The implicit genome:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
New York [u.a.]
Oxford University Press
2006
|
Schlagworte: | |
Online-Zugang: | Table of contents Inhaltsverzeichnis |
Beschreibung: | Includes bibliographical references and index |
Beschreibung: | XI, 385 S. Ill., graph. Darst. cm |
ISBN: | 0195172701 019517271X 9780195172706 9780195172713 |
Internformat
MARC
LEADER | 00000nam a2200000zc 4500 | ||
---|---|---|---|
001 | BV021313153 | ||
003 | DE-604 | ||
005 | 20060316 | ||
007 | t | ||
008 | 060130s2006 xxuad|| |||| 00||| eng d | ||
010 | |a 2005011590 | ||
020 | |a 0195172701 |c cloth : alk. paper |9 0-19-517270-1 | ||
020 | |a 019517271X |c paper : alk. paper |9 0-19-517271-X | ||
020 | |a 9780195172706 |9 978-0-19-517270-6 | ||
020 | |a 9780195172713 |9 978-0-19-517271-3 | ||
035 | |a (OCoLC)493674956 | ||
035 | |a (DE-599)BVBBV021313153 | ||
040 | |a DE-604 |b ger |e aacr | ||
041 | 0 | |a eng | |
044 | |a xxu |c US | ||
049 | |a DE-M49 | ||
050 | 0 | |a QH390 | |
082 | 0 | |a 572.8/38 |2 22 | |
084 | |a BIO 180f |2 stub | ||
084 | |a BIO 175f |2 stub | ||
245 | 1 | 0 | |a The implicit genome |c edited by Lynn Helena Caporale |
264 | 1 | |a New York [u.a.] |b Oxford University Press |c 2006 | |
300 | |a XI, 385 S. |b Ill., graph. Darst. |c cm | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
500 | |a Includes bibliographical references and index | ||
505 | 8 | |a Sequence-dependent properties of DNA and their role in function / Donald Crothers -- Mutation as a phenotype / Errol C. Friedberg -- Repeats and variation in pathogen selection / Chris Bayliss and Richard Moxon -- Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection / David G. King, Edward N. Trifonov, Yechezkel Kashi -- Implicit information in eukaryotic pathogens as the basis of antigenic variation / J. Dave Barry -- The role of repeat sequences in bacterial genetic adaptation to stress / Eduardo P.C. Rocha -- The role of mobile DNA in the evolution of prokaryotic genomes / Ian Paulsen & Claire Fraser -- -- Eukaryotic transposable elements: teaching old genomes new tricks / Susan R. Wessler -- Assembling genes in the immune system / Ellen Hsu -- Focused mutation in the immune system / Rupert Beale, Dagmar Iber -- Regulated and unregulated recombination of G-rich genomic regions / Nancy Maizels -- The role of the genome in the initiation of meiotic | |
650 | 2 | |a Génome | |
650 | 7 | |a Génétique de l'évolution |2 ram | |
650 | 2 | |a Immunité - génétique | |
650 | 2 | |a Séquences répétées d'acides nucléiques - physiology | |
650 | 2 | |a Évolution moléculaire | |
650 | 4 | |a Evolutionary genetics | |
650 | 4 | |a Genome | |
650 | 4 | |a Evolution, Molecular | |
650 | 4 | |a Immunity |x genetics | |
650 | 4 | |a Repetitive Sequences, Nucleic Acid |x physiology | |
650 | 0 | 7 | |a Genetik |0 (DE-588)4071711-2 |2 gnd |9 rswk-swf |
650 | 0 | 7 | |a Evolution |0 (DE-588)4071050-6 |2 gnd |9 rswk-swf |
655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
689 | 0 | 0 | |a Genetik |0 (DE-588)4071711-2 |D s |
689 | 0 | 1 | |a Evolution |0 (DE-588)4071050-6 |D s |
689 | 0 | |C b |5 DE-604 | |
700 | 1 | |a Caporale, Lynn Helena |e Sonstige |4 oth | |
856 | 4 | |u http://www.loc.gov/catdir/toc/ecip0511/2005011590.html |3 Table of contents | |
856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014633677&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
999 | |a oai:aleph.bib-bvb.de:BVB01-014633677 |
Datensatz im Suchindex
_version_ | 1804135117883441152 |
---|---|
adam_text | Contents
Contributors jx
An Overview of the Implicit Genome 3
Lynn Helena Caporale
1. Sequence Dependent Properties of DNA and
Their Role in Function 23
Donald M. Crothers
2. Mutation as a Phenotype 39
Errol C. Friedberg
3. Repeats and Variation in Pathogen Selection 54
Christopher D. Bayliss and E. Richard Moxon
4. Tuning Knobs in the Genome: Evolution of
Simple Sequence Repeats by Indirect Selection 77
David G. King, Edward N. Trifonov, and Yechezkel Kashi
5. Implicit Information in Eukaryotic Pathogens as the
Basis of Antigenic Variation 91
J. David Barry
6. The Role of Repeat Sequences in Bacterial
Genetic Adaptation to Stress 107
Eduardo P. C. Rocha
7. The Role of Mobile DNA in the Evolution
of Prokaryotic Genomes 121
Garry Myers, Ian Paulsen, and Claire Fraser
vii
viii Contents
8. Eukaryotic Transposable Elements: Teaching
Old Genomes New Tricks 138
Susan R. Wessler
9. Immunoglobulin Recombination Signal
Sequences: Somatic and Evolutionary Functions 163
Ellen Hsu
10. Somatic Evolution of Antibody Genes 177
Rupert Beale and Dagmar Iber
11. Regulated and Unregulated Recombination of
G rich Genomic Regions 191
Nancy Maizels
12. The Role of the Genome in the Initiation
of Meiotic Recombination 208
Rhona H. Borts and David T. Kirkpatrick
13. Nuclear Duality and the Genesis of Unusual
Genomes in Ciliated Protozoa
Carolyn L. Jahn 225
14. Editing Informational Content of Expressed
DNA Sequences and Their Transcripts 248
Harold C. Smith
15. Alternative Splicing: One Gene, Many Products 266
Brenton R. Graveley
16. Imprinting: The Hidden Genome 282
Alyson Ashe and Emma Whitelaw
Epilogue: An Engineering Perspective: The Implicit Protocols 294
John Doyle, Marie Csete, and Lynn Caporale
References 299
List of Acronyms 363
Index 365
|
adam_txt |
Contents
Contributors jx
An Overview of the Implicit Genome 3
Lynn Helena Caporale
1. Sequence Dependent Properties of DNA and
Their Role in Function 23
Donald M. Crothers
2. Mutation as a Phenotype 39
Errol C. Friedberg
3. Repeats and Variation in Pathogen Selection 54
Christopher D. Bayliss and E. Richard Moxon
4. Tuning Knobs in the Genome: Evolution of
Simple Sequence Repeats by Indirect Selection 77
David G. King, Edward N. Trifonov, and Yechezkel Kashi
5. Implicit Information in Eukaryotic Pathogens as the
Basis of Antigenic Variation 91
J. David Barry
6. The Role of Repeat Sequences in Bacterial
Genetic Adaptation to Stress 107
Eduardo P. C. Rocha
7. The Role of Mobile DNA in the Evolution
of Prokaryotic Genomes 121
Garry Myers, Ian Paulsen, and Claire Fraser
vii
viii Contents
8. Eukaryotic Transposable Elements: Teaching
Old Genomes New Tricks 138
Susan R. Wessler
9. Immunoglobulin Recombination Signal
Sequences: Somatic and Evolutionary Functions 163
Ellen Hsu
10. Somatic Evolution of Antibody Genes 177
Rupert Beale and Dagmar Iber
11. Regulated and Unregulated Recombination of
G rich Genomic Regions 191
Nancy Maizels
12. The Role of the Genome in the Initiation
of Meiotic Recombination 208
Rhona H. Borts and David T. Kirkpatrick
13. Nuclear Duality and the Genesis of Unusual
Genomes in Ciliated Protozoa
Carolyn L. Jahn 225
14. Editing Informational Content of Expressed
DNA Sequences and Their Transcripts 248
Harold C. Smith
15. Alternative Splicing: One Gene, Many Products 266
Brenton R. Graveley
16. Imprinting: The Hidden Genome 282
Alyson Ashe and Emma Whitelaw
Epilogue: An Engineering Perspective: The Implicit Protocols 294
John Doyle, Marie Csete, and Lynn Caporale
References 299
List of Acronyms 363
Index 365 |
any_adam_object | 1 |
any_adam_object_boolean | 1 |
building | Verbundindex |
bvnumber | BV021313153 |
callnumber-first | Q - Science |
callnumber-label | QH390 |
callnumber-raw | QH390 |
callnumber-search | QH390 |
callnumber-sort | QH 3390 |
callnumber-subject | QH - Natural History and Biology |
classification_tum | BIO 180f BIO 175f |
contents | Sequence-dependent properties of DNA and their role in function / Donald Crothers -- Mutation as a phenotype / Errol C. Friedberg -- Repeats and variation in pathogen selection / Chris Bayliss and Richard Moxon -- Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection / David G. King, Edward N. Trifonov, Yechezkel Kashi -- Implicit information in eukaryotic pathogens as the basis of antigenic variation / J. Dave Barry -- The role of repeat sequences in bacterial genetic adaptation to stress / Eduardo P.C. Rocha -- The role of mobile DNA in the evolution of prokaryotic genomes / Ian Paulsen & Claire Fraser -- -- Eukaryotic transposable elements: teaching old genomes new tricks / Susan R. Wessler -- Assembling genes in the immune system / Ellen Hsu -- Focused mutation in the immune system / Rupert Beale, Dagmar Iber -- Regulated and unregulated recombination of G-rich genomic regions / Nancy Maizels -- The role of the genome in the initiation of meiotic |
ctrlnum | (OCoLC)493674956 (DE-599)BVBBV021313153 |
dewey-full | 572.8/38 |
dewey-hundreds | 500 - Natural sciences and mathematics |
dewey-ones | 572 - Biochemistry |
dewey-raw | 572.8/38 |
dewey-search | 572.8/38 |
dewey-sort | 3572.8 238 |
dewey-tens | 570 - Biology |
discipline | Biologie |
discipline_str_mv | Biologie |
format | Book |
fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03219nam a2200601zc 4500</leader><controlfield tag="001">BV021313153</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20060316 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">060130s2006 xxuad|| |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2005011590</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0195172701</subfield><subfield code="c">cloth : alk. paper</subfield><subfield code="9">0-19-517270-1</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">019517271X</subfield><subfield code="c">paper : alk. paper</subfield><subfield code="9">0-19-517271-X</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780195172706</subfield><subfield code="9">978-0-19-517270-6</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780195172713</subfield><subfield code="9">978-0-19-517271-3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)493674956</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV021313153</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">xxu</subfield><subfield code="c">US</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-M49</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH390</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.8/38</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 180f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 175f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The implicit genome</subfield><subfield code="c">edited by Lynn Helena Caporale</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York [u.a.]</subfield><subfield code="b">Oxford University Press</subfield><subfield code="c">2006</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XI, 385 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield><subfield code="c">cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">Sequence-dependent properties of DNA and their role in function / Donald Crothers -- Mutation as a phenotype / Errol C. Friedberg -- Repeats and variation in pathogen selection / Chris Bayliss and Richard Moxon -- Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection / David G. King, Edward N. Trifonov, Yechezkel Kashi -- Implicit information in eukaryotic pathogens as the basis of antigenic variation / J. Dave Barry -- The role of repeat sequences in bacterial genetic adaptation to stress / Eduardo P.C. Rocha -- The role of mobile DNA in the evolution of prokaryotic genomes / Ian Paulsen & Claire Fraser -- -- Eukaryotic transposable elements: teaching old genomes new tricks / Susan R. Wessler -- Assembling genes in the immune system / Ellen Hsu -- Focused mutation in the immune system / Rupert Beale, Dagmar Iber -- Regulated and unregulated recombination of G-rich genomic regions / Nancy Maizels -- The role of the genome in the initiation of meiotic</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">Génome</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Génétique de l'évolution</subfield><subfield code="2">ram</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">Immunité - génétique</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">Séquences répétées d'acides nucléiques - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">Évolution moléculaire</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Evolutionary genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Evolution, Molecular</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunity</subfield><subfield code="x">genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Repetitive Sequences, Nucleic Acid</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Evolution</subfield><subfield code="0">(DE-588)4071050-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Evolution</subfield><subfield code="0">(DE-588)4071050-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Caporale, Lynn Helena</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://www.loc.gov/catdir/toc/ecip0511/2005011590.html</subfield><subfield code="3">Table of contents</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014633677&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-014633677</subfield></datafield></record></collection> |
genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
genre_facet | Aufsatzsammlung |
id | DE-604.BV021313153 |
illustrated | Illustrated |
index_date | 2024-07-02T13:56:38Z |
indexdate | 2024-07-09T20:35:25Z |
institution | BVB |
isbn | 0195172701 019517271X 9780195172706 9780195172713 |
language | English |
lccn | 2005011590 |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014633677 |
oclc_num | 493674956 |
open_access_boolean | |
owner | DE-M49 DE-BY-TUM |
owner_facet | DE-M49 DE-BY-TUM |
physical | XI, 385 S. Ill., graph. Darst. cm |
publishDate | 2006 |
publishDateSearch | 2006 |
publishDateSort | 2006 |
publisher | Oxford University Press |
record_format | marc |
spelling | The implicit genome edited by Lynn Helena Caporale New York [u.a.] Oxford University Press 2006 XI, 385 S. Ill., graph. Darst. cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Sequence-dependent properties of DNA and their role in function / Donald Crothers -- Mutation as a phenotype / Errol C. Friedberg -- Repeats and variation in pathogen selection / Chris Bayliss and Richard Moxon -- Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection / David G. King, Edward N. Trifonov, Yechezkel Kashi -- Implicit information in eukaryotic pathogens as the basis of antigenic variation / J. Dave Barry -- The role of repeat sequences in bacterial genetic adaptation to stress / Eduardo P.C. Rocha -- The role of mobile DNA in the evolution of prokaryotic genomes / Ian Paulsen & Claire Fraser -- -- Eukaryotic transposable elements: teaching old genomes new tricks / Susan R. Wessler -- Assembling genes in the immune system / Ellen Hsu -- Focused mutation in the immune system / Rupert Beale, Dagmar Iber -- Regulated and unregulated recombination of G-rich genomic regions / Nancy Maizels -- The role of the genome in the initiation of meiotic Génome Génétique de l'évolution ram Immunité - génétique Séquences répétées d'acides nucléiques - physiology Évolution moléculaire Evolutionary genetics Genome Evolution, Molecular Immunity genetics Repetitive Sequences, Nucleic Acid physiology Genetik (DE-588)4071711-2 gnd rswk-swf Evolution (DE-588)4071050-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Genetik (DE-588)4071711-2 s Evolution (DE-588)4071050-6 s b DE-604 Caporale, Lynn Helena Sonstige oth http://www.loc.gov/catdir/toc/ecip0511/2005011590.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014633677&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | The implicit genome Sequence-dependent properties of DNA and their role in function / Donald Crothers -- Mutation as a phenotype / Errol C. Friedberg -- Repeats and variation in pathogen selection / Chris Bayliss and Richard Moxon -- Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection / David G. King, Edward N. Trifonov, Yechezkel Kashi -- Implicit information in eukaryotic pathogens as the basis of antigenic variation / J. Dave Barry -- The role of repeat sequences in bacterial genetic adaptation to stress / Eduardo P.C. Rocha -- The role of mobile DNA in the evolution of prokaryotic genomes / Ian Paulsen & Claire Fraser -- -- Eukaryotic transposable elements: teaching old genomes new tricks / Susan R. Wessler -- Assembling genes in the immune system / Ellen Hsu -- Focused mutation in the immune system / Rupert Beale, Dagmar Iber -- Regulated and unregulated recombination of G-rich genomic regions / Nancy Maizels -- The role of the genome in the initiation of meiotic Génome Génétique de l'évolution ram Immunité - génétique Séquences répétées d'acides nucléiques - physiology Évolution moléculaire Evolutionary genetics Genome Evolution, Molecular Immunity genetics Repetitive Sequences, Nucleic Acid physiology Genetik (DE-588)4071711-2 gnd Evolution (DE-588)4071050-6 gnd |
subject_GND | (DE-588)4071711-2 (DE-588)4071050-6 (DE-588)4143413-4 |
title | The implicit genome |
title_auth | The implicit genome |
title_exact_search | The implicit genome |
title_exact_search_txtP | The implicit genome |
title_full | The implicit genome edited by Lynn Helena Caporale |
title_fullStr | The implicit genome edited by Lynn Helena Caporale |
title_full_unstemmed | The implicit genome edited by Lynn Helena Caporale |
title_short | The implicit genome |
title_sort | the implicit genome |
topic | Génome Génétique de l'évolution ram Immunité - génétique Séquences répétées d'acides nucléiques - physiology Évolution moléculaire Evolutionary genetics Genome Evolution, Molecular Immunity genetics Repetitive Sequences, Nucleic Acid physiology Genetik (DE-588)4071711-2 gnd Evolution (DE-588)4071050-6 gnd |
topic_facet | Génome Génétique de l'évolution Immunité - génétique Séquences répétées d'acides nucléiques - physiology Évolution moléculaire Evolutionary genetics Genome Evolution, Molecular Immunity genetics Repetitive Sequences, Nucleic Acid physiology Genetik Evolution Aufsatzsammlung |
url | http://www.loc.gov/catdir/toc/ecip0511/2005011590.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014633677&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT caporalelynnhelena theimplicitgenome |