Advanced time-correlated single photon counting techniques:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2005
|
| Schriftenreihe: | Springer series in chemical physics
81 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturverz. S. 351 - 387 |
| Beschreibung: | XIX, 401 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9783540260479 3540260471 |
Internformat
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| 100 | 1 | |a Becker, Wolfgang |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Advanced time-correlated single photon counting techniques |c W. Becker |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2005 | |
| 300 | |a XIX, 401 S. |b Ill., graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Springer series in chemical physics |v 81 | |
| 500 | |a Literaturverz. S. 351 - 387 | ||
| 650 | 4 | |a Corrélation de photons | |
| 650 | 7 | |a Fotônica |2 larpcal | |
| 650 | 7 | |a Física moderna |2 larpcal | |
| 650 | 4 | |a Photon correlation | |
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Datensatz im Suchindex
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| adam_text | CONTENTS
LIST OF TECHNICAL TERMS AND
SYMBOLS........................................ XIII
1 OPTICAL SIGNAL RECORDING
................................................................. 1
2 OVERVIEW OF PHOTON COUNTING
TECHNIQUES................................... 11
2.1 STEADY-STATE PHOTON COUNTING
............................................... 11
2.2 GATED PHOTON COUNTING
.......................................................... 12
2.3 MULTICHANNEL SCALERS
.............................................................. 16
2.4 TIME-CORRELATED SINGLE PHOTON COUNTING (TCSPC) .............. 20
2.4.1 GENERAL PRINCIPLE
...................................................... 20
2.4.2 THE CLASSIC TCSPC SETUP ........................................
23
2.4.3 REVERSED START-STOP
.................................................. 24
3 MULTIDIMENSIONAL TCSPC TECHNIQUES
......................................... 27
3.1 MULTIDETECTOR
TCSPC............................................................. 29
3.2 MULTIPLEXED TCSPC
............................................................... 33
3.3 SEQUENTIAL RECORDING TECHNIQUES
.......................................... 35
3.4 SCANNING
TECHNIQUES..............................................................
37
3.5 IMAGING BY POSITION-SENSITIVE DETECTION
............................... 39
3.6 TIME-TAG RECORDING
.............................................................. 43
3.7 MULTIMODULE
SYSTEMS............................................................. 45
4 BUILDING BLOCKS OF ADVANCED TCSPC DEVICES
............................. 47
4.1 CONSTANT-FRACTION DISCRIMINATORS
.......................................... 47
4.2 TIME MEASUREMENT BLOCK
...................................................... 50
4.2.1 TIME MEASUREMENT BY FAST TAC / ADC PRINCIPLE... 50
4.2.2 DIGITAL
TDCS............................................................. 55
4.2.3 SINE-WAVE CONVERSION .............................................
59
5 APPLICATION OF MODERN TCSPC
TECHNIQUES................................. 61
5.1 CLASSIC FLUORESCENCE LIFETIME EXPERIMENTS ..........................
61
5.1.1 TIME-RESOLVED FLUORESCENCE.................................... 61
5.1.2 FLUORESCENCE LIFETIME SPECTROMETERS....................... 65
5.1.3 FLUORESCENCE DEPOLARISATION EFFECTS......................... 69
VIII CONTENTS
5.1.4 REABSORPTION AND REEMISSION................................... 72
5.1.5 HIGH-EFFICIENCY DETECTION SYSTEMS.......................... 72
5.1.6 MEASUREMENT OF THE INSTRUMENT RESPONSE
FUNCTION
.................................................................... 75
5.1.7 WHAT IS THE SHORTEST LIFETIME THAT CAN
BE MEASURED?
............................................................ 77
5.1.8 FLUORESCENCE ANISOTROPY ..........................................
79
5.1.9 TIME RESOLVED SPECTRA
............................................. 82
5.2 MULTISPECTRAL FLUORESCENCE LIFETIME EXPERIMENTS................. 84
5.3 EXCITATION-WAVELENGTH MULTIPLEXING
..................................... 87
5.4 TRANSIENT FLUORESCENCE LIFETIME PHENOMENA ........................
90
5.4.1 CHLOROPHYLL
TRANSIENTS.............................................. 90
5.4.2 CONTINUOUS-FLOW MIXING TECHNIQUES ...................... 94
5.4.3 STOPPED-FLOW TECHNIQUES ........................................
95
5.5 DIFFUSE OPTICAL TOMOGRAPHY (DOT) AND PHOTON MIGRATION.. 97
5.5.1 PRINCIPLE OF DIFFUSE OPTICAL TOMOGRAPHY ................ 97
5.5.2 SCANNING MAMMOGRAPHY ........................................ 102
5.5.3 BRAIN IMAGING
......................................................... 106
5.5.4 MUSCLE AND BONE STUDIES........................................
112
5.5.5 EXOGENOUS ABSORBERS .............................................
112
5.5.6 FLUORESCENCE
........................................................... 113
5.5.7 SMALL-ANIMAL IMAGING............................................
115
5.5.8 TECHNICAL ASPECTS OF TCSPC-BASED DOT ............. 117
5.6 AUTOFLUORESCENCE OF BIOLOGICAL TISSUE
................................ 121
5.6.1 AUTOFLUORESCENCE DETECTION
BY MULTISPECTRAL TCSPC ......................................... 122
5.6.2 TWO-PHOTON AUTOFLUORESCENCE ............................... 124
5.6.3 OPHTHALMIC IMAGING ...............................................
126
5.7 TCSPC LASER SCANNING MICROSCOPY....................................
129
5.7.1 THE LASER SCANNING MICROSCOPE............................. 131
5.7.2 LIFETIME IMAGING TECHNIQUES FOR LASER
SCANNING MICROSCOPY.............................................. 134
5.7.3 IMPLEMENTATION OF MULTIDIMENSIONAL TCSPC ........ 137
5.7.4 MULTISPECTRAL
FLIM................................................. 143
5.7.5 HIGH COUNT-RATE SYSTEMS....................................... 146
5.7.6 FRET MEASUREMENTS BY TCSPC FLIM.................. 149
5.7.7 TECHNICAL DETAILS OF TCSPC LASER SCANNING
MICROSCOPY .............................................................
154
5.8 OTHER TCSPC MICROSCOPY TECHNIQUES ................................
163
5.8.1 TCSPC LIFETIME IMAGING BY SCAN STAGES .............. 163
5.8.2
MICROFLUOROMETRY.................................................... 166
CONTENTS IX
5.8.3 TIME-RESOLVED SCANNING NEAR-FIELD OPTICAL
MICROSCOPY .............................................................
167
5.8.4 TCSPC WIDE-FIELD MICROSCOPY ............................. 168
5.9 PICOSECOND PHOTON CORRELATION
............................................ 169
5.9.1 ANTIBUNCHING EXPERIMENTS..................................... 170
5.9.2 PRACTICAL DETAILS
...................................................... 173
5.10 FLUORESCENCE CORRELATION SPECTROSCOPY
............................... 176
5.10.1 COMBINED FCS/LIFETIME EXPERIMENTS
BY TCSPC ...............................................................
177
5.10.2 FCS IN LASER SCANNING MICROSCOPES ...................... 182
5.10.3 PRACTICAL TIPS
.......................................................... 184
5.11 COMBINATIONS OF CORRELATION TECHNIQUES.............................
187
5.11.1 COMBINING PICOSECOND CORRELATION AND FCS ......... 188
5.11.2 CORRELATION OF DELAYED DETECTOR SIGNALS ................ 188
5.11.3 SYNCHRONISATION OF TCSPC MODULES ...................... 189
5.12 THE PHOTON COUNTING
HISTOGRAM.......................................... 191
5.13 TIME-RESOLVED SINGLE MOLECULE SPECTROSCOPY.................... 193
5.13.1 BURST-INTEGRATED FLUORESCENCE LIFETIME (BIFL)
EXPERIMENTS ............................................................
194
5.13.2 IDENTIFICATION OF SINGLE MOLECULES.......................... 196
5.13.3 MULTIPARAMETER SPECTROSCOPY OF
SINGLE MOLECULES.....................................................
198
5.14 MISCELLANEOUS TCSPC APPLICATIONS
.................................... 201
5.14.1 TWO-PHOTON FLUORESCENCE WITH DIODE LASER
EXCITATION
................................................................ 201
5.14.2 REMOTE SENSING
...................................................... 204
5.14.3 LASER RANGING
......................................................... 206
5.14.4 POSITRON LIFETIME EXPERIMENTS ............................... 206
5.14.5 DIAGNOSTICS OF BARRIER DISCHARGES .......................... 208
5.14.6
SONOLUMINESCENCE................................................... 210
5.14.7 THE TCSPC OSCILLOSCOPE .......................................
211
6 DETECTORS FOR PHOTON
COUNTING.................................................... 213
6.1 DETECTOR PRINCIPLES
............................................................... 213
6.1.1 CONVENTIONAL PHOTOMULTIPLIER TUBES ...................... 213
6.1.2 CHANNEL AND MICROCHANNEL PMTS........................... 214
6.1.3 POSITION-SENSITIVE PMTS.........................................
215
6.1.4 SINGLE-PHOTON AVALANCHE PHOTODIODES................... 217
6.1.5 HYBRID PMTS
.......................................................... 220
6.1.6 OTHER DETECTOR PRINCIPLES........................................
221
X CONTENTS
6.2 CHARACTERISATION OF DETECTORS
............................................... 222
6.2.1
GAIN.........................................................................
222
6.2.2 SINGLE-ELECTRON RESPONSE .......................................
222
6.2.3 SIGNAL TRANSIT TIME
................................................ 224
6.2.4 TRANSIT TIME
SPREAD................................................ 224
6.2.5 PULSE AMPLITUDE
JITTER............................................. 226
6.2.6 CATHODE
EFFICIENCY.................................................. 229
6.2.7 DARK COUNT RATE
..................................................... 231
6.2.8 AFTERPULSING PROBABILITY..........................................
233
6.2.9 PREPULSES
................................................................. 234
6.3 MEASUREMENT OF PMT
PARAMETERS........................................ 234
6.3.1 SINGLE ELECTRON RESPONSE .......................................
234
6.3.2 TRANSIT TIME
SPREAD................................................ 236
6.3.3 PULSE AMPLITUDE DISTRIBUTION ................................. 237
6.3.4 AFTERPULSING PROBABILITY..........................................
239
6.3.5 LUMINOUS SENSITIVITY AND QUANTUM EFFICIENCY ...... 241
6.4 PHOTON COUNTING PERFORMANCE OF SELECTED DETECTORS .......... 242
6.4.1
MCP-PMTS.............................................................
243
6.4.2 COOLED PMT MODULES WITH GAAS BASED
CATHODES..................................................................
245
6.4.3 PMT MODULES WITH INTERNAL DISCRIMINATORS ........... 247
6.4.4 MINIATURE PMTS IN TO
*
8 HOUSING......................... 248
6.4.5 PHOTOSENSOR MODULES ..............................................
249
6.4.6 MULTIANODE PMTS
................................................... 252
6.4.7 LINEAR FOCUSED PMTS .............................................
254
6.4.8 SIDE-WINDOW PMTS................................................
256
6.4.9 CHANNEL PHOTOMULTIPLIERS........................................
258
6.4.10 SINGLE PHOTON AVALANCHE PHOTODIODES ................... 258
7 PRACTICE OF TCSPC EXPERIMENTS
................................................. 263
7.1 EXCITATION
SOURCES................................................................
263
7.2 OPTICAL
SYSTEMS....................................................................
268
7.2.1 LENSES
.....................................................................
269
7.2.2 FILTERS
......................................................................
273
7.2.3 BEAM
SPLITTERS......................................................... 278
7.2.4 MONOCHROMATORS AND POLYCHROMATORS .................... 279
7.2.5 OPTICAL
FIBRES.......................................................... 282
7.2.6 REFLECTIONS IN OPTICAL SYSTEMS ............................... 285
7.2.7 BAFFLES, APERTURE STOPS AND FIELD STOPS ................. 288
7.2.8 DETECTORS
................................................................. 289
7.2.9 CHOOSING THE DETECTOR.............................................
289
7.2.10 QUICK TEST OF
PMTS................................................ 292
CONTENTS XI
7.2.11 SIGNAL-DEPENDENT BACKGROUND ............................... 294
7.2.12 INSTABILITY IN PMTS
................................................. 295
7.2.13 TIMING STABILITY
...................................................... 296
7.2.14 PMT VOLTAGE DIVIDERS............................................
299
7.2.15 PREAMPLIFIERS
........................................................... 300
7.3 DETECTOR CONTROL AND OVERLOAD PROTECTION ...........................
302
7.4 GENERATING THE SYNCHRONISATION SIGNAL
................................ 304
7.5 SYSTEM CONNECTIONS
............................................................. 307
7.5.1 CONNECTOR
SYSTEMS.................................................. 307
7.5.2
CABLES......................................................................
308
7.5.3 ATTENUATORS AND POWER SPLITTERS.............................. 310
7.5.4 SHIELDING AND GROUNDING ........................................
311
7.6 SAFETY
CONSIDERATIONS...........................................................
315
7.7 SETTING THE TCSPC SYSTEM PARAMETERS ................................
317
7.7.1 OPTIMISATION OF THE CFD IN THE DETECTOR
CHANNEL
................................................................... 317
7.7.2 REFERENCE
CFD........................................................ 322
7.7.3 ADJUSTING THE DELAY IN THE DETECTOR
AND REFERENCE CHANNEL ............................................ 323
7.7.4 CHOOSING THE TAC PARAMETERS................................. 326
7.8 DIFFERENTIAL NONLINEARITY
....................................................... 330
7.9 COUNTING LOSS IN TCSPC
SYSTEMS........................................ 332
7.9.1 CLASSIC PILE-UP
EFFECT.............................................. 332
7.9.2 COUNTING LOSS
.......................................................... 338
7.9.3 DEAD-TIME-RELATED SIGNAL DISTORTION ..................... 343
7.10 CALIBRATION OF THE TIME
SCALE................................................ 345
8 FINAL
REMARKS................................................................................
347
9 REFERENCES
......................................................................................
351
INDEX
...............................................................................................
389
|
| any_adam_object | 1 |
| author | Becker, Wolfgang |
| author_facet | Becker, Wolfgang |
| author_role | aut |
| author_sort | Becker, Wolfgang |
| author_variant | w b wb |
| building | Verbundindex |
| bvnumber | BV020045453 |
| callnumber-first | Q - Science |
| callnumber-label | QC793 |
| callnumber-raw | QC793.5.P422 |
| callnumber-search | QC793.5.P422 |
| callnumber-sort | QC 3793.5 P422 |
| callnumber-subject | QC - Physics |
| classification_rvk | UH 5710 UH 6900 VG 8750 |
| ctrlnum | (OCoLC)61320823 (DE-599)BVBBV020045453 |
| dewey-full | 539.7/217 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 539 - Modern physics |
| dewey-raw | 539.7/217 |
| dewey-search | 539.7/217 |
| dewey-sort | 3539.7 3217 |
| dewey-tens | 530 - Physics |
| discipline | Chemie / Pharmazie Physik |
| format | Book |
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| id | DE-604.BV020045453 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:11:36Z |
| institution | BVB |
| isbn | 9783540260479 3540260471 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013366463 |
| oclc_num | 61320823 |
| open_access_boolean | |
| owner | DE-384 DE-20 DE-703 DE-83 DE-11 DE-188 DE-355 DE-BY-UBR |
| owner_facet | DE-384 DE-20 DE-703 DE-83 DE-11 DE-188 DE-355 DE-BY-UBR |
| physical | XIX, 401 S. Ill., graph. Darst. 24 cm |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Springer |
| record_format | marc |
| series | Springer series in chemical physics |
| series2 | Springer series in chemical physics |
| spelling | Becker, Wolfgang Verfasser aut Advanced time-correlated single photon counting techniques W. Becker Berlin [u.a.] Springer 2005 XIX, 401 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Springer series in chemical physics 81 Literaturverz. S. 351 - 387 Corrélation de photons Fotônica larpcal Física moderna larpcal Photon correlation Einzelmolekülspektroskopie (DE-588)4396226-9 gnd rswk-swf Photonenzähler (DE-588)4482977-2 gnd rswk-swf Pikosekundenbereich (DE-588)4115562-2 gnd rswk-swf Fluoreszenzspektroskopie (DE-588)4017701-4 gnd rswk-swf Zeitauflösung (DE-588)4245662-9 gnd rswk-swf Optische Tomografie (DE-588)4491198-1 gnd rswk-swf Photonenzähler (DE-588)4482977-2 s Zeitauflösung (DE-588)4245662-9 s Pikosekundenbereich (DE-588)4115562-2 s Fluoreszenzspektroskopie (DE-588)4017701-4 s Einzelmolekülspektroskopie (DE-588)4396226-9 s Optische Tomografie (DE-588)4491198-1 s DE-604 Springer series in chemical physics 81 (DE-604)BV000000670 81 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013366463&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Becker, Wolfgang Advanced time-correlated single photon counting techniques Springer series in chemical physics Corrélation de photons Fotônica larpcal Física moderna larpcal Photon correlation Einzelmolekülspektroskopie (DE-588)4396226-9 gnd Photonenzähler (DE-588)4482977-2 gnd Pikosekundenbereich (DE-588)4115562-2 gnd Fluoreszenzspektroskopie (DE-588)4017701-4 gnd Zeitauflösung (DE-588)4245662-9 gnd Optische Tomografie (DE-588)4491198-1 gnd |
| subject_GND | (DE-588)4396226-9 (DE-588)4482977-2 (DE-588)4115562-2 (DE-588)4017701-4 (DE-588)4245662-9 (DE-588)4491198-1 |
| title | Advanced time-correlated single photon counting techniques |
| title_auth | Advanced time-correlated single photon counting techniques |
| title_exact_search | Advanced time-correlated single photon counting techniques |
| title_full | Advanced time-correlated single photon counting techniques W. Becker |
| title_fullStr | Advanced time-correlated single photon counting techniques W. Becker |
| title_full_unstemmed | Advanced time-correlated single photon counting techniques W. Becker |
| title_short | Advanced time-correlated single photon counting techniques |
| title_sort | advanced time correlated single photon counting techniques |
| topic | Corrélation de photons Fotônica larpcal Física moderna larpcal Photon correlation Einzelmolekülspektroskopie (DE-588)4396226-9 gnd Photonenzähler (DE-588)4482977-2 gnd Pikosekundenbereich (DE-588)4115562-2 gnd Fluoreszenzspektroskopie (DE-588)4017701-4 gnd Zeitauflösung (DE-588)4245662-9 gnd Optische Tomografie (DE-588)4491198-1 gnd |
| topic_facet | Corrélation de photons Fotônica Física moderna Photon correlation Einzelmolekülspektroskopie Photonenzähler Pikosekundenbereich Fluoreszenzspektroskopie Zeitauflösung Optische Tomografie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013366463&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000670 |
| work_keys_str_mv | AT beckerwolfgang advancedtimecorrelatedsinglephotoncountingtechniques |