Development of sustainable bioprocesses: modeling and assessment
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2006
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Hier auch später erschienene, unveränderte Nachdrucke ohne CD-ROM |
| Beschreibung: | XXI, 294 S. graph. Darst., Tab. 1 CD-ROM (12 cm) |
| ISBN: | 0470015594 9780470015599 |
Internformat
MARC
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| 245 | 1 | 0 | |a Development of sustainable bioprocesses |b modeling and assessment |c Elmar Heinzle ; Arno P. Biwer ; Charles L. Cooney |
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| 650 | 4 | |a Biological Products |x chemistry | |
| 650 | 4 | |a Bioreactors | |
| 650 | 4 | |a Biotechnology |x methods | |
| 650 | 4 | |a Chemical Engineering | |
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Datensatz im Suchindex
| _version_ | 1804135120066576384 |
|---|---|
| adam_text | Contents
Preface Page xiii
Acknowledgments xvii
List of Contributors xix
PART I THEORETICAL INTRODUCTION
1 Introduction 3
1.1 Bioprocesses 3
1.1.1 History of Biotechnology and Today s Situation 3
1.1.2 Future Perspectives 6
1.2 Modeling and Assessment in Process Development 7
2 Development of Bioprocesses 11
2.1 Types of Bioprocess and Bioproduct 11
2.1.1 Biocatalysts and Process Types 11
2.1.2 Raw Materials 17
2.1.3 Bioproducts 20
2.2 Bioreaction Stoichiometry, Thermodynamics, and Kinetics 23
2.2.1 Stoichiometry 23
2.2.2 Thermodynamics 28
2.2.3 Kinetics 29
Development of Sustainable Biopmcesses E. Heinzle, A. Biwer and C. Cooney
© 2006 John Wiley Sons, Ltd
w /7 Contents
2.3 Elements of Bioprocesses (Unit Operations and Unit Procedures) 32
2.3.1 Upstream Processing 33
2.3.2 Bioreactor 36
2.3.3 Downstream Processing 40
2.3.4 Waste Treatment, Reduction and Recycling 50
2.4 The Development Process 52
2.4.1 Introduction 52
2.4.2 Development Steps and Participants 53
3 Modeling and Simulation of Bioprocesses 61
3.1 Problem Structuring, Process Analysis, and Process Scheme 62
3.1.1 Model Boundaries and General Structure 62
3.1.2 Modeling Steps 63
3.2 Implementation and Simulation 66
3.2.1 Spreadsheet Model 66
3.2.2 Modeling using a Process Simulator 66
3.3 Uncertainty Analysis 71
3.3.1 Scenario Analysis 72
3.3.2 Sensitivity Analysis 73
3.3.3 Monte Carlo Simulation 75
4 Sustainability Assessment 81
4.1 Sustainability 81
4.2 Economic Assessment 82
4.2.1 Capital Cost Estimation 83
4.2.2 Operating Cost Estimation 88
4.2.3 Profitability Assessment 94
4.3 Environmental Assessment 95
4.3.1 Introduction 95
4.3.2 Structure oftheMethod 96
4.3.3 Impact Categories and Groups 99
4.3.4 Calculation of Environmental Factors 103
4.3.5 Calculation oflndices 105
4.3.6 Example Cleavage of Penicillin G 105
4.4 Assessing Social Aspects 107
4.4.1 Introduction 107
4.4.2 Indicators for Social Assessment 108
4.5 Interactions between the Different Sustainability Dimensions 112
PART II BIOPROCESS CASE STUDIES
Introduction to Case Studies 121
5 Citric Acid Alternative Process using Starch 125
5.1 Introduction 125
5.2 Fermentation Model 125
Contents ix
5.3 Process Model 128
5.4 Inventory Analysis 130
5.5 Environmental Assessment 132
5.6 Economic Assessment 134
5.7 Conclusions 135
6 Pyruvic Acid Fermentation with Alternative Downstream Processes 137
6.1 Introduction 137
6.2 Fermentation Model 137
6.3 Process Model 138
6.3.1 Bioreaction and Upstream 138
6.3.2 Downstream Processing 141
6.4 Inventory Analysis 142
6.5 Environmental Assessment 144
6.6 Economic Assessment 145
6.7 Conclusions 145
7 L Lysine Coupling of Bioreaction and Process Model 155
Arnd Knoll, Jochen Buechs
7.1 Introduction 155
7.2 Basic Strategy 156
7.3 Bioreaction Model 156
7.4 Process Model 159
7.5 Coupling of Bioreaction and Process Model 162
7.5.1 Assumptions 163
7.6 Results and Discussion 164
8 Riboflavin Vitamin B2 169
Wilfried Storhas, Rolf Metz
8.1 Introduction 169
8.2 Biosynthesis and Fermentation 170
8.3 Production Process and Process Model 171
8.3.1 Upstream Processing 172
8.3.2 Fermentation 174
8.3.3 Downstream Processing 174
8.4 Inventory Analysis 174
8.5 Ecological Assessment 175
8.6 Economic Assessment 176
8.7 Discussion and Concluding Remarks 177
9 a Cydodextrin 181
9.1 Introduction l81
9.2 Reaction Model l82
x Contents
9.3 Process Model 182
9.3.1 Solvent Process 182
9.3.2 Non solvent Process 184
9.4 Inventory Analysis 185
9.5 Environmental Assessment 186
9.6 Economic Assessment 186
9.7 Conclusions 189
10 Penicillin V 193
10.1 Introduction 193
10.2 Modeling Base Case 193
10.2.1 Fermentation Model 193
10.2.2 Process Model 194
10.3 Inventory Analysis 196
10.4 Environmental Assessment 197
10.5 Economic Assessment 197
10.6 Monte Carlo Simulations 198
10.6.1 Objective Functions, Variables, and Probability Distributions 198
10.6.2 Results 201
10.7 Conclusions 206
11 Recombinant Human Serum Albumin 211
M. Abdul Kholiq, Elmar Heimle
11.1 Introduction 211
11.2 Bioreaction Model 212
11.2.1 Stoichiometry 212
11.2.2 Multi stage Fermentation and Feeding Plan 213
11.2.3 Total Broth Volume in Production Scale and Raw Material
Consumption 214
11.3 Process Model 215
11.3.1 Bioreaction 215
11.3.2 Downstream Processing 215
11.4 Economic Assessment 218
11.5 Ecological Assessment 219
11.6 Conclusions 221
12 Recombinant Human Insulin 225
Demetri Petrides
12.1 Introduction 225
12.1.1 Two chain Method 226
12.1.2 Proinsulin Method 226
12.2 Market Analysis and Design Basis 226
12.2.1 Process Description 227
Contents xi
12.2.2 Inventory Analysis and Environmental Assessment 233
12.2.3 Production Scheduling 234
12.3 Economic Assessment 235
12.4 Throughput Increase Options 237
12.5 Conclusions 238
13 Monoclonal Antibodies 241
13.1 Introduction 241
13.2 Process Model 241
13.3 Inventory Analysis 243
13.4 Economic Assessment 245
13.5 Environmental Assessment 246
13.6 Uncertainty Analysis 247
13.6.1 Scenarios 247
13.6.2 Sensitivity Analysis 248
13.6.3 Monte Carlo Simulations 249
13.7 Conclusions 255
14 a 1 Antitrypsin from Transgenic Plant Cell Suspension Cultures 261
Elizabeth Zapalac, Karen McDonald
14.1 Introduction 261
14.2 Process Description 263
14.3 Model Description 263
14.4 Discussion 265
14.5 Conclusions 268
15 Plasmid DNA 271
Sindelia S. Freitas, Jose A. L. Santos, D. Miguel F. Pmzeres
15.1 Introduction 271
15.1.1 General 271
15.1.2 Case Introduction 272
15.1.3 Process Description 272
15.2 Model Description 275
15.2.1 Bioreaction Section 275
15.2.2 Downstream Sections 276
15.3 Inventory Analysis 277
15.4 Economic Assessment 278
15.5 Environmental Assessment 281
15.6 Discussion 282
15.7 Conclusions 283
Index 287
|
| adam_txt |
Contents
Preface Page xiii
Acknowledgments xvii
List of Contributors xix
PART I THEORETICAL INTRODUCTION
1 Introduction 3
1.1 Bioprocesses 3
1.1.1 History of Biotechnology and Today's Situation 3
1.1.2 Future Perspectives 6
1.2 Modeling and Assessment in Process Development 7
2 Development of Bioprocesses 11
2.1 Types of Bioprocess and Bioproduct 11
2.1.1 Biocatalysts and Process Types 11
2.1.2 Raw Materials 17
2.1.3 Bioproducts 20
2.2 Bioreaction Stoichiometry, Thermodynamics, and Kinetics 23
2.2.1 Stoichiometry 23
2.2.2 Thermodynamics 28
2.2.3 Kinetics 29
Development of Sustainable Biopmcesses E. Heinzle, A. Biwer and C. Cooney
© 2006 John Wiley Sons, Ltd
w'/7 Contents
2.3 Elements of Bioprocesses (Unit Operations and Unit Procedures) 32
2.3.1 Upstream Processing 33
2.3.2 Bioreactor 36
2.3.3 Downstream Processing 40
2.3.4 Waste Treatment, Reduction and Recycling 50
2.4 The Development Process 52
2.4.1 Introduction 52
2.4.2 Development Steps and Participants 53
3 Modeling and Simulation of Bioprocesses 61
3.1 Problem Structuring, Process Analysis, and Process Scheme 62
3.1.1 Model Boundaries and General Structure 62
3.1.2 Modeling Steps 63
3.2 Implementation and Simulation 66
3.2.1 Spreadsheet Model 66
3.2.2 Modeling using a Process Simulator 66
3.3 Uncertainty Analysis 71
3.3.1 Scenario Analysis 72
3.3.2 Sensitivity Analysis 73
3.3.3 Monte Carlo Simulation 75
4 Sustainability Assessment 81
4.1 Sustainability 81
4.2 Economic Assessment 82
4.2.1 Capital Cost Estimation 83
4.2.2 Operating Cost Estimation 88
4.2.3 Profitability Assessment 94
4.3 Environmental Assessment 95
4.3.1 Introduction 95
4.3.2 Structure oftheMethod 96
4.3.3 Impact Categories and Groups 99
4.3.4 Calculation of Environmental Factors 103
4.3.5 Calculation oflndices 105
4.3.6 Example Cleavage of Penicillin G 105
4.4 Assessing Social Aspects 107
4.4.1 Introduction 107
4.4.2 Indicators for Social Assessment 108
4.5 Interactions between the Different Sustainability Dimensions 112
PART II BIOPROCESS CASE STUDIES
Introduction to Case Studies 121
5 Citric Acid Alternative Process using Starch 125
5.1 Introduction 125
5.2 Fermentation Model 125
Contents ix
5.3 Process Model 128
5.4 Inventory Analysis 130
5.5 Environmental Assessment 132
5.6 Economic Assessment 134
5.7 Conclusions 135
6 Pyruvic Acid Fermentation with Alternative Downstream Processes 137
6.1 Introduction 137
6.2 Fermentation Model 137
6.3 Process Model 138
6.3.1 Bioreaction and Upstream 138
6.3.2 Downstream Processing 141
6.4 Inventory Analysis 142
6.5 Environmental Assessment 144
6.6 Economic Assessment 145
6.7 Conclusions 145
7 L Lysine Coupling of Bioreaction and Process Model 155
Arnd Knoll, Jochen Buechs
7.1 Introduction 155
7.2 Basic Strategy 156
7.3 Bioreaction Model 156
7.4 Process Model 159
7.5 Coupling of Bioreaction and Process Model 162
7.5.1 Assumptions 163
7.6 Results and Discussion 164
8 Riboflavin Vitamin B2 169
Wilfried Storhas, Rolf Metz
8.1 Introduction 169
8.2 Biosynthesis and Fermentation 170
8.3 Production Process and Process Model 171
8.3.1 Upstream Processing 172
8.3.2 Fermentation 174
8.3.3 Downstream Processing 174
8.4 Inventory Analysis 174
8.5 Ecological Assessment 175
8.6 Economic Assessment 176
8.7 Discussion and Concluding Remarks 177
9 a Cydodextrin 181
9.1 Introduction l81
9.2 Reaction Model l82
x Contents
9.3 Process Model 182
9.3.1 Solvent Process 182
9.3.2 Non solvent Process 184
9.4 Inventory Analysis 185
9.5 Environmental Assessment 186
9.6 Economic Assessment 186
9.7 Conclusions 189
10 Penicillin V 193
10.1 Introduction 193
10.2 Modeling Base Case 193
10.2.1 Fermentation Model 193
10.2.2 Process Model 194
10.3 Inventory Analysis 196
10.4 Environmental Assessment 197
10.5 Economic Assessment 197
10.6 Monte Carlo Simulations 198
10.6.1 Objective Functions, Variables, and Probability Distributions 198
10.6.2 Results 201
10.7 Conclusions 206
11 Recombinant Human Serum Albumin 211
M. Abdul Kholiq, Elmar Heimle
11.1 Introduction 211
11.2 Bioreaction Model 212
11.2.1 Stoichiometry 212
11.2.2 Multi stage Fermentation and Feeding Plan 213
11.2.3 Total Broth Volume in Production Scale and Raw Material
Consumption 214
11.3 Process Model 215
11.3.1 Bioreaction 215
11.3.2 Downstream Processing 215
11.4 Economic Assessment 218
11.5 Ecological Assessment 219
11.6 Conclusions 221
12 Recombinant Human Insulin 225
Demetri Petrides
12.1 Introduction 225
12.1.1 Two chain Method 226
12.1.2 Proinsulin Method 226
12.2 Market Analysis and Design Basis 226
12.2.1 Process Description 227
Contents xi
12.2.2 Inventory Analysis and Environmental Assessment 233
12.2.3 Production Scheduling 234
12.3 Economic Assessment 235
12.4 Throughput Increase Options 237
12.5 Conclusions 238
13 Monoclonal Antibodies 241
13.1 Introduction 241
13.2 Process Model 241
13.3 Inventory Analysis 243
13.4 Economic Assessment 245
13.5 Environmental Assessment 246
13.6 Uncertainty Analysis 247
13.6.1 Scenarios 247
13.6.2 Sensitivity Analysis 248
13.6.3 Monte Carlo Simulations 249
13.7 Conclusions 255
14 a 1 Antitrypsin from Transgenic Plant Cell Suspension Cultures 261
Elizabeth Zapalac, Karen McDonald
14.1 Introduction 261
14.2 Process Description 263
14.3 Model Description 263
14.4 Discussion 265
14.5 Conclusions 268
15 Plasmid DNA 271
Sindelia S. Freitas, Jose A. L. Santos, D. Miguel F. Pmzeres
15.1 Introduction 271
15.1.1 General 271
15.1.2 Case Introduction 272
15.1.3 Process Description 272
15.2 Model Description 275
15.2.1 Bioreaction Section 275
15.2.2 Downstream Sections 276
15.3 Inventory Analysis 277
15.4 Economic Assessment 278
15.5 Environmental Assessment 281
15.6 Discussion 282
15.7 Conclusions 283
Index 287 |
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| illustrated | Illustrated |
| index_date | 2024-07-02T13:57:03Z |
| indexdate | 2024-07-09T20:35:27Z |
| institution | BVB |
| isbn | 0470015594 9780470015599 |
| language | English |
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| physical | XXI, 294 S. graph. Darst., Tab. 1 CD-ROM (12 cm) |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley |
| record_format | marc |
| spelling | Heinzle, Elmar Verfasser (DE-588)113728085 aut Development of sustainable bioprocesses modeling and assessment Elmar Heinzle ; Arno P. Biwer ; Charles L. Cooney Chichester Wiley 2006 XXI, 294 S. graph. Darst., Tab. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Hier auch später erschienene, unveränderte Nachdrucke ohne CD-ROM Biological Products chemistry Bioreactors Biotechnology methods Chemical Engineering Models, Theoretical Bioverfahrenstechnik (DE-588)4307166-1 gnd rswk-swf Wirtschaftlichkeit (DE-588)4066424-7 gnd rswk-swf Nachhaltigkeit (DE-588)4326464-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bioverfahrenstechnik (DE-588)4307166-1 s Wirtschaftlichkeit (DE-588)4066424-7 s Nachhaltigkeit (DE-588)4326464-5 s 1\p DE-604 Biwer, Arno P. Verfasser (DE-588)128432977 aut Cooney, Charles L. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014635157&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Heinzle, Elmar Biwer, Arno P. Cooney, Charles L. Development of sustainable bioprocesses modeling and assessment Biological Products chemistry Bioreactors Biotechnology methods Chemical Engineering Models, Theoretical Bioverfahrenstechnik (DE-588)4307166-1 gnd Wirtschaftlichkeit (DE-588)4066424-7 gnd Nachhaltigkeit (DE-588)4326464-5 gnd |
| subject_GND | (DE-588)4307166-1 (DE-588)4066424-7 (DE-588)4326464-5 (DE-588)4143413-4 |
| title | Development of sustainable bioprocesses modeling and assessment |
| title_auth | Development of sustainable bioprocesses modeling and assessment |
| title_exact_search | Development of sustainable bioprocesses modeling and assessment |
| title_exact_search_txtP | Development of sustainable bioprocesses modeling and assessment |
| title_full | Development of sustainable bioprocesses modeling and assessment Elmar Heinzle ; Arno P. Biwer ; Charles L. Cooney |
| title_fullStr | Development of sustainable bioprocesses modeling and assessment Elmar Heinzle ; Arno P. Biwer ; Charles L. Cooney |
| title_full_unstemmed | Development of sustainable bioprocesses modeling and assessment Elmar Heinzle ; Arno P. Biwer ; Charles L. Cooney |
| title_short | Development of sustainable bioprocesses |
| title_sort | development of sustainable bioprocesses modeling and assessment |
| title_sub | modeling and assessment |
| topic | Biological Products chemistry Bioreactors Biotechnology methods Chemical Engineering Models, Theoretical Bioverfahrenstechnik (DE-588)4307166-1 gnd Wirtschaftlichkeit (DE-588)4066424-7 gnd Nachhaltigkeit (DE-588)4326464-5 gnd |
| topic_facet | Biological Products chemistry Bioreactors Biotechnology methods Chemical Engineering Models, Theoretical Bioverfahrenstechnik Wirtschaftlichkeit Nachhaltigkeit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014635157&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT heinzleelmar developmentofsustainablebioprocessesmodelingandassessment AT biwerarnop developmentofsustainablebioprocessesmodelingandassessment AT cooneycharlesl developmentofsustainablebioprocessesmodelingandassessment |