Investigation on intradermal delivery of drug powder by needle-free injection:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Erlangen-Nürnberg, Univ., Diss., 2005. - Zsfass. in dt. Sprache |
| Beschreibung: | 109 S. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | INVESTIGATION ON INTRADERMAI DELIVERY OF DRUG POWDER BY NEEDLE-FREE
INJECTION DEN NATURWISSENSCHAFTLICHEN FAKULTATEN DER FRIEDRICH
-ALEXANDER- UNIVERSITAT ERLANGEN -NURNBERG ZUR ERLANGUNG DES
DOKTORGRADES VORGELEGT VON KATJA LAHM AUS STEINHORING - 2005 - TABLE OF
CONTENT 1 INTRODUCTION 1 1.1 THE APPLICATION ROUTES 2 1.2 STRUCTURE AND
FUNCTION OF THE SKIN 3 1.2.1 THE EPIDERMIS 4 1.2.2 THE DERMAL -
EPIDERMAL JUNCTION 6 1.2.3 THEDERMIS 6 1.2.4 BLOOD VESSELS AND
LYMPHVESSELS 7 1.3 THE POWDERJECT* DEVICE 7 1.3.1 THEND- 1 RESEARCH
DEVICE 8 1.3.2 THE FIVE-PIECE DRUG CASSETTE 10 1.4 BIOPHARMACEUTICAL
ASPECTS 11 1.4.1 PHARMACOKINETICS 11 1.4.2 PHYSIOLOGICAL RESPONSE 11
1.4.3 BIOMECHANIC PROPERTIES OF THE SKIN 12 2 OBJECTIVES OF THE PROJECT
16 3 MATERIALS AND METHODS : 18 3.1 MODEL COMPOUND 18 3.2 POWDER
PROCESSING CONSIDERATIONS 20 3.3 MILLING 20 3.3.1 SELECTION OF MILLS 22
3.3.2 SELECTION OF OPERATION PARAMETERS 23 3.4 SIEVING 25 3.5
CHARACTERIZATION 28 3.5.1 PARTICLE SIZE DISTRIBUTION 28 3.5.2 SEPARATION
EFFICIENCY 31 3.6 MODIFIED COMPOUNDS 34 3.6.1 ATTRITION RESISTANT
COMPOUNDS 34 3.6.2 HIGHER DENSITY COMPOUNDS 36 3.7 MEASUREMENT OF
ATTRITION 37 3.7.1 IMAGE ANALYSIS 38 3.7.2 IN-SITU MEASUREMENT 39 3.7.3
IN-VITRO ACTUATION 40 3.8 EXPERIMENTAL INJECTIONS 41 3.8.1 THE TEST RIG
42 3.8.2 DOSAGE 43 3.8.3 POLYETHYLENEGLYCOL TEST BEDS 43 3.8.4 GELATINE
TEST BEDS 44 3.8.5 COMPOSITE TEST BEDS 45 3.8.6 EX-VIVO TEST BEDS 46
3.8.6.1 STORAGE OF EXCISED SKIN 46 3.8.6.2 TAPE STRIPPING OF STRATUM
CORNEUM 47 3.8.6.3 SKIN SOLUBILIZATION 47 3.9 QUANTIATATIVE ANALYSIS OF
IBUPROFEN 48 3.9.1 UV-SPECTROSCOPY 48 3.9.2 REVERSED PHASE HPLC 48
3.9.2.1 SAMPLE PREPARATION 49 3.9.2.2 VALIDATION 49 3.10 COMPLEMENTARY
METHODS 51 3.10.1 CASTS 51 3.10.2 DERMATOSCOPY ....- 52 4 RESULTS AND
DISCUSSION 53 4.1 ATTRITION ; 53 4.1.1 PRELIMINARY EXAMINATIONS 53 4.1.2
IN-SITU MEASUREMENTS 54 4.1.3 IN-VITRO ACTUATION 67 4.1.4 CONCLUSIONS 73
4.2 ACTUATIONS ONTO TEST BEDS 74 4.2.1 SENSITIVITY TO VARIED CONDITIONS
74 4.2.2 DELIVERY OF VARIED MASSES ONTO PEG OF VARIED COMPOSITION 78
4.2.3 DELIVERY OF SD5 INTO PEG 84 4.2.4 COMPOSITE TEST BEDS 85 4.3
EX-VIVO EXPERIMENTS 88 4.3.1 PRELIMINARY EXPERIMENTS 88 4.3.2 ACTUATION
OF DIFFERENT DOSES 89 4.3.3 ACTUATION OF MODIFIED COMPOUNDS .91 4.3.4
CONCLUSIONS 92 4.4 VISUALISATION METHODS 93 4.4.1 CASTS 95 4.2.2
DERMATOSCOPY 99 5 SUMMARY 101 6 ZUSAMMENFASSUNG 102 7 REFERENCES 104
|
| adam_txt |
INVESTIGATION ON INTRADERMAI DELIVERY OF DRUG POWDER BY NEEDLE-FREE
INJECTION DEN NATURWISSENSCHAFTLICHEN FAKULTATEN DER FRIEDRICH
-ALEXANDER- UNIVERSITAT ERLANGEN -NURNBERG ZUR ERLANGUNG DES
DOKTORGRADES VORGELEGT VON KATJA LAHM AUS STEINHORING - 2005 - TABLE OF
CONTENT 1 INTRODUCTION 1 1.1 THE APPLICATION ROUTES 2 1.2 STRUCTURE AND
FUNCTION OF THE SKIN 3 1.2.1 THE EPIDERMIS 4 1.2.2 THE DERMAL -
EPIDERMAL JUNCTION 6 1.2.3 THEDERMIS 6 1.2.4 BLOOD VESSELS AND
LYMPHVESSELS 7 1.3 THE POWDERJECT* DEVICE 7 1.3.1 THEND- 1 RESEARCH
DEVICE 8 1.3.2 THE FIVE-PIECE DRUG CASSETTE 10 1.4 BIOPHARMACEUTICAL
ASPECTS 11 1.4.1 PHARMACOKINETICS 11 1.4.2 PHYSIOLOGICAL RESPONSE 11
1.4.3 BIOMECHANIC PROPERTIES OF THE SKIN 12 2 OBJECTIVES OF THE PROJECT
16 3 MATERIALS AND METHODS : 18 3.1 MODEL COMPOUND 18 3.2 POWDER
PROCESSING CONSIDERATIONS 20 3.3 MILLING 20 3.3.1 SELECTION OF MILLS 22
3.3.2 SELECTION OF OPERATION PARAMETERS 23 3.4 SIEVING 25 3.5
CHARACTERIZATION 28 3.5.1 PARTICLE SIZE DISTRIBUTION 28 3.5.2 SEPARATION
EFFICIENCY 31 3.6 MODIFIED COMPOUNDS 34 3.6.1 ATTRITION RESISTANT
COMPOUNDS 34 3.6.2 HIGHER DENSITY COMPOUNDS 36 3.7 MEASUREMENT OF
ATTRITION 37 3.7.1 IMAGE ANALYSIS 38 3.7.2 IN-SITU MEASUREMENT 39 3.7.3
IN-VITRO ACTUATION 40 3.8 EXPERIMENTAL INJECTIONS 41 3.8.1 THE TEST RIG
42 3.8.2 DOSAGE 43 3.8.3 POLYETHYLENEGLYCOL TEST BEDS 43 3.8.4 GELATINE
TEST BEDS 44 3.8.5 COMPOSITE TEST BEDS 45 3.8.6 EX-VIVO TEST BEDS 46
3.8.6.1 STORAGE OF EXCISED SKIN 46 3.8.6.2 TAPE STRIPPING OF STRATUM
CORNEUM 47 3.8.6.3 SKIN SOLUBILIZATION 47 3.9 QUANTIATATIVE ANALYSIS OF
IBUPROFEN 48 3.9.1 UV-SPECTROSCOPY 48 3.9.2 REVERSED PHASE HPLC 48
3.9.2.1 SAMPLE PREPARATION 49 3.9.2.2 VALIDATION 49 3.10 COMPLEMENTARY
METHODS 51 3.10.1 CASTS 51 3.10.2 DERMATOSCOPY .- 52 4 RESULTS AND
DISCUSSION 53 4.1 ATTRITION ; 53 4.1.1 PRELIMINARY EXAMINATIONS 53 4.1.2
IN-SITU MEASUREMENTS 54 4.1.3 IN-VITRO ACTUATION 67 4.1.4 CONCLUSIONS 73
4.2 ACTUATIONS ONTO TEST BEDS 74 4.2.1 SENSITIVITY TO VARIED CONDITIONS
74 4.2.2 DELIVERY OF VARIED MASSES ONTO PEG OF VARIED COMPOSITION 78
4.2.3 DELIVERY OF SD5 INTO PEG 84 4.2.4 COMPOSITE TEST BEDS 85 4.3
EX-VIVO EXPERIMENTS 88 4.3.1 PRELIMINARY EXPERIMENTS 88 4.3.2 ACTUATION
OF DIFFERENT DOSES 89 4.3.3 ACTUATION OF MODIFIED COMPOUNDS .91 4.3.4
CONCLUSIONS 92 4.4 VISUALISATION METHODS 93 4.4.1 CASTS 95 4.2.2
DERMATOSCOPY 99 5 SUMMARY 101 6 ZUSAMMENFASSUNG 102 7 REFERENCES 104 |
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| author | Lahm, Katja 1968- |
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| author_facet | Lahm, Katja 1968- |
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| index_date | 2024-07-02T13:29:22Z |
| indexdate | 2024-07-09T20:28:26Z |
| institution | BVB |
| language | English |
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| spelling | Lahm, Katja 1968- Verfasser (DE-588)130400971 aut Investigation on intradermal delivery of drug powder by needle-free injection von Katja Lahm 2005 109 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 2005. - Zsfass. in dt. Sprache Erlangen-Nürnberg, Univ., Diss., 2005 Injektion (DE-588)4027017-8 gnd rswk-swf Haut (DE-588)4023838-6 gnd rswk-swf Pulver (DE-588)4219041-1 gnd rswk-swf Arzneistoffträger (DE-588)4278196-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Arzneistoffträger (DE-588)4278196-6 s Pulver (DE-588)4219041-1 s Haut (DE-588)4023838-6 s Injektion (DE-588)4027017-8 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014277404&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lahm, Katja 1968- Investigation on intradermal delivery of drug powder by needle-free injection Injektion (DE-588)4027017-8 gnd Haut (DE-588)4023838-6 gnd Pulver (DE-588)4219041-1 gnd Arzneistoffträger (DE-588)4278196-6 gnd |
| subject_GND | (DE-588)4027017-8 (DE-588)4023838-6 (DE-588)4219041-1 (DE-588)4278196-6 (DE-588)4113937-9 |
| title | Investigation on intradermal delivery of drug powder by needle-free injection |
| title_auth | Investigation on intradermal delivery of drug powder by needle-free injection |
| title_exact_search | Investigation on intradermal delivery of drug powder by needle-free injection |
| title_exact_search_txtP | Investigation on intradermal delivery of drug powder by needle-free injection |
| title_full | Investigation on intradermal delivery of drug powder by needle-free injection von Katja Lahm |
| title_fullStr | Investigation on intradermal delivery of drug powder by needle-free injection von Katja Lahm |
| title_full_unstemmed | Investigation on intradermal delivery of drug powder by needle-free injection von Katja Lahm |
| title_short | Investigation on intradermal delivery of drug powder by needle-free injection |
| title_sort | investigation on intradermal delivery of drug powder by needle free injection |
| topic | Injektion (DE-588)4027017-8 gnd Haut (DE-588)4023838-6 gnd Pulver (DE-588)4219041-1 gnd Arzneistoffträger (DE-588)4278196-6 gnd |
| topic_facet | Injektion Haut Pulver Arzneistoffträger Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014277404&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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