Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis: = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Köln, Univ., Diss., 2005 |
| Beschreibung: | 61 S. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis |b = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |c vorgelegt von Guanyu Wang |
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| 500 | |a Köln, Univ., Diss., 2005 | ||
| 546 | |a Zsfassung in dt. Sprache | ||
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
(INHALTSVERZEICHNIS)
Page (Seite)
1. Introduction 1
1.1 Dysregulative lymphoma pathogenesis 1
1.2 T cell differentiation and the thymic microenvironment 3
1.3 Mathematical modeling 3
1.4 Why we choose an age-structured model 6
1.4.1 Kinetic diversity 6
1.4.2 Definition of maturity 9 9
2. Basic (physiologic) model 11
2.1 Model design 11
2.2 Data acquisition scheme 13
2.3 Computational method 14
2.4 Numerical example 16
3. Disturbed (pathologic) model 20
3.1 Modell 20
3.2 Model II 25
4. Inverse problems 28
4.1 Introduction 28
4.2 Inverse problems 29
4.2.1 Data acquisition 30
4.2.2 Approximation of functions 31
4.2.3 Simplification of the direct problem 31
4.2.4 Parameter identification 32
4.3 Numerical examples 35
5. Potential implementation of the mouse system 40
5.1 Introduction 40
5.1.1 Study of normal mice 40
5.1.2 Study of diseased mice 41
5.2 Theoretical preparations for data acquisition 42
5.2.1 Determining the mean proliferation rate 42
5.2.2 Determining the mean apoptosis rate 43
5.3 Experimental design 44
5.3.1 Outline 45
5.3.2 Data acquisition 46
6. Conclusion (Discussion) 49
7. Summary 52
8. Zusammenfassung 53
9. References 54
|
| adam_txt |
TABLE OF CONTENTS
(INHALTSVERZEICHNIS)
Page (Seite)
1. Introduction 1
1.1 Dysregulative lymphoma pathogenesis 1
1.2 T cell differentiation and the thymic microenvironment 3
1.3 Mathematical modeling 3
1.4 Why we choose an age-structured model 6
1.4.1 Kinetic diversity 6
1.4.2 Definition of maturity 9 9
2. Basic (physiologic) model 11
2.1 Model design 11
2.2 Data acquisition scheme 13
2.3 Computational method 14
2.4 Numerical example 16
3. Disturbed (pathologic) model 20
3.1 Modell 20
3.2 Model II 25
4. Inverse problems 28
4.1 Introduction 28
4.2 Inverse problems 29
4.2.1 Data acquisition 30
4.2.2 Approximation of functions 31
4.2.3 Simplification of the direct problem 31
4.2.4 Parameter identification 32
4.3 Numerical examples 35
5. Potential implementation of the mouse system 40
5.1 Introduction 40
5.1.1 Study of normal mice 40
5.1.2 Study of diseased mice 41
5.2 Theoretical preparations for data acquisition 42
5.2.1 Determining the mean proliferation rate 42
5.2.2 Determining the mean apoptosis rate 43
5.3 Experimental design 44
5.3.1 Outline 45
5.3.2 Data acquisition 46
6. Conclusion (Discussion) 49
7. Summary 52
8. Zusammenfassung 53
9. References 54 |
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| author | Wang, Guanyu 1972- |
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| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Book |
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| illustrated | Illustrated |
| index_date | 2024-07-02T13:21:34Z |
| indexdate | 2024-07-09T20:26:46Z |
| institution | BVB |
| language | English |
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| physical | 61 S. Ill., graph. Darst. |
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| spelling | Wang, Guanyu 1972- Verfasser (DE-588)130374466 aut Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese vorgelegt von Guanyu Wang Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese 2005 61 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Köln, Univ., Diss., 2005 Zsfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014178432&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wang, Guanyu 1972- Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| subject_GND | (DE-588)4113937-9 |
| title | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| title_alt | Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| title_auth | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| title_exact_search | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| title_exact_search_txtP | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| title_full | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese vorgelegt von Guanyu Wang |
| title_fullStr | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese vorgelegt von Guanyu Wang |
| title_full_unstemmed | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese vorgelegt von Guanyu Wang |
| title_short | Age-structured model for simulating T cell differentiation during normal development and in leukemogenesis |
| title_sort | age structured model for simulating t cell differentiation during normal development and in leukemogenesis model zur altersabhangigen simulation der t zell differenzierung wahrend der normalen entwicklung und wahrend der leukamogenese |
| title_sub | = Model zur altersabhängigen Simulation der T-Zell-Differenzierung während der normalen Entwicklung und während der Leukämogenese |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014178432&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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