Introduction to bioinformatics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2003
|
| Ausgabe: | Reprinted |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 283 S., [2] Bl. Ill., graph. Darst. |
| ISBN: | 0199251967 |
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| adam_text | INTRODUCTION TO BIOINFORMATICS ARTHUR M. LESK UNIVERSITY OF CAMBRIDGE IN
NATURE S INFINITE BOOK OF SECRECY A LITTLE I CAN READ. - ANTHONY AND
CLEOPATRA OXPORD UNIVBRSITY PMSS I CONTENTS PLAN OF THE BOOK XVII 1
INTRODUCTION 1 A SCENARIO 3 LIFE IN SPACE AND TIME 4 DOGMAS: CENTRAL AND
PERIPHERAL 5 OBSERVABLES AND DATA ARCHIVES 8 CURATION, ANNOTATION, AND
QUALITY CONTROL 1 0 THE WORLD WIDE WEB 11 THE HURLY-BURLY 13 ELECTRONIC
PUBLICATION 13 COMPUTERS AND COMPUTER SCIENCE 14 PROGRAMMING 15
BIOLOGICAL CLASSIFICATION AND NOMENCLATURE 19 USE OF SEQUENCES TO
DETERMINE PHYLOGENETIC RELATIONSHIPS 22 USE OF SINES AND LINES TO DERIVE
PHYLOGENETIC RELATIONSHIPS 29 SEARCHING FOR SIMILAR SEQUENCES IN
DATABASES: PSI-BLAST 31 INTRODUCTION TO PROTEIN STRUCTURE 39 THE
HIERARCHICAL NATURE OF PROTEIN ARCHITECTURE 40 CLASSIFICATION OF PROTEIN
STRUCTURES 43 PROTEIN STRUCTURE PREDICTION AND ENGINEERING 48 CRITICAL
ASSESSMENT OF STRUCTURE PREDICTION (CASP) 49 PROTEIN ENGINEERING 50
CLINICAL IMPLICATIONS 50 THE FUTURE 53 RECOMMENDED READING 54 EXERCISES,
PROBLEMS, AND WEBLEMS 55 2 GENOME ORGANIZATION AND EVOLUTION 62 GENOMICS
AND PROTEOMICS 62 GENES 63 PROTEINS 65 PROTEOMES 66 EAVESDROPPING ON THE
TRANSMISSION OF GENETIC INFORMATION 69 MAPPINGS BETWEEN THE MAPS 71
HIGH-RESOLUTION MAPS 74 XIV CONTENTS PICKING OUT GENES IN GENOMES 77
GENOMES OF PROKARYOTES 78 THE GENOME OF THE BACTERIUM ESCHERICHIA COLI
78 THE GENOME OF THE ARCHAEON METHANOCOCCUS JANNASCHII 82 THE GENOME OF
ONE OF THE SIMPLEST ORGANISMS: MYCOPLASMA GENLTALIUM 83 GENOMES OF
EUKARYOTES 83 THE GENOME OF SACCHAROMYCES CEREVISIAE (BAKER S YEAST) 86
THE GENOME OF CAENORHABDITIS ELEGANS 89 THE GENOME OF DROSOPHILA
MELANOGASTER 90 THE GENOME OF ARABIDOPSIS THALIANA 92 THE GENOME OF HOMO
SAPIENS (THE HUMAN GENOME) 93 PROTEIN-CODING GENES 94 REPEAT SEQUENCES
96 RNA 97 SINGLE-NUDEOTIDE POLYMORPHISMS (SNPS) 97 GENETIC DIVERSITY IN
ANTHROPOLOGY 100 GENETIC DIVERSITY AND PERSONAL IDENTIFICATION 101
GENETIC ANALYSIS OF CATTLE DOMESTICATION 1 01 EVOLUTION OF GENOMES 102
PLEASE PASS THE GENES: HORIZONTAL GENE TRANSFER 106 COMPARATIVE GENOMICS
OF EUKARYOTES 108 RECOMMENDED READING 109 EXERCISES, PROBLEMS, AND
WEBLEMS 110 3 ARCHIVES AND INFORMATION RETRIEVAL 115 INTRODUCTION 115
DATABASE INDEXING AND SPECIFICATION OF SEARCH TERMS 115 FOLLOW-UP
QUESTIONS 117 ANALYSIS OF RETRIEVED DATA 117 THE ARCHIVES 118 NUCLEIC
ACID SEQUENCE DATABASES 118 GENOME DATABASES 121 PROTEIN SEQUENCE
DATABASES 121 DATABASES OF STRUCTURES 125 SPECIALIZED, OR BOUTIQUE
DATABASES 133 EXPRESSION AND PROTEOMICS DATABASES 134 DATABASES OF
METABOLIC PATHWAYS 136 BIBLIOGRAPHIC DATABASES 137 SURVEYS OF MOLECULAR
BIOLOGY DATABASES AND SERVERS 138 GATEWAYS TO ARCHIVES 138 ACCESS TO
DATABASES IN MOLECULAR BIOLOGY 139 ENTREZ 13 O THE SEQUENCE RETRIEVAL
SYSTEM (SRS) 148 THE PROTEIN IDENTIFICATION RESOURCE (PIR) 150 EXPASY -
EXPERT PROTEIN ANALYSIS SYSTEM 153 ENSEMBL 15 5 WHERE DO WE GO FROM
HERE? 156 CONTENTS XV RECOMMENDED READING 157 EXERCISES, PROBLEMS, AND
WEBLEMS 157 4 ALIGNMENTS AND PHYLOGENETIC TREES 160 INTRODUCTION TO
SEQUENCE ALIGNMENT 160 THEDOTPLOT 161 DOTPLOTS AND SEQUENCE ALIGNMENTS
167 MEASURES OF SEQUENCE SIMILARITY 172 SCORING SCHEMES 1 72 COMPUTING
THE ALIGNMENT OF TWO SEQUENCES 175 VARIATIONS AND GENERALIZATIONS 177
APPROXIMATE METHODS FOR QUICK SCREENING OF DATABASES 1 77 THE DYNAMIC
PROGRAMMING ALGORITHM FOR OPTIMAL PAIRWISE SEQUENCE ALIGNMENT 178
SIGNIFICANCE OF ALIGNMENTS 184 MULTIPLE SEQUENCE ALIGNMENT 187
STRUCTURAL INFERENCES FROM MULTIPLE SEQUENCE ALIGNMENTS 188 APPLICATIONS
OF MULTIPLE SEQUENCE ALIGNMENTS TO DATABASE SEARCHING 189 PROFILES 190
PSI-BLAST 192 HIDDEN MARKOV MODELS (HMMS) 194 PHYLOGENY 196 PHYLOGENETIC
TREES 200 CLUSTERING METHODS 201 CLADISTIC METHODS 204 THE PROBLEM OF
VARYING RATES OF EVOLUTION 205 COMPUTATIONAL CONSIDERATIONS 206
RECOMMENDED READING 207 EXERCISES, PROBLEMS, AND WEBLEMS 208 5 PROTEIN
STRUCTURE AND DRUG DISCOVERY 216 INTRODUCTION 216 PROTEIN STABILITY AND
FOLDING 219 THE SASISEKHARAN-RAMAKRISHNAN-RAMACHANDRAN PLOT DESCRIBES
ALLOWED MAINCHAIN CONFORMATIONS 219 THE SIDECHAINS 221 PROTEIN STABILITY
AND DENATURATION 221 PROTEIN FOLDING 224 APPLICATIONS OF HYDROPHOBICITY
225 SUPERPOSITION OF STRUCTURES, AND STRUCTURAL ALIGNMENTS 230 DALI
(DISTANCE-MATRIX ALIGNMENT) 232 EVOLUTION OF PROTEIN STRUCTURES 233
CLASSIFICATIONS OF PROTEIN STRUCTURES 234 SCOP 236 PROTEIN STRUCTURE
PREDICTION AND MODELLING 237 CRITICAL ASSESSMENT OF STRUCTURE PREDICTION
(CASP) 238 SECONDARY STRUCTURE PREDICTION 240 HOMOLOGY MODELLING 245
FOLD RECOGNITION 247 XVI CONTENTS FOLD RECOGNITION AT CASP2000 251
CONFORMATIONAL ENERGY CALCULATIONS AND MOLECULAR DYNAMICS 251 ROSETTA
255 LINUS * 255 ASSIGNMENT OF PROTEIN STRUCTURES TO GENOMES 258
PREDICTION OF PROTEIN FUNCTION 260 DIVERGENCE OF FUNCTION: ORTHOLOGUES
AND PARALOGUES 261 DRUG DISCOVERY AND DEVELOPMENT 263 THE LEAD COMPOUND
266 COMPUTER-ASSISTED DRUG DESIGN 268 RECOMMENDED READING 271 EXERCISES,
PROBLEMS, AND WEBLEMS 272 CONCLUSIONS TIL INDEX 278 COLOUR PLATES
|
| adam_txt |
INTRODUCTION TO BIOINFORMATICS ARTHUR M. LESK UNIVERSITY OF CAMBRIDGE IN
NATURE'S INFINITE BOOK OF SECRECY A LITTLE I CAN READ. - ANTHONY AND
CLEOPATRA OXPORD UNIVBRSITY PMSS I CONTENTS PLAN OF THE BOOK XVII 1
INTRODUCTION 1 A SCENARIO 3 LIFE IN SPACE AND TIME 4 DOGMAS: CENTRAL AND
PERIPHERAL 5 OBSERVABLES AND DATA ARCHIVES 8 CURATION, ANNOTATION, AND
QUALITY CONTROL 1 0 THE WORLD WIDE WEB 11 THE HURLY-BURLY 13 ELECTRONIC
PUBLICATION 13 COMPUTERS AND COMPUTER SCIENCE 14 PROGRAMMING 15
BIOLOGICAL CLASSIFICATION AND NOMENCLATURE 19 USE OF SEQUENCES TO
DETERMINE PHYLOGENETIC RELATIONSHIPS 22 USE OF SINES AND LINES TO DERIVE
PHYLOGENETIC RELATIONSHIPS 29 SEARCHING FOR SIMILAR SEQUENCES IN
DATABASES: PSI-BLAST 31 INTRODUCTION TO PROTEIN STRUCTURE 39 THE
HIERARCHICAL NATURE OF PROTEIN ARCHITECTURE 40 CLASSIFICATION OF PROTEIN
STRUCTURES 43 PROTEIN STRUCTURE PREDICTION AND ENGINEERING 48 CRITICAL
ASSESSMENT OF STRUCTURE PREDICTION (CASP) 49 PROTEIN ENGINEERING 50
CLINICAL IMPLICATIONS 50 THE FUTURE 53 RECOMMENDED READING 54 EXERCISES,
PROBLEMS, AND WEBLEMS 55 2 GENOME ORGANIZATION AND EVOLUTION 62 GENOMICS
AND PROTEOMICS 62 GENES 63 PROTEINS 65 PROTEOMES 66 EAVESDROPPING ON THE
TRANSMISSION OF GENETIC INFORMATION 69 MAPPINGS BETWEEN THE MAPS 71
HIGH-RESOLUTION MAPS 74 XIV CONTENTS PICKING OUT GENES IN GENOMES 77
GENOMES OF PROKARYOTES 78 THE GENOME OF THE BACTERIUM ESCHERICHIA COLI
78 THE GENOME OF THE ARCHAEON METHANOCOCCUS JANNASCHII 82 THE GENOME OF
ONE OF THE SIMPLEST ORGANISMS: MYCOPLASMA GENLTALIUM 83 GENOMES OF
EUKARYOTES 83 THE GENOME OF SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) 86
THE GENOME OF CAENORHABDITIS ELEGANS 89 THE GENOME OF DROSOPHILA
MELANOGASTER 90 THE GENOME OF ARABIDOPSIS THALIANA 92 THE GENOME OF HOMO
SAPIENS (THE HUMAN GENOME) 93 PROTEIN-CODING GENES 94 REPEAT SEQUENCES
96 RNA 97 SINGLE-NUDEOTIDE POLYMORPHISMS (SNPS) 97 GENETIC DIVERSITY IN
ANTHROPOLOGY 100 GENETIC DIVERSITY AND PERSONAL IDENTIFICATION 101
GENETIC ANALYSIS OF CATTLE DOMESTICATION 1 01 EVOLUTION OF GENOMES 102
PLEASE PASS THE GENES: HORIZONTAL GENE TRANSFER 106 COMPARATIVE GENOMICS
OF EUKARYOTES 108 RECOMMENDED READING 109 EXERCISES, PROBLEMS, AND
WEBLEMS 110 3 ARCHIVES AND INFORMATION RETRIEVAL 115 INTRODUCTION 115
DATABASE INDEXING AND SPECIFICATION OF SEARCH TERMS 115 FOLLOW-UP
QUESTIONS 117 ANALYSIS OF RETRIEVED DATA 117 THE ARCHIVES 118 NUCLEIC
ACID SEQUENCE DATABASES 118 GENOME DATABASES 121 PROTEIN SEQUENCE
DATABASES 121 DATABASES OF STRUCTURES 125 SPECIALIZED, OR 'BOUTIQUE'
DATABASES 133 EXPRESSION AND PROTEOMICS DATABASES 134 DATABASES OF
METABOLIC PATHWAYS 136 BIBLIOGRAPHIC DATABASES 137 SURVEYS OF MOLECULAR
BIOLOGY DATABASES AND SERVERS 138 GATEWAYS TO ARCHIVES 138 ACCESS TO
DATABASES IN MOLECULAR BIOLOGY 139 ENTREZ 13 O THE SEQUENCE RETRIEVAL
SYSTEM (SRS) 148 THE PROTEIN IDENTIFICATION RESOURCE (PIR) 150 EXPASY -
EXPERT PROTEIN ANALYSIS SYSTEM 153 ENSEMBL 15 5 WHERE DO WE GO FROM
HERE? 156 CONTENTS XV RECOMMENDED READING 157 EXERCISES, PROBLEMS, AND
WEBLEMS 157 4 ALIGNMENTS AND PHYLOGENETIC TREES 160 INTRODUCTION TO
SEQUENCE ALIGNMENT 160 THEDOTPLOT 161 DOTPLOTS AND SEQUENCE ALIGNMENTS
167 MEASURES OF SEQUENCE SIMILARITY 172 SCORING SCHEMES 1 72 COMPUTING
THE ALIGNMENT OF TWO SEQUENCES 175 VARIATIONS AND GENERALIZATIONS 177
APPROXIMATE METHODS FOR QUICK SCREENING OF DATABASES 1 77 THE DYNAMIC
PROGRAMMING ALGORITHM FOR OPTIMAL PAIRWISE SEQUENCE ALIGNMENT 178
SIGNIFICANCE OF ALIGNMENTS 184 MULTIPLE SEQUENCE ALIGNMENT 187
STRUCTURAL INFERENCES FROM MULTIPLE SEQUENCE ALIGNMENTS 188 APPLICATIONS
OF MULTIPLE SEQUENCE ALIGNMENTS TO DATABASE SEARCHING 189 PROFILES 190
PSI-BLAST 192 HIDDEN MARKOV MODELS (HMMS) 194 PHYLOGENY 196 PHYLOGENETIC
TREES 200 CLUSTERING METHODS 201 CLADISTIC METHODS 204 THE PROBLEM OF
VARYING RATES OF EVOLUTION 205 COMPUTATIONAL CONSIDERATIONS 206
RECOMMENDED READING 207 EXERCISES, PROBLEMS, AND WEBLEMS 208 5 PROTEIN
STRUCTURE AND DRUG DISCOVERY 216 INTRODUCTION 216 PROTEIN STABILITY AND
FOLDING 219 THE SASISEKHARAN-RAMAKRISHNAN-RAMACHANDRAN PLOT DESCRIBES
ALLOWED MAINCHAIN CONFORMATIONS 219 THE SIDECHAINS 221 PROTEIN STABILITY
AND DENATURATION 221 PROTEIN FOLDING 224 APPLICATIONS OF HYDROPHOBICITY
225 SUPERPOSITION OF STRUCTURES, AND STRUCTURAL ALIGNMENTS 230 DALI
(DISTANCE-MATRIX ALIGNMENT) 232 EVOLUTION OF PROTEIN STRUCTURES 233
CLASSIFICATIONS OF PROTEIN STRUCTURES 234 SCOP 236 PROTEIN STRUCTURE
PREDICTION AND MODELLING 237 CRITICAL ASSESSMENT OF STRUCTURE PREDICTION
(CASP) 238 SECONDARY STRUCTURE PREDICTION 240 HOMOLOGY MODELLING 245
FOLD RECOGNITION 247 XVI CONTENTS FOLD RECOGNITION AT CASP2000 251
CONFORMATIONAL ENERGY CALCULATIONS AND MOLECULAR DYNAMICS 251 ROSETTA
255 LINUS * 255 ASSIGNMENT OF PROTEIN STRUCTURES TO GENOMES 258
PREDICTION OF PROTEIN FUNCTION 260 DIVERGENCE OF FUNCTION: ORTHOLOGUES
AND PARALOGUES 261 DRUG DISCOVERY AND DEVELOPMENT 263 THE LEAD COMPOUND
266 COMPUTER-ASSISTED DRUG DESIGN 268 RECOMMENDED READING 271 EXERCISES,
PROBLEMS, AND WEBLEMS 272 CONCLUSIONS TIL INDEX 278 COLOUR PLATES |
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| spelling | Lesk, Arthur M. Verfasser aut Introduction to bioinformatics Arthur M. Lesk Reprinted Oxford [u.a.] Oxford Univ. Press 2003 XVI, 283 S., [2] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Bioinformatik (DE-588)4611085-9 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Bioinformatik (DE-588)4611085-9 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014177346&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
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| subject_GND | (DE-588)4611085-9 (DE-588)4123623-3 |
| title | Introduction to bioinformatics |
| title_auth | Introduction to bioinformatics |
| title_exact_search | Introduction to bioinformatics |
| title_exact_search_txtP | Introduction to bioinformatics |
| title_full | Introduction to bioinformatics Arthur M. Lesk |
| title_fullStr | Introduction to bioinformatics Arthur M. Lesk |
| title_full_unstemmed | Introduction to bioinformatics Arthur M. Lesk |
| title_short | Introduction to bioinformatics |
| title_sort | introduction to bioinformatics |
| topic | Bioinformatik (DE-588)4611085-9 gnd |
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