Biofunctionalization of nanomaterials:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2005
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Nanotechnologies for the life sciences
1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 366 S. zahlr. Ill., graph. Darst. |
| ISBN: | 3527313818 9783527313815 |
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Contents
Preface XIII
ListofContributors XVII
1 Biofunctionalization of Fluorescent Nanoparticles 1
Michael J. Murcia and Christoph A. Naumann
1.1 Introduction 2
1.2 Fluorescent Nanopartide Probes 2
1.2.1 Dye doped Nanoparticles 3
1.2.2 Quantum Dots (QDs) 5
1.2.3 Metal Nanoparticles 7
1.2.4 Hybrid Architectures Involving Fluorescent Nanoprobes 9
1.2.4.1 Metal Dye 9
1.2.4.2 Dye doped Silica Shells 9
1.2.4.3 Quantum Dot containing Microspheres 10
1.3 Bioconjugation of Fluorescent Nanoparticles 11
1.3.1 General Considerati ons 11
1.3.1.1 Overview 11
1.3.1.2 Common Coupling Reactions 13
1.3.2 Bioconjugation of Polymeric Nanoparticles 13
1.3.2.1 Noncovalent Approaches 13
1.3.2.2 Covalent Approaches 15
1.3.3 Bioconjugation of Quantum Dots 25
1.3.3.1 Noncovalent Approaches 16
1.3.3.2 Covalent Approaches 16
1.3.4 Bioconjugation of Metallic Nanoprobes 16
1.3.4.1 Noncovalent Approaches 17
1.3.4.2 Covalent Approaches 17
1.4 Design of Biocompatible Coatings 17
1.4.1 General Considerations 17
1.4.1.1 Overview 17
1.4.1.2 Colloidal Stability 28
1.4.1.3 Biocompatible Surfaces 29
Nanotechnologies for the Life Sdences Vol. 1
Biofunctionalization of Nanomaterials. Edited by Challa S. S. R. Kumar
Copyright © 2005 WILEY VCH Verlag GmbH Co. KGaA, Weinheim
ISBN: 3 527 31381 8
VI I Contents
1.4.1.4 Cytotoxicity 20
1.4.2 Nanoparticle stabilizing Coatings 21
1.4.3 Low Cytotoxicity Coatings 23
1.5 Applications 23
1.5.1 Biosensing 24
1.5.1.1 Polymeric Sensors 25
1.5.1.2 Quantum Dot Sensors 25
1.5.1.3 Metallic Sensors 26
1.5.2 Fluorescent Nanoparticles as Labels in Biological Imaging 27
1.5.2.1 Dye doped Nanoparticles 27
1.5.2.2 Quantum Dots 27
References 29
2 Biofunctionalization of Carbon Nanotubes 41
Elena Bekyarova, Robert C. Haddon, and Vladimir Parpura
2.1 Introduction 41
2.2 Carbon Nanotubes Types, Structures and Properties 42
2.3 Synthesis of Carbon Nanotubes 43
2.4 Approaches to Aqueous Solubilization of Carbon Nanotubes 47
2.4.1 Chemical Modifications 47
2.4.2 Use of Water compatible Surfactants 47
2.4.3 Functionalization with Water soluble Polymers 48
2.4.4 Interaction and Functionalization with Biological Molecules 49
2.4.4.1 Noncovalent Biofunctionalization 50
2.4.4.2 Covalent Biofunctionalization 52
2.5 Applications of Biofunctionalized Carbon Nanotubes 54
2.5.1 Assembly of Electronic Devices 54
2.5.2 Biosensing 58
2.5.3 Substrates for Neuronal Growth 63
2.6 Concluding Remarks 65
Acknowledgments 65
References 65
3 Biofunctionalization of Magnetic Nanoparticles 72
Yong Gao
3.1 Introduction 72
3.2 Functionalization of Magnetic Nanoparticles for In Vitro Protein/Cell
Separation 74
3.3 Functionalization of Magnetic Nanoparticles for Biochemkal/Chemical
Synthesis of Therapeutic Drugs and Their Intermediates 80
3.4 Functionalization of Magnetic Nanoparticles for In Vivo Bio imaging,
Drug Targeting and Tumor Hyperthermia Treatments 82
3.4.1 MR Imaging 83
3.4.2 Targeted Drug Delivery 86 J
3.4.3 Magnetic Hyperthermia 87 J
Contents I VII
3.5 Condusions 88
Acknowledgments 89
References 89
4 Biofunctionalization of Gold Nanoparticles 99
Ming Zheng and Xueying Huang
4.1 Introduction 99
4.2 General Synthetic Routes 99
4.2.1 Direct Synthesis of Ligand protected Au NPs 100
4.2.1.1 Strongly Ionic Ligand protected Au NPs 102
} 4.2.1.2 Weakly Ionic Ligand protected Au NPs 102
4.2.1.3 Au NPs Protected with Neutral Ligands 102
, 4.2.2 Iigand Exchange Reaction 103
4.3 Preparative scale Synthesis and Solution phase Characterization of DNA
directed Nanopartide Assemblies 103
4.4 Bifunctional Proteins for Programmable Assembly of
Nanopartides 111
4.5 Strategies for Eliminating Nonspecifk Interactions and Enabling Specific
Binding with Biomolecules 113
4.6 Biological Applications 118
4.6.1 NudeicAcids 228
4.6.2 Proteins 118
4.6.3 Cells and Virus 119
Acknowledgments 120
References 220
5 Biofunctionalization of Phospholipid Polymer Nanoparticles 225
Junji Watanabe, Jongwon Park, Tomomi Ito, Madoka Takai, and Kazuhiko
Ishihara
5.1 Introduction 225
5.2 Nanofabrication for Biomedical Applications 226
5.2.1 Nano scaled Processing 226
5.2.2 Key Materials for Nanofabrication 227
5.3 Design of Bioconjugate Nanoparticles 229
5.3.1 Bioconjugate Phospholipid Polymer 229
5.3.2 Solution Properties by Fluorescence Probe 229
5.3.3 Bioconjugate Nanoparticles 131
5.3.4 Surface Elemental Analysis by X ray Photoelectron Spectroscopy 232
5.3.5 Surface f Potential on Nanopartides 232
5.3.6 Partide Size by Dynamic Light Scattering and Morphology by Scanning
Electron Microscope 234
5.3.7 Determination of Active Ester Groups on Nanopartides 235
5.4 Biofunction on Nanopartides 237
5.4.1 Design of Sequential Enzymatic Reaction 237
5.4.2 Amplified Signal on Nanopartides 238
VIIII Contents
5.5 Application for Molecular Diagnosis 139
5.5.1 Example of C reactive Protein Detection Using Nanopartides 139
5.5.2 High performance Diagnosis in Serum 143
5.6 Condusions 245
Adoiowledgments 345
References 145
6 Biofunctionalization of Metallic Nanopartides and Microarrays for
Biomolecular Detection 150
Crit Festag, Uwe Klenz, Thomas Henkel, Andrea Csäki, and Wolfgang Fritzsche
6.1 Introduction 150
6.1.1 Applications 151
6.1.2 Array Fabrication 151
6.1.3 Detection Methods 153
6.1.3.1 Optical Absorbance 153
6.1.3.2 SPR Imaging 155
6.1.3.3 Raman Scattering 255
6.1.3.4 Electrical Detection 156
6.1.3.5 Electrochemical Detection 156
6.1.3.6 Gravimetric 158
6.2 Nanopartides and their Biofunctionalization 158
6.2.1 Types of Nanopartides used for Biomolecular Detection 159
6.2.1.1 Metal Nanopartides 159
6.2.1.2 Core/Shell Particles 159
6.2.1.3 Magnetic Nanopartides 160
6.2.1.4 Quantum Dots 160
6.2.2 Synthesis of Gold (Silver) Nanopartides 261
6.2.3 Biofunctionalization 262
6.2.3.1 Modification of Gold Nanopartides with Oligonucleotides/DNA 262
6.2.3.2 Modification of Gold Nanopartides with Proteins 265
6.2.3.3 Biofunctionalization of other Metal Nanopartides 267
6.2.4 Biological Applications of Gold Nanopartides 267
6.3 Substrates and their Biofunctionalization 168
6.3.1 Molecular Thin Films 269
6.3.1.1 Self assembly Monolayers 269
6.3.1.2 Optimization of Gold Nanoparticle based Microarrays for DNA
Detection 171
6.3.2 Nanoporous Gels 272
6.4 Outlook 275
References 176
7 Conjugation of Nanomaterials with Proteins 183
Mohammed J. Meziani, Yi Lin, and Ya Ping Sun
7.1 Introduction 283
7.2 Coupling of Inorganic Nanopartides with Proteins 284
Contents IX
7.2.1 Chemical Functionalization Methods 184
7.2.2 Protein assisted Assemblies of Inorganic Nanoparticles 188
7.2.2.1 Crosslinking Route through Protein Recognition 188
7.2.2.2 Template directed Approach 191
7.2.3 Supercritical Fluid Methods 195
7.2.3.1 BSA conjugated Silver Nanoparticles 296
7.2.3.2 BSA conjugated Semiconductor Nanoparticles 197
7.2.3.3 Assembly and Disassembly of Nanoparticles through Protein Isomeric
Conversion 202
7.3 Coupling of Carbon Nanotubes and Proteins 204
7.3.1 Non specific Adsorption 206
7.3.2 Specific Conjugation and Biorecognition 211
7.4 Condusions and Perspectives 221
Acknowledgment 222
References 222
8 Stabilization and Functionalization of Metallic Nanoparticles: the Peptide
Route 235
Raphael Levy and R. Christopher Doty
8.1 Introduction 235
8.2 Metallic Nanoparticles An Overview 236
8.2.1 Metallic Nanoparticles Preparation 236
8.2.2 Metallic Nanoparticles Optical Properties 238
8.2.3 Metallic Nanoparticles Applications 242
8.3 Stabilization and Functionalization of Metallic Nanoparticles The
Peptide Route 248
8.3.1 Peptides, Proteins and Nanoscale Science 248
8.3.2 Peptide Toolbox for Bionanotechnology 249
8.3.3 Peptides as Capping Ligands 250
8.3.3.1 Interactions ofAmino Adds with Noble Metals 250
8.3.3.2 Peptides as Reducing Agent and Template in Metallic Nanoparticle
Synthesis 250
8.3.3.3 Rational Design of a Peptide Capping Ligands for Gold Nanoparticles:
CALNN 251
8.3.3.4 Combinatorial Exploration of Peptides as Capping Ligands: the CALNN
Family 252
8.3.3.5 Peptide capped Silver Nanoparticles 252
8.3.3.6 Peptides as Capping Ligands for Fluorescent and Magnetic
Nanopartides 252
8.3.4 Peptide Extensions to Introduce Functionalities 253
8.3.4.1 Biotin and Strep tag II 253
8.3.4.2 Peptide DNA Hybrids 254
8.3.4.3 His tag and Nickel Nitrilotriacetic Acid (Ni NTA) 254
8.3.5 Chromatography of Peptide capped Nanoparticles 255
8.3.5.1 Size exclusion Chromatography 256
xl Contents
8.3.5.2 Affinity Chromatography 256
8.3.6 Recognition of Materials 256
8.3.7 Peptide based Linkers 258
8.3.7.1 A Peptide Peptide Linker Based on Leudne zipper Sequences 259
8.3.7.2 A Peptide DNA Linker Based on Metallopeptides 259
8.3.7.3 A Peptide Texas Red Linker Obtained by Phage Display 259
8.3.8 BiologicaHy Active Peptides 259
8.3.9 Self assembling Peptides 260
8.3.9.1 Fibers and Nanotubes 260
8.3.9.2 Peptide based Amphiphiles 262
8.4 Conduding Remarks 262
References 263
9 Folate Iinked Lipid based Nanoparticles for Tumor targeted Gene
Therapy 270
Yoshiyuki Hattori and Yoshie Maitani
9.1 Introduction 270
9.2 Gene Delivery and Expression System 270
9.3 Nanoparticles for Gene Delivery System 271
9.4 Folate Iinked Vectors 272
9.4.1 Folate Receptors 273
9A.2 Folate Receptor targeting Liposomes 273
9.5 Folate Iinked Lipid based Nanopartides 277
9.5.1 Formulations 277
9.5.2 Nanoplex and Transfection Activity In Vitro 280
9.5.3 Selectivity of Folate Iinked Nanopartide 282
9.5.4 Transfection Activity In Vivo 285
9.6 Application of Suicide Gene Therapy 287
9.7 Conclusions 291
List of Abbreviations 292
References 293
10 Magnetic Core Conducting Polymer Shell Nanocomposites for DNA
Attachment and Hybridization 299
Jean Paul Lellouche
10.1 Introduction 299
10.2 Chemical Design of DPyr and DCbz containing Monomers:
Introduction of Molecular Diversity 301
10.3 Synthetic Approaches for Mono and Dicarboxylated DPyr /DCbz based
Monomers 302
10.4 Oxidative Polymerization of DPyr /DCbz based Monomers around
Magnetite Nanopartides 305
10.4.1 General Considerations 305
10.4.2 Characterization of Magnetically Responsive PolyDPyr and PolyDCbz
Magnetite Nanocomposites 307
Contents IXI
10.5 Development of a DNA based Biological System for Nanocomposite
Parallel Screening 311
10.5.1 Covalent Attachment of an NH2 5 modified 20 mer DNA Probe onto
NCs towards DNA Biofunctionalized NCs. Covalent Amide Bond
Chemistry and Resulting NC Supported DNA Hybridizations 313
10.5.2 Attachment of a Biotin 5 modined 20 mer DNA Probe to DNA
biofunctionalized NCs. Quasi covalent Linkage Using the Streptavidin
Biotin System and the Resulting NC supported DNA
Hybridizations 318
10.5.3 Storage: Medium term Stability of Some PolyDPyr /PolyDCbz Magnetite
NCs 320
10.6 Typical Experimental Procedures for NC Fabrication and NC Supported
DNA Hybridizations 320
10.6.1 Typical Optimized Procedures for NC Fabrication Including Magnetite
Preparation 320
10.6.1.1 Magnetite Preparation Using the (Mdative Hydrolysis of Iron(n) Sulfate
in an Alkaline KOH Medium 320
10.6.1.2 PolyDPyr Magnetite Nanocomposites 322
10.6.1.3 PolyDCbz Magnetite Nanocomposites 322
10.6.2 Covalent Attachment of an Aminated NH2 5 modified DNA Probe.
Hybridization Experiments onto PolyDPyr /PolyDCbz Magnetite NCs.
Typical Experimental Procedures 323
10.6.2.1 Specific Reagents, Buffers and Washing/Assay Solutions 324
10.6.3 Quasi covalent Attachment of a Biotin 5 modified DNA Probe and DNA
Hybridization Experiments onto Streptavidin modified
PolyDPyr (5a)/PolyDCbz(5b) magnetite NCs. Typical Experimental
Procedures 324
10.7 Condusions and Research Outlook 325
Acknowledgments 325
References 326
11 Celatin Nanoparticles and Their Biofunctionalization 330
Sushma Kommareddy, Dinesh B. Shenoy, and Mansoor M. Amiji
11.1 Introduction 330
11.2 Gelatin and Gelatin Derivatives 331
11.2.1 Gelatin 331
11.2.2 Chemical Modifikation of Gelatin 332
11.2.2.1 PEGylation 333
11.2.2.2 Thiolation 335
11.2.2.3 Other Conjugates of Gelatin 335
11.3 Nanoparticulate Carriers of Gelatin and Gelatin Derivatives 337
11.3.1 Desolvation 337
11.3.1.1 Desolvation Using Ethanol 338
11.3.1.2 Two step Desolvation 338
11.3.2 Coacervation 338
XII I Contents
11.3.3 Nano encapsulation by Water in oil Emulsion Method 339
11.4 Characterization of Gelatin and Modified Gelatin Nanopartides 340
11.5 Loading and Release of Payload from Gelatin Nanopartides 342
11.6 Biocompatibility Studies 343
11.7 Applications of Gelatin and Modified Gelatin Nanopartides 344
11.8 Condusions 347
References 348
Index 353
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV020030867 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:11:15Z |
| institution | BVB |
| isbn | 3527313818 9783527313815 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013352089 |
| oclc_num | 61703213 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-703 DE-29 DE-19 DE-BY-UBM DE-1051 DE-1043 DE-634 DE-11 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-703 DE-29 DE-19 DE-BY-UBM DE-1051 DE-1043 DE-634 DE-11 DE-578 |
| physical | XIX, 366 S. zahlr. Ill., graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Wiley-VCH |
| record_format | marc |
| series | Nanotechnologies for the life sciences |
| series2 | Nanotechnologies for the life sciences |
| spelling | Biofunctionalization of nanomaterials ed. by Challa S. S. R. Kumar 1. ed. Weinheim Wiley-VCH 2005 XIX, 366 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nanotechnologies for the life sciences 1 Biomedical Technology Biomedical materials Nanostructured materials Nanostructures Nanotechnology Nanopartikel (DE-588)4333369-2 gnd rswk-swf Biomolekül (DE-588)4135124-1 gnd rswk-swf Nanostrukturiertes Material (DE-588)4342626-8 gnd rswk-swf Biomaterial (DE-588)4267769-5 gnd rswk-swf Funktionalisierung Chemie (DE-588)4279323-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nanopartikel (DE-588)4333369-2 s Biomolekül (DE-588)4135124-1 s Funktionalisierung Chemie (DE-588)4279323-3 s DE-604 Nanostrukturiertes Material (DE-588)4342626-8 s Biomaterial (DE-588)4267769-5 s Kumar, Challa S. S. R. Sonstige (DE-588)129740470 oth Nanotechnologies for the life sciences 1 (DE-604)BV020030849 1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013352089&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biofunctionalization of nanomaterials Nanotechnologies for the life sciences Biomedical Technology Biomedical materials Nanostructured materials Nanostructures Nanotechnology Nanopartikel (DE-588)4333369-2 gnd Biomolekül (DE-588)4135124-1 gnd Nanostrukturiertes Material (DE-588)4342626-8 gnd Biomaterial (DE-588)4267769-5 gnd Funktionalisierung Chemie (DE-588)4279323-3 gnd |
| subject_GND | (DE-588)4333369-2 (DE-588)4135124-1 (DE-588)4342626-8 (DE-588)4267769-5 (DE-588)4279323-3 (DE-588)4143413-4 |
| title | Biofunctionalization of nanomaterials |
| title_auth | Biofunctionalization of nanomaterials |
| title_exact_search | Biofunctionalization of nanomaterials |
| title_full | Biofunctionalization of nanomaterials ed. by Challa S. S. R. Kumar |
| title_fullStr | Biofunctionalization of nanomaterials ed. by Challa S. S. R. Kumar |
| title_full_unstemmed | Biofunctionalization of nanomaterials ed. by Challa S. S. R. Kumar |
| title_short | Biofunctionalization of nanomaterials |
| title_sort | biofunctionalization of nanomaterials |
| topic | Biomedical Technology Biomedical materials Nanostructured materials Nanostructures Nanotechnology Nanopartikel (DE-588)4333369-2 gnd Biomolekül (DE-588)4135124-1 gnd Nanostrukturiertes Material (DE-588)4342626-8 gnd Biomaterial (DE-588)4267769-5 gnd Funktionalisierung Chemie (DE-588)4279323-3 gnd |
| topic_facet | Biomedical Technology Biomedical materials Nanostructured materials Nanostructures Nanotechnology Nanopartikel Biomolekül Nanostrukturiertes Material Biomaterial Funktionalisierung Chemie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013352089&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV020030849 |
| work_keys_str_mv | AT kumarchallassr biofunctionalizationofnanomaterials |