Turning up the heat on pain: TRPV1 receptors in pain and inflammation:
Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Basel [u.a.]
Birkhäuser
2005
|
| Schriftenreihe: | PIR - Progress in Inflammation Research
|
| Schlagworte: | |
| Zusammenfassung: | Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor may lead to important advances in analgesic drug development. Insights into the prospects for the therapeutic potential of TRPV1 activation or inhibition, particularly in various painful or inflammatory conditions, are provided. The volume is written for basic scientists and clinicians interested in the mechanisms of pain, inflammation and the treatment of these conditions. |
| Beschreibung: | XII, 249 S. |
| ISBN: | 3764370807 9783764370800 |
Internformat
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| 520 | 3 | |a Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor may lead to important advances in analgesic drug development. Insights into the prospects for the therapeutic potential of TRPV1 activation or inhibition, particularly in various painful or inflammatory conditions, are provided. The volume is written for basic scientists and clinicians interested in the mechanisms of pain, inflammation and the treatment of these conditions. | |
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| id | DE-604.BV020828678 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T20:20:11Z |
| institution | BVB |
| isbn | 3764370807 9783764370800 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013833928 |
| oclc_num | 60651130 |
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| owner_facet | DE-355 DE-BY-UBR DE-29 |
| physical | XII, 249 S. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Birkhäuser |
| record_format | marc |
| series2 | PIR - Progress in Inflammation Research |
| spelling | Turning up the heat on pain: TRPV1 receptors in pain and inflammation Annika Malmberg ... (eds.) Basel [u.a.] Birkhäuser 2005 XII, 249 S. txt rdacontent n rdamedia nc rdacarrier PIR - Progress in Inflammation Research Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor may lead to important advances in analgesic drug development. Insights into the prospects for the therapeutic potential of TRPV1 activation or inhibition, particularly in various painful or inflammatory conditions, are provided. The volume is written for basic scientists and clinicians interested in the mechanisms of pain, inflammation and the treatment of these conditions. Capsaicin analogs & derivatives Capsaicin pharmacology Inflammation Inflammation Mediators Inflammation drug therapy Nociceptors Pain Pain drug therapy Receptors, Drug antagonists & inhibitors Receptors, Drug physiology Entzündung (DE-588)4014975-4 gnd rswk-swf Schmerz (DE-588)4052823-6 gnd rswk-swf Nozizeptor (DE-588)4042724-9 gnd rswk-swf Nozizeptor (DE-588)4042724-9 s Schmerz (DE-588)4052823-6 s Entzündung (DE-588)4014975-4 s DE-604 Malmberg, Annika B. 1966- Sonstige (DE-588)123254140 oth |
| spellingShingle | Turning up the heat on pain: TRPV1 receptors in pain and inflammation Capsaicin analogs & derivatives Capsaicin pharmacology Inflammation Inflammation Mediators Inflammation drug therapy Nociceptors Pain Pain drug therapy Receptors, Drug antagonists & inhibitors Receptors, Drug physiology Entzündung (DE-588)4014975-4 gnd Schmerz (DE-588)4052823-6 gnd Nozizeptor (DE-588)4042724-9 gnd |
| subject_GND | (DE-588)4014975-4 (DE-588)4052823-6 (DE-588)4042724-9 |
| title | Turning up the heat on pain: TRPV1 receptors in pain and inflammation |
| title_auth | Turning up the heat on pain: TRPV1 receptors in pain and inflammation |
| title_exact_search | Turning up the heat on pain: TRPV1 receptors in pain and inflammation |
| title_full | Turning up the heat on pain: TRPV1 receptors in pain and inflammation Annika Malmberg ... (eds.) |
| title_fullStr | Turning up the heat on pain: TRPV1 receptors in pain and inflammation Annika Malmberg ... (eds.) |
| title_full_unstemmed | Turning up the heat on pain: TRPV1 receptors in pain and inflammation Annika Malmberg ... (eds.) |
| title_short | Turning up the heat on pain: TRPV1 receptors in pain and inflammation |
| title_sort | turning up the heat on pain trpv1 receptors in pain and inflammation |
| topic | Capsaicin analogs & derivatives Capsaicin pharmacology Inflammation Inflammation Mediators Inflammation drug therapy Nociceptors Pain Pain drug therapy Receptors, Drug antagonists & inhibitors Receptors, Drug physiology Entzündung (DE-588)4014975-4 gnd Schmerz (DE-588)4052823-6 gnd Nozizeptor (DE-588)4042724-9 gnd |
| topic_facet | Capsaicin analogs & derivatives Capsaicin pharmacology Inflammation Inflammation Mediators Inflammation drug therapy Nociceptors Pain Pain drug therapy Receptors, Drug antagonists & inhibitors Receptors, Drug physiology Entzündung Schmerz Nozizeptor |
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