Handbook of pharmaceutical manufacturing formulations: 1 Compressed solid products
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press
2004
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| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 296 S. 29 cm |
| ISBN: | 0849317460 |
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| 100 | 1 | |a Niazi, Sarfaraz K. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Handbook of pharmaceutical manufacturing formulations |n 1 |p Compressed solid products |c Sarfaraz K. Niazi |
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press |c 2004 | |
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| adam_text | H A N D B O O K OF PHARMACEUTICAL MANUFACTURING FORMULATIONS COMPRESSED
SOLID PRODUCTS VOLUME 1 SARFARAZ K. NIAZI CRC PRESS BOCA RATON LONDON
NEW YORK WASHINGTON, D.C. TABLE OF CONTENTS PARTI REGULATORY AND
MANUFACTURING REQUIREMENTS IN COMPRESSED SOLID DOSAGE FORMS CHAPTER 1
BIOAVAILABILITY AND BIOEQUIVALENCE STUDIES FOR ORALLY ADMINISTERED DRUG
PRODUCTS 3 I. INTRODUCTION 3 II. BACKGROUND 3 A. GENERAL 3 B.
BIOAVAILABILITY 4 C. BIOEQUIVALENCE 4 1. INDS/NDAS 4 2. ANDAS 5 3.
POSTAPPROVAL CHANGES 5 III. METHODS TO DOCUMENT BA AND BE 5 A.
PHARMACOKINETIC STUDIES 5 1. GENERAL CONSIDERATIONS 5 2. PILOT STUDY 6
3. PIVOTAL BIOEQUIVALENCE STUDIES 6 4. STUDY DESIGNS 6 5. STUDY
POPULATION 6 6. SINGLE-DOSE/MULTIPLE-DOSE STUDIES 6 7. BIOANALYTICAL
METHODOLOGY 6 8. PHARMACOKINETIC MEASURES OF SYSTEMIC EXPOSURE 7 B.
PHARMACODYNAMIC STUDIES 7 C. COMPARATIVE CLINICAL STUDIES 7 D. IN VITRO
STUDIES 7 IV. COMPARISON OF BA MEASURES IN BE STUDIES 8 V. DOCUMENTATION
OF BA AND BE 8 A. SOLUTIONS 9 B. SUSPENSIONS 9 C. IMMEDIATE-RELEASE
PRODUCTS: CAPSULES AND TABLETS 9 1. GENERAL RECOMMENDATIONS 9 2. WAIVERS
OF IN VIVO BE STUDIES (BIOWAIVERS) 9 D. MODIFIED-RELEASE PRODUCTS 10 1.
NDAS: BA AND BE STUDIES 10 2. ANDAS: BE STUDIES 10 3. WAIVERS OF IN VIVO
BE STUDIES (BIOWAIVERS): NDAS AND ANDAS 1 4. POSTAPPROVAL CHANGES 1 E.
MISCELLANEOUS DOSAGE FORMS 1 VI. SPECIAL TOPICS 1 A. FOOD-EFFECT STUDIES
1 B. MOIETIES TO BE MEASURED 1 1. PARENT DRUG VS. METABOLITES 1 2.
ENANTIOMERS VS. RACEMATES 12 3. DRUG PRODUCTS WITH COMPLEX MIXTURES AS
THE ACTIVE INGREDIENTS 12 C. LONG HALF-LIFE DRUGS 12 D. FIRST POINT C
MAX 13 E. ORALLY ADMINISTERED DRUGS INTENDED FOR LOCAL ACTION 13 F.
NARROW THERAPEUTIC RANGE DRUGS 13 APPENDIX 1A * GENERAL PHARMACOKINETIC
STUDY DESIGN AND DATA HANDLING 15 CHAPTER 2 GUIDANCE ON FORMULATING
COMPRESSED SOLIDS 17 I. ABBREVIATED DIRECTIONS 17 II. API 17 III. BIO
VS. PRODUCTION BATCHES 17 IV. CLEANING VALIDATION 17 V COATINGS 17 VI.
COMPLIANCE WITH REGULATORY REQUIREMENTS 18 VII. COMPRESSION PROCESS
CONTROL 18 VIII. CONTENT UNIFORMITY 18 IX. CROSS-CONTAMINATION 18 X.
DESEGREGATION OF POWDERS 18 XI. DISINTEGRATION TEST 19 A. UNCOATED
TABLETS 19 B. PLAIN COATED TABLETS 19 C. DELAYED-RELEASE
(ENTERIC-COATED) TABLETS 19 D. BUCCAL TABLETS 19 E. SUBLINGUAL TABLETS
19 XII. DISSOLUTION 19 XIII. DISINTEGRATION AND DISSOLUTION 20 XIV. DRUG
SUBSTANCE CHARACTERIZATION 20 XV DRYING PROCESS 20 XVI. DYES IN
FORMULATIONS 20 XVII. EQUIPMENT 20 A. BLENDERS 20 1. PONY PAN 21 2.
RIBBON 21 3. TUMBLER 21 4. HIGH-SHEAR (HIGH-ENERGY) 21 5. PLASTIC BAG 22
B. DRYERS 22 C. TABLET COMPRESSION EQUIPMENT 22 D. COATING EQUIPMENT 22
XVIII. EXCIPIENTS 23 A. COATING AGENT 23 B. GLIDANT 23 C. TABLET BINDER
23 D. DILUENT 23 E. DISINTEGRANT 23 F. LUBRICANT 23 XIX. FILL WEIGHTS 24
XX. FINAL PACKAGING 24 XXI. FINAL TESTING 25 XXII. FINES 25 XXIII.
FORMULA EXCESSES 25 XXIV. GEOMETRIC DILUTION 25 XXV. GRANULATION/MIX
ANALYSIS 25 XXVI. INGREDIENT WARNING 26 XXVII. IN-PROCESS TESTING 26
XXVIII. LOSS ON DRYING (LOD) 26 XXIX. MANUFACTURING YIELDS 27 XXX.
MASTER FORMULA 27 XXXI. MULTIPLE-ITEM ENTRIES 27 XXXII. MULTIPLE
STRENGTHS OF FORMULATIONS 27 XXXIII. NOVEL DRUG DELIVERY SYSTEMS 27
XXXIV. PARTICLE COATING 28 XXXV. PRESERVATIVES IN COMPRESSED SOLID
DOSAGE FORMULATIONS 28 XXXVI. PUNCH SIZE AND SHAPE 28 XXXVII. REWORKING
CULLS 28 XXXVIII. SCALE-UP 28 XXXIV SEGREGATION 29 XXXV. SIFTING
INGREDIENTS AND GRANULES 29 XXXVI. SPECIFICATIONS 29 XXXVII. STABILITY
TESTING 29 XXXVIII. STORAGE OF IN-PROCESS MATERIAL 30 XXXIX. TABLET
FRIABILITY 30 XL. TABLET MANUFACTURING 30 XLI. TABLETS 30 XLII.
WATER-PURIFIED USP 31 XLIII. WEIGHT VARIATION AND CONTENT UNIFORMITY 31
XLIV. WET GRANULATION VS. DRY GRANULATION OR DIRECT COMPRESSION 32 PART
II COMPRESSED SOLID FORMULATIONS 33 ACETAMINOPHEN, IBUPROFEN, AND
ORPHENADRINE TABLETS (250 MG/200 MG/200 MG) 35 ACETAMINOPHEN,
NOREPHEDRINE, AND PHENYLTOLOXAMINE TABLETS (300 MG/25 MG/22 MG) 35
ACETAMINOPHEN AND PHENPROBAMAT TABLETS (200 MG/200 MG) 36 ACETAMINOPHEN
AND ORPHENADRINE CITRATE TABLETS (450 MG/35 MG) 37 ACETAMINOPHEN
TABLETS, CHEWABLE 38 ACETAMINOPHEN, DEXTROPROPOXYPHEN HYDROCHLORIDE
TABLETS (325 MG/32 MG) 39 ACETAMINOPHEN AND CODEINE TABLETS [34] 40
ACETAMINOPHEN, SALICYLAMIDE, CAFFEINE, AND CODEINE TABLETS (150 MG/200
MG/50 MG/10 MG) 41 ACYCLOVIR TABLETS [162] 42 ACYCLOVIR
WATER-DISPERSIBLE TABLETS (800 MG) 42 ALBENDAZOLE TABLETS (200 MG) 43
ALENDRONATE TABLETS [38] 44 ALENDRONATE TABLETS, EFFERVESCENT (10 MG) 44
ALENDRONATE SODIUM TABLETS (50 MG) 44 ALLOPURINOL TABLETS (100 MG) [84]
45 ALLOPURINOL TABLETS (300 MG) 46 ALPRAZOLAM TABLETS (0.25 MG/0.50
MG/1.0 MG) 47 4-AMINO-L-HYDROXYBUTYLIDENE-L.L-BISPHOSPHONIC ACID TABLETS
(5 MG) 48 AMINOPHYLLINE TABLETS (100 MG) 48 AMIODARONE TABLETS (200 MG)
49 AMLODIPINE BESYLATE TABLETS |9] 50 AMITRIPTYLINE TABLETS (50 MG) [42]
51 AMOXICILLIN TABLETS (250 MG/500 MG/1 G) 52 AMOXICILLIN TRIHYDRATE AND
CLAVULANATE POTASSIUM TABLETS (500 MG/125 MG) 53 AMOXICILLIN AND
POTASSIUM CLAVULANATE TABLETS (250 MG/62.5 MG) 54 AMPHETAMINE SALTS
TABLETS 54 ATENOLOL TABLETS (50 MG/100 MG) 55 ATORVASTATIN TABLETS (10
MG/20 MG) 57 AZITHROMYCIN TABLETS (250 MG) 58 BENZAFIBRATE TABLETS (200
MG) 59 BENAZEPRIL HYDROCHLORIDE TABLETS 60 BETAMETHASONE TABLETS (0.50
MG) 61 BIRB 796 TABLETS (100 MG) 61 BISOPROLOL FUMARATE AND
HYDROCHLOROTHIAZIDE TABLETS 62 BROMAZEPAM TABLETS (3 MG) 62 BROMHEXINE
TABLETS (8 MG) 63 BROMOCRIPTINE TABLETS 63 BUFIOMEDIL HYDROCHLORIDE
TABLETS (150 MG/300 MG) 64 BUFLOMEDIL HYDROCHLORIDE TABLETS (600 MG) 65
BUPROPION HYDROCHLORIDE TABLETS 66 BUSPIRONE HYDROCHLORIDE TABLETS 67
BUSPIRONE HYDROCHLORIDE TABLETS, CONTROLLED-RELEASE (30 MG) 67 CAPTOPRIL
TABLETS (25 MG) 68 CARBAMAZEPINE TABLETS (200 MG) 69 CARBAMAZEPINE
TABLETS (200 MG) 70 CARBIDOPA AND LEVODOPA TABLETS 70 CARISOPRODOL
TABLETS 71 CARVEDILOL TABLETS 71 CEFADROXIL DISPERSIBLE TABLETS (250 MG)
72 CEFDINIR TABLETS (300 MG) 72 CEFIXIME TABLETS (400 MG) 73 CEFPROZIL
TABLETS (250 MG) 73 CELECOXIB TABLETS 74 CEPHALEXIN TABLETS 74
CETIRIZINE AND PSEUDOEPHEDRINE DELAYED-RELEASE TABLETS (5 MG/120 MG) 74
CETIRIZINE HYDROCHLORIDE TABLETS (10 MG) 75 CHLORCYCLIZINE HYDROCHLORIDE
TABLETS (50 MG) 75 CHLORDIAZEPOXIDE AND CLINIDIUM BROMIDE TABLETS (5
MG/2.5 MG) 76 CHLORDIAZEPOXIDE TABLETS (10 MG) 76 CHLOROQUINE TABLETS
(250 MG) 77 CHOLINE THEOPHYLLINATE TABLETS (100 MG) 77 CHYMOTRYPSINE
TABLETS (25 MG) 77 CILAZAPRIL TABLETS (2.5 MG) 78 CIMETIDINE TABLETS
(200 MG) 79 CIPROFLOXACIN TABLETS (500 MG) 80 CIPROFLOXACIN TABLETS (750
MG) 81 CISAPRIDE TABLETS (5 MG) 82 CITALOPRAM HYDROBROMIDE TABLETS 82
CLARITHROMYCIN TABLETS (250 MG/500 MG) 83 CLENBUTEROL TABLETS (20 MEG)
84 CLINDAMYCIN TABLETS (20 MG) 84 CLOBAZAM TABLETS (10 MG) 85 CLOMIFEN
CITRATE TABLETS (50 MG) 85 CLOMIPRAMINE HYDROCHLORIDE TABLETS,
EFFERVESCENT (300 MG) 85 CLOMIPRAMINE HYDROCHLORIDE TABLETS, BUCCAL (10
MG) 86 CLONAZEPAM TABLETS (1 MG/2 MG) 86 CLONIDINE TABLETS (0.1 MG/0.2
MG/0.3 MG) 86 CLOPIDOGREL BISULFATE TABLETS (75 MG) 87 CODEINE,
ACETAMINOPHEN, AND PENTOBARBITAL TABLETS (15 MG/300 MG/30 MG) 87
CONJUGATED ESTROGENS (0.3-2.50 MG) 88 CONJUGATED ESTROGENS AND
MEDROXYPROGESTERONE TABLETS 89 COUMADIN TABLETS 89 CYCLOBENZAPRINE
HYDROCHLORIDE TABLETS (10 MG) [64] 90 CYPROHEPTADINE TABLETS (4 MG) 90
DAPSONE TABLETS (50 MG) 91 DESLORATIDINE TABLETS (5 MG) 91 DESOGESTREL
AND ETHINYL ESTRADIOL TABLETS (0.15 MG/0.03 MG) 91 DIAZEPAM TABLETS (2
MG/5 MG/10 MG) 92 DICLOFENAC SODIUM TABLETS (25 MG) 93 DICLOFENAC SODIUM
TABLETS (50 MG) 94 DICLOFENAC SODIUM TABLETS (100 MG) 94 DIDANOSINE
TABLETS (50 MG) 95 DIETHYLCARBAMAZINE TABLETS (100 MG) 95 DIFENOXIN AND
ATROPINE TABLETS (0.5 MG/0.025 MG) 96 DIGOXIN TABLETS (0.125 MG/0.25 MG)
[92] 96 DILTIAZEM HYDROCHLORIDE TABLETS (60 MG) 97 DILTIAZEM TABLETS 60
MG [95] 98 DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE TABLETS (2.5
MG/0.025 MG) 98 DIVALPROATE SODIUM TABLETS (125 MG) [121] 99 DIVALPROEX
SODIUM TABLETS (400 MG) 100 DOXAZOSIN MESYLATE TABLETS (1 MG/2 MG/4 MG/8
MG) [112] 100 DOXYCYCLINE HYDROCHLORIDE TABLETS (100 MG) [91] 101
ENALAPRIL MALEATE TABLETS (2.5 MG/5 MG/10 MG/20 MG) [66] 102 ENALAPRIL
MALEATE TABLETS (10 MG) 102 ENOXACIN TABLETS (400 MG) 103 ERYTHROMYCIN
ETHYLSUCCINATE TABLETS (400 MG) 104 ERYTHROMYCIN PARTICLE-COATED TABLETS
(150 MG) 105 ERYTHROMYCIN TABLETS (100 MG) 106 ERYTHROMYCIN TABLETS (100
MG) 106 ERYTHROMYCIN TABLETS (500 MG) 107 ESTAZOLAM TABLETS (1 MG) 109
ESTAZOLAM TABLETS (2 MG) 109 ESTRADIOL TABLETS (0.5 MG/1 MG/2 MG) [85]
110 ESTROPIPATE TABLETS (0.626 MG/1.25 MG/2.25 MG/5 MG) 110 ETHAMBUTOL
TABLETS (400 MG) 111 ETHAMBUTOL TABLETS (800 MG) 112 ETOPHYLLINE AND
THEOPHYLLINE TABLETS (100 MG/22 MG) 113 ETOPHYLLINE AND THEOPHYLLINE
TABLETS (100 MG/22 MG) 113 FAMCICLOVIR TABLETS (125 MG/250 MG) 114
FAMOTIDINE TABLETS (20 MG) [146] 115 FAMOTIDINE TABLETS (40 MG) 116
FEXOFENADINE TABLETS (30 MG/60 MG/180 MG) [26] 116 FEXOFENADINE AND
PSEUDOEPHEDRINE TABLETS (10 MG/240 MG) [111] 117 FINASTERIDE TABLETS (5
MG) 118 FLUCONAZOLE TABLETS (50 MG/100 MG/200 MG) [75] 118 FLUVOXAMINE
MALEATE TABLETS (50 MG) 119 FLUOXETINE HYDROCHLORIDE TABLETS (10 MG/20
MG/40 MG) [33] 120 FLUOXETINE HYDROCHLORIDE TABLETS (12.5 MG/25.0 MG)
CONTROLLED-RELEASE BILAYER 121 FOSINOPRIL TABLETS (20 MG) [ 133] 122
FUCIDINE TABLETS (125 MG) 122 FURAZOLIDONE TABLETS (100 MG) 123
FUROSEMIDE TABLETS (40 MG) [7] 123 FUROSEMIDE TABLETS (40 MG) 124
FUROSEMIDE TABLETS (200 MG) 125 GABAPENTIN TABLETS (600 MG) 125
GALANTHAMINE HYDROBROMIDE TABLETS (1 MG) 126 GEMFIBROZIL TABLETS (600
MG) [114] 127 GLIBENCLAMIDE TABLETS (2.5 MG) 128 GLIBENCLAMIDE TABLETS
(5 MG) 129 GLICLAZIDE TABLETS (80 MG) 130 GLIMEPIRIDE TABLETS (1 MG/2
MG) [129] 131 GLIPIZIDE TABLETS (5 MG) [71] 132 GLIPIZIDE TABLETS CR (5
MG) 133 GLYBURIDE AND METFORMIN TABLETS (250 MG/500 MG; 1.25 MG/2.50 MG)
[124] 134 GLYBURIDE TABLETS (5 MG) [81] 135 GRISEOFULVIN TABLETS (125
MG) 136 GRISEOFULVIN TABLETS (500 MG) 136 HYDROCHLOROTHIAZIDE AND
POTASSIUM CHLORIDE (50 MG/300 MG) 137 HYDROCHLOROTHIAZIDE TABLETS (50
MG) [10] 137 HYDROCHLOROTHIAZIDE TABLETS (50 MG) 138 HYDROCODONE AND
ACETAMINOPHEN TABLETS (5.0 MG/500 MG; 7.50 MG/750 MG) 139 HYDROCODONE
AND IBUPROFEN TABLETS 140 HYDROXYZINE TABLETS [132] 140 HYOSCINE BUTYL
BROMIDE TABLETS (10 MG) 141 IBUPROFEN TABLETS (400 MG) [19] 142
IBUPROFEN TABLETS (400 MG) 143 IBUPROFEN TABLETS (600 MG) 144 IMIPRAMINE
TABLETS (25 MG) 144 IRBESARTAN TABLETS (75 MG/150 MG/300 MG) [149] 145
ISONIAZID TABLETS (100 MG) 146 ISOSORBIDE DINITRATE TABLETS (5 MG) [68]
147 ISOSORBIDE DINITRATE TABLETS (10 MG) 147 KETOTIFEN TABLETS (1 MG)
148 LAMOTRIGINE TABLETS (100 MG) 148 LANSOPRAZOLE TABLETS (10 MG OR 20
MG) 149 LANSOPRAZOLE TABLETS (10 MG OR 20 MG) 149 LANSOPRAZOLE TABLETS
CHEWABLE (10 MG/20 MG) 149 LANSOPRAZOLE TABLETS, RAPID DISSOLUTION (20
MG) 150 LEVAMISOLE HYDROCHLORIDE TABLETS (40 MG) 150 LEVAMISOLE TABLETS
(150 MG) 151 LEVOFLOXACIN TABLETS (250 MG) [69] 151 LEVOTHYROXINE
TABLETS [4] 151 LEVOTHYROXINE TABLETS (50 MEG) [25] 152 LEVOTHYROXINE
TABLETS (0.025 MG) 152 LINEZOLID TABLETS (400 MG) 153 LISINOPRIL TABLETS
(10 MG) [52] 153 LOMEFLOXACIN HYDROCHLORIDE TABLETS (400 MG) 154
LOPERAMIDE HYDROCHLORIDE TABLETS (2 MG) 154 LORATADINE AND
PSEUDOEPHEDRINE SULFATE TABLETS (10 MG/240 MG) [127] 155 LORATADINE
TABLETS (10 MG) [32] 156 LORAZEPAM TABLETS (0.50 MG/1 MG/2 MG) [37] 157
LOSARTAN AND HYDROCHLOROTHIAZIDE TABLETS (50 MG/12.5 MG) [118] 157
LOSARTAN POTASSIUM TABLETS (50 MG) [93] 158 MEBENDAZOL TABLETS (100 MG)
159 MECLIZINE HYDROCHLORIDE TABLETS (25 MG) [135] 159
MEDROXYPROGESTERONE ACETATE TABLETS (2.5 MG/5 MG/10 MG) [89] 159
MEFANAMIC ACID AND DICYCLOMINE HYDROCHLORIDE TABLETS (250 MG/10 MG) 160
MEFENAMIC ACID TABLETS (250 MG) 160 MEFLOQUINE HYDROCHLORIDE TABLETS
(250 MG) 161 MEPROBAMATE AND PHENOBARBITAL TABLETS (400 MG/30 MG) 161
MEPROBAMATE AND PHENOBARBITAL TABLETS (400 MG/30 MG) 162 MEPROBAMATE
TABLETS (400 MG) 162 MEPROBAMATE TABLETS (400 MG) 163 METAMIZOL TABLETS
(500 MG) 163 METAMIZOL TABLETS (500 MG) 164 METFORMIN HYDROCHLORIDE
TABLETS, EXTENDED RELEASE (500 MG) 165 METFORMIN TABLETS (500 MG) [40]
166 METFORMIN TABLETS, EXTENDED RELEASE (500 MG) 167 METHENAMINE TABLETS
(500 MG) 167 METHYCLOTHIAZIDE AND DESERPIDINE TABLETS (5 MG/0.25 MG) 168
METHYCLOTHIAZIDE TABLETS (5 MG) 169 METHYLERGOTAMINE MALATE TABLETS (0.5
MG) 170 METHYLPHENIDATE HYDROCHLORIDE TABLETS EXTENDED RELEASE (18 MG/36
MG) [122] 170 METHYLPREDNISOLONE TABLETS (2 MG/4 MG/8 MG/16 MG/24 MG/32
MG) [99] 171 METOCLOPRAMIDE TABLETS (10 MG) [138] 171 METOCLOPRAMIDE
TABLETS (20 MG) 172 METOPROLOL SUCCINATE TABLETS (95 MG) [21] 173
METOPROLOL TARTRATE TABLETS [36] 173 METRONIDAZOLE EFFERVESCENT VAGINAL
TABLETS (500 MG) 174 METRONIDAZOLE, FURAZOLIDONE, AND LOPERAMIDE TABLETS
(200 MG/25 MG/2 MG) 174 METRONIDAZOLE TABLETS (200 MG) 175 METRONIDAZOLE
TABLETS (200 MG/400 MG) 176 METRONIDAZOLE TABLETS (400 MG) [147] 177
METRONIDAZOLE TABLETS (500 MG) 177 MIRTAZAPINE TABLETS [145] 178
MONTELUKAST SODIUM TABLETS (5 MG) [54] 178 NALIDIXIC ACID TABLETS (500
MG) 179 NALIDIXIC ACID TABLETS (500 MG) 179 NAPROXEN TABLETS (250 MG)
[58] 180 NAPROXEN TABLETS (250 MG/500 MG) 181 NAPROXEN TABLETS (450 MG)
182 NEOMYCIN TABLETS (250 MG) 182 NIFEDIPINE TABLETS (5 MG) 183
NIFEDIPINE TABLETS (10 MG) 183 NIMESULIDE DISPERSIBLE TABLETS (100 MG)
184 NITRENDIPINE TABLETS (25 MG) 184 NITROFURANTOIN TABLETS (100 MG) 185
NITROFURANTOIN TABLETS (100 MG) 185 NITROGLYCERINE TABLETS (0.3 MG) 186
NORAMIDOPYRINE METHANSULFONATE AND DICYCLOMINE HYDROCHLORIDE TABLETS
(500 MG/10 MG) 187 NORETHINDRONE AND ETHINYL ESTRADIOL TABLETS (0.75
MG/0.035 MG; 0.50 MG/0.035 MG: 1.0 MG/O.O35 MG) [1311 188 NORFLOXACIN
TABLETS (400 MG) 189 NORGESTIMATE AND ETHINYL ESTRADIOL TABLETS (0.18
MG/0.035 MG: 0.215 MG/0.035; 0.25 MG/0.035 MG) [27] 190 NYSTATIN TABLETS
(50 MG) 190 NYSTATIN TABLETS (200 MG) 191 OLANZAPINE TABLETS [110] 191
OMEPRAZOLE AND IBUPROFEN TABLETS (10 MG/400 MG) 192 OMEPRAZOLE TABLETS
(10 MG/20 MG) 192 OMEPRAZOLE TABLETS (10 MG/20 MG) 193 OMEPRAZOLE
TABLETS, CHEWABLE (10 MG/20 MG) 193 OMEPRAZOLE TABLETS, RAPID
DISSOLUTION (20 MG) 193 OXYBUTYNIN CHLORIDE TABLETS (5 MG/10 MG) [194]
194 OXYCODONE HYDROCHLORIDE AND ACETAMINOPHEN TABLETS (5 MG/325 MG) (90]
195 OXYCODONE HYDROCHLORIDE TABLETS (5 MG) [119] 196 OXYTETRACYCLINE
TABLETS (250 MG) 196 PANTOPRAZOLE TABLETS [77] 1% PANTOPROZOLE TABLETS
(10 MG/20 MG) 197 PANTOPRAZOLE TABLETS, CHEWABLE (10 MG/20 MG) 197
PANTOPRAZOLE TABLETS, RAPID DISSOLUTION (20 MG) 198 PARA AMINO SALICYLIC
ACID TABLETS (500 MG) 199 PAROXETINE HYDROCHLORIDE TABLETS (10 MG/20
MG/30 MG/40 MG) [15] 200 PENICILLIN CHEWABLE TABLETS (125 MG) [103] 201
PERFLOXACIN TABLETS (400 MG) 202 PHENDIMETRAZIN TABLETS (35 MG) 202
PHENINDION TABLETS (50 MG) 203 PHENOXYMETHYL PENICILLIN POTASSIUM
TABLETS (250 MG) 204 PHENYLBUTAZONE TABLETS (100 MG) 205
PHENYLPROPANOLAMINE HYDROCHLORIDE TABLETS (60 MG) 206 PHENYTOIN SODIUM
TABLETS (100 MG) 206 PHENYTOIN SODIUM TABLETS (100 MG) 207 PHENYTOIN
TABLETS (100 MG) 207 PIOGLITAZONE HYDROCHLORIDE TABLETS (15 MG/30 MG/45
MG) [87] 208 PIPEMIDIC ACID TABLETS (200 MG) 209 PIPOBROMAN TABLETS (25
MG) 210 POTASSIUM CHLORIDE TABLETS (30 MG) [56, 137] 211 PRAVASTATIN
SODIUM TABLETS (10 TO 40 MG) [48] 212 PRAZOSIN TABLETS (5 MG) 212
PREDNISOLONE TABLETS (5 MG) 213 PREDNISOLONE TABLETS (10 MG) 214
PREDNISOLONE TABLETS (20 MG) 214 PREDNISOLONE TABLETS (20 MG) 214
PREDNISONE TABLETS (10 MG) 215 PROBENECID TABLETS (500 MG) 215
PROMETHAZINE HYDROCHLORIDE TABLETS (10 MG) [107] 216 PROMETHAZINE
HYDROCHLORIDE TABLETS (25 MG) 217 PROPRANOLOL HYDROCHLORIDE TABLETS (10
MG) 217 PROPRANOLOL TABLETS (40 MG) 217 PROPRANOLOL HYDROCHLORIDE
TABLETS (10 MG) [141] 218 PYRAZINAMIDE TABLETS (500 MG) 219 PYRAZINAMIDE
TABLETS (500 MG) 219 PYRAZINAMIDE TABLETS (500 MG) 220 PYRIDOSTIGMINE
BROMIDE TABLETS (10 MG) 221 QUETIAPINE FUMARATE TABLETS (25 MG/100
MG/200 MG) [161] 221 QUINAPRIL HYDROCHLORIDE TABLETS (5 MG/10 MG/20
MG/40 MG) [51] 222 QUININE SULFATE TABLETS (300 MG) 223 QUINOLONE
ANTIBIOTIC TABLETS (100 MG) 223 RABEPRAZOLE SODIUM TABLETS (20 MG) [109]
224 RALOXIFENE TABLETS (60 MG) [100] 225 RANITIDINE HYDROCHLORIDE
TABLETS (150 MG) 226 RANITIDINE TABLETS (75 MG) 226 RANITIDINE TABLETS
(150 MG) [41] 227 RANITIDINE TABLETS (300 MG) 228 RIFAMPICIN, ISONIAZID,
ETHAMBUTOL, AND PYRIDOXINE TABLETS (300 MG/200 MG/25 MG) 229 RIFAMPICIN
TABLETS (300 MG) 231 RIFAMPICIN TABLETS (450 MG) 232 RISEDRONATE SODIUM
TABLETS (5 MG/30 MG) [188] 233 RISPERIDONE TABLETS (4 MG) [1050] 234
ROFECOXIB TABLETS (12.5 MG/25 MG/50 MG) [31] 234 ROSIGLITAZONE MALEATE
TABLETS (2 MG/4 MG/8 MG) [86] 235 ROXITHROMYCIN DISPERSIBLE TABLETS (200
MG) 235 SALBUTAMOL TABLETS (2 MG) 236 SALBUTAMOL TABLETS (4 MG) 237
SERRATIOPEPTIDASE TABLETS (10 MG) 237 SERRATIOPEPTIDASE TABLETS (10 MG)
238 SERTRALINE HYDROCHLORIDE TABLETS (25 MG/50 MG/100 MG) [14] 238
SILDENAFIL TABLETS (25 MG/50 MG/100 MG) [43] 239 SILIMARIN TABLETS (35
MG) 240 SIMVASTATIN TABLETS (10 MG) [17] 241 SIMVASTATIN TABLETS (20 MG)
242 SPIRONOLACTONE TABLETS (25 MG/50 MG/100 MG)) [130] 242 STALOL
HYDROCHLORIDE TABLETS (500 MG) 243 SULFADIMIDINE TABLETS (500 MG) 243
SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS (400 MG/80 MG; 800 MG/160 MG;
100 MG/20 MG) ) [106] 244 SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS (400
MG/80 MG) 245 SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS (800 MG/160 MG;
400 MG/80 MG) 245 SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS, DISPERSIBLE
(800 MG/160 MG) 246 SULFATHIAZOLE TABLETS (250 MG) 247 SUMATRIPTAN
SUCCINATE TABLETS (25 MG/50 MG) [125] 247 TAMOXIFEN TABLETS (10 MG/20
MG) [191] 248 TEMAFLOXACIN HYDROCHLORIDE TABLETS (200 MG/300 MG) 249
TENOXICAM TABLETS (20 MG) 250 TERAZOSIN TABLETS (1 MG-10 MG) [126] 250
TERAZOSIN TABLETS (1 MG) 251 TERBINAFINE TABLETS (250 MG) 252
TERFENADINE TABLETS (60 MG) 252 TETRACYCLINE TABLETS (125 MG) 253
TETRACYCLINE TABLETS (250 MG) 253 TETRAZEPAM TABLETS (50 MG) 254
THEOPHYLLINE AND EPHEDRINE TABLETS (130 MG/15 MG) 254 THEOPHYLLINE
TABLETS (100 MG) 254 THEOPHYLLINE TABLETS (100 MG) 255 THEOPHYLLINE
TABLETS CR (200 MG) 255 TIBOLONE TABLETS (0.3 MG) 256 TICLOPIDINE
HYDROCHLORIDE TABLETS (250 MG) 256 TOLTERODINE TABLETS (1 MG/2 MG) [171]
257 TOPIRAMATE TABLETS (100 MG/200 MG) [189] 257 TOSUFLOXACIN TOSYLATE
TABLETS (75 MG) 257 TRAZODONE HYDROCHLORIDE TABLETS (100 MG) [61] 258
TRIAMCINOLONE TABLETS (4 MG) 258 TRIFLUOPERAZINE TABLETS (5 MG) 258
TULOBUTEROL HYDROCHLORIDE TABLETS (1 MG) 259 VALACYCLOVIR HYDROCHLORIDE
TABLETS (500 MG/1 G) [144] 259 VALDECOXIB TABLETS (10 MG/20 MG) [148]
260 VALPROATE SODIUM TABLETS (500 MG) [121] 260 VALSARTAN AND
HYDROCHLOROTHIAZIDE TABLETS (80 MG/12.5 MG: 160 MG/25 MG) [108] 261
VENLAFAXINE HYDROCHLORIDE TABLETS (25 MG/37.5 MG/50 MG) [53] 262
VERAPAMIL TABLETS (120 MG) [65] 263 WARFARIN TABLETS (1, 2, 2.5, 3. 4,
5, 6, 7.5. AND 10 MG) [59] 264 ZOLPIDEM TARTRATE TABLETS (5 MG/10 MG)
[35] 265 APPENDIX COATING SOLUTIONS 267 I. INTRODUCTION 267 II.
HYDROXYPROPYL METHYLCELLULOSE (METHOCEL, HPMC) AQUEOUS COATINGS 268 A.
BRITE ROSE 268 B. CHERRY RED 268 C. GERANIUM ROSE 269 D. GLOSS 269 E.
RED 269 F. MODERATE RED 269 G. CLEAR 270 H. GREEN 270 I. HOLBERRY RED
271 J. SUN ORANGE 271 K. OPADRY YELLOW (CAPLETS) 271 L. OPADRY YELLOW
(TABS) 272 M. OPADRY RED 272 N. OPADRY GREEN 272 O. WHITE COATING 273
III. HYDROXYPROPYL METHYLCELLULOSE OPAQUE ORGANIC COATING 273 A. BRITE
GREEN 273 B. RED MAHOGANY 274 C. SUN ORANGE 274 D. DARK RED 275 E. DEEP
YELLOW 275 F PALE YELLOW 275 G. SCARLET RED 275 IV. HYDROXYPROPYL METHYL
CELLULOSE-HYDROXYPROPYL CELLULOSE (KLUCEL) COATING 276 A. WHITE 276 V.
HYDROXYPROPYL METHYLCELLULOSE-ETHYLCELLULOSE COATING 276 A. REDDISH
ORANGE OPAQUE 276 B. SUBCOATING SOLUTION 277 VI. HYDROXYMETHYL CELLULOSE
AND HYDROXY CELLULOSE COATING 277 A. BLUE 277 B. CLEAR (50:50) 277 VII.
HYDROXYMETHYL CELLULOSE AND ETHYL CELLULOSE COATING 278 A. CLEAR 278
VIII. POLYVINYLPYRROLIDONE COATINGS 278 A. SUBCOATING 278 B. KOLLIDON
VA64 279 C. KOLLIDON VA 64 AND POLYVINYL ALCOHOL 279 D. KOLLIDON 30 AND
SHELLAC 280 E. KOLLIDON VA 64 AND HYDROXYPROPYLMETHYL CELLULOSE 280 F.
POVIDONE, ETHYLCELLULOSE, AND TALC 281 IX. CELLULOSE ACETATE PHTHALATE
AND CARBOWAX COATINGS 281 A. BRITE GREEN 281 B. CHERRY RED 281 C. CLEAR
282 D. ORANGE 282 E. RED MAHOGANY 282 F. ORANGE 282 X. SUGAR COATINGS
282 A. BASIC 282 B. AUTOMATIC 283 C. MANUAL WHITE 283 XI. ENTERIC
COATINGS 284 A. KOLLICOAT AND KOLLIDON ENTERIC FILM COATING 284 B.
EUDRAGIT ENTERIC AQUEOUS 284 1. BRICK RED 284 2. YELLOW 285 3. BROWN 285
4. DARK ORANGE 285 5. ORANGE 286 6. DISPERSED ORANGE 286 C.
HYDROXYPROPYL METHYLCELLULOSE PHTHALATE ENTERIC COATING 286 1. CLEAR
ENTERIC 286 2. ORCHID PINK OPAQUE 287 3. LIGHT APRICOT ORANGE 287 INDEX
289
|
| adam_txt |
H A N D B O O K OF PHARMACEUTICAL MANUFACTURING FORMULATIONS COMPRESSED
SOLID PRODUCTS VOLUME 1 SARFARAZ K. NIAZI CRC PRESS BOCA RATON LONDON
NEW YORK WASHINGTON, D.C. TABLE OF CONTENTS PARTI REGULATORY AND
MANUFACTURING REQUIREMENTS IN COMPRESSED SOLID DOSAGE FORMS CHAPTER 1
BIOAVAILABILITY AND BIOEQUIVALENCE STUDIES FOR ORALLY ADMINISTERED DRUG
PRODUCTS 3 I. INTRODUCTION 3 II. BACKGROUND 3 A. GENERAL 3 B.
BIOAVAILABILITY 4 C. BIOEQUIVALENCE 4 1. INDS/NDAS 4 2. ANDAS 5 3.
POSTAPPROVAL CHANGES 5 III. METHODS TO DOCUMENT BA AND BE 5 A.
PHARMACOKINETIC STUDIES 5 1. GENERAL CONSIDERATIONS 5 2. PILOT STUDY 6
3. PIVOTAL BIOEQUIVALENCE STUDIES 6 4. STUDY DESIGNS 6 5. STUDY
POPULATION 6 6. SINGLE-DOSE/MULTIPLE-DOSE STUDIES 6 7. BIOANALYTICAL
METHODOLOGY 6 8. PHARMACOKINETIC MEASURES OF SYSTEMIC EXPOSURE 7 B.
PHARMACODYNAMIC STUDIES 7 C. COMPARATIVE CLINICAL STUDIES 7 D. IN VITRO
STUDIES 7 IV. COMPARISON OF BA MEASURES IN BE STUDIES 8 V. DOCUMENTATION
OF BA AND BE 8 A. SOLUTIONS 9 B. SUSPENSIONS 9 C. IMMEDIATE-RELEASE
PRODUCTS: CAPSULES AND TABLETS 9 1. GENERAL RECOMMENDATIONS 9 2. WAIVERS
OF IN VIVO BE STUDIES (BIOWAIVERS) 9 D. MODIFIED-RELEASE PRODUCTS 10 1.
NDAS: BA AND BE STUDIES 10 2. ANDAS: BE STUDIES 10 3. WAIVERS OF IN VIVO
BE STUDIES (BIOWAIVERS): NDAS AND ANDAS 1 4. POSTAPPROVAL CHANGES 1 E.
MISCELLANEOUS DOSAGE FORMS 1 VI. SPECIAL TOPICS 1 A. FOOD-EFFECT STUDIES
1 B. MOIETIES TO BE MEASURED 1 1. PARENT DRUG VS. METABOLITES 1 2.
ENANTIOMERS VS. RACEMATES 12 3. DRUG PRODUCTS WITH COMPLEX MIXTURES AS
THE ACTIVE INGREDIENTS 12 C. LONG HALF-LIFE DRUGS 12 D. FIRST POINT C
MAX 13 E. ORALLY ADMINISTERED DRUGS INTENDED FOR LOCAL ACTION 13 F.
NARROW THERAPEUTIC RANGE DRUGS 13 APPENDIX 1A * GENERAL PHARMACOKINETIC
STUDY DESIGN AND DATA HANDLING 15 CHAPTER 2 GUIDANCE ON FORMULATING
COMPRESSED SOLIDS 17 I. ABBREVIATED DIRECTIONS 17 II. API 17 III. BIO
VS. PRODUCTION BATCHES 17 IV. CLEANING VALIDATION 17 V COATINGS 17 VI.
COMPLIANCE WITH REGULATORY REQUIREMENTS 18 VII. COMPRESSION PROCESS
CONTROL 18 VIII. CONTENT UNIFORMITY 18 IX. CROSS-CONTAMINATION 18 X.
DESEGREGATION OF POWDERS 18 XI. DISINTEGRATION TEST 19 A. UNCOATED
TABLETS 19 B. PLAIN COATED TABLETS 19 C. DELAYED-RELEASE
(ENTERIC-COATED) TABLETS 19 D. BUCCAL TABLETS 19 E. SUBLINGUAL TABLETS
19 XII. DISSOLUTION 19 XIII. DISINTEGRATION AND DISSOLUTION 20 XIV. DRUG
SUBSTANCE CHARACTERIZATION 20 XV DRYING PROCESS 20 XVI. DYES IN
FORMULATIONS 20 XVII. EQUIPMENT 20 A. BLENDERS 20 1. PONY PAN 21 2.
RIBBON 21 3. TUMBLER 21 4. HIGH-SHEAR (HIGH-ENERGY) 21 5. PLASTIC BAG 22
B. DRYERS 22 C. TABLET COMPRESSION EQUIPMENT 22 D. COATING EQUIPMENT 22
XVIII. EXCIPIENTS 23 A. COATING AGENT 23 B. GLIDANT 23 C. TABLET BINDER
23 D. DILUENT 23 E. DISINTEGRANT 23 F. LUBRICANT 23 XIX. FILL WEIGHTS 24
XX. FINAL PACKAGING 24 XXI. FINAL TESTING 25 XXII. FINES 25 XXIII.
FORMULA EXCESSES 25 XXIV. GEOMETRIC DILUTION 25 XXV. GRANULATION/MIX
ANALYSIS 25 XXVI. INGREDIENT WARNING 26 XXVII. IN-PROCESS TESTING 26
XXVIII. LOSS ON DRYING (LOD) 26 XXIX. MANUFACTURING YIELDS 27 XXX.
MASTER FORMULA 27 XXXI. MULTIPLE-ITEM ENTRIES 27 XXXII. MULTIPLE
STRENGTHS OF FORMULATIONS 27 XXXIII. NOVEL DRUG DELIVERY SYSTEMS 27
XXXIV. PARTICLE COATING 28 XXXV. PRESERVATIVES IN COMPRESSED SOLID
DOSAGE FORMULATIONS 28 XXXVI. PUNCH SIZE AND SHAPE 28 XXXVII. REWORKING
CULLS 28 XXXVIII. SCALE-UP 28 XXXIV SEGREGATION 29 XXXV. SIFTING
INGREDIENTS AND GRANULES 29 XXXVI. SPECIFICATIONS 29 XXXVII. STABILITY
TESTING 29 XXXVIII. STORAGE OF IN-PROCESS MATERIAL 30 XXXIX. TABLET
FRIABILITY 30 XL. TABLET MANUFACTURING 30 XLI. TABLETS 30 XLII.
WATER-PURIFIED USP 31 XLIII. WEIGHT VARIATION AND CONTENT UNIFORMITY 31
XLIV. WET GRANULATION VS. DRY GRANULATION OR DIRECT COMPRESSION 32 PART
II COMPRESSED SOLID FORMULATIONS 33 ACETAMINOPHEN, IBUPROFEN, AND
ORPHENADRINE TABLETS (250 MG/200 MG/200 MG) 35 ACETAMINOPHEN,
NOREPHEDRINE, AND PHENYLTOLOXAMINE TABLETS (300 MG/25 MG/22 MG) 35
ACETAMINOPHEN AND PHENPROBAMAT TABLETS (200 MG/200 MG) 36 ACETAMINOPHEN
AND ORPHENADRINE CITRATE TABLETS (450 MG/35 MG) 37 ACETAMINOPHEN
TABLETS, CHEWABLE 38 ACETAMINOPHEN, DEXTROPROPOXYPHEN HYDROCHLORIDE
TABLETS (325 MG/32 MG) 39 ACETAMINOPHEN AND CODEINE TABLETS [34] 40
ACETAMINOPHEN, SALICYLAMIDE, CAFFEINE, AND CODEINE TABLETS (150 MG/200
MG/50 MG/10 MG) 41 ACYCLOVIR TABLETS [162] 42 ACYCLOVIR
WATER-DISPERSIBLE TABLETS (800 MG) 42 ALBENDAZOLE TABLETS (200 MG) 43
ALENDRONATE TABLETS [38] 44 ALENDRONATE TABLETS, EFFERVESCENT (10 MG) 44
ALENDRONATE SODIUM TABLETS (50 MG) 44 ALLOPURINOL TABLETS (100 MG) [84]
45 ALLOPURINOL TABLETS (300 MG) 46 ALPRAZOLAM TABLETS (0.25 MG/0.50
MG/1.0 MG) 47 4-AMINO-L-HYDROXYBUTYLIDENE-L.L-BISPHOSPHONIC ACID TABLETS
(5 MG) 48 AMINOPHYLLINE TABLETS (100 MG) 48 AMIODARONE TABLETS (200 MG)
49 AMLODIPINE BESYLATE TABLETS |9] 50 AMITRIPTYLINE TABLETS (50 MG) [42]
51 AMOXICILLIN TABLETS (250 MG/500 MG/1 G) 52 AMOXICILLIN TRIHYDRATE AND
CLAVULANATE POTASSIUM TABLETS (500 MG/125 MG) 53 AMOXICILLIN AND
POTASSIUM CLAVULANATE TABLETS (250 MG/62.5 MG) 54 AMPHETAMINE SALTS
TABLETS 54 ATENOLOL TABLETS (50 MG/100 MG) 55 ATORVASTATIN TABLETS (10
MG/20 MG) 57 AZITHROMYCIN TABLETS (250 MG) 58 BENZAFIBRATE TABLETS (200
MG) 59 BENAZEPRIL HYDROCHLORIDE TABLETS 60 BETAMETHASONE TABLETS (0.50
MG) 61 BIRB 796 TABLETS (100 MG) 61 BISOPROLOL FUMARATE AND
HYDROCHLOROTHIAZIDE TABLETS 62 BROMAZEPAM TABLETS (3 MG) 62 BROMHEXINE
TABLETS (8 MG) 63 BROMOCRIPTINE TABLETS 63 BUFIOMEDIL HYDROCHLORIDE
TABLETS (150 MG/300 MG) 64 BUFLOMEDIL HYDROCHLORIDE TABLETS (600 MG) 65
BUPROPION HYDROCHLORIDE TABLETS 66 BUSPIRONE HYDROCHLORIDE TABLETS 67
BUSPIRONE HYDROCHLORIDE TABLETS, CONTROLLED-RELEASE (30 MG) 67 CAPTOPRIL
TABLETS (25 MG) 68 CARBAMAZEPINE TABLETS (200 MG) 69 CARBAMAZEPINE
TABLETS (200 MG) 70 CARBIDOPA AND LEVODOPA TABLETS 70 CARISOPRODOL
TABLETS 71 CARVEDILOL TABLETS 71 CEFADROXIL DISPERSIBLE TABLETS (250 MG)
72 CEFDINIR TABLETS (300 MG) 72 CEFIXIME TABLETS (400 MG) 73 CEFPROZIL
TABLETS (250 MG) 73 CELECOXIB TABLETS 74 CEPHALEXIN TABLETS 74
CETIRIZINE AND PSEUDOEPHEDRINE DELAYED-RELEASE TABLETS (5 MG/120 MG) 74
CETIRIZINE HYDROCHLORIDE TABLETS (10 MG) 75 CHLORCYCLIZINE HYDROCHLORIDE
TABLETS (50 MG) 75 CHLORDIAZEPOXIDE AND CLINIDIUM BROMIDE TABLETS (5
MG/2.5 MG) 76 CHLORDIAZEPOXIDE TABLETS (10 MG) 76 CHLOROQUINE TABLETS
(250 MG) 77 CHOLINE THEOPHYLLINATE TABLETS (100 MG) 77 CHYMOTRYPSINE
TABLETS (25 MG) 77 CILAZAPRIL TABLETS (2.5 MG) 78 CIMETIDINE TABLETS
(200 MG) 79 CIPROFLOXACIN TABLETS (500 MG) 80 CIPROFLOXACIN TABLETS (750
MG) 81 CISAPRIDE TABLETS (5 MG) 82 CITALOPRAM HYDROBROMIDE TABLETS 82
CLARITHROMYCIN TABLETS (250 MG/500 MG) 83 CLENBUTEROL TABLETS (20 MEG)
84 CLINDAMYCIN TABLETS (20 MG) 84 CLOBAZAM TABLETS (10 MG) 85 CLOMIFEN
CITRATE TABLETS (50 MG) 85 CLOMIPRAMINE HYDROCHLORIDE TABLETS,
EFFERVESCENT (300 MG) 85 CLOMIPRAMINE HYDROCHLORIDE TABLETS, BUCCAL (10
MG) 86 CLONAZEPAM TABLETS (1 MG/2 MG) 86 CLONIDINE TABLETS (0.1 MG/0.2
MG/0.3 MG) 86 CLOPIDOGREL BISULFATE TABLETS (75 MG) 87 CODEINE,
ACETAMINOPHEN, AND PENTOBARBITAL TABLETS (15 MG/300 MG/30 MG) 87
CONJUGATED ESTROGENS (0.3-2.50 MG) 88 CONJUGATED ESTROGENS AND
MEDROXYPROGESTERONE TABLETS 89 COUMADIN TABLETS 89 CYCLOBENZAPRINE
HYDROCHLORIDE TABLETS (10 MG) [64] 90 CYPROHEPTADINE TABLETS (4 MG) 90
DAPSONE TABLETS (50 MG) 91 DESLORATIDINE TABLETS (5 MG) 91 DESOGESTREL
AND ETHINYL ESTRADIOL TABLETS (0.15 MG/0.03 MG) 91 DIAZEPAM TABLETS (2
MG/5 MG/10 MG) 92 DICLOFENAC SODIUM TABLETS (25 MG) 93 DICLOFENAC SODIUM
TABLETS (50 MG) 94 DICLOFENAC SODIUM TABLETS (100 MG) 94 DIDANOSINE
TABLETS (50 MG) 95 DIETHYLCARBAMAZINE TABLETS (100 MG) 95 DIFENOXIN AND
ATROPINE TABLETS (0.5 MG/0.025 MG) 96 DIGOXIN TABLETS (0.125 MG/0.25 MG)
[92] 96 DILTIAZEM HYDROCHLORIDE TABLETS (60 MG) 97 DILTIAZEM TABLETS 60
MG [95] 98 DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE TABLETS (2.5
MG/0.025 MG) 98 DIVALPROATE SODIUM TABLETS (125 MG) [121] 99 DIVALPROEX
SODIUM TABLETS (400 MG) 100 DOXAZOSIN MESYLATE TABLETS (1 MG/2 MG/4 MG/8
MG) [112] 100 DOXYCYCLINE HYDROCHLORIDE TABLETS (100 MG) [91] 101
ENALAPRIL MALEATE TABLETS (2.5 MG/5 MG/10 MG/20 MG) [66] 102 ENALAPRIL
MALEATE TABLETS (10 MG) 102 ENOXACIN TABLETS (400 MG) 103 ERYTHROMYCIN
ETHYLSUCCINATE TABLETS (400 MG) 104 ERYTHROMYCIN PARTICLE-COATED TABLETS
(150 MG) 105 ERYTHROMYCIN TABLETS (100 MG) 106 ERYTHROMYCIN TABLETS (100
MG) 106 ERYTHROMYCIN TABLETS (500 MG) 107 ESTAZOLAM TABLETS (1 MG) 109
ESTAZOLAM TABLETS (2 MG) 109 ESTRADIOL TABLETS (0.5 MG/1 MG/2 MG) [85]
110 ESTROPIPATE TABLETS (0.626 MG/1.25 MG/2.25 MG/5 MG) 110 ETHAMBUTOL
TABLETS (400 MG) 111 ETHAMBUTOL TABLETS (800 MG) 112 ETOPHYLLINE AND
THEOPHYLLINE TABLETS (100 MG/22 MG) 113 ETOPHYLLINE AND THEOPHYLLINE
TABLETS (100 MG/22 MG) 113 FAMCICLOVIR TABLETS (125 MG/250 MG) 114
FAMOTIDINE TABLETS (20 MG) [146] 115 FAMOTIDINE TABLETS (40 MG) 116
FEXOFENADINE TABLETS (30 MG/60 MG/180 MG) [26] 116 FEXOFENADINE AND
PSEUDOEPHEDRINE TABLETS (10 MG/240 MG) [111] 117 FINASTERIDE TABLETS (5
MG) 118 FLUCONAZOLE TABLETS (50 MG/100 MG/200 MG) [75] 118 FLUVOXAMINE
MALEATE TABLETS (50 MG) 119 FLUOXETINE HYDROCHLORIDE TABLETS (10 MG/20
MG/40 MG) [33] 120 FLUOXETINE HYDROCHLORIDE TABLETS (12.5 MG/25.0 MG)
CONTROLLED-RELEASE BILAYER 121 FOSINOPRIL TABLETS (20 MG) [ 133] 122
FUCIDINE TABLETS (125 MG) 122 FURAZOLIDONE TABLETS (100 MG) 123
FUROSEMIDE TABLETS (40 MG) [7] 123 FUROSEMIDE TABLETS (40 MG) 124
FUROSEMIDE TABLETS (200 MG) 125 GABAPENTIN TABLETS (600 MG) 125
GALANTHAMINE HYDROBROMIDE TABLETS (1 MG) 126 GEMFIBROZIL TABLETS (600
MG) [114] 127 GLIBENCLAMIDE TABLETS (2.5 MG) 128 GLIBENCLAMIDE TABLETS
(5 MG) 129 GLICLAZIDE TABLETS (80 MG) 130 GLIMEPIRIDE TABLETS (1 MG/2
MG) [129] 131 GLIPIZIDE TABLETS (5 MG) [71] 132 GLIPIZIDE TABLETS CR (5
MG) 133 GLYBURIDE AND METFORMIN TABLETS (250 MG/500 MG; 1.25 MG/2.50 MG)
[124] 134 GLYBURIDE TABLETS (5 MG) [81] 135 GRISEOFULVIN TABLETS (125
MG) 136 GRISEOFULVIN TABLETS (500 MG) 136 HYDROCHLOROTHIAZIDE AND
POTASSIUM CHLORIDE (50 MG/300 MG) 137 HYDROCHLOROTHIAZIDE TABLETS (50
MG) [10] 137 HYDROCHLOROTHIAZIDE TABLETS (50 MG) 138 HYDROCODONE AND
ACETAMINOPHEN TABLETS (5.0 MG/500 MG; 7.50 MG/750 MG) 139 HYDROCODONE
AND IBUPROFEN TABLETS 140 HYDROXYZINE TABLETS [132] 140 HYOSCINE BUTYL
BROMIDE TABLETS (10 MG) 141 IBUPROFEN TABLETS (400 MG) [19] 142
IBUPROFEN TABLETS (400 MG) 143 IBUPROFEN TABLETS (600 MG) 144 IMIPRAMINE
TABLETS (25 MG) 144 IRBESARTAN TABLETS (75 MG/150 MG/300 MG) [149] 145
ISONIAZID TABLETS (100 MG) 146 ISOSORBIDE DINITRATE TABLETS (5 MG) [68]
147 ISOSORBIDE DINITRATE TABLETS (10 MG) 147 KETOTIFEN TABLETS (1 MG)
148 LAMOTRIGINE TABLETS (100 MG) 148 LANSOPRAZOLE TABLETS (10 MG OR 20
MG) 149 LANSOPRAZOLE TABLETS (10 MG OR 20 MG) 149 LANSOPRAZOLE TABLETS
CHEWABLE (10 MG/20 MG) 149 LANSOPRAZOLE TABLETS, RAPID DISSOLUTION (20
MG) 150 LEVAMISOLE HYDROCHLORIDE TABLETS (40 MG) 150 LEVAMISOLE TABLETS
(150 MG) 151 LEVOFLOXACIN TABLETS (250 MG) [69] 151 LEVOTHYROXINE
TABLETS [4] 151 LEVOTHYROXINE TABLETS (50 MEG) [25] 152 LEVOTHYROXINE
TABLETS (0.025 MG) 152 LINEZOLID TABLETS (400 MG) 153 LISINOPRIL TABLETS
(10 MG) [52] 153 LOMEFLOXACIN HYDROCHLORIDE TABLETS (400 MG) 154
LOPERAMIDE HYDROCHLORIDE TABLETS (2 MG) 154 LORATADINE AND
PSEUDOEPHEDRINE SULFATE TABLETS (10 MG/240 MG) [127] 155 LORATADINE
TABLETS (10 MG) [32] 156 LORAZEPAM TABLETS (0.50 MG/1 MG/2 MG) [37] 157
LOSARTAN AND HYDROCHLOROTHIAZIDE TABLETS (50 MG/12.5 MG) [118] 157
LOSARTAN POTASSIUM TABLETS (50 MG) [93] 158 MEBENDAZOL TABLETS (100 MG)
159 MECLIZINE HYDROCHLORIDE TABLETS (25 MG) [135] 159
MEDROXYPROGESTERONE ACETATE TABLETS (2.5 MG/5 MG/10 MG) [89] 159
MEFANAMIC ACID AND DICYCLOMINE HYDROCHLORIDE TABLETS (250 MG/10 MG) 160
MEFENAMIC ACID TABLETS (250 MG) 160 MEFLOQUINE HYDROCHLORIDE TABLETS
(250 MG) 161 MEPROBAMATE AND PHENOBARBITAL TABLETS (400 MG/30 MG) 161
MEPROBAMATE AND PHENOBARBITAL TABLETS (400 MG/30 MG) 162 MEPROBAMATE
TABLETS (400 MG) 162 MEPROBAMATE TABLETS (400 MG) 163 METAMIZOL TABLETS
(500 MG) 163 METAMIZOL TABLETS (500 MG) 164 METFORMIN HYDROCHLORIDE
TABLETS, EXTENDED RELEASE (500 MG) 165 METFORMIN TABLETS (500 MG) [40]
166 METFORMIN TABLETS, EXTENDED RELEASE (500 MG) 167 METHENAMINE TABLETS
(500 MG) 167 METHYCLOTHIAZIDE AND DESERPIDINE TABLETS (5 MG/0.25 MG) 168
METHYCLOTHIAZIDE TABLETS (5 MG) 169 METHYLERGOTAMINE MALATE TABLETS (0.5
MG) 170 METHYLPHENIDATE HYDROCHLORIDE TABLETS EXTENDED RELEASE (18 MG/36
MG) [122] 170 METHYLPREDNISOLONE TABLETS (2 MG/4 MG/8 MG/16 MG/24 MG/32
MG) [99] 171 METOCLOPRAMIDE TABLETS (10 MG) [138] 171 METOCLOPRAMIDE
TABLETS (20 MG) 172 METOPROLOL SUCCINATE TABLETS (95 MG) [21] 173
METOPROLOL TARTRATE TABLETS [36] 173 METRONIDAZOLE EFFERVESCENT VAGINAL
TABLETS (500 MG) 174 METRONIDAZOLE, FURAZOLIDONE, AND LOPERAMIDE TABLETS
(200 MG/25 MG/2 MG) 174 METRONIDAZOLE TABLETS (200 MG) 175 METRONIDAZOLE
TABLETS (200 MG/400 MG) 176 METRONIDAZOLE TABLETS (400 MG) [147] 177
METRONIDAZOLE TABLETS (500 MG) 177 MIRTAZAPINE TABLETS [145] 178
MONTELUKAST SODIUM TABLETS (5 MG) [54] 178 NALIDIXIC ACID TABLETS (500
MG) 179 NALIDIXIC ACID TABLETS (500 MG) 179 NAPROXEN TABLETS (250 MG)
[58] 180 NAPROXEN TABLETS (250 MG/500 MG) 181 NAPROXEN TABLETS (450 MG)
182 NEOMYCIN TABLETS (250 MG) 182 NIFEDIPINE TABLETS (5 MG) 183
NIFEDIPINE TABLETS (10 MG) 183 NIMESULIDE DISPERSIBLE TABLETS (100 MG)
184 NITRENDIPINE TABLETS (25 MG) 184 NITROFURANTOIN TABLETS (100 MG) 185
NITROFURANTOIN TABLETS (100 MG) 185 NITROGLYCERINE TABLETS (0.3 MG) 186
NORAMIDOPYRINE METHANSULFONATE AND DICYCLOMINE HYDROCHLORIDE TABLETS
(500 MG/10 MG) 187 NORETHINDRONE AND ETHINYL ESTRADIOL TABLETS (0.75
MG/0.035 MG; 0.50 MG/0.035 MG: 1.0 MG/O.O35 MG) [1311 188 NORFLOXACIN
TABLETS (400 MG) 189 NORGESTIMATE AND ETHINYL ESTRADIOL TABLETS (0.18
MG/0.035 MG: 0.215 MG/0.035; 0.25 MG/0.035 MG) [27] 190 NYSTATIN TABLETS
(50 MG) 190 NYSTATIN TABLETS (200 MG) 191 OLANZAPINE TABLETS [110] 191
OMEPRAZOLE AND IBUPROFEN TABLETS (10 MG/400 MG) 192 OMEPRAZOLE TABLETS
(10 MG/20 MG) 192 OMEPRAZOLE TABLETS (10 MG/20 MG) 193 OMEPRAZOLE
TABLETS, CHEWABLE (10 MG/20 MG) 193 OMEPRAZOLE TABLETS, RAPID
DISSOLUTION (20 MG) 193 OXYBUTYNIN CHLORIDE TABLETS (5 MG/10 MG) [194]
194 OXYCODONE HYDROCHLORIDE AND ACETAMINOPHEN TABLETS (5 MG/325 MG) (90]
195 OXYCODONE HYDROCHLORIDE TABLETS (5 MG) [119] 196 OXYTETRACYCLINE
TABLETS (250 MG) 196 PANTOPRAZOLE TABLETS [77] 1% PANTOPROZOLE TABLETS
(10 MG/20 MG) 197 PANTOPRAZOLE TABLETS, CHEWABLE (10 MG/20 MG) 197
PANTOPRAZOLE TABLETS, RAPID DISSOLUTION (20 MG) 198 PARA AMINO SALICYLIC
ACID TABLETS (500 MG) 199 PAROXETINE HYDROCHLORIDE TABLETS (10 MG/20
MG/30 MG/40 MG) [15] 200 PENICILLIN CHEWABLE TABLETS (125 MG) [103] 201
PERFLOXACIN TABLETS (400 MG) 202 PHENDIMETRAZIN TABLETS (35 MG) 202
PHENINDION TABLETS (50 MG) 203 PHENOXYMETHYL PENICILLIN POTASSIUM
TABLETS (250 MG) 204 PHENYLBUTAZONE TABLETS (100 MG) 205
PHENYLPROPANOLAMINE HYDROCHLORIDE TABLETS (60 MG) 206 PHENYTOIN SODIUM
TABLETS (100 MG) 206 PHENYTOIN SODIUM TABLETS (100 MG) 207 PHENYTOIN
TABLETS (100 MG) 207 PIOGLITAZONE HYDROCHLORIDE TABLETS (15 MG/30 MG/45
MG) [87] 208 PIPEMIDIC ACID TABLETS (200 MG) 209 PIPOBROMAN TABLETS (25
MG) 210 POTASSIUM CHLORIDE TABLETS (30 MG) [56, 137] 211 PRAVASTATIN
SODIUM TABLETS (10 TO 40 MG) [48] 212 PRAZOSIN TABLETS (5 MG) 212
PREDNISOLONE TABLETS (5 MG) 213 PREDNISOLONE TABLETS (10 MG) 214
PREDNISOLONE TABLETS (20 MG) 214 PREDNISOLONE TABLETS (20 MG) 214
PREDNISONE TABLETS (10 MG) 215 PROBENECID TABLETS (500 MG) 215
PROMETHAZINE HYDROCHLORIDE TABLETS (10 MG) [107] 216 PROMETHAZINE
HYDROCHLORIDE TABLETS (25 MG) 217 PROPRANOLOL HYDROCHLORIDE TABLETS (10
MG) 217 PROPRANOLOL TABLETS (40 MG) 217 PROPRANOLOL HYDROCHLORIDE
TABLETS (10 MG) [141] 218 PYRAZINAMIDE TABLETS (500 MG) 219 PYRAZINAMIDE
TABLETS (500 MG) 219 PYRAZINAMIDE TABLETS (500 MG) 220 PYRIDOSTIGMINE
BROMIDE TABLETS (10 MG) 221 QUETIAPINE FUMARATE TABLETS (25 MG/100
MG/200 MG) [161] 221 QUINAPRIL HYDROCHLORIDE TABLETS (5 MG/10 MG/20
MG/40 MG) [51] 222 QUININE SULFATE TABLETS (300 MG) 223 QUINOLONE
ANTIBIOTIC TABLETS (100 MG) 223 RABEPRAZOLE SODIUM TABLETS (20 MG) [109]
224 RALOXIFENE TABLETS (60 MG) [100] 225 RANITIDINE HYDROCHLORIDE
TABLETS (150 MG) 226 RANITIDINE TABLETS (75 MG) 226 RANITIDINE TABLETS
(150 MG) [41] 227 RANITIDINE TABLETS (300 MG) 228 RIFAMPICIN, ISONIAZID,
ETHAMBUTOL, AND PYRIDOXINE TABLETS (300 MG/200 MG/25 MG) 229 RIFAMPICIN
TABLETS (300 MG) 231 RIFAMPICIN TABLETS (450 MG) 232 RISEDRONATE SODIUM
TABLETS (5 MG/30 MG) [188] 233 RISPERIDONE TABLETS (4 MG) [1050] 234
ROFECOXIB TABLETS (12.5 MG/25 MG/50 MG) [31] 234 ROSIGLITAZONE MALEATE
TABLETS (2 MG/4 MG/8 MG) [86] 235 ROXITHROMYCIN DISPERSIBLE TABLETS (200
MG) 235 SALBUTAMOL TABLETS (2 MG) 236 SALBUTAMOL TABLETS (4 MG) 237
SERRATIOPEPTIDASE TABLETS (10 MG) 237 SERRATIOPEPTIDASE TABLETS (10 MG)
238 SERTRALINE HYDROCHLORIDE TABLETS (25 MG/50 MG/100 MG) [14] 238
SILDENAFIL TABLETS (25 MG/50 MG/100 MG) [43] 239 SILIMARIN TABLETS (35
MG) 240 SIMVASTATIN TABLETS (10 MG) [17] 241 SIMVASTATIN TABLETS (20 MG)
242 SPIRONOLACTONE TABLETS (25 MG/50 MG/100 MG)) [130] 242 STALOL
HYDROCHLORIDE TABLETS (500 MG) 243 SULFADIMIDINE TABLETS (500 MG) 243
SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS (400 MG/80 MG; 800 MG/160 MG;
100 MG/20 MG) ) [106] 244 SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS (400
MG/80 MG) 245 SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS (800 MG/160 MG;
400 MG/80 MG) 245 SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS, DISPERSIBLE
(800 MG/160 MG) 246 SULFATHIAZOLE TABLETS (250 MG) 247 SUMATRIPTAN
SUCCINATE TABLETS (25 MG/50 MG) [125] 247 TAMOXIFEN TABLETS (10 MG/20
MG) [191] 248 TEMAFLOXACIN HYDROCHLORIDE TABLETS (200 MG/300 MG) 249
TENOXICAM TABLETS (20 MG) 250 TERAZOSIN TABLETS (1 MG-10 MG) [126] 250
TERAZOSIN TABLETS (1 MG) 251 TERBINAFINE TABLETS (250 MG) 252
TERFENADINE TABLETS (60 MG) 252 TETRACYCLINE TABLETS (125 MG) 253
TETRACYCLINE TABLETS (250 MG) 253 TETRAZEPAM TABLETS (50 MG) 254
THEOPHYLLINE AND EPHEDRINE TABLETS (130 MG/15 MG) 254 THEOPHYLLINE
TABLETS (100 MG) 254 THEOPHYLLINE TABLETS (100 MG) 255 THEOPHYLLINE
TABLETS CR (200 MG) 255 TIBOLONE TABLETS (0.3 MG) 256 TICLOPIDINE
HYDROCHLORIDE TABLETS (250 MG) 256 TOLTERODINE TABLETS (1 MG/2 MG) [171]
257 TOPIRAMATE TABLETS (100 MG/200 MG) [189] 257 TOSUFLOXACIN TOSYLATE
TABLETS (75 MG) 257 TRAZODONE HYDROCHLORIDE TABLETS (100 MG) [61] 258
TRIAMCINOLONE TABLETS (4 MG) 258 TRIFLUOPERAZINE TABLETS (5 MG) 258
TULOBUTEROL HYDROCHLORIDE TABLETS (1 MG) 259 VALACYCLOVIR HYDROCHLORIDE
TABLETS (500 MG/1 G) [144] 259 VALDECOXIB TABLETS (10 MG/20 MG) [148]
260 VALPROATE SODIUM TABLETS (500 MG) [121] 260 VALSARTAN AND
HYDROCHLOROTHIAZIDE TABLETS (80 MG/12.5 MG: 160 MG/25 MG) [108] 261
VENLAFAXINE HYDROCHLORIDE TABLETS (25 MG/37.5 MG/50 MG) [53] 262
VERAPAMIL TABLETS (120 MG) [65] 263 WARFARIN TABLETS (1, 2, 2.5, 3. 4,
5, 6, 7.5. AND 10 MG) [59] 264 ZOLPIDEM TARTRATE TABLETS (5 MG/10 MG)
[35] 265 APPENDIX COATING SOLUTIONS 267 I. INTRODUCTION 267 II.
HYDROXYPROPYL METHYLCELLULOSE (METHOCEL, HPMC) AQUEOUS COATINGS 268 A.
BRITE ROSE 268 B. CHERRY RED 268 C. GERANIUM ROSE 269 D. GLOSS 269 E.
RED 269 F. MODERATE RED 269 G. CLEAR 270 H. GREEN 270 I. HOLBERRY RED
271 J. SUN ORANGE 271 K. OPADRY YELLOW (CAPLETS) 271 L. OPADRY YELLOW
(TABS) 272 M. OPADRY RED 272 N. OPADRY GREEN 272 O. WHITE COATING 273
III. HYDROXYPROPYL METHYLCELLULOSE OPAQUE ORGANIC COATING 273 A. BRITE
GREEN 273 B. RED MAHOGANY 274 C. SUN ORANGE 274 D. DARK RED 275 E. DEEP
YELLOW 275 F PALE YELLOW 275 G. SCARLET RED 275 IV. HYDROXYPROPYL METHYL
CELLULOSE-HYDROXYPROPYL CELLULOSE (KLUCEL) COATING 276 A. WHITE 276 V.
HYDROXYPROPYL METHYLCELLULOSE-ETHYLCELLULOSE COATING 276 A. REDDISH
ORANGE OPAQUE 276 B. SUBCOATING SOLUTION 277 VI. HYDROXYMETHYL CELLULOSE
AND HYDROXY CELLULOSE COATING 277 A. BLUE 277 B. CLEAR (50:50) 277 VII.
HYDROXYMETHYL CELLULOSE AND ETHYL CELLULOSE COATING 278 A. CLEAR 278
VIII. POLYVINYLPYRROLIDONE COATINGS 278 A. SUBCOATING 278 B. KOLLIDON
VA64 279 C. KOLLIDON VA 64 AND POLYVINYL ALCOHOL 279 D. KOLLIDON 30 AND
SHELLAC 280 E. KOLLIDON VA 64 AND HYDROXYPROPYLMETHYL CELLULOSE 280 F.
POVIDONE, ETHYLCELLULOSE, AND TALC 281 IX. CELLULOSE ACETATE PHTHALATE
AND CARBOWAX COATINGS 281 A. BRITE GREEN 281 B. CHERRY RED 281 C. CLEAR
282 D. ORANGE 282 E. RED MAHOGANY 282 F. ORANGE 282 X. SUGAR COATINGS
282 A. BASIC 282 B. AUTOMATIC 283 C. MANUAL WHITE 283 XI. ENTERIC
COATINGS 284 A. KOLLICOAT AND KOLLIDON ENTERIC FILM COATING 284 B.
EUDRAGIT ENTERIC AQUEOUS 284 1. BRICK RED 284 2. YELLOW 285 3. BROWN 285
4. DARK ORANGE 285 5. ORANGE 286 6. DISPERSED ORANGE 286 C.
HYDROXYPROPYL METHYLCELLULOSE PHTHALATE ENTERIC COATING 286 1. CLEAR
ENTERIC 286 2. ORCHID PINK OPAQUE 287 3. LIGHT APRICOT ORANGE 287 INDEX
289 |
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| illustrated | Not Illustrated |
| index_date | 2024-07-02T13:37:48Z |
| indexdate | 2024-07-09T20:33:42Z |
| institution | BVB |
| isbn | 0849317460 |
| language | English |
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| spelling | Niazi, Sarfaraz K. Verfasser aut Handbook of pharmaceutical manufacturing formulations 1 Compressed solid products Sarfaraz K. Niazi Boca Raton [u.a.] CRC Press 2004 296 S. 29 cm txt rdacontent n rdamedia nc rdacarrier (DE-604)BV021244478 1 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014565995&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Niazi, Sarfaraz K. Handbook of pharmaceutical manufacturing formulations |
| title | Handbook of pharmaceutical manufacturing formulations |
| title_auth | Handbook of pharmaceutical manufacturing formulations |
| title_exact_search | Handbook of pharmaceutical manufacturing formulations |
| title_exact_search_txtP | Handbook of pharmaceutical manufacturing formulations |
| title_full | Handbook of pharmaceutical manufacturing formulations 1 Compressed solid products Sarfaraz K. Niazi |
| title_fullStr | Handbook of pharmaceutical manufacturing formulations 1 Compressed solid products Sarfaraz K. Niazi |
| title_full_unstemmed | Handbook of pharmaceutical manufacturing formulations 1 Compressed solid products Sarfaraz K. Niazi |
| title_short | Handbook of pharmaceutical manufacturing formulations |
| title_sort | handbook of pharmaceutical manufacturing formulations compressed solid products |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014565995&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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