Molecular biotechnology: principles and applications of recombinant DNA
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C.
ASM Press
2003
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| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIII, 760 S. Ill., graph. Darst. |
| ISBN: | 1555812244 1555812694 |
Internformat
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| 245 | 1 | 0 | |a Molecular biotechnology |b principles and applications of recombinant DNA |c Bernard R. Glick ; Jack J. Pasternak |
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| 650 | 4 | |a Génie génétique | |
| 650 | 4 | |a Ingeniería genética | |
| 650 | 7 | |a Recombinant DNA |2 gtt | |
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Datensatz im Suchindex
| _version_ | 1804133546510516224 |
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| adam_text | THIRD EDITION BERNARD R.GIICK JACK J. PASTERNAK DEPARTMENT OF BIOLOGY,
UNIVERSITY OF WATERLOO WATERLOO, ONTARIO, CANADA ASM PRESS WASHINGTON,
D.C. CONTENTS PREFACE XIX PREFACE TO THE FIRST EDITION XXI FUNDAMENTALS
OF MOLECULAR BIOTECHNOLOGY 1 1 THE MOLECULAR BIOTECHNOLOGY REVOLUTION 3
RECOMBINANT DNA TECHNOLOGY 3 EMERGENCE OF MOLECULAR BIOTECHNOLOGY 5
COMMERCIALIZATION OF MOLECULAR BIOTECHNOLOGY 7 CONCERNS AND CONSEQUENCES
10 SUMMARY 12 . REFERENCES 13 REVIEW QUESTIONS 13 2 MOLECULAR
BIOTECHNOLOGY BIOLOGICAL SYSTEMS 14 PROKARYOTIC AND EUKARYOTIC ORGANISMS
14 ESCHERICHIA COLI 15 SACCHAROMYCES CEREVISIAE 17 SECRETION PATHWAYS IN
PROKARYOTIC AND EUKARYOTIC ORGANISMS 18 EUKARYOTIC CELLS IN CULTURE 21
SUMMARY 22 REFERENCES 22 REVIEW QUESTIONS 22 DNA, RNA, AND PROTEIN
SYNTHESIS 23 STRUCTURE OF DNA 23 DNA REPLICATION 27 VII VIII CONTENTS
DECODING GENETIC INFORMATION: RNA AND PROTEIN 28 TRANSLATION 34
REGULATION OF MRNA TRANSCRIPTION IN BACTERIA 38 REGULATION OF MRNA
TRANSCRIPTION IN EUKARYOTES 42 SUMMARY 45 REFERENCES 46 REVIEW QUESTIONS
46 RECOMBINANT DNA TECHNOLOGY 47 RESTRICTION ENDONUCLEASES 49 PLASMID
CLONING VECTORS 57 PLASMID CLONING VECTOR PBR322 58 TRANSFORMATION AND
SELECTION 60 OTHER PLASMID CLONING VECTORS 61 CREATING AND SCREENING A
LIBRARY 64 MAKING A GENE LIBRARY 64 SCREENING BY DNA HYBRIDIZATION 67
SCREENING BY IMMUNOLOGICAL ASSAY 73 SCREENING BY PROTEIN ACTIVITY 73
CLONING DNA SEQUENCES THAT ENCODE EUKARYOTIC PROTEINS 75 VECTORS FOR
CLONING LARGE PIECES OF DNA 80 BACTERIOPHAGE X, VECTORS 80 COSMIDS 83
HIGH-CAPACITY BACTERIAL VECTOR SYSTEMS 86 GENETIC TRANSFORMATION OF
PROKARYOTES 86 TRANSFERRING DNA INTO E. COLI 86 ELECTROPORATION 86
CONJUGATION 87 SUMMARY 89 REFERENCES 89 REVIEW QUESTIONS 90 CHEMICAL
SYNTHESIS, SEQUENCING, AND AMPLIFICATION OF DNA 91 CHEMICAL SYNTHESIS OF
DNA 91 THE PHOSPHORAMIDITE METHOD 92 USES OF SYNTHESIZED
OLIGONUCLEOTIDES 96 DNA SEQUENCING TECHNIQUES 101 DIDEOXYNUCLEOTIDE
PROCEDURE FOR SEQUENCING DNA 102 AUTOMATED DNA SEQUENCING 106 USING
BACTERIOPHAGE M13 AS A DNA SEQUENCING VECTOR 107 PRIMER WALKING 110 PCR
110 GENE SYNTHESIS BY PCR 115 CYCLE SEQUENCING 115 CONTENTS IX SUMMARY
118 REFERENCES 119 REVIEW QUESTIONS 120 . MANIPULATION OF GENE
EXPRESSION IN PROKARYOTES 121 GENE EXPRESSION FROM STRONG AND
REGULATABLE PROMOTERS 122 REGULATABLE PROMOTERS 122 INCREASING PROTEIN
PRODUCTION 126 LARGE-SCALE SYSTEMS 126 EXPRESSION IN OTHER
MICROORGANISMS 128 FUSION PROTEINS 130 CLEAVAGE OF FUSION PROTEINS 131
USES OF FUSION PROTEINS 131 SURFACE DISPLAY 135 UNIDIRECTIONAL TANDEM
GENE ARRAYS 136 TRANSLATION EXPRESSION VECTORS 138 INCREASING PROTEIN
STABILITY 142 PROTEIN FOLDING 142 OVERCOMING OXYGEN LIMITATION 145 USE
OF PROTEASE-DEFICIENT HOST STRAINS 145 BACTERIAL HEMOGLOBIN 145 DNA
INTEGRATION INTO THE HOST CHROMOSOME 146 REMOVING SELECTABLE MARKER
GENES 149 INCREASING SECRETION 151 L-FORM BACTERIA 153 METABOLIC LOAD
155 SUMMARY 159 REFERENCES 159 REVIEW QUESTIONS 161 7 HETEROLOGOUS
PROTEIN PRODUCTION IN EUKARYOTIC CELLS 163 SACCHAROMYCES CETEVISIAE
EXPRESSION SYSTEMS 165 S. CEREVISIAE VECTORS 166 INTRACELLULAR
PRODUCTION OF HETEROLOGOUS PROTEINS IN S. CEREVISIAE 169 SECRETION OF
HETEROLOGOUS PROTEINS BY S. CEREVISIAE 171 PICHIA PASTORIS AND OTHER
YEAST EXPRESSION SYSTEMS 171 BACULOVIRUS-LNSECT CELL EXPRESSION SYSTEM
174 BACULOVIRUS EXPRESSION VECTOR SYSTEM 175 INCREASING THE YIELD OF
RECOMBINANT BACULOVIRUS 175 CONSTRUCTION OF AN E. CO/R-INSECT CELL
BACULOVIRUS SHUTTLE VECTOR 177 MAMMALIAN GLYCOSYLATION AND PROCESSING OF
PRECURSOR PROTEINS IN INSECT CELLS 180 MAMMALIAN CELL EXPRESSION SYSTEMS
181 SELECTABLE MARKER SYSTEMS FOR MAMMALIAN EXPRESSION VECTORS 185
CONTENTS SUMMARY 187 REFERENCES 187 REVIEW QUESTIONS 189 DIRECTED
MUTAGENESIS AND PROTEIN ENGINEERING 190 DIRECTED MUTAGENESIS PROCEDURES
191 OLIGONUCLEOTIDE-DIRECTED MUTAGENESIS WITH M13 DNA 192
OLIGONUCLEOTIDE-DIRECTED MUTAGENESIS WITH PLASMID DNA 194 PCR-AMPLIFIED
OLIGONUCLEOTIDE-DIRECTED MUTAGENESIS 195 RANDOM MUTAGENESIS WITH
DEGENERATE OLIGONUCLEOTIDE PRIMERS 198 RANDOM MUTAGENESIS WITH
NUCLEOTIDE ANALOGUES 201 ERROR-PRONE PCR 201 DNA SHUFFLING 203 MUTANT
PROTEINS WITH UNUSUAL AMINO ACIDS 204 PROTEIN ENGINEERING 205 ADDING
DISULFIDE BONDS 205 CHANGING ASPARAGINE TO OTHER AMINO ACIDS 209
REDUCING THE NUMBER OF FREE SULFHYDRYL RESIDUES 209 INCREASING ENZYMATIC
ACTIVITY 211 MODIFYING METAL COFACTOR REQUIREMENTS 212 DECREASING
PROTEASE SENSITIVITY 214 MODIFYING PROTEIN SPECIFICITY 215 INCREASING
ENZYME STABILITY AND SPECIFICITY 218 ALTERING MULTIPLE PROPERTIES 219
SUMMARY 221 REFERENCES 222 REVIEW QUESTIONS 223 MOLECULAR BIOTECHNOLOGY
OF MICROBIAL SYSTEMS 225 MOLECULAR DIAGNOSTICS 227 IMMUNOLOGICAL
DIAGNOSTIC PROCEDURES 228 ENZYME-LINKED IMMUNOSORBENT ASSAY 229
MONOCLONAL ANTIBODIES 230 FORMATION AND SELECTION OF HYBRID CELLS 231
IDENTIFICATION OF SPECIFIC ANTIBODY-PRODUCING HYBRID CELL LINES 232 DNA
DIAGNOSTIC SYSTEMS 234 HYBRIDIZATION PROBES 235 DIAGNOSIS OF MALARIA 236
DETECTION OF TRYPANOSOMA CRUZI 236 NONRADIOACTIVE HYBRIDIZATION
PROCEDURES 237 MOLECULAR BEACONS 240 DNA FINGERPRINTING 241 CONTENTS XI
RANDOM AMPLIFIED POLYMORPHIC DNA 242 BACTERIAL BIOSENSORS 244 MOLECULAR
DIAGNOSIS OF GENETIC DISEASE 245 SCREENING FOR CYSTIC FIBROSIS 246
SICKLE-CELL ANEMIA 246 THE PCR/OLA PROCEDURE 248 PADLOCK PROBES 250
GENOTYPING WITH FLUORESCENCE-LABELED PCR PRIMERS 250 SUMMARY 253
REFERENCES 253 REVIEW QUESTIONS 254 10 THERAPEUTIC AGENTS 256
PHARMACEUTICALS 257 ISOLATION OF INTERFERON CDNAS 257 HUMAN INTERFERONS
258 HUMAN GROWTH HORMONE 259 TUMOR NECROSIS FACTOR ALPHA 260 OPTIMIZING
GENE EXPRESSION 261 THERAPEUTICS PRODUCED AND DELIVERED BY INTESTINAL
BACTERIA 262 ENZYMES 263 DNASE I 263 ALGINATE LYASE 265 PHENYLALANINE
AMMONIA LYASE 266 OJ-ANTITRYPSIN 267 MONOCLONAL ANTIBODIES AS
THERAPEUTIC AGENTS 267 STRUCTURE AND FUNCTION OF ANTIBODIES 269
PREVENTING REJECTION OF TRANSPLANTED ORGANS 270 TREATING BRAIN TUMORS
270 CHEMICALLY LINKED MONOCLONAL ANTIBODIES 271 HUMAN MONOCLONAL
ANTIBODIES 272 HYBRID HUMAN-MOUSE MONOCLONAL ANTIBODIES 274 PRODUCTION
OF ANTIBODIES IN E. COLI 277 PHAGE COMBINATORIAL LIBRARIES 277 SHUFFLING
CDR SEQUENCES 280 SINGLE-CHAIN ANTIBODIES 282 NUCLEIC ACIDS AS
THERAPEUTIC AGENTS 283 ANTISENSE RNA 284 ANTISENSE OLIGONUCLEOTIDES 284
RIBOZYMES 288 CHIMERIC RNA-DNA MOLECULES 291 INTERFERING RNAS 292
ANTIBODY GENES 294 TREATING GENETIC DISORDERS 295 HUMAN GENE THERAPY 298
PRODRUG ACTIVATION THERAPY 303 SUMMARY 304 CONTENTS REFERENCES 305
REVIEW QUESTIONS 307 11 VACCINES 309 SUBUNIT VACCINES 312 HERPES SIMPLEX
VIRUS 312 FOOT-AND-MOUTH DISEASE 313 PEPTIDE VACCINES 315 GENETIC
IMMUNIZATION: DNA VACCINES 317 ATTENUATED VACCINES 322 CHOLERA 322
SALMONELLA SPECIES 324 LEISHMANIA SPECIES 325 HERPES SIMPLEX VIRUS 326
VECTOR VACCINES 327 VACCINES DIRECTED AGAINST VIRUSES 327 VACCINES
DIRECTED AGAINST BACTERIA 333 BACTERIA AS ANTIGEN DELIVERY SYSTEMS 335
SUMMARY 336 REFERENCES 337 REVIEW QUESTIONS 338 12 SYNTHESIS OF
COMMERCIAL PRODUCTS BY RECOMBINANT MICROORGANISMS 340 RESTRICTION
ENDONUCLEASES 340 SMALL BIOLOGICAL MOLECULES 344 SYNTHESIS OF L-ASCORBIC
ACID 345 MICROBIAL SYNTHESIS OF INDIGO 349 SYNTHESIS OF AMINO ACIDS 350
REMOVAL OF LIPIDS 354 ANTIBIOTICS 355 CLONING ANTIBIOTIC BIOSYNTHESIS
GENES 356 SYNTHESIS OF NOVEL ANTIBIOTICS 360 ENGINEERING POLYKETIDE
ANTIBIOTICS 361 IMPROVING ANTIBIOTIC PRODUCTION 365 PEPTIDE ANTIBIOTICS
367 BIOPOLYMERS 367 ENGINEERING XANTHOMONAS CAMPESTRIS FOR XANTHAN GUM
PRODUCTION 367 ISOLATION OF MELANIN BIOSYNTHESIS GENES 369 SYNTHESIS OF
AN ANIMAL ADHESIVE BIOPOLYMER IN MICROBIAL CELLS 370 MICROBIAL SYNTHESIS
OF RUBBER 372 MICROBIAL PRODUCTION OF POLYHYDROXYALKANOATES 372 SUMMARY
375 REFERENCES 375 REVIEW QUESTIONS 377 CONTENTS XIII 13 BIOREMEDIATION
AND BIOMASS UTILIZATION 378 MICROBIAL DEGRADATION OF XENOBIOTICS 378
GENETIC ENGINEERING OF BIODEGRADATIVE PATHWAYS 382 MANIPULATION BY
TRANSFER OF PLASMIDS 384 MANIPULATION BY GENE ALTERATION 385 UTILIZATION
OF STARCH AND SUGARS 394 COMMERCIAL PRODUCTION OF FRUCTOSE AND ALCOHOL
395 IMPROVING ALCOHOL PRODUCTION 396 IMPROVING FRUCTOSE PRODUCTION 398
ZYMOMONAS MOBILIS 400 SILAGE FERMENTATION 404 UTILIZATION OF CELLULOSE
405 COMPONENTS OF LIGNOCELLULOSE 406 ISOLATION OF PROKARYOTIC CELLULASE
GENES 408 ISOLATION OF EUKARYOTIC CELLULASE GENES 410 MANIPULATION OF
CELLULASE GENES 412 SUMMARY 413 REFERENCES 414 REVIEW QUESTIONS 415 14
PLANT GROWTH-PROMOTING BACTERIA 416 NITROGEN FIXATION 417 NITROGENASE
419 COMPONENTS OF NITROGENASE 419 GENETIC ENGINEERING OF THE NITROGENASE
GENE CLUSTER 421 GLYCOGEN SYNTHASE MUTANTS 425 ENGINEERING OXYGEN LEVELS
427 HYDROGENASE 427 HYDROGEN METABOLISM 428 GENETIC ENGINEERING OF
HYDROGENASE GENES 428 NODULATION 430 COMPETITION AMONG NODULATING
ORGANISMS 430 GENETIC ENGINEERING OF NODULATION GENES 431 GROWTH
PROMOTION BY FREE-LIVING BACTERIA 435 DECREASING PLANT STRESS 438
PHYTOREMEDIATION 440 BIOCONTROL OF PATHOGENS 442 SIDEROPHORES 443
ANTIBIOTICS 445 ENZYMES 447 ICE NUCLEATION AND ANTIFREEZE PROTEINS 447
ETHYLENE 449 ROOT COLONIZATION 451 SUMMARY 451 REFERENCES 452 REVIEW
QUESTIONS 453 XIV CONTENTS MICROBIAL INSECTICIDES 455 INSECTICIDAL TOXIN
OF B. THURINGIENSIS 456 MODE OF ACTION AND USE 456 TOXIN GENE ISOLATION
460 ENGINEERING OF B. THURINGIENSIS TOXIN GENES 462 PREVENTING THE
DEVELOPMENT OF RESISTANCE 470 GENETIC ENGINEERING FOR IMPROVED
BIOCONTROL 472 BACULOVIRUSES AS BIOCONTROL AGENTS 473 MODE OF ACTION 473
GENETIC ENGINEERING FOR IMPROVED BIOCONTROL 475 SUMMARY 477 REFERENCES
478 REVIEW QUESTIONS 480 LARGE-SCALE PRODUCTION OF PROTEINS FROM
RECOMBINANT MICROORGANISMS 481 PRINCIPLES OF MICROBIAL GROWTH 483 BATCH
FERMENTATION 483 FED-BATCH FERMENTATION 485 CONTINUOUS FERMENTATION 486
MAXIMIZING THE EFFICIENCY OF THE FERMENTATION PROCESS 488 HIGH-DENSITY
CELL CULTURES 489 BIOREACTORS 490 TYPICAL LARGE-SCALE FERMENTATION
SYSTEMS 494 TWO-STAGE FERMENTATION IN TANDEM AIRLIFT REACTORS 495
TWO-STAGE FERMENTATION IN A SINGLE STIRRED-TANK REACTOR 496 BATCH VERSUS
FED-BATCH FERMENTATION 497 HARVESTING MICROBIAL CELLS 499 DISRUPTING
MICROBIAL CELLS 502 DOWNSTREAM PROCESSING 504 PROTEIN SOLUBILIZATION 506
LARGE-SCALE PRODUCTION OF PLASMID DNA 506 SUMMARY 507 REFERENCES 507
REVIEW QUESTIONS 509 EUKARYOTIC SYSTEMS 511 GENETIC ENGINEERING OF
PLANTS: METHODOLOGY 513 PLANT TRANSFORMATION WITH THE TI PLASMID OF
AGROBACTERIUM TUMEFACIENS 514 TI PLASMID-DERIVED VECTOR SYSTEMS 517
PHYSICAL METHODS OF TRANSFERRING GENES TO PLANTS 520 CONTENTS XV
MICROPROJECTILE BOMBARDMENT 522 USE OF REPORTER GENES IN TRANSFORMED
PLANT CELLS 523 MANIPULATION OF GENE EXPRESSION IN PLANTS 525 ISOLATION
AND USE OF DIFFERENT PROMOTERS 526 TARGETED ALTERATIONS IN PLANT DNA 527
TARGETED ALTERATIONS IN PLANT RNA 528 TARGETING FOREIGN DNA TO THE
CHLOROPLAST GENOME 529 SECRETION OF FOREIGN PROTEINS 532 PRODUCTION OF
MARKER-FREE TRANSGENIC PLANTS 532 REMOVING MARKER GENES FROM NUCLEAR DNA
533 REMOVING MARKER GENES FROM CHLOROPLAST DNA 534 SUMMARY 535
REFERENCES 535 REVIEW QUESTIONS 537 18 GENETIC ENGINEERING OF PLANTS:
APPLICATIONS 538 DEVELOPMENT OF INSECT-, PATHOGEN-, AND
HERBICIDE-RESISTANT PLANTS 538 INSECT-RESISTANT PLANTS 538
VIRUS-RESISTANT PLANTS 547 HERBICIDE-RESISTANT PLANTS 554 FUNGUS- AND
BACTERIUM-RESISTANT PLANTS 556 DEVELOPMENT OF STRESS- AND
SENESCENCE-TOLERANT PLANTS 560 OXIDATIVE STRESS 561 SALT STRESS 562
FRUIT RIPENING AND FLOWER WILTING 564 GENETIC MANIPULATION OF FLOWER
PIGMENTATION 566 MODIFICATION OF PLANT NUTRITIONAL CONTENT 569 AMINO
ACIDS 569 LIPIDS 571 VITAMINS 573 IRON 575 MODIFICATION OF FOOD PLANT
TASTE AND APPEARANCE 577 PREVENTING DISCOLORATION 577 SWEETNESS 578
STARCH 579 PLANTS AS BIOREACTORS 582 ANTIBODIES 583 POLYMERS 583 FOREIGN
PROTEINS IN PLANTS 584 EDIBLE VACCINES 585 PLANT YIELD 586 INCREASING
IRON CONTENT 587 ALTERING LIGNIN CONTENT 587 INCREASING OXYGEN CONTENT
588 SUMMARY 589 XVI CONTENTS REFERENCES 590 REVIEW QUESTIONS 593 )
TRANSGENIC ANIMALS 594 TRANSGENIC MICE: METHODOLOGY 596 RETROVIRAL
VECTOR METHOD 596 DNA MICROINJECTION METHOD 596 ENGINEERED EMBRYONIC
STEM CELL METHOD 599 GENETIC MODIFICATION WITH THE CRE-ZOXP
RECOMBINATION SYSTEM 603 TRANSGENESIS WITH HIGH-CAPACITY VECTORS 607
TRANSGENIC MICE: APPLICATIONS 609 TRANSGENIC MODELS FOR ALZHEIMER
DISEASE 610 USING TRANSGENIC MICE AS TEST SYSTEMS 611 CONDITIONAL
REGULATION OF GENE EXPRESSION 613 CONDITIONAL CONTROL OF CELL DEATH 615
CLONING LIVESTOCK BY NUCLEAR TRANSFER 616 TRANSGENIC CATTLE, SHEEP,
GOATS, AND PIGS 618 TRANSGENIC BIRDS 623 TRANSGENIC FISH 626 SUMMARY 629
REFERENCES 630 REVIEW QUESTIONS 632 :0 HUMAN MOLECULAR GENETICS 633
MODES OF HUMAN INHERITANCE 634 GENETIC LINKAGE AND GENE MAPPING 636
DETECTION AND ESTIMATION OF GENETIC LINKAGE IN HUMANS 639 GENETIC
MAPPING OF HUMAN CHROMOSOMES 643 GENETIC POLYMORPHISM 643 RESTRICTION
FRAGMENT LENGTH POLYMORPHISM 644 SHORT TANDEM REPEAT POLYMORPHISM 647
COMPREHENSIVE HUMAN LINKAGE MAPS 650 MAPPING OF A GENETIC DISEASE LOCUS
TO A CHROMOSOME LOCATION 650 WHOLE-GENOME BAC MAP 652 RADIATION HYBRID
MAPPING 653 HUMAN GENOME SEQUENCE 655 DETECTION OF MUTATIONS IN HUMAN
GENES 657 SINGLE-STRAND CONFORMATION ANALYSIS 657 DENATURING GRADIENT
GEL ELECTROPHORESIS 659 HETERODUPLEX ANALYSIS 660 CHEMICAL MISMATCH
CLEAVAGE 661 DIRECT DNA SEQUENCING 663 DETERMINING GENE FUNCTION 663
SUMMARY 668 REFERENCES 669 REVIEW QUESTIONS 670 CONTENTS XVII IF
REGULATING AND PATENTING MOLECULAR BIOTECHNOLOGY 671 21 REGULATING THE
USE OF BIOTECHNOLOGY 673 REGULATING RECOMBINANT DNA TECHNOLOGY 674
REGULATING FOOD AND FOOD INGREDIENTS 676 CHYMOSIN 676 TRYPTOPHAN 677
BOVINE SOMATOTROPIN 678 DELIBERATE RELEASE OF GMOS 680 ICE-MINUS P.
SYRINGAE 680 OPEN-FIELD TESTS OF OTHER GMOS 682 CONTROVERSY ABOUT GMOS
685 HUMAN GENE THERAPY 688 DEVELOPMENT OF A POLICY FOR SOMATIC CELL GENE
THERAPY 688 ACCUMULATION OF DEFECTIVE GENES IN FUTURE GENERATIONS 691
HUMAN GERM LINE GENE THERAPY 692 CLONING HUMANS? 692 SUMMARY 693
REFERENCES 694 REVIEW QUESTIONS 695 2 PATENTING BIOTECHNOLOGY INVENTIONS
697 PATENTING 698 PATENTING IN DIFFERENT COUNTRIES 700 PATENTING DNA
SEQUENCES 701 PATENTING MULTICELLULAR ORGANISMS 702 PATENTING AND
FUNDAMENTAL RESEARCH 703 SUMMARY 704 REFERENCES 705 REVIEW QUESTIONS 705
GLOSSARY 707 INDEX 733
|
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| author | Glick, Bernard R. Pasternak, Jack J. |
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| discipline | Chemie / Pharmazie Biologie Chemie-Ingenieurwesen Biotechnologie |
| edition | 3. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV019997307 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:10:26Z |
| institution | BVB |
| isbn | 1555812244 1555812694 |
| language | English |
| lccn | 2002013148 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013319102 |
| oclc_num | 50448011 |
| open_access_boolean | |
| owner | DE-20 DE-M49 DE-BY-TUM DE-634 DE-11 |
| owner_facet | DE-20 DE-M49 DE-BY-TUM DE-634 DE-11 |
| physical | XXIII, 760 S. Ill., graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | ASM Press |
| record_format | marc |
| spelling | Glick, Bernard R. Verfasser aut Molecular biotechnology principles and applications of recombinant DNA Bernard R. Glick ; Jack J. Pasternak 3. ed. Washington, D.C. ASM Press 2003 XXIII, 760 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologia molecular larpcal Biologie moléculaire Biología molecular Biotechnologie Biotechnologie gtt Biotecnologia larpcal Biotecnología Engenharia genética larpcal Génie génétique Ingeniería genética Recombinant DNA gtt Biotechnology Genetic Engineering Genetic engineering Molecular Biology Molecular biology Biotechnologie (DE-588)4069491-4 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Rekombinante DNS (DE-588)4225578-8 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Gentechnologie (DE-588)4071722-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Biotechnologie (DE-588)4069491-4 s Molekularbiologie (DE-588)4039983-7 s Rekombinante DNS (DE-588)4225578-8 s DE-604 Molekulargenetik (DE-588)4039987-4 s 1\p DE-604 Gentechnologie (DE-588)4071722-7 s 2\p DE-604 Pasternak, Jack J. Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013319102&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Glick, Bernard R. Pasternak, Jack J. Molecular biotechnology principles and applications of recombinant DNA Biologia molecular larpcal Biologie moléculaire Biología molecular Biotechnologie Biotechnologie gtt Biotecnologia larpcal Biotecnología Engenharia genética larpcal Génie génétique Ingeniería genética Recombinant DNA gtt Biotechnology Genetic Engineering Genetic engineering Molecular Biology Molecular biology Biotechnologie (DE-588)4069491-4 gnd Molekularbiologie (DE-588)4039983-7 gnd Rekombinante DNS (DE-588)4225578-8 gnd Molekulargenetik (DE-588)4039987-4 gnd Gentechnologie (DE-588)4071722-7 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4039983-7 (DE-588)4225578-8 (DE-588)4039987-4 (DE-588)4071722-7 (DE-588)4123623-3 |
| title | Molecular biotechnology principles and applications of recombinant DNA |
| title_auth | Molecular biotechnology principles and applications of recombinant DNA |
| title_exact_search | Molecular biotechnology principles and applications of recombinant DNA |
| title_full | Molecular biotechnology principles and applications of recombinant DNA Bernard R. Glick ; Jack J. Pasternak |
| title_fullStr | Molecular biotechnology principles and applications of recombinant DNA Bernard R. Glick ; Jack J. Pasternak |
| title_full_unstemmed | Molecular biotechnology principles and applications of recombinant DNA Bernard R. Glick ; Jack J. Pasternak |
| title_short | Molecular biotechnology |
| title_sort | molecular biotechnology principles and applications of recombinant dna |
| title_sub | principles and applications of recombinant DNA |
| topic | Biologia molecular larpcal Biologie moléculaire Biología molecular Biotechnologie Biotechnologie gtt Biotecnologia larpcal Biotecnología Engenharia genética larpcal Génie génétique Ingeniería genética Recombinant DNA gtt Biotechnology Genetic Engineering Genetic engineering Molecular Biology Molecular biology Biotechnologie (DE-588)4069491-4 gnd Molekularbiologie (DE-588)4039983-7 gnd Rekombinante DNS (DE-588)4225578-8 gnd Molekulargenetik (DE-588)4039987-4 gnd Gentechnologie (DE-588)4071722-7 gnd |
| topic_facet | Biologia molecular Biologie moléculaire Biología molecular Biotechnologie Biotecnologia Biotecnología Engenharia genética Génie génétique Ingeniería genética Recombinant DNA Biotechnology Genetic Engineering Genetic engineering Molecular Biology Molecular biology Molekularbiologie Rekombinante DNS Molekulargenetik Gentechnologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013319102&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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