Thermal biophysics of membranes:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2007
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| Schriftenreihe: | Tutorials in biophysics
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 363 S. Ill., graph. Darst. |
| ISBN: | 9783527404711 |
Internformat
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| 245 | 1 | 0 | |a Thermal biophysics of membranes |c Thomas Heimburg |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2007 | |
| 300 | |a XV, 363 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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| adam_text | Contents
Preface XIII
1 Membranes—An Introduction 1
1.1 Overton (1895) 1
1.2 Langmuir (1917) and Gorter and Grendel (1925) 2
1.3 Danielli and Davson (1935) 2
1.4 Robertson (1958) 4
1.5 The Fluid Mosaic Model of Singer and Nicolson (1972) 5
1.6 The Mattress Model by Mouritsen and Bloom (1984) 7
1.7 Domain Formation and Protein Clusters 8
1.8 Perspectives of this Book 10
1.9 Summary: Key Ideas of Chapter 1 13
2 Membrane Structure 15
2.1 Lipid Membrane Structure 15
2.2 X Ray Diffraction 18
2.3 Nonlamellar Lipid Phases 23
2.3.1 Inverse Hexagonal Phase (Hn Phase) 23
2.3.2 Cubic Phases 24
2.3.3 Sponge Phases 25
2.4 Summary: Key Ideas of Chapter 2 27
3 The Composition of Biological Membranes 29
3.1 Composition of Membranes 29
3.2 Head Group Composition 30
3.3 Hydrocarbon Chain Composition 33
3.4 Asymmetry Across Membranes 34
3.5 Dependence of Lipid Composition on Growth Temperature 35
3.6 Dependence of Lipid Composition on Pressure 37
Thermal Biophysics of Membranes. Thomas Heimburg
Copyright © 2007 WILEY VCH Verlag GmbH Co. KGaA, Weinheim
ISBN: 978 3 527 40471 1
VI Contents
3.7 Dependence of Lipid Composition on Changes in Other
Thermodynamic Variables 39
3.8 Summary: Key Ideas of Chapter 3 40
4 Introduction Into Thermodynamics 41
4.1 Functions of State 41
4.2 First Law of Thermodynamics 42
4.3 Second Law of Thermodynamics 44
4.4 Other Functions of State 45
4.5 The Chemical Potential 47
4.6 The Gibbs Duhem Equation 48
4.7 Chemical Equilibrium in Solutions 48
4.8 Statistical Interpretation of Entropy 50
4.9 Statistical Averages 52
4.10 Heat Capacity and Elastic Constants 53
4.10.1 Heat Capacity 53
4.10.2 Isothermal Volume and Area Compressibility 54
4.11 Maxwell Relations 55
4.12 Adiabatic Compressibility 56
4.13 Thermodynamic Forces and Fluxes 58
4.14 Summary: Key Ideas of Chapter 4 60
5 Water 63
5.1 The Electrostatic Potential 64
5.2 The Electrostatic Potential in Electrolytes 65
5.3 The Hydrophobic Effect 66
5.3.1 Temperature Dependence of the Hydrophobic Effect 67
5.4 The Wimley White Hydrophobicity Scale 70
5.5 Hydrophobic Matching 71
5.6 Hofmeister Series 72
5.7 Summary: Key Ideas of Chapter 5 74
6 Lipid Melting 75
6.1 Lipid Melting 75
6.1.1 Calorimetry and Heat Capacity 75
6.1.2 Melting of Membranes Consisting of One Lipid Species 78
6.1.3 Some Simple Considerations on the Melting Enthalpies and
Entropies 83
6.2 Cooperativity and Cooperative Unit Size 85
6.3 Influence of Pressure 87
6.4 Metastable States 90
6.5 Melting of Membranes Consisting of Lipid Mixtures 91
Contents VII
6.6 Melting in Biological Membranes 92
6.7 Lipid Monolayers 93
6.8 Summary: Key Ideas of Chapter 6 97
7 Phase Diagrams 99
7.1 Ideal Mixture 99
7.2 On the Number of Coexisting Phases 104
7.2.1 Gibbs Phase Rule 105
7.2.2 The Role of Water as a Component 106
7.2.3 What Exactly is a Phase? 107
7.3 Regular Solution 109
7.3.1 Simple Eutectic Phase Diagram 110
7.3.2 Melting Point Depression and the Effect of Anesthetics 111
7.3.3 Regular Solution Theory 113
7 A Experimental Phase Diagrams 116
7A.I Mixtures of Phospholipids 116
7.4.2 Mixtures of Phospholipids with Other Lipids 118
7A3 Ternary Phase Diagrams: Mixtures of Three Lipids 120
7.5 Conclusions 121
7.6 Summary: Key Ideas of Chapter 7 122
8 Statistical Models for Lipid Melting 123
8.1 Monte Carlo Simulations 124
8.1.1 Simple Monte Carlo Procedure 124
8.1.2 Metropolis Algorithm 125
8.2 Magnitude of Fluctuations 126
8.3 Simple Statistical Thermodynamics Model 128
8.4 Monte Carlo Simulations 129
8.5 Derivation of the Partition Function for a Known Distribution of all
States: The Ferrenberg Swendsen Method 132
8.6 Two Component Membranes 135
8.7 Local Fluctuations at Domain Boundaries 137
8.8 The 10 State Pink Model 138
8.9 Molecular Dynamics 139
8.10 Summary: Key Ideas of Chapter 8 140
9 Lipid Protein Interactions 141
9.1 Hydrophobic Matching 141
9.2 Integral Proteins 143
9.2.1 Ising Model for the Interaction with Integral Proteins 143
9.2.2 Lipid Fluctuations at Protein Interfaces 150
9.2.3 Pore Formation 151
VIII Contents
9.2.4 Hydrophobic Matching and Integral Protein Function 252
9.3 Binding of Peripheral Proteins to One Component Membranes 152
9.3.1 Ising Model for the Interaction with Peripheral Proteins 152
9.3.2 Monte Carlo Simulations on the Binding of Proteins to
Membranes 155
9.4 Action of Phospholipases on Membrane Domains 157
9.5 Domains and Rafts in Biological Membranes 258
9.6 Summary: Key Ideas of Chapter 9 262
10 Diffusion 165
10.1 Percolation 266
10.2 Diffusion Models 268
10.3 Diffusion of Lipids and Proteins 269
10.4 Summary: Key Ideas of Chapter 10 272
11 Electrostatics 173
11.1 Diffuse Double Layer—Gouy Chapman Theory 273
11.2 Potential and Free Energy of Membranes 280
11.3 Influence of Electrostatics on Melting Temperatures of
Membranes 282
11.4 Titration of Charged Lipid Membranes with Protons 283
11.5 Binding of Charged Proteins 284
11.6 Lateral Pressure Induced by Charges 285
11.7 Summary: Key Ideas of Chapter 11 287
12 Adsorption, Binding, and Insertion of Proteins 189
12.1 The Langmuir Isotherm 289
12.2 The Adsorption to a Continuous Surface 292
12.2.1 The Protein Adsorbate as a Two Dimensional Gas 293
12.2.2 The van der Waals Adsorption Isotherm 294
12.2.3 Scaled Particle Theory 295
12.3 Aggregation Equilibria of Adsorbed Proteins 296
12.4 Binding of Asymmetric Proteins 297
12.5 Binding in the Presence of Electrostatic Interactions 299
12.6 Lateral Pressure Changes Induced by Protein Binding 202
12.7 Protein Insertion and Pore Formation 202
12.7.1 Insertion Triggered by the Binding of Secondary Proteins 205
12.8 Binding to Mixed Lipid Membranes 207
12.9 Summary: Key Ideas of Chapter 12 220
Contents IX
13 Elasticity and Curvature 211
13.1 Liquid Crystalline Phases 222
13.2 Elastic Theory of Incompressible Liquid Crystalline Phases 222
13.2.1 Using Symmetries 214
13.2.2 Apolar Molecules 215
13.2.3 Achiral and Apolar Molecules 215
13.2.4 Spontaneous Curvature 226
13.3 Elastic Theory of Membrane Bending 227
13.3.1 Membranes Without Twist 217
13.3.2 Radii of Curvature 218
13.3.3 Topology of Vesicles and Saddle Points 220
13.3.4 Vesicles with Fixed Volume/Area Ratio 222
13.3.5 Fusion Pores 222
13.4 Summary: Key Ideas of Chapter 13 223
14 Thermodynamics of the Elastic Constants 225
14.1 Heat Capacity 226
14.2 Volume and Area Compressibility 227
14.2.1 Volume Compressibility 227
14.2.2 Area Compressibility 228
14.3 The Coupling Between Area Compressibility and Curvature
Elasticity 230
14.4 The Temperature Dependence of the Elastic Constants 231
14.4.1 Proportionality Between Enthalpy and Volume Changes 232
14.4.2 Proportionality Between Enthalpy and Volume Changes by Pressure
Calorimetry 234
14.4.3 Proportionality Between Isothermal Volume Compressibility and
Heat Capacity Changes 237
14.4.4 Proportionality Between Enthalpy and Area Changes 237
14.4.5 Proportionality Between Isothermal Compressibility, Bending
Elasticity and Heat Capacity Changes 237
14.4.6 The Relations Between Heat Capacity and the Elastic
Constants 238
14.4.7 Proportionality Between Bending Elasticity and Heat Capacity 239
14.5 Adiabatic Volume Compressibility 242
14.6 Sound Propagation in Vesicle Dispersions 243
14.7 Curvature Fluctuations and Critical Swelling of Multilayers 245
14.7.1 Curvature Fluctuations 245
14.7.2 Critical Swelling of Multilayered Membranes 246
14.8 Local Fluctuations at Domain Interfaces 248
14.9 Summary: Key Ideas of Chapter 14 250
X Contents
15 Structural Transitions 251
15.1 Coupling of Curvature and Domain Distribution 252
15.2 Secretion, Endo and Exocytosis in the Chain Melting Regime 252
15.3 Curvature and the Broadening of the Melting Transition 253
15.4 Structural Transitions of Vesicles in the Melting Regime 255
15.5 Charged Lipid Membranes 258
15.5.1 DMPG 259
15.5.2 Geometry Changes Introduced by Charged Drugs 260
15.6 The Ripple Phase 262
15.6.1 Geometrical Considerations 264
15.6.2 Modeling the Pretransition 266
15.7 Peculiarities in the Melting of Zwitterionic Lipids 270
15.7.1 Short Chains 272
15.7.2 The Sub Main Transition 272
15.8 Summary: Key Ideas of Chapter 15 275
16 Relaxation Processes in Membranes 277
16.1 Thermodynamic Forces and Fluxes and Their Relation to
Relaxation 278
16.2 Relaxation Times of Domain Formation Processes 280
16.2.1 Coupling Between Relaxation Times and Excess Heat Capacity 282
16.2.2 Relaxation Experiments 284
16.2.3 Relaxation Times of Biomembranes 285
16.3 Summary: Key Ideas of Chapter 16 288
17 Permeability 289
17.1 Permeability of Lipid Membranes in the Melting Transition 289
17.2 Lipid Pores 292
17.3 Quantized Currents in Pure Lipid Membranes and Their
Dependence on Thermodynamic Variables 292
17.3.1 Temperature 293
17.3.2 Calcium and Protons 294
17.3.3 Lateral Pressure and Mechanosensitivity 296
17.4 The Coupling of Lipid Phase Behavior and Ion Channels
Proteins 297
17.5 Summary: Key Ideas of Chapter 17 300
18 Nerve Pulse Propagation 301
18.1 The Hodgkin Huxley Model 302
18.2 Thermodynamics of the Nerve Pulse 305
18.2.1 Heat Changes During the Action Potential 306
18.2.2 Mechanical Changes During the Action Potential 309
Contents XI
18.2.3 Are There Phase Transitions During the Action Potential? 310
18.3 Isentropic Pulse Propagation 311
18.3.1 Solitons 312
18.3.2 Energy of the Solitons 326
18.3.3 Thickness Changes 318
18.4 Consequences of the Isentropic Theory 319
18.5 Summary: Key Ideas of Chapter 18 321
19 Anesthesia 323
19.1 The Meyer Overton Rule 324
19.2 The Effect of Anesthetics on the Lipid Melting Points 327
19.3 The Lateral Pressure Profile 330
19 A Dependence of Anesthesia on Hydrostatic Pressure 332
19.5 pH Dependence of Anesthesia 333
19.6 Neurotransmitters 334
19.7 Summary: Key Ideas of Chapter 19 335
Appendix
Abbreviations Used in this Book 337
References 339
Index 353
Acknowledgments 363
|
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| isbn | 9783527404711 |
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| spelling | Heimburg, Thomas Verfasser (DE-588)111734568 aut Thermal biophysics of membranes Thomas Heimburg Weinheim Wiley-VCH 2007 XV, 363 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Tutorials in biophysics Biomembran (DE-588)4006884-5 gnd rswk-swf Temperaturverhalten (DE-588)4457534-8 gnd rswk-swf Biomembran (DE-588)4006884-5 s Temperaturverhalten (DE-588)4457534-8 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013349212&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heimburg, Thomas Thermal biophysics of membranes Biomembran (DE-588)4006884-5 gnd Temperaturverhalten (DE-588)4457534-8 gnd |
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| title | Thermal biophysics of membranes |
| title_auth | Thermal biophysics of membranes |
| title_exact_search | Thermal biophysics of membranes |
| title_full | Thermal biophysics of membranes Thomas Heimburg |
| title_fullStr | Thermal biophysics of membranes Thomas Heimburg |
| title_full_unstemmed | Thermal biophysics of membranes Thomas Heimburg |
| title_short | Thermal biophysics of membranes |
| title_sort | thermal biophysics of membranes |
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