Molecular imaging of the lungs:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
Taylor & Francis
2005
|
| Schriftenreihe: | Lung biology in health and disease
203 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XVIII, 450 S. zahlr. Ill., graph. Darst. |
| ISBN: | 1574448544 |
Internformat
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| 245 | 1 | 0 | |a Molecular imaging of the lungs |c ed. by Daniel P. Schuster ... |
| 264 | 1 | |a Boca Raton [u.a.] |b Taylor & Francis |c 2005 | |
| 300 | |a XVIII, 450 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Lung biology in health and disease |v 203 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Lungs |x Imaging | |
| 650 | 4 | |a Lungs |x Diseases |x Molecular diagnosis | |
| 650 | 4 | |a Diagnostic Imaging |x methods | |
| 650 | 4 | |a Lung |x cytology | |
| 650 | 4 | |a Molecular Diagnostic Techniques | |
| 650 | 0 | 7 | |a Bildgebendes Verfahren |0 (DE-588)4006617-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekulare Diagnostik |0 (DE-588)4589005-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lungenkrankheit |0 (DE-588)4036660-1 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
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| 689 | 0 | 1 | |a Bildgebendes Verfahren |0 (DE-588)4006617-4 |D s |
| 689 | 0 | 2 | |a Molekulare Diagnostik |0 (DE-588)4589005-5 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Schuster, Daniel P. |e Sonstige |4 oth | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-013191623 | |
Datensatz im Suchindex
| _version_ | 1809493931643109376 |
|---|---|
| adam_text |
Contents
Introduction Hi
Preface v
Contributors ix
SECTION 1: METHODOLOGIES
I. Molecular Imaging Probes for PET and SPECT 3
Raffaella Rossin and Michael J. Welch
1. Introduction . 5
II. Radionuclides for PET and SPECT Molecular Imaging Probes . 6
HI. Radiotracers for Molecular Imaging . 12
IV. Summary 25
References . 25
2. "Micro" Instruments for Molecular Imaging with
PET and SPECT 41
Richard LaForest
I. Introduction . 41
xiii
xiv Contents
II. Single Photon Emission Computed Tomography . 43
III. Positron Emission Tomography . 46
IV. Combined Systems . 54
V. Conclusions . 55
References . 55
3. PET and SPECT as Platforms for Molecular Imaging 59
Buck E. Rogers
I. Introduction . 60
II. SPECT Imaging 60
III. PET Imaging 64
IV. SPECT Imaging vs. PET Imaging . 67
V. Applications of PET and SPECT Molecular Imaging 69
VI. Summary . 80
Acknowledgments . 80
References . 81
4. Imaging Cellular and Molecular Processes in the Lung
Using Bioluminescent Reporter Genes 95
Christopher H. Contag
I. Overview . 96
II. Introduction . 96
III. Luciferase and Related Proteins . 98
IV. Luciferins and Biodistribution In Vivo . 102
V. Instrumentation Used in BLI . 103
VI. Multifunctional Reporter Genes . 104
VII. Validation of In Vivo Data Using
Ex Vivo Assays . 105
VIII. Applications of BLI in the Lung . 705
IX. Summary and Future Outlook . 108
Acknowledgments . 108
References 108
5. Magnetic Resonance Imaging 113
Joel R. Garbow, Cassandra B. Orellana, and
Jeffrey J. Neil
I. Introduction . 114
II. Molecular MRI 115
m. MRI of Lung 119
IV. Future Prospects 128
Acknowledgment . 725
References . 725
Contents xv
6. Imaging the Mouse Lung with Micro CT 135
Wolfgang Recheis, Geoffrey McLennan, Alan F. Ross,
Eric A. Hoffman, Ann V. Clough, and Steven T. Haworth
I. Introduction . 136
II. Technical Principals and Overview of Micro CT . 137
III. Small Animal Lung Imaging . 152
References . 166
7. Noninvasive Imaging Strategies to Visualize
Tissue Specific Gene Expression Using Transcriptional
Amplification Approaches 171
Meera Iyer and Sanjiv S. Gambhir
I. Introduction . 172
II. GAL4 Transactivating System . 772
III. Tissue Specific Promoters . 776
IV. Strategies to Enhance Transcriptional
Activation of Weak, Tissue Specific Promoters . 7 77
V. Role of Molecular Imaging in the Noninvasive
Monitoring of Gene Expression In Vivo . 757
VI. Gene Therapy Vectors . 785
VII. Imaging Pulmonary Gene Expression In Vivo . 790
VIII. Transgenic Mouse Models . 194
IX. Conclusion 796
References . 796
SECTION 2: APPLICATION TO THE LUNGS
8. Pulmonary Transgene Expression Imaging 209
Daniel P. Schuster
I. Introduction . 270
II. Platforms for Gene Expression Imaging . 270
III. Strategies for Gene Expression Imaging . 213
IV. Gene Expression Studies of the Lungs
with PET 219
V. Applications . 229
References . 230
9. Inflammation Imaging in the Lungs 237
Hazel A. Jones
I. Introduction . 237
II. Lung Water 239
HI. Amine Kinetics 239
IV. Components of the Pulmonary
Inflammatory Process . 240
xvi Contents
V. Progression of Lung Disease . 253
VI. Summary . 254
References . 255
10. Bioluminescence Imaging of Transcription Factor
Activity in the Lungs 259
E. Duco Jansen and Timothy S. Blackwell
I. Introduction . 260
II. Imaging Methodology . 260
III. Applications . 266
IV. Challenges and Future Directions . 276
References . 279
11. Molecular Imaging of Lung Cancer 285
Philipp Mayer Kuckuk, Michael Doubrovin, Inna Serganova,
and Ronald G. Blasberg
I. Molecular Imaging Strategies . 286
II. Oncogenic Cell Transformation . 293
III. Imaging Oncogenesis in Genetic Mouse Models . 297
IV. Imaging Oncogenesis Pathways . 298
V. Imaging Tumor Treatment . 303
Acknowledgments . 305
References . 306
12. Molecular Imaging of Protein Protein Interactions in
Living Animals 313
David Piwnica Worms, Kathryn E. Luker, and
Victor M. Villalobos
I. Introduction . 313
II. Detecting Protein Interactions in Intact Cells and Animals . 315
III. Applications In Vivo . 321
IV. Concluding Comments . 322
Acknowledgments . 323
References . 323
13. Functional Imaging of Cellular Death 327
Robert H. Mach
I. Introduction . 327
II. Apoptosis vs. Necrosis . 328
III. The Need to Discriminate Between Apoptosis
and Necrosis . 331
IV. Measurement of Apoptosis and Necrosis In Vitro . 333
V. Measurement of Apoptosis and Necrosis {
In Vivo Using Functional Imaging Techniques . 335 |
Contents xvii
VI. Imaging Cell Death During Lung Health
and Disease . 343
VII. Conclusion . 345
Acknowledgments . 345
References . 345
14. Imaging Cell Trafficking 349
Naoto Oku and Tomohiro Asai
I. Introduction . 349
II. Relationship Between Tumor Cell Trafficking
and Metastatic Potential . 351
III. Involvement of Cell Adhesion Molecules in
Metastatic Cell Trafficking 353
IV. Determination of Intraorgan Trafficking of
Metastatic Cells 357
V. Topological Distribution of Metastatic Cells as
Analyzed by Whole Body Autoradiography . 358
VI. Influence of the Immune Surveillance
System on Metastasis Cell Trafficking . 360
VII. Conclusions and Future Prospects . 364
References . 364
15. Imaging Angiogenesis in the Lung 367
Wayne Mitzner and Elizabeth Wagner
I. Imaging Neovascularization in the Lung:
Challenges for Measurement . 367
II. Imaging Neovascularization in Asthma . 368
III. Imaging Neovascularization after Pulmonary
Artery Obstruction . 371
IV. Imaging Neovascularization in Lung Cancer . 377
V. Concluding Comments and Future Expectations . 382
References . 382
16. New Methods for Visualizing the Airways 385
William Lunn and Armin Ernst
I. Introduction . 355
II. Cellular Evolution of Lung Cancer 387
III. Imaging Modalities . 387
IV. Conclusions . 395
References . 396
17. Functional Imaging of Rodent Lungs 397
Delphine L. Chen and Daniel P. Schuster
I. Introduction 397
xviii Contents
II. Definitions 398
III. Conclusion . 410
References . 411
18. Prospects for Molecular Imaging in Humans 415
Johannes Czernin and Wolfgang Weber
I. Introduction . 475
II. Molecular Imaging Assays . 417
III. Imaging Targets, Probes, Processes, and Applications . 479
IV. Using Analogs of Therapeutic Drugs as Imaging Probes . 429
V. Imaging Tyrosine Kinase Receptor Densities . 430
VI. Imaging the Distribution of Radiolabeled
Chemotherapeutic Agents . 431
VII. Imaging of the av)33 Integrin . 432
VIII. Summary 434
References . 434
Index 441 |
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| illustrated | Illustrated |
| indexdate | 2024-09-07T00:11:27Z |
| institution | BVB |
| isbn | 1574448544 |
| language | English |
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| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Molecular imaging of the lungs ed. by Daniel P. Schuster ... Boca Raton [u.a.] Taylor & Francis 2005 XVIII, 450 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 203 Includes bibliographical references and index Lungs Imaging Lungs Diseases Molecular diagnosis Diagnostic Imaging methods Lung cytology Molecular Diagnostic Techniques Bildgebendes Verfahren (DE-588)4006617-4 gnd rswk-swf Molekulare Diagnostik (DE-588)4589005-5 gnd rswk-swf Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenkrankheit (DE-588)4036660-1 s Bildgebendes Verfahren (DE-588)4006617-4 s Molekulare Diagnostik (DE-588)4589005-5 s b DE-604 Schuster, Daniel P. Sonstige oth Lung biology in health and disease 203 (DE-604)BV000008326 203 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013191623&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular imaging of the lungs Lung biology in health and disease Lungs Imaging Lungs Diseases Molecular diagnosis Diagnostic Imaging methods Lung cytology Molecular Diagnostic Techniques Bildgebendes Verfahren (DE-588)4006617-4 gnd Molekulare Diagnostik (DE-588)4589005-5 gnd Lungenkrankheit (DE-588)4036660-1 gnd |
| subject_GND | (DE-588)4006617-4 (DE-588)4589005-5 (DE-588)4036660-1 (DE-588)4143413-4 |
| title | Molecular imaging of the lungs |
| title_auth | Molecular imaging of the lungs |
| title_exact_search | Molecular imaging of the lungs |
| title_full | Molecular imaging of the lungs ed. by Daniel P. Schuster ... |
| title_fullStr | Molecular imaging of the lungs ed. by Daniel P. Schuster ... |
| title_full_unstemmed | Molecular imaging of the lungs ed. by Daniel P. Schuster ... |
| title_short | Molecular imaging of the lungs |
| title_sort | molecular imaging of the lungs |
| topic | Lungs Imaging Lungs Diseases Molecular diagnosis Diagnostic Imaging methods Lung cytology Molecular Diagnostic Techniques Bildgebendes Verfahren (DE-588)4006617-4 gnd Molekulare Diagnostik (DE-588)4589005-5 gnd Lungenkrankheit (DE-588)4036660-1 gnd |
| topic_facet | Lungs Imaging Lungs Diseases Molecular diagnosis Diagnostic Imaging methods Lung cytology Molecular Diagnostic Techniques Bildgebendes Verfahren Molekulare Diagnostik Lungenkrankheit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013191623&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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