield><subfield code="9">0-521-60633-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)61859804</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV021443550</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">xxk</subfield><subfield code="c">GB</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29</subfield><subfield code="a">DE-20</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC261</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.99/4</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XH 1500</subfield><subfield code="0">(DE-625)152870:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The biological basis of cancer</subfield><subfield code="c">Robert G. McKinnell ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">2. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge [u.a.]</subfield><subfield code="b">Cambridge University Press</subfield><subfield code="c">2006</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVII, 475 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Biologische aspecten</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cancer</subfield><subfield code="2">ram</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancérogenèse</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cancérogenèse</subfield><subfield code="2">ram</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cellules cancéreuses</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cellules cancéreuses</subfield><subfield code="2">ram</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Etiologie (geneeskunde)</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Kanker</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carcinogenesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplasms</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplastic Processes</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Carcinogenese</subfield><subfield code="0">(DE-588)4069853-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Krebs</subfield><subfield code="g">Medizin</subfield><subfield code="0">(DE-588)4073781-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Carcinogenese</subfield><subfield code="0">(DE-588)4069853-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Krebs</subfield><subfield code="g">Medizin</subfield><subfield code="0">(DE-588)4073781-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McKinnell, Robert Gilmore</subfield><subfield code="d">1926-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)10981181X</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://www.loc.gov/catdir/toc/ecip061/2005028814.html</subfield><subfield code="3">Table of contents</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014660564&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-014660564</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield></record></collection> |
| id | DE-604.BV021443550 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:03:50Z |
| indexdate | 2024-07-09T20:36:03Z |
| institution | BVB |
| isbn | 0521844584 0521606330 |
| language | English |
| lccn | 2005028814 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014660564 |
| oclc_num | 61859804 |
| open_access_boolean | |
| owner | DE-29 DE-20 |
| owner_facet | DE-29 DE-20 |
| physical | XVII, 475 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Cambridge University Press |
| record_format | marc |
| spelling | The biological basis of cancer Robert G. McKinnell ... 2. ed. Cambridge [u.a.] Cambridge University Press 2006 XVII, 475 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Biologische aspecten gtt Cancer Cancer ram Cancérogenèse Cancérogenèse ram Cellules cancéreuses Cellules cancéreuses ram Etiologie (geneeskunde) gtt Kanker gtt Carcinogenesis Cancer cells Neoplasms Neoplastic Processes Carcinogenese (DE-588)4069853-1 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Carcinogenese (DE-588)4069853-1 s DE-604 Krebs Medizin (DE-588)4073781-0 s 1\p DE-604 McKinnell, Robert Gilmore 1926- Sonstige (DE-588)10981181X oth http://www.loc.gov/catdir/toc/ecip061/2005028814.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014660564&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | The biological basis of cancer Biologische aspecten gtt Cancer Cancer ram Cancérogenèse Cancérogenèse ram Cellules cancéreuses Cellules cancéreuses ram Etiologie (geneeskunde) gtt Kanker gtt Carcinogenesis Cancer cells Neoplasms Neoplastic Processes Carcinogenese (DE-588)4069853-1 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4069853-1 (DE-588)4073781-0 |
| title | The biological basis of cancer |
| title_auth | The biological basis of cancer |
| title_exact_search | The biological basis of cancer |
| title_exact_search_txtP | The biological basis of cancer |
| title_full | The biological basis of cancer Robert G. McKinnell ... |
| title_fullStr | The biological basis of cancer Robert G. McKinnell ... |
| title_full_unstemmed | The biological basis of cancer Robert G. McKinnell ... |
| title_short | The biological basis of cancer |
| title_sort | the biological basis of cancer |
| topic | Biologische aspecten gtt Cancer Cancer ram Cancérogenèse Cancérogenèse ram Cellules cancéreuses Cellules cancéreuses ram Etiologie (geneeskunde) gtt Kanker gtt Carcinogenesis Cancer cells Neoplasms Neoplastic Processes Carcinogenese (DE-588)4069853-1 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Biologische aspecten Cancer Cancérogenèse Cellules cancéreuses Etiologie (geneeskunde) Kanker Carcinogenesis Cancer cells Neoplasms Neoplastic Processes Carcinogenese Krebs Medizin |
| url | http://www.loc.gov/catdir/toc/ecip061/2005028814.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014660564&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mckinnellrobertgilmore thebiologicalbasisofcancer |