Ion channels in the pulmonary vasculature:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
Taylor & Francis
2005
|
| Schriftenreihe: | Lung biology in health and disease
197 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xxv, 791 S. Ill., graph. Darst. 24 cm |
| ISBN: | 0824759680 9780824759681 |
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| 300 | |a xxv, 791 S. |b Ill., graph. Darst. |c 24 cm | ||
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| 490 | 1 | |a Lung biology in health and disease |v 197 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Lungs |x Blood-vessels | |
| 650 | 4 | |a Lungs |x Blood-vessels |x Diseases | |
| 650 | 4 | |a Ion channels | |
| 650 | 4 | |a Lung |x blood supply | |
| 650 | 4 | |a Ion Channels |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804133578002399232 |
|---|---|
| adam_text | Contents
Introduction Claude Lenfant Hi
Preface v
Contributors /x
I. CELL PHYSIOLOGY
1. Membrane Electrical Properties of Vascular Smooth Muscle Cells of the
Pulmonary Circulation 1
Sean M. Wilson and Normand Leblanc
I. Introduction .... 1
II. Ion Distribution, Passive Ion Fluxes, and Ionic
Equilibria .... 2
III. Ion Channels Contributing to the Resting Membrane Potential of
Pulmonary Artery Myocytes .... 9
IV. The Active State of Pulmonary Arterial Smooth Muscle Cells .... 14
V. Summary and Concluding Remarks .... 19
References .... 20
2. Excitation Contraction Coupling in the Pulmonary Vasculature 25
Luke J. Janssen
I. Introduction .... 25
II. Excitation Contraction Coupling in Muscle—General
Concepts .... 26
III. Excitation Contraction Coupling in Smooth Muscle—Roles of Myosin
Light Chain Kinase and Phosphatase .... 29
IV. Heterogeneity in the Pulmonary Vasculature .... 29
V. Excitation Contraction Coupling in Vascular Smooth
Muscle .... 32
VI. Pathophysiological Perspective .... 48
xv
xvi Contents
VII. Future Directions .... 51
References .... 52
3. Ion Channel Heterogeneity in the Pulmonary
Vascular Bed: A Basis for Site Specific Responses to Vasoactive Stimuli .... 61
Stephen L. Archer and Nancy J. Rusch
I. Introduction .... 61
II. Molecular Identification and Function of Ca^ Kv, and BKca
Channels .... 62
III. Diversity of CaL, Kv, and BKCa Channels Within the Pulmonary
Circulation .... 67
IV. Heterogeneous Populations of Oxygen Sensitive Ion
Channels .... 71
V. Conclusions .... 77
References .... 78
II. Ca2+ PERMEABLE CHANNELS
4. Voltage Gated Ca2+ Channels in the Pulmonary
Vasculature 83
Gregory A. Knock and Philip I. Aaronson
I. Introduction .... 83
II. VGCCs in Systemic Vascular Smooth Muscle .... 84
III. VGCCs in Pulmonary VSM 87
References .... 93
5. Receptor Operated Ca2+ Channels 99
Songwei Wu, Donna L. Cioffi, and Troy Stevens
I. Introduction .... 99
II. Global [Ca2+]i, Currents, and Channels .... 100
III. Signal Transduction .... 102
IV. Receptor Operated Ca2+ Channels—Control by Second
Messengers .... 106
V. Receptor Operated Ca2+ Channels—Smooth
Muscle .... 114
VI. Receptor Operated Ca2+ Channels—Endothelium .... 115
VII. Receptor Operated Ca2+ Channels—Reciprocal Regulation
ofCa2+ Entry 116
References .... 117
6. Transient Receptor Potential Cation Channels and Store Operated
Ca2+ Channels 125
Donna L. Cioffi, Songwei Wu, and Troy Stevens
I. Introduction .... 125
II. Ca2+ Selective and Nonselective SOCE .... 126
III. Molecular Basis for SOCE .... 129
Contents xvii
IV. Role of Individual TRPC Proteins in SOCE .... 133
V. Activating SOCE Channels .... 135
VI. TRPC Expression and Function in the Lung .... 137
VII. Summary .... 140
References .... 140
7. Ca2+ Releasing Channels in Pulmonary Vascular Smooth Muscle Cells .... 147
Yuji Imaizumi and Katsuhiko Muraki
I. Introduction .... 147
II. Molecular Basis of Ca2+ Releasing Channels .... 147
III. RyRs: Channel Characteristics, Expression, and Physiological
Functions in SMCs .... 149
IV. IP3Rs: Their Expression, Regulation of Activity, and Functions in
SMCs 156
V. Ca2+ Releasing Channels and Pulmonary Vascular
Diseases .... 159
VI. Summary .... 159
References .... 160
8. Agonist Mediated Regulation of Ca2+ Transients in PASMCs 167
Jean Pierre Savineau, Christelle Guibert, and Roger Marthan
I. Introduction .... 167
II. Characteristics of Agonist Induced Ca Transient in Isolated
PASMCs .... 168
III. Cellular Mechanisms of Agonist Induced [Ca2+]; Responses
in PASMCs 171
IV. Functional Role of Ca2+ Oscillations .... 175
V. Modulation of Agonist Induced Ca2+ Oscillations by Physical,
Chemical, or Pharmacological Agents: Implication in the
Pathophysiology of the Pulmonary Circulation .... 176
VI. Summary and Conclusions .... 180
References .... 180
III. Na+ PERMEABLE CHANNELS
9. Epithelial Sodium Channel Function in Health and Disease in the
Adult Lung 185
Ian C. Davis, Lawrence S. Prince, and Sadis Matalon
I. Introduction: The Role of Sodium Channels in Lung Physiology .... 185
II. Biology of ENaC in the Lung .... 186
III. ENaCs in Adult Lung Disease .... 187
IV. Effect of Pulmonary Pathogens on Na+ Transport .... 187
V. ENaC Modulation by Purinergic Nucleotides .... 189
VI. Protein Kinase C as a Central Regulator of ENaC
Function? .... 190
VII. Inflammatory Mediators of ENaC Dysfunction in
Pulmonary Disease .... 191
xviii Contents
VIII. Summary and Conclusions .... 192
References .... 193
10. Voltage Dependent Na+ Channels in Pulmonary Vascular Smooth
Muscle Cells 199
Kenji Kitamura and Hirosi Kuriyama
I. Introduction .... 199
II. Electrophysiological Evidence for Voltage Dependent Na Channels in
Smooth Muscle Cells .... 200
III. Structure and Function of Voltage Dependent Na
Channels .... 202
IV. Physiological Importance of Voltage Dependent Na Channels in
Pulmonary Artery and Other Smooth Muscle Cells . . . .210
V. Conclusions . . . .213
References . . . .213
IV. K+ PERMEABLE CHANNELS
11. Voltage Gated Potassium Channels in Pulmonary Artery Smooth
Muscle Cells 217
Kristen O Connell, Aaron Norris, Elizabeth A. Coppock, and Michael M. Tamkun
I. Introduction .... 217
II. Diversity of Voltage Gated K+ Currents in Pulmonary Artery
VSMCs 219
III. Overview of Molecular Approaches to Voltage Gated
K+ Channels 220
IV. Cloning and Functional Analysis of Kv Channel Expression in the
Pulmonary Artery Vascular Smooth Muscle Cell .... 223
V. Subcellular Localization of Kv Channels in the Pulmonary
Vasculature .... 228
VI. Relation of Cloned Channels with Native Currents .... 231
VII. Summary and Conclusions .... 232
References .... 232
12. Ca2+ Activated, Voltage Dependent K+ Channels 237
Ligia Tom, Abderrahmane Alioua, Rong Lu, Jesus Garcia Valdes, Kazuhide
Nishimaru, Mansoureh Eghbali, Enrico Stefani, and
Masoud M. Zarei
I. Introduction .... 238
II. Gene Structure and Molecular Properties .... 238
III. Regulation of Channel Activity and Expression .... 244
IV. Functional Roles of the Channel .... 249
V. Relationship to Vascular Disease and Aging .... 251
VI. Conclusions .... 253
References .... 253
Contents xix
13. ATP Sensitive and Inward Rectifier K+ Channels 257
Lucie H. Clapp and Brian P. Tennant
I. Introduction .... 257
II. KATP Channels .... 258
III. Strong Inward Rectifier K+ Channels .... 264
IV. Functional Role of KATp and IRK Channels .... 272
V. Inwardly Rectifying K+ Channels and Pulmonary Vascular
Disease .... 275
VI. Concluding Remarks .... 279
References .... 281
14. 2P Domain K+ Channels and Their Role
in Chemoreception 287
Amanda J. Patel and Eric Honore
I. Introduction .... 287
II. TWIK 1, TWIK 2, and KCNK7 289
III. TASK 1, TASK 3, and TASK 5 291
IV. TREK 1, TREK 2, and TRAAK 296
V. TASK 2, TALK 1, and TALK 2 300
VI. THIK 1 and THIK 2 301
VII. Conclusions .... 301
References .... 302
V. Cl PERMEABLE CHANNELS
15. Ca2+ Activated Cl~ Channels and Pulmonary
Vascular Tone 311
William A. Large and Angela S. Piper
I. Introduction .... 311
II. Properties of Unitary Ca2+ Activated Cl~ Channels in Pulmonary Artery
Smooth Muscle Cells .... 312
III. Regulation of Ca2+ Activated Cl Channels .... 316
IV. Pharmacology of Ca2+ Activated Cl Channels .... 317
V. Function of Ca2+ Activated Cl Channels in the Pulmonary
Vasculature .... 322
VI. Molecular Biology of Ca2+ Activated Cl Channels .... 325
VII. Conclusions 329
References .... 330
16. Volume Sensitive Cl Channels in Pulmonary Vascular Smooth Muscle and
Endothelial Cells 335
Amy Sanguinetti, Normand Leblanc, and Iain A. Greenwood
I. Introduction .... 335
II. Chloride Currents in Smooth Muscle Cells .... 336
III. Biophysical Characteristics of /cusweii) ¦ ¦ • ¦ 336
IV. Modulation of /Ci(sweii) in Smooth Muscle Cells .... 340
V. /ci(Sweii) in Endothelial Cells .... 341
xx Contents
VI. Molecular Candidates for /cusweii) ¦• • • 343
VII. Physiological Roles of /cusweii) ¦ •¦ • 344
VIII. Conclusions .... 348
References .... 348
VI. O2 SENSITIVE ION CHANNELS
17. Molecular Physiology of O2 Sensitive Ion Channels 353
Kristen O Connell, Elizabeth A. Coppock, Aaron Norris, and Michael M. Tamkun
I. Introduction .... 353
II. O2 Sensitive K+ Channels .... 357
III. O2 Sensitivity of Cloned Kv Channels Expressed in
Heterologous Systems .... 361
IV. Calcium Channels and Hypoxia .... 365
V. Hypoxia Sensitive Kv Currents in Native PASMCs .... 366
VI. Mechanisms of O2 Sensing .... 368
VII. Conclusions .... 371
References .... 371
18. Hypoxia Induced Modulation of O2 Sensitive K+ Channels in Pulmonary Vascular
Smooth Muscle Cells 379
Carmelle V. Remillard, Oleksandr Platoshyn, Tiffany Sison, and
Jason X. J. Yuan
I. Introduction .... 379
II. K+ Channels and the Regulation of Membrane Potential .... 380
III. Acute Hypoxia Decreases K+ Channel Activity .... 380
IV. Chronic Hypoxia Downregulates K+ Channel Expression .... 388
V. Colocalization of O2 Sensors and Effectors Within Microdomains .... 395
VI. Summary .... 396
References .... 398
19. Ion Channels and the Effects of Hypoxia in Pulmonary Artery Endothelial
Cells 409
Andrew R. L. Davies, Dayle S. Hogg, and Roland Z. Kozlowski
I. Introduction .... 409
II. Ion Channels in Pulmonary Artery Endothelial
Cells 413
III. Effects of Hypoxia on Pulmonary Artery Endothelial
Cell Ion Channels .... 421
IV. Conclusions .... 425
References .... 426
VII. WATER CHANNELS
20. Aquaporins in the Vasculature 431
Venkataramana Sidhaye and London S. King
I. Introduction .... 431
II. The Aquaporin Family .... 432
Contents xxi
III. Aquaporin Structure and Function .... 432
IV. Aquaporin 1 .... 434
V. Regulation of AQP1 .... 435
VI. Aquaporins and Human Pathophysiology .... 437
VII. Aquaporin 1 Function in the Lung .... 438
VIII. Conclusion .... 440
References .... 440
VIII. FUNCTIONAL ROLES OF CYTOPLASMIC IONS AND ION
CHANNELS
21. Functional Roles of Ion Channels in the Regulation of Membrane Potential and
Pulmonary Vascular Tone 447
Alison M. Gurney
I. Introduction .... 447
II. The Resting Membrane Potential .... 448
III. Molecular Identification of the K+ Channels Underlying the
Resting Membrane Potential .... 449
IV. Ion Channels Mediating a Depolarizing Influence on the Resting
Potential .... 453
V. Influence of Other Ion Transporters on Resting Potential .... 454
VI. The Resting Potential and Pulmonary Vascular Disease .... 454
VII. Functional Importance of the Resting Potential .... 455
VIII. Summary .... 456
References .... 458
22. Calcium Channels, Calcium Signaling, and Lung Vascular
Barrier Regulation 463
Bryan J. McVerry, Steven M. Dudek, Dolly Mehta, and
Joe G. N. Garcia
I. Introduction .... 463
II. Calcium Channels .... 464
III. Calcium Signaling .... 466
IV. Regulation of Calcium Entry .... 468
V. Calcium Signaling to the Cytoskeleton and Permeability
Pathways .... 472
VI. Calcium Independent Permeability Mechanisms .... 474
VII. Microvascular Versus Macrovascular Endothelial
Permeability .... 474
VIII. Summary and Future Directions .... 477
References .... 478
23. Role of Ca2+ Sparks in the Regulation of Pulmonary Vascular Tone 483
James S. K. Sham, Anita Umesh, Xiao Ru Yang, and Mo Jun Lin
I. Introduction .... 483
II. Ryanodine Receptor: the Mediator of Ca2+ Sparks .... 484
HI. Ca2+ Sparks of Systemic Vascular Smooth Muscle .... 492
xxii Contents
IV. Ca2+ Sparks of PASMCs 494
V. Physiological Roles of Ca2+ Spark in PASMCs 502
VI. Concluding Remarks .... 503
References .... 504
24. Ion Channels and Hypoxic Pulmonary
Vasoconstriction 513
Vladimir A. Snetkov and Jeremy P. T. Ward
I. Introduction .... 513
II. Ca2+ Entry Pathways .... 514
III. Depolarization and Voltage Gated Ca2+ Channels .... 514
IV. Channels Causing Depolarization: K+ and Cr
Channels .... 515
V. PROS and CONS of the K+ Channel and Depolarization
Hypothesis .... 519
VI. Voltage Independent Ca2+ Entry in HPV .... 520
VII. Mechanisms of Oxygen Sensitivity of Ion Channels .... 521
VIII. Conclusion .... 522
References .... 523
25. Essential Role of Anion Channels in Induction of Apoptotic and Necrotic Cell
Death 527
Yasunobu Okada, Emi Maeno, Takashi Nabekura, and Shin ichiro Mori
I. Introduction .... 527
II. Volume Regulation Dysfunction Associated with the Cell
Death Process .... 528
III. Roles of K+ and CX~ Channels in the Induction
of AVD 528
IV. Caspase Independent Induction of AVD .... 530
V. Rescue from Apoptotic Cell Death by Anion Channel
Block .... 531
VI. Roles of Ion Channels and Transporters in the Induction
of NVI 532
VII. Protection Against Necrotic Cell Death by Manipulation
of Anion Channels .... 534
References .... 535
IX. ROLE OF ION CHANNELS IN PULMONARY VASCULATURE DISEASE
26. Downreguiated Kv Channels and Upregulated TRPC Channels
in Primary Pulmonary Hypertension 543
Donna D. Tigno, Mehran Mandegar, Carmelle V. Remillard, and Jason X. J
Yuan
I. Introduction .... 543
II. Role of Ca2+ in Pulmonary Vasoconstriction and PASMC
Proliferation .... 544
Contents xxiii
III. Role of Dysfunctional or Downregulated Kv Channels in the
Development of PPH .... 549
IV. Role of Upregulated TRPC Channels and Enhanced
Capacitative Ca2+ Entry in the Development
of PPH .... 553
V. Summary .... 561
References .... 562
27. Developmental Regulation of Ion Channel Function and Expression in the
Pulmonary Vasculature 567
David N. Cornfield
I. Introduction .... 567
II. K+ Channel Physiology in the Perinatal Pulmonary
Circulation .... 569
III. Ontogeny of Pulmonary Vascular K+ Channels .... 573
IV. Developmental Regulation of Ryanodine Sensitive Stores .... 576
V. Conclusion .... 578
References .... 579
28. Anorexigens and Pulmonary Arterial Hypertension: The Role
of Potassium Channels 583
Sean McMurtry and Evangelos D. Michelakis
I. Introduction .... 583
II. History .... 584
III. The 5 HT Story 586
IV. The K+ Channel Story 589
V. A Proposed Unifying Mechanism .... 595
VI. Lessons for the Future .... 596
References .... 598
X. METHODOLOGICAL APPROACHES
29. Isolation and Culture of Pulmonary Artery Smooth Muscle Cells 605
Shen Zhang, Carmelle V. Remillard, Oleksandr Platoshyn, and Jason X. J. Yuan
I. Introduction .... 605
II. Isolation of PASMCs from Rats and Humans .... 606
III. Morphological Characteristics of Primary and Subcultured
Cells .... 609
IV. Sample Uses of Cultured PASMCs .... 611
V. Summary .... 611
References .... 612
30. Measurement of Ion Channel Function Using Conventional
Patch Clamp Techniques 615
Carmelle V. Remillard and Jason X. J. Yuan
I. Introduction .... 615
II. Brief Historical Perspective of Patch Clamp
Electrophysiology .... 616
xxiv Contents
HI. Description of the Patch Clamp Technique . . . .616
IV. Voltage and Current Clamp Modes .... 621
V. Characterizing Ion Channel Currents .... 621
VI. Summary .... 631
References .... 632
31. Planar Electrodes: The Future of Voltage Clamp 635
Antonio Guia and Jia Xu
I. Introduction .... 635
II. Pioneers and Their Methods .... 638
III. Devices Currently Available .... 645
IV. Summary and Future Directions .... 648
References .... 649
32. Correlation of Ion Channel Activity with Gene Expression Using Single Cell
RT PCR and Patch Clamp Techniques 653
Ying Yu, Oleksandr Platoshyn, and Jason X. J. Yuan
I. Introduction .... 653
II. Combination of Patch Clamp Recording and Single Cell
RT PCR Analysis .... 654
III. Application of Patch Clamp and Single Cell RT PCR Assay
in PASMCs 659
IV. Summary .... 661
References .... 661
33. Ion Channel Trafficking 665
Steve H. Keller, Bethany H. Parker, and Jason X. J. Yuan
I. Introduction .... 665
II. Methods To Study Ion Channel Trafficking .... 673
III. Summary and Conclusion .... 681
References .... 681
34. Functional Study of Cloned Ion Channels in Mammalian Transfection Systems
Using Site Directed Mutagenesis 687
Elena E. Brevnova, Bethany H. Parker, Oleksandr Platoshyn, and Jason X. J.
Yuan
I. Introduction .... 687
II. Overview of the Mutagenesis Approach .... 688
III. Expression of Foreign Genes Using Mammalian Expression
Systems .... 688
IV. DNA Sequence Alterations .... 691
V. Analysis of Expression and Function of Heterologous Ion
Channels .... 701
VI. Application of Site Directed Mutagenesis for Study of Ion
Channel Functions .... 704
VII. Summary .... 706
References .... 707
Contents xxv
35. Screening for mRNA Expression Using the Polymerase Chain Reaction ... 711
Ivana Fantozzi, Carmelle V. Remillard, Mehran Mandegar, and Jason X. J. Yuan
I. Introduction .... 711
II. The Polymerase Chain Reaction Technique .... 712
III. Reverse Transcription Methodology .... 717
IV. Primers 722
V. Visualization and Quantification of the RT PCR
Products .... 725
VI. Real Time PCR .... 727
VII. Useful Hints and Reminders .... 728
VIII. Summary .... 729
References .... 729
36. Practical Aspects of Confocal Imaging of Ca2+ Sparks and Cytoplasmic Ca2
Concentration 733
James S. K. Sham and Christopher Ian Spencer
I. Introduction .... 733
II. General Aspects of Ca2+ Measurement .... 734
III. Detection of Ca2+ Sparks 739
IV. Analysis of Ca2+ Sparks 742
V. Concluding Remarks .... 746
References .... 746
37. Use of Transgenic and Gene Targeted Mice to Study Ion Channel Function in the
Pulmonary Vasculature 751
Barry London and Maninder Singh Bedi
I. Introduction .... 751
II. Generating Transgenic and Gene Targeted Mice .... 752
III. Studying Transgenic and Gene Targeted Mice .... 755
IV. Targeting Ion Channels in the Pulmonary
Vasculature .... 757
V. Transgenic and Gene Targeted Mouse Models of Pulmonary
Vascular Disease .... 759
VI. Summary/Conclusion .... 761
References .... 761
Index 765
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV020017869 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:10:56Z |
| institution | BVB |
| isbn | 0824759680 9780824759681 |
| language | English |
| lccn | 2005043939 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013339309 |
| oclc_num | 58790049 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | xxv, 791 S. Ill., graph. Darst. 24 cm |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Taylor & Francis |
| record_format | marc |
| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Ion channels in the pulmonary vasculature edited by Jason X.-J. Yuan Boca Raton [u.a.] Taylor & Francis 2005 xxv, 791 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 197 Includes bibliographical references and index Lungs Blood-vessels Lungs Blood-vessels Diseases Ion channels Lung blood supply Ion Channels physiology Gefäßmuskulatur (DE-588)4156220-3 gnd rswk-swf Gefäßtonus (DE-588)4226052-8 gnd rswk-swf Lunge (DE-588)4036651-0 gnd rswk-swf Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf Ionenkanal (DE-588)4138699-1 gnd rswk-swf Gefäßkrankheit (DE-588)4071631-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenkrankheit (DE-588)4036660-1 s Gefäßkrankheit (DE-588)4071631-4 s Gefäßmuskulatur (DE-588)4156220-3 s Ionenkanal (DE-588)4138699-1 s DE-604 Lunge (DE-588)4036651-0 s Gefäßtonus (DE-588)4226052-8 s b DE-604 Yuan, Jason X.-J. Sonstige oth Lung biology in health and disease 197 (DE-604)BV000008326 197 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013339309&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ion channels in the pulmonary vasculature Lung biology in health and disease Lungs Blood-vessels Lungs Blood-vessels Diseases Ion channels Lung blood supply Ion Channels physiology Gefäßmuskulatur (DE-588)4156220-3 gnd Gefäßtonus (DE-588)4226052-8 gnd Lunge (DE-588)4036651-0 gnd Lungenkrankheit (DE-588)4036660-1 gnd Ionenkanal (DE-588)4138699-1 gnd Gefäßkrankheit (DE-588)4071631-4 gnd |
| subject_GND | (DE-588)4156220-3 (DE-588)4226052-8 (DE-588)4036651-0 (DE-588)4036660-1 (DE-588)4138699-1 (DE-588)4071631-4 (DE-588)4143413-4 |
| title | Ion channels in the pulmonary vasculature |
| title_auth | Ion channels in the pulmonary vasculature |
| title_exact_search | Ion channels in the pulmonary vasculature |
| title_full | Ion channels in the pulmonary vasculature edited by Jason X.-J. Yuan |
| title_fullStr | Ion channels in the pulmonary vasculature edited by Jason X.-J. Yuan |
| title_full_unstemmed | Ion channels in the pulmonary vasculature edited by Jason X.-J. Yuan |
| title_short | Ion channels in the pulmonary vasculature |
| title_sort | ion channels in the pulmonary vasculature |
| topic | Lungs Blood-vessels Lungs Blood-vessels Diseases Ion channels Lung blood supply Ion Channels physiology Gefäßmuskulatur (DE-588)4156220-3 gnd Gefäßtonus (DE-588)4226052-8 gnd Lunge (DE-588)4036651-0 gnd Lungenkrankheit (DE-588)4036660-1 gnd Ionenkanal (DE-588)4138699-1 gnd Gefäßkrankheit (DE-588)4071631-4 gnd |
| topic_facet | Lungs Blood-vessels Lungs Blood-vessels Diseases Ion channels Lung blood supply Ion Channels physiology Gefäßmuskulatur Gefäßtonus Lunge Lungenkrankheit Ionenkanal Gefäßkrankheit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013339309&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
| work_keys_str_mv | AT yuanjasonxj ionchannelsinthepulmonaryvasculature |