The cell: a molecular approach
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C.
ASM Press
2004
Sunderland, Mass. Sinauer Associates |
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XX, 713 S. zahlr. Ill., graph. Darst. - zahlr. Ill., graph. Darst. |
| ISBN: | 0878932143 |
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| 100 | 1 | |a Cooper, Geoffrey M. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The cell |b a molecular approach |c Geoffrey M. Cooper ; Robert E. Hausman |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Washington, D.C. |b ASM Press |c 2004 | |
| 264 | 1 | |a Sunderland, Mass. |b Sinauer Associates | |
| 300 | |a XX, 713 S. |b zahlr. Ill., graph. Darst. - zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Biologia celular |2 larpcal | |
| 650 | 7 | |a Biologia molecular |2 larpcal | |
| 650 | 4 | |a Biologie moléculaire | |
| 650 | 7 | |a Celbiologie |2 gtt | |
| 650 | 4 | |a Cytologie | |
| 650 | 7 | |a Moleculaire biologie |2 gtt | |
| 650 | 4 | |a Cell Biology | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Molecular biology | |
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Datensatz im Suchindex
| _version_ | 1804134599904722944 |
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| adam_text | THE CELL A MOLECULAR APPROACH THIRD EDITION GEOFFREY M. COOPER * ROBERT
E. HAUSMAN BOSTON UNIVERSITY UNIVERSITSTS- UND LANDSS- BIBLIOTHEK
DARMSTADT BIBLIOTHEK BIOLOGIA ASM PRESS ASM SINAUER ASSOCIATES, INC.
WASHINGTON, D.C. PRESS SUNDERLAND, MASSACHUSETTS CONTENTS IN BRIEF I I
PART I INTRODUCTION 1 1 AN OVERVIEW OF CELLS AND CELL RESEARCH 3 | 2
THE CHEMISTRY OF CELLS 41 | 3 FUNDAMENTALS OF MOLECULAR BIOLOGY 89 PART
II THE FLOW OF GENETIC INFORMATION 137 4 THE ORGANIZATION AND SEQUENCES
OF CELLULAR GENOMES 139 5 REPLICATION, MAINTENANCE, AND REARRANGEMENTS
OF GENOMIC DNA 179 6 RNA SYNTHESIS AND PROCESSING 231 7 PROTEIN
SYNTHESIS, PROCESSING, AND REGULATION 281 PART III CELL STRUCTURE AND
FUNCTION 321 8 THE NUCLEUS 323 9 PROTEIN SORTING AND TRANSPORT: THE
ENDOPLASMIC RETICULUM, GOLGI APPARATUS, AND LYSOSOMES 355 10
BIOENERGETICS AND METABOLISM: MITOCHONDRIA, CHOLOROPLASTS, AND
PEROXISOMES 399 11 THE CYTOSKELETON AND CELL MOVEMENT 435 12 THE CELL
SURFACE 483 IJPARTLV CELL REGULATION 539 13 CELL SIGNALING 541 14 THE
CELL CYCLE 591 15 CANCER 631 CONTENTS PREFACE XV ORGANIZATION AND
FEATURES OF THE CELL XVII SUPPLEMENTS TO ACCOMPANY THE CELL XIX PARTI
INTRODUCTION 1 AN OVERVIEW OF CELLS AND CELL RESEARCH 3 THE ORIGIN AND
EVOLUTION OF CELLS 4 THE FIRST CELL 4 THE EVOLUTION OF METABOLISM 7
PRESENT-DAY PROKARYOTES 8 EUKARYOTIC CELLS 9 THE DEVELOPMENT OF
MULTICELLULAR ORGANISMS 12 CELLS AS EXPERIMENTAL MODELS 15 E. COLI 15
YEASTS 16 DICTYOSTELIUM DISCOIDEUM 17 CAENORHABDITIS ELEGANS 17
DROSOPHILA MELANOGASTER 18 ARABIDOPSIS THALIANA 18 VERTEBRATES 19 TOOLS
OF CELL BIOLOGY 20 LIGHT MICROSCOPY 21 ELECTRON MICROSCOPY 25
SUBCELLULAR FRACTIONATION 28 GROWTH OF ANIMAL CELLS IN CULTURE 29
CULTURE OF PLANT CELLS 34 VIRUSES 34 KEY EXPERIMENT ANIMAL CELL CULTURE
32 MOLECULAR MEDICINE VIRUSES AND CANCER 35 SUMMARY AND KEYTERMS 37
QUESTIONS 38 REFERENCES AND FURTHER READING 39 2 THE CHEMISTRY OF CELLS
41 THE MOLECULAR COMPOSITION OF CELLS 41 CARBOHYDRATES 42 LIPIDS 44
NUCLEIC ACIDS 47 PROTEINS 50 THE CENTRAL ROLE OF ENZYMES AS BIOLOGICAL
CATALYSTS 56 THE CATALYTIC ACTIVITY OF ENZYMES 56 MECHANISMS OF
ENZYMATIC CATALYSIS 57 COENZYMES 59 REGULATION OF ENZYME ACTIVITY 61
METABOLIC ENERGY 63 FREE ENERGY AND ATP 64 THE GENERATION OF ATP FROM
GLUCOSE 66 THE DERIVATION OF ENERGY FROM OTHER ORGANIC MOLECULES 71
PHOTOSYNTHESIS 72 THE BIOSYNTHESIS OF CELL CONSTITUENTS 74 CARBOHYDRATES
74 LIPIDS 75 PROTEINS 76 NUCLEIC ACIDS 79 CELL MEMBRANES 80 MEMBRANE
LIPIDS 80 MEMBRANE PROTEINS 81 TRANSPORT ACROSS CELL MEMBRANES 83 KEY
EXPERIMENT THE FOLDING OF POLYPEPTIDE CHAINS 52 MOLECULAR MEDICINE
PHENYLKETONURIA 79 SUMMARY AND KEYTERMS 85 QUESTIONS 87 REFERENCES AND
FURTHER READING 87 3 FUNDAMENTALS OF MOLECULAR BIOLOGY 89 HEREDITY,
GENES, AND DNA 89 GENES AND CHROMOSOMES 90 GENES AND ENZYMES 91
IDENTIFICATION OF DNA AS THE GENETIC MATERIAL 93 THE STRUCTURE OF DNA 94
REPLICATION OF DNA 95 CONTENTS IX EXPRESSION OF GENETIC INFORMATION 96
COLINEARITY OF GENES AND PROTEINS 97 THE ROLE OF MESSENGER RN A 98 THE
GENETIC CODE 99 RNA VIRUSES AND REVERSE TRANSCRIPTION 100 RECOMBINANT
DNA 104 RESTRICTION ENDONUCLEASES 104 GENERATION OF RECOMBINANT DNA
MOLECULES 107 VECTORS FOR RECOMBINANT DNA 108 DNA SEQUENCING 111
EXPRESSION OF CLONED GENES 113 AMPLIFICATION OF DNA BY THE POLYMERASE
CHAIN REACTION 115 DETECTION OF NUCLEIC ACIDS AND PROTEINS 117 NUCLEIC
ACID HYBRIDIZATION 117 DETECTION OF SMALL AMOUNTS OF DNA ORRNABYPCR 119
ANTIBODIES AS PROBES FOR PROTEINS 119 PROBES FOR SCREENING RECOMBINANT
DNA LIBRARIES 121 GENE FUNCTION IN EUKARYOTES 123 GENETIC ANALYSIS IN
YEASTS 123 GENE TRANSFER IN PLANTS AND ANIMALS 125 MUTAGENESIS OF CLONED
DNAS 128 INTRODUCING MUTATIONS INTO CELLULAR GENES 128 KEY EXPERIMENT
THE DNA PROVIRUS HYPOTHESIS 102 MOLECULAR MEDICINE HIV AND AIDS 105
SUMMARY AND KEYTERMS 132 QUESTIONS 134 REFERENCES AND FURTHER READING
135 PARTII THE FLOW OF GENETIC INFORMATION 4 THE ORGANIZATION AND
SEQUENCES OF CELLULAR [GENOMES 139 THE COMPLEXITY OF EUKARYOTIC GENOMES
139 ; INTRONS AND EXONS 141 REPETITIVE DNA SEQUENCES 145 I GENE
DUPLICATION AND PSEUDOGENES 148 STHE COMPOSITION OF HIGHER T EUKARYOTIC
GENOMES 149 I CHROMOSOMES AND CHROMATIN 150 * CHROMATIN 150 S
CENTROMERES 154 ITELOMERES 157 THE SEQUENCES OF COMPLETE GENOMES 158 *
PROKARYOTIC GENOMES 159 THE YEAST GENOME 161 |THE GENOMES OF
CAENORHABDITIS ELEGANS F AND DROSOPHILA MELANOGASTER 163 | PLANT GENOMES
165 I THE HUMAN GENOME 167 I * |KEY EXPERIMENT THE DISCOVERY OF INTRONS
142 [KEYEXPERIMENT THE-HUMAN GENOME SUMMARY AND KEYTERMS 173 QUESTIONS
175 REFERENCES AND FURTHER READING 175 5 170 REPLICATION, MAINTENANCE,
AND REARRANGEMENTS OF GENOMIC DNA 179 DNA REPLICATION 179 DNAPOLYMERASES
180 THE REPLICATION FORK 182 THE FIDELITY OF REPLICATION 188 ORIGINS AND
THE INITIATION OF REPLICATION 189 TELOMERES AND TELOMERASE: REPLICATING
THE ENDS OF CHROMOSOMES 191 DNA REPAIR 192 DIRECT REVERSAL OF DNA DAMAGE
194 EXCISION REPAIR 197 ERROR-PRONE REPAIR 201 RECOMBINATIONAL REPAIR
202 RECOMBINATION BETWEEN HOMOLOGOUS DNA SEQUENCES 204 DNA MOLECULES
RECOMBINE BY BREAKING AND REJOINING 205 MODELS OF HOMOLOGOUS
RECOMBINATION 207 ENZYMES INVOLVED IN HOMOLOGOUS RECOMBINATION 209 DNA
REARRANGEMENTS 211 SITE-SPECIFIC RECOMBINATION 211 TRANSPOSITION VIA DNA
INTERMEDIATES 216 TRANSPOSITION VIA RNA . INTERMEDIATES 220 GENE
AMPLIFICATION 225 KEY EXPERIMENT REARRANGEMENT OF IMMUNOGLOBULIN GENES
218 MOLECULAR MEDICINE COLON CANCER AND DNA REPAIR 203 SUMMARY AND
KEYTERMS 227 QUESTIONS 228 REFERENCES AND FURTHER READING 229 6 RNA
SYNTHESIS AND PROCESSING 231 TRANSCRIPTION IN PROKARYOTES 231 RNA
POLYMERASE AND TRANSCRIPTION 232 REPRESSORS AND NEGATIVE CONTROL OF
TRANSCRIPTION 236 POSITIVE CONTROL OF TRANSCRIPTION 238 X CONTENTS
EUKARYOTIC RNA POLYMERASES AND GENERAL TRANSCRIPTION FACTORS 239
EUKARYOTICRNAPOLYMERASES 239 GENERAL TRANSCRIPTION FACTORS AND
INITIATION OF TRANSCRIPTION BY RNA POLYMERASE II 240 TRANSCRIPTION BY
RNA POLYMERASES I AND III 243 REGULATION OF TRANSCRIPTION IN EUKARYOTES
244 CFS-ACTING REGULATORY SEQUENCES: PROMOTERS AND ENHANCERS 245
TRANSCRIPTIONAL REGULATORY PROTEINS 249 J STRUCTURE AND FUNCTION OF
TRANSCRIPTIONAL ACTIVATORS 252 EUKARYOTIC REPRESSORS 254 RELATIONSHIP OF
CHROMATIN STRUCTURE TO TRANSCRIPTION 256 REGULATION OF TRANSCRIPTION BY
NONCODING RNAS 259 DNAMETHYLATION 260 RNA PROCESSING AND TURNOVER 261
PROCESSING OF RIBOSOMAL AND TRANSFER RNAS 262 PROCESSING OF MRNA IN
EUKARYOTES 264 SPLICING MECHANISMS 266 ALTERNATIVE SPLICING 272 RNA
EDITING 273 RNA DEGRADATION 274 KEY EXPERIMENT ISOLATION OF A EUKARY-
OTIC TRANSCRIPTION FACTOR 251 KEY EXPERIMENT THE DISCOVERY OF SNRNPS 268
SUMMARY AND KEYTERMS 276 QUESTIONS 278 REFERENCES AND FURTHER READING
279 7 PROTEIN SYNTHESIS, PROCESSING, AND REGULATION 281 TRANSLATION OF
MRNA 281 TRANSFER RNAS 282 THERIBOSOME 283 THE ORGANIZATION OF MRNAS AND
THE INITIATION OF TRANSLATION 289 THE PROCESS OF TRANSLATION 290
REGULATION OF TRANSLATION 296 PROTEIN FOLDING AND PROCESSING 298
CHAPERBNES AND PROTEIN FOLDING 298 ENZYMES AND PROTEIN FOLDING 303
PROTEIN CLEAVAGE 303 GLYCOSYLATION 305 ATTACHMENT OF LIPIDS 307
REGULATION OF PROTEIN FUNCTION 309 REGULATION BY SMALL MOLECULES 310
PROTEIN PHOSPHORYLATION 311 PROTEIN-PROTEIN INTERACTIONS 313 PROTEIN
DEGRADATION 313 THE UBIQUITIN-PROTEASOME PATHWAY 313 LYSOSOMAL
PROTEOLYSIS 315 KEY EXPERIMENT CATALYTIC ROLE OF RIBOSOMAL RNA 288
MOLECULAR MEDICINE ANTIBIOTICS AND PROTEIN SYNTHESIS 292 SUMMARY AND
KEYTERMS 316 QUESTIONS 318 REFERENCES AND FURTHER READING 318 PARTIII
CELL STRUCTURE AND FUNCTION 8 THE NUCLEUS 323 THE NUCLEAR ENVELOPE AND
TRAFFIC BETWEEN THE NUCLEUS AND CYTOPLASM 323 STRUCTURE OF THE NUCLEAR
ENVELOPE 324 THE NUCLEAR PORE COMPLEX 326 SELECTIVE TRANSPORT OF
PROTEINS TO AND FROM THE NUCLEUS 328 REGULATION OF NUCLEAR PROTEIN
IMPORT 332 TRANSPORT OF RNAS 334 INTERNAL ORGANIZATION OF THE NUCLEUS
335 CHROMOSOMES AND HIGHER-ORDER CHROMATIN STRUCTURE 335 FUNCTIONAL
DOMAINS WITHIN THE NUCLEUS 337 THE NUCLEOLUS 339 RIBOSOMAL RNA GENES AND
THE ORGANIZATION OF THE NUCLEOLUS 339 TRANSCRIPTION AND PROCESSING
OFRRNA 342 RIBOSOME ASSEMBLY 344 THE NUCLEUS DURING MITOSIS 345
DISSOLUTION OF THE NUCLEAR ENVELOPE 345 CHROMOSOME CONDENSATION 348
RE-FORMATION OF THE INTERPHASE NUCLEUS 349 KEY EXPERIMENT IDENTIFICATION
OF NUCLEAR LOCALIZATION SIGNALS 330 MOLECULAR MEDICINE NUCLEAR LAMINA
DISEASES 340 SUMMARY AND KEYTERMS 351 QUESTIONS 352 REFERENCES AND
FURTHER READING 353 CONTENTS XI 9 10 11 PROTEIN SORTING AND
/TRANSPORT: (THE ENDOPLASMIC RETICULUM, GOLGI APPARATUS, TANDLYSOSOMES
355 THE ENDOPLASMIC RETICULUM 355 , THE ENDOPLASMIC RETICULUM AND
PROTEIN SECRETION 356 |* TARGETING PROTEINS TO THE ENDOPLASMIC RETICULUM
357 * INSERTION OF PROTEINS INTO THE ER MEMBRANE 362 PROTEIN FOLDING
AND PROCESSING INTHEER 366 THE SMOOTH ER AND LIPID SYNTHESIS 369 JEXPORT
OF PROTEINS AND LIPIDS FROM THEER 372 THE GOLGI APPARATUS 374
FORGANIZATION OF THE GOLGI 375 FPROTEIN GLYCOSYLATION WITHIN THE GOLGI
377 JLIPID AND POLYSACCHARIDE METABOLISM IN THE GOLGI 379 JJPROTEIN
SORTING AND EXPORT FROM THE GOLGI APPARATUS 380 THE MECHANISM OF
VESICULAR [TRANSPORT 382 EXPERIMENTAL APPROACHES TO UNDER- STANDING
VESICULAR TRANSPORT 383 JFCOAT PROTEINS, CARGO SELECTION, AND VESICLE
BUDDING 385 RESIDE FUSION 387 LYSOSOMES 389 ILYSOSOMAL ACID HYDROLASES
389 NDOCYTOSIS AND LYSOSOME FORMATION 390 AGOCYTOSIS AND AUTOPHAGY 393
||EY EXPERIMENT THE SIGNAL HYPOTHESIS 360 MOLECULAR MEDICINE GAUCHER S
DISEASE 392 SUMMARY AND KEYTERMS 394 IPUESTIONS 396 REFERENCES AND
FURTHER READING 396 BIOENERGETICS AND METABOLISM: MITOCHONDRIA,
CHLOROPLASTS, AND PEROXISOMES 399 MITOCHONDRIA 399 ORGANIZATION AND
FUNCTION OF MITOCHONDRIA 400 THE GENETIC SYSTEM OF MITOCHONDRIA 401
PROTEIN IMPORT AND MITOCHONDRIAL ASSEMBLY 403 THE MECHANISM OF OXIDATIVE
PHOSPHORYLATION 408 THE ELECTRON TRANSPORT CHAIN 408 CHEMIOSMOTIC
COUPLING 410 TRANSPORT OF METABOLITES ACROSS THE INNER MEMBRANE 414
CHLOROPLASTS AND OTHER PLASTIDS 415 THE STRUCTURE AND FUNCTION OF
CHLOROPLASTS 415 THE CHLOROPLAST GENOME 417 IMPORT AND SORTING OF
CHLOROPLAST PROTEINS 418 OTHER PLASTIDS 420 PHOTOSYNTHESIS 422 ELECTRON
FLOW THROUGH PHOTOSYSTEMS I AND II 422 CYCLIC ELECTRON FLOW 425 ATP
SYNTHESIS 426 PEROXISOMES 426 FUNCTIONS OF PEROXISOMES 427 PEROXISOME
ASSEMBLY 429 I KEY EXPERIMENT THE CHEMIOSMOTIC THEORY 412 MOLECULAR
MEDICINE DISEASES OF MITO- CHONDRIA: LEBER S HEREDITARY OPTIC NEUROPATHY
406 SUMMARY AND KEYTERMS 430 QUESTIONS 432 REFERENCES AND FURTHER
READING 433 THE CYTOSKELETON AND CELL MOVEMENT 435 STRUCTURE AND
ORGANIZATION OF ACTIN FILAMENTS 435 ASSEMBLY AND DISASSEMBLY OF ACTIN
FILAMENTS 436 ORGANIZATION OF ACTIN FILAMENTS 440 ASSOCIATION OF ACTIN
FILAMENTS WITH THE PLASMA MEMBRANE 442 PROTRUSIONS OF THE CELL SURFACE
445 ACTIN, MYOSIN, AND CELL MOVEMENT 447 MUSCLE CONTRACTION 447
CONTRACTILE ASSEMBLIES OF ACTIN AND MYOSIN IN NONMUSCLE CELLS 451
UNCONVENTIONAL MYOSINS 453 CELL MIGRATION AND CRAWLING 454 INTERMEDIATE
FILAMENTS 455 INTERMEDIATE FILAMENT PROTEINS 455 ASSEMBLY OF
INTERMEDIATE FILAMENTS 456 INTRACELLULAR ORGANIZATION OF INTERMEDIATE
FILAMENTS 457 FUNCTIONS OF KERATINS AND NEURO- FILAMENTS: DISEASES OF
THE SKIN AND NERVOUS SYSTEM 459 MICROTUBULES 462 STRUCTURE, ASSEMBLY,
AND DYNAMIC INSTABILITY OF MICROTUBULES 462 THE CENTROSOME, CENTRIOLES,
AND MICROTUBULE ORGANIZATION 463 REORGANIZATION OF MICROTUBULES DURING
MITOSIS 466 STABILIZATION OF MICROTUBULES AND CELL POLARITY 467
MICROTUBULE MOTORS AND MOVEMENTS 468 IDENTIFICATION OF MICROTUBULE MOTOR
PROTEINS 468 ORGANELLE TRANSPORT AND INTRACELLULAR ORGANIZATION 472
SEPARATION OF MITOTIC CHROMOSOMES 474 CILIA AND FLAGELLA 474 KEY
EXPERIMENT EXPRESSION OF MUTANT KERATIN CAUSES ABNORMAL SKIN DEVELOPMENT
460 KEY EXPERIMENT THE ISOLATION OF KINESIN 470 XII CONTENTS SUMMARY AND
KEYTERMS 478 QUESTIONS 480 REFERENCES AND FURTHER READING 481 12 THE
CELL SURFACE 483 STRUCTURE OF THE PLASMA MEMBRANE 483 THE PHOSPHOLIPID
BILAYER 483 MEMBRANE PROTEINS 486 MOBILITY OF MEMBRANE PROTEINS 490 THE
GLYCOCALYX 492 TRANSPORT OF SMALL MOLECULES 493 PASSIVE DIFFUSION 494
FACILITATED DIFFUSION AND CARRIER PROTEINS 494 ION CHANNELS 496 ACTIVE
TRANSPORT DRIVEN BY ATP HYDROLYSIS 503 ACTIVE TRANSPORT DRIVEN BY ION
GRADIENTS 507 ENDOCYTOSIS 510 PHAGOCYTOSIS 510 RECEPTOR-MEDIATED
ENDOCYTOSIS 511 PROTEIN TRAFFICKING IN ENDOCYTOSIS 515 CELL WALLS AND
THE EXTRA- CELLULAR MATRIX 518 BACTERIAL CELL WALLS 518 PLANT CELL WALLS
519 THE EXTRACELLULAR MATRIX 522 CELL-CELL INTERACTIONS 528 CELL
ADHESION PROTEINS 528 TIGHT JUNCTIONS 531 GAP JUNCTIONS 532 PLANT CELL
ADHESION AND PLASMODESMATA 532 KEY EXPERIMENT THE LDL RECEPTOR 512
MOLECULAR MEDICINE CYSTIC FIBROSIS 509 SUMMARY AND KEYTERMS 533
QUESTIONS 535 REFERENCES AND FURTHER READING 536 CELL REGULATION 13 CELL
SIGNALING 541 SIGNALING MOLECULES AND THEIR RECEPTORS 541 MODES OF
CELL-CELL SIGNALING 542 STEROID HORMONES AND THE NUCLEAR RECEPTOR
SUPERFAMILY 543 NITRIC OXIDE AND CARBON MONOXIDE 545 NEUROTRANSMITTERS
546 PEPTIDE HORMONES AND GROWTH FACTORS 546 EICOSANOIDS 548 PLANT
HORMONES 549 FUNCTIONS OF CELL SURFACE RECEPTORS 550 G PROTEIN-COUPLED
RECEPTORS 551 RECEPTOR PROTEIN-TYROSINE KINASES 553 CYTOKINE RECEPTORS
AND NONRECEPTOR PROTEIN-TYROSINE KINASES 557 RECEPTORS LINKED TO OTHER
ENZYMATIC ACTIVITIES 557 PATHWAYS OF INTRACELLULAR SIGNAL TRANSDUCTION
558 THE CAMP PATHWAY: SECOND MESSENGERS AND PROTEIN PHOSPHORYLATION 559
CYCLIC GMP 561 PHOSPHOLIPIDS AND CA 2+ 562 RAS, RAF, AND THE MAP KINASE
PATHWAY 565 THE JAK/STAT PATHWAY 570 SIGNAL TRANSDUCTION AND
THECYTOSKELETON 571 INTEGRINS AND SIGNAL TRANSDUCTION 571 REGULATION OF
THE ACTIN CYTOSKELETON 574 SIGNALING IN DEVELOPMENT AND DIFFERENTIATION
575 THE RECEPTOR TYROSINE KINASE /RAS/ RAF/ERK PATHWAY IN DROSOPHILA AND
C. ELEGANS 575 HEDGEHOG AND WNT 577 NOTCH SIGNALING 578 REGULATION OF
PROGRAMMED CELL DEATH 579 CASPASES AND APOPTOSIS 580 CELL DEATH
RECEPTORS AND CASPASE ACTIVATION 582 SIGNALING CELL SURVIVAL 582 KEY
EXPERIMENT THE SRC PROTEIN- TYROSINE KINASE 554 MOLECULAR MEDICINE
CANCER: SIGNAL TRANSDUCTION, AND THE RAS ONCOGENES 572 SUMMARY AND
KEYTERMS 584 QUESTIONS 587 REFERENCES AND FURTHER READING 587 14 THE
CELL CYCLE 591 THE EUKARYOTIC CELL CYCLE ( PHASES OF THE CELL CYCLE 592
REGULATION OF THE CELL CYCLE BY CELL GROWTH AND EXTRACELLULAR SIGNALS
594 CELL CYCLE CHECKPOINTS 596 RESTRICTING DNA REPLICATION TO ONCE PER
CELL CYCLE 598 REGULATORS OF CELL N CYCLE PROGRESSION 599Y MPF: A DIMER
OF CDC2 AND CYCLIN 599 FAMILIES OF CYCLINS AND CYCLIN- DEPENDENT KINASES
603 GROWTH FACTORS AND THE D-TYPE CYCLINS 605 INHIBITORS OF CELL CYCLE
PROGRESSION 606 THE EVENTS OF M PHASE 608 STAGES OF MITOSIS 608 CONTENTS
XIII JMPF AND PROGRESSION TO METAPHASE 611 IPROTEOLYSIS AND THE
INACTIVATION OF MPF: ANAPHASE AND TELOPHASE 613 JCYTOKINESIS 614 MEIOSIS
AND FERTILIZATION 615 |THE PROCESS OF MEIOSIS 615 |REGULATION OF OOCYTE
MEIOSIS 618 FERTILIZATION 620 ITEM CELLS AND THE MAINTENANCE
OFADULTTISSUES 621 PROLIFERATION OF DIFFERENTIATED CELLS 621 STEM CELLS
622 PEDICAL APPLICATIONS OF STEM CELLS 624 |EY EXPERIMENT THE DISCOVERY
OF MPF 600 KE Y EXPERIMENT CULTURE OF EMBRYONIC STEM CELLS 622 GJLIMMARY
AND KEYTERMS 625 |UESTIONS 628 REFERENCES AND FURTHER READING 628 15
CANCER 631 THE DEVELOPMENT AND CAUSES OF CANCER 631 TYPES OF CANCER 631
THE DEVELOPMENT OF CANCER 633 CAUSES OF CANCER 634 PROPERTIES OF CANCER
CELLS 636 TRANSFORMATION OF CELLS IN CULTURE 640 TUMOR VIRUSES 640
HEPATITIS B AND C VIRUSES 641 SV40 AND POLYOMAVIRUS 641 PAPILLOMAVIRUSES
642 ADENOVIRUSES 642 HERPESVIRUSES 643 RETROVIRUSES 644 ONCOGENES 644
RETROVIRAL ONCOGENES 645 PROTO-ONCOGENES 646 ONCOGENES IN HUMAN CANCER
649 FUNCTIONS OF ONCOGENE PRODUCTS 653 TUMOR SUPPRESSOR GENES 657
IDENTIFICATION OF TUMOR SUPPRESSOR GENES 657 FUNCTIONS OF TUMOR
SUPPRESSOR GENE PRODUCTS 660 ROLES OF ONCOGENES AND TUMOR SUPPRESSOR
GENES IN TUMOR DEVELOPMENT 663 APPLICATIONS OF MOLECULAR BIOLOGY TO
CANCER PREVENTION AND TREATMENT 664 PREVENTION AND EARLY DETECTION 664
MOLECULAR DIAGNOSIS 665 TREATMENT 666 KEY EXPERIMENT THE DISCOVERY OF
PROTO-ONCOGENES 648 MOLECULAR MEDICINE STI-571: CANCER TREATMENT
TARGETED AGAINST THE BCR/ABL ONCOGENE 667 SUMMARY AND KEYTERMS 669
QUESTIONS 671 REFERENCES AND FURTHER READING 671 ANSWERS TO QUESTIONS
675 GLOSSARY 681 INDEX 699
|
| adam_txt |
THE CELL A MOLECULAR APPROACH THIRD EDITION GEOFFREY M. COOPER * ROBERT
E. HAUSMAN BOSTON UNIVERSITY UNIVERSITSTS- UND LANDSS- BIBLIOTHEK
DARMSTADT BIBLIOTHEK BIOLOGIA ASM PRESS ASM SINAUER ASSOCIATES, INC.
WASHINGTON, D.C. PRESS SUNDERLAND, MASSACHUSETTS CONTENTS IN BRIEF I I
PART I INTRODUCTION 1 1 AN OVERVIEW OF CELLS AND CELL RESEARCH 3 | 2
THE CHEMISTRY OF CELLS 41 | 3 FUNDAMENTALS OF MOLECULAR BIOLOGY 89 PART
II THE FLOW OF GENETIC INFORMATION 137 4 THE ORGANIZATION AND SEQUENCES
OF CELLULAR GENOMES 139 5 REPLICATION, MAINTENANCE, AND REARRANGEMENTS
OF GENOMIC DNA 179 6 RNA SYNTHESIS AND PROCESSING 231 7 PROTEIN
SYNTHESIS, PROCESSING, AND REGULATION 281 PART III CELL STRUCTURE AND
FUNCTION 321 8 THE NUCLEUS 323 9 PROTEIN SORTING AND TRANSPORT: THE
ENDOPLASMIC RETICULUM, GOLGI APPARATUS, AND LYSOSOMES 355 10
BIOENERGETICS AND METABOLISM: MITOCHONDRIA, CHOLOROPLASTS, AND
PEROXISOMES 399 11 THE CYTOSKELETON AND CELL MOVEMENT 435 12 THE CELL
SURFACE 483 IJPARTLV CELL REGULATION 539 13 CELL SIGNALING 541 14 THE
CELL CYCLE 591 15 CANCER 631 CONTENTS PREFACE XV ORGANIZATION AND
FEATURES OF THE CELL XVII SUPPLEMENTS TO ACCOMPANY THE CELL XIX PARTI
INTRODUCTION 1 AN OVERVIEW OF CELLS AND CELL RESEARCH 3 THE ORIGIN AND
EVOLUTION OF CELLS 4 THE FIRST CELL 4 THE EVOLUTION OF METABOLISM 7
PRESENT-DAY PROKARYOTES 8 EUKARYOTIC CELLS 9 THE DEVELOPMENT OF
MULTICELLULAR ORGANISMS 12 CELLS AS EXPERIMENTAL MODELS 15 E. COLI 15
YEASTS 16 DICTYOSTELIUM DISCOIDEUM 17 CAENORHABDITIS ELEGANS 17
DROSOPHILA MELANOGASTER 18 ARABIDOPSIS THALIANA 18 VERTEBRATES 19 TOOLS
OF CELL BIOLOGY 20 LIGHT MICROSCOPY 21 ELECTRON MICROSCOPY 25
SUBCELLULAR FRACTIONATION 28 GROWTH OF ANIMAL CELLS IN CULTURE 29
CULTURE OF PLANT CELLS 34 VIRUSES 34 KEY EXPERIMENT ANIMAL CELL CULTURE
32 MOLECULAR MEDICINE VIRUSES AND CANCER 35 SUMMARY AND KEYTERMS 37
QUESTIONS 38 REFERENCES AND FURTHER READING 39 2 THE CHEMISTRY OF CELLS
41 THE MOLECULAR COMPOSITION OF CELLS 41 CARBOHYDRATES 42 LIPIDS 44
NUCLEIC ACIDS 47 PROTEINS 50 THE CENTRAL ROLE OF ENZYMES AS BIOLOGICAL
CATALYSTS 56 THE CATALYTIC ACTIVITY OF ENZYMES 56 MECHANISMS OF
ENZYMATIC CATALYSIS 57 COENZYMES 59 REGULATION OF ENZYME ACTIVITY 61
METABOLIC ENERGY 63 FREE ENERGY AND ATP 64 THE GENERATION OF ATP FROM
GLUCOSE 66 THE DERIVATION OF ENERGY FROM OTHER ORGANIC MOLECULES 71
PHOTOSYNTHESIS 72 THE BIOSYNTHESIS OF CELL CONSTITUENTS 74 CARBOHYDRATES
74 LIPIDS 75 PROTEINS 76 NUCLEIC ACIDS 79 CELL MEMBRANES 80 MEMBRANE
LIPIDS 80 MEMBRANE PROTEINS 81 TRANSPORT ACROSS CELL MEMBRANES 83 KEY
EXPERIMENT THE FOLDING OF POLYPEPTIDE CHAINS 52 MOLECULAR MEDICINE
PHENYLKETONURIA 79 SUMMARY AND KEYTERMS 85 QUESTIONS 87 REFERENCES AND
FURTHER READING 87 3 FUNDAMENTALS OF MOLECULAR BIOLOGY 89 HEREDITY,
GENES, AND DNA 89 GENES AND CHROMOSOMES 90 GENES AND ENZYMES 91
IDENTIFICATION OF DNA AS THE GENETIC MATERIAL 93 THE STRUCTURE OF DNA 94
REPLICATION OF DNA 95 CONTENTS IX EXPRESSION OF GENETIC INFORMATION 96
COLINEARITY OF GENES AND PROTEINS 97 THE ROLE OF MESSENGER RN A 98 THE
GENETIC CODE 99 RNA VIRUSES AND REVERSE TRANSCRIPTION 100 RECOMBINANT
DNA 104 RESTRICTION ENDONUCLEASES 104 GENERATION OF RECOMBINANT DNA
MOLECULES 107 VECTORS FOR RECOMBINANT DNA 108 DNA SEQUENCING 111
EXPRESSION OF CLONED GENES 113 AMPLIFICATION OF DNA BY THE POLYMERASE
CHAIN REACTION 115 DETECTION OF NUCLEIC ACIDS AND PROTEINS 117 NUCLEIC
ACID HYBRIDIZATION 117 DETECTION OF SMALL AMOUNTS OF DNA ORRNABYPCR 119
ANTIBODIES AS PROBES FOR PROTEINS 119 PROBES FOR SCREENING RECOMBINANT
DNA LIBRARIES 121 GENE FUNCTION IN EUKARYOTES 123 GENETIC ANALYSIS IN
YEASTS 123 GENE TRANSFER IN PLANTS AND ANIMALS 125 MUTAGENESIS OF CLONED
DNAS 128 INTRODUCING MUTATIONS INTO CELLULAR GENES 128 KEY EXPERIMENT
THE DNA PROVIRUS HYPOTHESIS 102 MOLECULAR MEDICINE HIV AND AIDS 105
SUMMARY AND KEYTERMS 132 QUESTIONS 134 REFERENCES AND FURTHER READING
135 PARTII THE FLOW OF GENETIC INFORMATION 4 THE ORGANIZATION AND
SEQUENCES OF CELLULAR [GENOMES 139 THE COMPLEXITY OF EUKARYOTIC GENOMES
139 ; INTRONS AND EXONS 141 \ REPETITIVE DNA SEQUENCES 145 I GENE
DUPLICATION AND PSEUDOGENES 148 STHE COMPOSITION OF HIGHER T EUKARYOTIC
GENOMES 149 I CHROMOSOMES AND CHROMATIN 150 *'CHROMATIN 150 S
CENTROMERES 154 ITELOMERES 157 THE SEQUENCES OF COMPLETE GENOMES 158 *
PROKARYOTIC GENOMES 159 THE YEAST GENOME 161 |THE GENOMES OF
CAENORHABDITIS ELEGANS F AND DROSOPHILA MELANOGASTER 163 | PLANT GENOMES
165 I THE HUMAN GENOME 167 I * |KEY EXPERIMENT THE DISCOVERY OF INTRONS
142 [KEYEXPERIMENT THE-HUMAN GENOME SUMMARY AND KEYTERMS 173 QUESTIONS
175 REFERENCES AND FURTHER READING 175 5 170 REPLICATION, MAINTENANCE,
AND REARRANGEMENTS OF GENOMIC DNA 179 DNA REPLICATION 179 DNAPOLYMERASES
180 THE REPLICATION FORK 182 THE FIDELITY OF REPLICATION 188 ORIGINS AND
THE INITIATION OF REPLICATION 189 TELOMERES AND TELOMERASE: REPLICATING
THE ENDS OF CHROMOSOMES 191 DNA REPAIR 192 DIRECT REVERSAL OF DNA DAMAGE
194 EXCISION REPAIR 197 ERROR-PRONE REPAIR 201 RECOMBINATIONAL REPAIR
202 RECOMBINATION BETWEEN HOMOLOGOUS DNA SEQUENCES 204 DNA MOLECULES
RECOMBINE BY BREAKING AND REJOINING 205 MODELS OF HOMOLOGOUS
RECOMBINATION 207 ENZYMES INVOLVED IN HOMOLOGOUS RECOMBINATION 209 DNA
REARRANGEMENTS 211 SITE-SPECIFIC RECOMBINATION 211 TRANSPOSITION VIA DNA
INTERMEDIATES 216 TRANSPOSITION VIA RNA . INTERMEDIATES 220 GENE
AMPLIFICATION 225 KEY EXPERIMENT REARRANGEMENT OF IMMUNOGLOBULIN GENES
218 MOLECULAR MEDICINE COLON CANCER AND DNA REPAIR 203 SUMMARY AND
KEYTERMS 227 QUESTIONS 228 REFERENCES AND FURTHER READING 229 6 RNA
SYNTHESIS AND PROCESSING 231 TRANSCRIPTION IN PROKARYOTES 231 RNA
POLYMERASE AND TRANSCRIPTION 232 REPRESSORS AND NEGATIVE CONTROL OF
TRANSCRIPTION 236 POSITIVE CONTROL OF TRANSCRIPTION 238 X CONTENTS
EUKARYOTIC RNA POLYMERASES AND GENERAL TRANSCRIPTION FACTORS 239
EUKARYOTICRNAPOLYMERASES 239 GENERAL TRANSCRIPTION FACTORS AND
INITIATION OF TRANSCRIPTION BY RNA POLYMERASE II 240 TRANSCRIPTION BY
RNA POLYMERASES I AND III 243 REGULATION OF TRANSCRIPTION IN EUKARYOTES
244 CFS-ACTING REGULATORY SEQUENCES: PROMOTERS AND ENHANCERS 245
TRANSCRIPTIONAL REGULATORY PROTEINS 249 J STRUCTURE AND FUNCTION OF
TRANSCRIPTIONAL ACTIVATORS 252 EUKARYOTIC REPRESSORS 254 RELATIONSHIP OF
CHROMATIN STRUCTURE TO TRANSCRIPTION 256 REGULATION OF TRANSCRIPTION BY
NONCODING RNAS 259 DNAMETHYLATION 260 RNA PROCESSING AND TURNOVER 261
PROCESSING OF RIBOSOMAL AND TRANSFER RNAS 262 PROCESSING OF MRNA IN
EUKARYOTES 264 SPLICING MECHANISMS 266 ALTERNATIVE SPLICING 272 RNA
EDITING 273 RNA DEGRADATION 274 KEY EXPERIMENT ISOLATION OF A EUKARY-
OTIC TRANSCRIPTION FACTOR 251 KEY EXPERIMENT THE DISCOVERY OF SNRNPS 268
SUMMARY AND KEYTERMS 276 QUESTIONS 278 REFERENCES AND FURTHER READING
279 7 PROTEIN SYNTHESIS, PROCESSING, AND REGULATION 281 TRANSLATION OF
MRNA 281 TRANSFER RNAS 282 THERIBOSOME 283 THE ORGANIZATION OF MRNAS AND
THE INITIATION OF TRANSLATION 289 THE PROCESS OF TRANSLATION 290
REGULATION OF TRANSLATION 296 PROTEIN FOLDING AND PROCESSING 298
CHAPERBNES AND PROTEIN FOLDING 298 ENZYMES AND PROTEIN FOLDING 303
PROTEIN CLEAVAGE 303 GLYCOSYLATION 305 ATTACHMENT OF LIPIDS 307
REGULATION OF PROTEIN FUNCTION 309 REGULATION BY SMALL MOLECULES 310
PROTEIN PHOSPHORYLATION 311 PROTEIN-PROTEIN INTERACTIONS 313 PROTEIN
DEGRADATION 313 THE UBIQUITIN-PROTEASOME PATHWAY 313 LYSOSOMAL
PROTEOLYSIS 315 KEY EXPERIMENT CATALYTIC ROLE OF RIBOSOMAL RNA 288
MOLECULAR MEDICINE ANTIBIOTICS AND PROTEIN SYNTHESIS 292 SUMMARY AND
KEYTERMS 316 QUESTIONS 318 REFERENCES AND FURTHER READING 318 PARTIII
CELL STRUCTURE AND FUNCTION 8 THE NUCLEUS 323 THE NUCLEAR ENVELOPE AND
TRAFFIC BETWEEN THE NUCLEUS AND CYTOPLASM 323 STRUCTURE OF THE NUCLEAR
ENVELOPE 324 THE NUCLEAR PORE COMPLEX 326 SELECTIVE TRANSPORT OF
PROTEINS TO AND FROM THE NUCLEUS 328 REGULATION OF NUCLEAR PROTEIN
IMPORT 332 TRANSPORT OF RNAS 334 INTERNAL ORGANIZATION OF THE NUCLEUS
335 CHROMOSOMES AND HIGHER-ORDER CHROMATIN STRUCTURE 335 FUNCTIONAL
DOMAINS WITHIN THE NUCLEUS 337 THE NUCLEOLUS 339 RIBOSOMAL RNA GENES AND
THE ORGANIZATION OF THE NUCLEOLUS 339 TRANSCRIPTION AND PROCESSING
OFRRNA 342 RIBOSOME ASSEMBLY 344 THE NUCLEUS DURING MITOSIS 345
DISSOLUTION OF THE NUCLEAR ENVELOPE 345 CHROMOSOME CONDENSATION 348
RE-FORMATION OF THE INTERPHASE NUCLEUS 349 KEY EXPERIMENT IDENTIFICATION
OF NUCLEAR LOCALIZATION SIGNALS 330 MOLECULAR MEDICINE NUCLEAR LAMINA
DISEASES 340 SUMMARY AND KEYTERMS 351 QUESTIONS 352 REFERENCES AND
FURTHER READING 353 CONTENTS XI 9 10 11 \PROTEIN SORTING AND
'/TRANSPORT: (THE ENDOPLASMIC 'RETICULUM, GOLGI APPARATUS, TANDLYSOSOMES
355 THE ENDOPLASMIC RETICULUM 355 ,\ THE ENDOPLASMIC RETICULUM AND
PROTEIN SECRETION 356 |* TARGETING PROTEINS TO THE ENDOPLASMIC RETICULUM
357 *" INSERTION OF PROTEINS INTO THE ER MEMBRANE 362 "PROTEIN FOLDING
AND PROCESSING INTHEER 366 THE SMOOTH ER AND LIPID SYNTHESIS 369 JEXPORT
OF PROTEINS AND LIPIDS FROM " THEER 372 THE GOLGI APPARATUS 374
FORGANIZATION OF THE GOLGI 375 FPROTEIN GLYCOSYLATION WITHIN THE " GOLGI
377 JLIPID AND POLYSACCHARIDE METABOLISM IN THE GOLGI 379 JJPROTEIN
SORTING AND EXPORT FROM THE GOLGI APPARATUS 380 THE MECHANISM OF
VESICULAR [TRANSPORT 382 EXPERIMENTAL APPROACHES TO UNDER- STANDING
VESICULAR TRANSPORT 383 JFCOAT PROTEINS, CARGO SELECTION, AND VESICLE
BUDDING 385 RESIDE FUSION 387 LYSOSOMES 389 ILYSOSOMAL ACID HYDROLASES
389 NDOCYTOSIS AND LYSOSOME FORMATION 390 AGOCYTOSIS AND AUTOPHAGY 393
||EY EXPERIMENT THE SIGNAL HYPOTHESIS 360 MOLECULAR MEDICINE GAUCHER'S
DISEASE 392 SUMMARY AND KEYTERMS 394 IPUESTIONS 396 REFERENCES AND
FURTHER READING 396 BIOENERGETICS AND METABOLISM: MITOCHONDRIA,
CHLOROPLASTS, AND PEROXISOMES 399 MITOCHONDRIA 399 ORGANIZATION AND
FUNCTION OF MITOCHONDRIA 400 THE GENETIC SYSTEM OF MITOCHONDRIA 401
PROTEIN IMPORT AND MITOCHONDRIAL ASSEMBLY 403 THE MECHANISM OF OXIDATIVE
PHOSPHORYLATION 408 THE ELECTRON TRANSPORT CHAIN 408 CHEMIOSMOTIC
COUPLING 410 TRANSPORT OF METABOLITES ACROSS THE INNER MEMBRANE 414
CHLOROPLASTS AND OTHER PLASTIDS 415 THE STRUCTURE AND FUNCTION OF
CHLOROPLASTS 415 THE CHLOROPLAST GENOME 417 IMPORT AND SORTING OF
CHLOROPLAST PROTEINS 418 OTHER PLASTIDS 420 PHOTOSYNTHESIS 422 ELECTRON
FLOW THROUGH PHOTOSYSTEMS I AND II 422 CYCLIC ELECTRON FLOW 425 ATP
SYNTHESIS 426 PEROXISOMES 426 FUNCTIONS OF PEROXISOMES 427 PEROXISOME
ASSEMBLY 429 I KEY EXPERIMENT THE CHEMIOSMOTIC THEORY 412 MOLECULAR
MEDICINE DISEASES OF MITO- CHONDRIA: LEBER'S HEREDITARY OPTIC NEUROPATHY
406 SUMMARY AND KEYTERMS 430 QUESTIONS 432 REFERENCES AND FURTHER
READING 433 THE CYTOSKELETON AND CELL MOVEMENT 435 STRUCTURE AND
ORGANIZATION OF ACTIN FILAMENTS 435 ASSEMBLY AND DISASSEMBLY OF ACTIN
FILAMENTS 436 ORGANIZATION OF ACTIN FILAMENTS 440 ASSOCIATION OF ACTIN
FILAMENTS WITH THE PLASMA MEMBRANE 442 PROTRUSIONS OF THE CELL SURFACE
445 ACTIN, MYOSIN, AND CELL MOVEMENT 447 MUSCLE CONTRACTION 447
CONTRACTILE ASSEMBLIES OF ACTIN AND MYOSIN IN NONMUSCLE CELLS 451
UNCONVENTIONAL MYOSINS 453 CELL MIGRATION AND CRAWLING 454 INTERMEDIATE
FILAMENTS 455 INTERMEDIATE FILAMENT PROTEINS 455 ASSEMBLY OF
INTERMEDIATE FILAMENTS 456 INTRACELLULAR ORGANIZATION OF INTERMEDIATE
FILAMENTS 457 FUNCTIONS OF KERATINS AND NEURO- FILAMENTS: DISEASES OF
THE SKIN AND NERVOUS SYSTEM 459 MICROTUBULES 462 STRUCTURE, ASSEMBLY,
AND DYNAMIC INSTABILITY OF MICROTUBULES 462 THE CENTROSOME, CENTRIOLES,
AND MICROTUBULE ORGANIZATION 463 REORGANIZATION OF MICROTUBULES DURING
MITOSIS 466 STABILIZATION OF MICROTUBULES AND CELL POLARITY 467
MICROTUBULE MOTORS AND MOVEMENTS 468 IDENTIFICATION OF MICROTUBULE MOTOR
PROTEINS 468 ORGANELLE TRANSPORT AND INTRACELLULAR ORGANIZATION 472
SEPARATION OF MITOTIC CHROMOSOMES 474 CILIA AND FLAGELLA 474 KEY
EXPERIMENT EXPRESSION OF MUTANT KERATIN CAUSES ABNORMAL SKIN DEVELOPMENT
460 KEY EXPERIMENT THE ISOLATION OF KINESIN 470 XII CONTENTS SUMMARY AND
KEYTERMS 478 QUESTIONS 480 REFERENCES AND FURTHER READING 481 12 THE
CELL SURFACE 483 STRUCTURE OF THE PLASMA MEMBRANE 483 THE PHOSPHOLIPID
BILAYER 483 MEMBRANE PROTEINS 486 MOBILITY OF MEMBRANE PROTEINS 490 THE
GLYCOCALYX 492 TRANSPORT OF SMALL MOLECULES 493 PASSIVE DIFFUSION 494
FACILITATED DIFFUSION AND CARRIER PROTEINS 494 ION CHANNELS 496 ACTIVE
TRANSPORT DRIVEN BY ATP HYDROLYSIS 503 ACTIVE TRANSPORT DRIVEN BY ION
GRADIENTS 507 ENDOCYTOSIS 510 PHAGOCYTOSIS 510 RECEPTOR-MEDIATED
ENDOCYTOSIS 511 PROTEIN TRAFFICKING IN ENDOCYTOSIS 515 CELL WALLS AND
THE EXTRA- CELLULAR MATRIX 518 BACTERIAL CELL WALLS 518 PLANT CELL WALLS
519 THE EXTRACELLULAR MATRIX 522 CELL-CELL INTERACTIONS 528 CELL
ADHESION PROTEINS 528 TIGHT JUNCTIONS 531 GAP JUNCTIONS 532 PLANT CELL
ADHESION AND PLASMODESMATA 532 KEY EXPERIMENT THE LDL RECEPTOR 512
MOLECULAR MEDICINE CYSTIC FIBROSIS 509 SUMMARY AND KEYTERMS 533
QUESTIONS 535 REFERENCES AND FURTHER READING 536 CELL REGULATION 13 CELL
SIGNALING 541 SIGNALING MOLECULES AND THEIR RECEPTORS 541 MODES OF
CELL-CELL SIGNALING 542' STEROID HORMONES AND THE NUCLEAR RECEPTOR
SUPERFAMILY 543 NITRIC OXIDE AND CARBON MONOXIDE 545 NEUROTRANSMITTERS
546 PEPTIDE HORMONES AND GROWTH FACTORS 546 EICOSANOIDS 548 PLANT
HORMONES 549 FUNCTIONS OF CELL SURFACE RECEPTORS 550 G PROTEIN-COUPLED
RECEPTORS 551 RECEPTOR PROTEIN-TYROSINE KINASES 553 CYTOKINE RECEPTORS
AND NONRECEPTOR PROTEIN-TYROSINE KINASES 557 RECEPTORS LINKED TO OTHER
ENZYMATIC ACTIVITIES 557 PATHWAYS OF INTRACELLULAR SIGNAL TRANSDUCTION
558 THE CAMP PATHWAY: SECOND MESSENGERS AND PROTEIN PHOSPHORYLATION 559
CYCLIC GMP 561 PHOSPHOLIPIDS AND CA 2+ 562 RAS, RAF, AND THE MAP KINASE
PATHWAY 565 THE JAK/STAT PATHWAY 570 SIGNAL TRANSDUCTION AND
THECYTOSKELETON 571 INTEGRINS AND SIGNAL TRANSDUCTION 571 REGULATION OF
THE ACTIN CYTOSKELETON 574 SIGNALING IN DEVELOPMENT AND DIFFERENTIATION
575 THE RECEPTOR TYROSINE KINASE /RAS/ RAF/ERK PATHWAY IN DROSOPHILA AND
C. ELEGANS 575 HEDGEHOG AND WNT 577 NOTCH SIGNALING 578 REGULATION OF
PROGRAMMED CELL DEATH 579 CASPASES AND APOPTOSIS 580 CELL DEATH
RECEPTORS AND CASPASE ACTIVATION 582 SIGNALING CELL SURVIVAL 582 KEY
EXPERIMENT THE SRC PROTEIN- TYROSINE KINASE 554 MOLECULAR MEDICINE
CANCER: SIGNAL TRANSDUCTION, AND THE RAS ONCOGENES 572 SUMMARY AND
KEYTERMS 584 QUESTIONS 587 REFERENCES AND FURTHER READING 587 14 THE
CELL CYCLE 591 THE EUKARYOTIC CELL CYCLE ( PHASES OF THE CELL CYCLE 592
REGULATION OF THE CELL CYCLE BY CELL GROWTH AND EXTRACELLULAR SIGNALS
594 CELL CYCLE CHECKPOINTS 596 RESTRICTING DNA REPLICATION TO ONCE PER
CELL CYCLE 598 REGULATORS OF CELL N CYCLE PROGRESSION 599Y MPF: A DIMER
OF CDC2 AND CYCLIN 599 FAMILIES OF CYCLINS AND CYCLIN- DEPENDENT KINASES
603 GROWTH FACTORS AND THE D-TYPE CYCLINS 605 INHIBITORS OF CELL CYCLE
PROGRESSION 606 THE EVENTS OF M PHASE 608 STAGES OF MITOSIS 608 CONTENTS
XIII JMPF AND PROGRESSION TO METAPHASE 611 IPROTEOLYSIS AND THE
INACTIVATION OF MPF: ANAPHASE AND TELOPHASE 613 JCYTOKINESIS 614 MEIOSIS
AND FERTILIZATION 615 |THE PROCESS OF MEIOSIS 615 |REGULATION OF OOCYTE
MEIOSIS 618 FERTILIZATION 620 ITEM CELLS AND THE MAINTENANCE
OFADULTTISSUES 621 PROLIFERATION OF DIFFERENTIATED CELLS 621 STEM CELLS
622 PEDICAL APPLICATIONS OF STEM CELLS 624 |EY EXPERIMENT THE DISCOVERY
OF MPF 600 KE Y EXPERIMENT CULTURE OF EMBRYONIC STEM CELLS 622 GJLIMMARY
AND KEYTERMS 625 |UESTIONS 628 REFERENCES AND FURTHER READING 628 15
CANCER 631 THE DEVELOPMENT AND CAUSES OF CANCER 631 TYPES OF CANCER 631
THE DEVELOPMENT OF CANCER 633 CAUSES OF CANCER 634 PROPERTIES OF CANCER
CELLS 636 TRANSFORMATION OF CELLS IN CULTURE 640 TUMOR VIRUSES 640
HEPATITIS B AND C VIRUSES 641 SV40 AND POLYOMAVIRUS 641 PAPILLOMAVIRUSES
642 ADENOVIRUSES 642 HERPESVIRUSES 643 RETROVIRUSES 644 ONCOGENES 644
RETROVIRAL ONCOGENES 645 PROTO-ONCOGENES 646 ONCOGENES IN HUMAN CANCER
649 FUNCTIONS OF ONCOGENE PRODUCTS 653 TUMOR SUPPRESSOR GENES 657
IDENTIFICATION OF TUMOR SUPPRESSOR GENES 657 FUNCTIONS OF TUMOR
SUPPRESSOR GENE PRODUCTS 660 ROLES OF ONCOGENES AND TUMOR SUPPRESSOR
GENES IN TUMOR DEVELOPMENT 663 APPLICATIONS OF MOLECULAR BIOLOGY TO
CANCER PREVENTION AND TREATMENT 664 PREVENTION AND EARLY DETECTION 664
MOLECULAR DIAGNOSIS 665 TREATMENT 666 KEY EXPERIMENT THE DISCOVERY OF
PROTO-ONCOGENES 648 MOLECULAR MEDICINE STI-571: CANCER TREATMENT
TARGETED AGAINST THE BCR/ABL ONCOGENE 667 SUMMARY AND KEYTERMS 669
QUESTIONS 671 REFERENCES AND FURTHER READING 671 ANSWERS TO QUESTIONS
675 GLOSSARY 681 INDEX 699 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Cooper, Geoffrey M. |
| author_facet | Cooper, Geoffrey M. |
| author_role | aut |
| author_sort | Cooper, Geoffrey M. |
| author_variant | g m c gm gmc |
| building | Verbundindex |
| bvnumber | BV020872670 |
| callnumber-first | Q - Science |
| callnumber-label | QH581 |
| callnumber-raw | QH581.2 |
| callnumber-search | QH581.2 |
| callnumber-sort | QH 3581.2 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | WE 1000 |
| classification_tum | CHE 800f BIO 180f BIO 220f BIO 200f BIO 470f BIO 770f |
| ctrlnum | (OCoLC)52121379 (DE-599)BVBBV020872670 |
| dewey-full | 571.6 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.6 |
| dewey-search | 571.6 |
| dewey-sort | 3571.6 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie |
| discipline_str_mv | Biologie Chemie |
| edition | 3. ed. |
| format | Book |
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| genre | 1\p (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV020872670 |
| illustrated | Illustrated |
| index_date | 2024-07-02T13:26:35Z |
| indexdate | 2024-07-09T20:27:11Z |
| institution | BVB |
| isbn | 0878932143 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014194390 |
| oclc_num | 52121379 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XX, 713 S. zahlr. Ill., graph. Darst. - zahlr. Ill., graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | ASM Press Sinauer Associates |
| record_format | marc |
| spelling | Cooper, Geoffrey M. Verfasser aut The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman 3. ed. Washington, D.C. ASM Press 2004 Sunderland, Mass. Sinauer Associates XX, 713 S. zahlr. Ill., graph. Darst. - zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Biologia celular larpcal Biologia molecular larpcal Biologie moléculaire Celbiologie gtt Cytologie Moleculaire biologie gtt Cell Biology Cytology Molecular Biology Molecular biology Cytologie (DE-588)4070177-3 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf CD-ROM (DE-588)4139307-7 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Cytologie (DE-588)4070177-3 s Molekularbiologie (DE-588)4039983-7 s DE-604 Zelle (DE-588)4067537-3 s CD-ROM (DE-588)4139307-7 s 2\p DE-604 Hausman, Robert E. Sonstige oth http://www.loc.gov/catdir/toc/fy038/2003008953.html Table of contents HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014194390&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cooper, Geoffrey M. The cell a molecular approach Biologia celular larpcal Biologia molecular larpcal Biologie moléculaire Celbiologie gtt Cytologie Moleculaire biologie gtt Cell Biology Cytology Molecular Biology Molecular biology Cytologie (DE-588)4070177-3 gnd Zelle (DE-588)4067537-3 gnd CD-ROM (DE-588)4139307-7 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4070177-3 (DE-588)4067537-3 (DE-588)4139307-7 (DE-588)4039983-7 (DE-588)4123623-3 |
| title | The cell a molecular approach |
| title_auth | The cell a molecular approach |
| title_exact_search | The cell a molecular approach |
| title_exact_search_txtP | The cell a molecular approach |
| title_full | The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman |
| title_fullStr | The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman |
| title_full_unstemmed | The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman |
| title_short | The cell |
| title_sort | the cell a molecular approach |
| title_sub | a molecular approach |
| topic | Biologia celular larpcal Biologia molecular larpcal Biologie moléculaire Celbiologie gtt Cytologie Moleculaire biologie gtt Cell Biology Cytology Molecular Biology Molecular biology Cytologie (DE-588)4070177-3 gnd Zelle (DE-588)4067537-3 gnd CD-ROM (DE-588)4139307-7 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Biologia celular Biologia molecular Biologie moléculaire Celbiologie Cytologie Moleculaire biologie Cell Biology Cytology Molecular Biology Molecular biology Zelle CD-ROM Molekularbiologie Lehrbuch |
| url | http://www.loc.gov/catdir/toc/fy038/2003008953.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014194390&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT coopergeoffreym thecellamolecularapproach AT hausmanroberte thecellamolecularapproach |