Eukaryotic DNA damage surveillance and repair:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Georgetown
Landes Bioscience / Eurekah.com [u.a.]
2004
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 161 S. Ill., graph. Darst. |
| ISBN: | 0306479877 |
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Datensatz im Suchindex
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|---|---|
| adam_text | MOLECULAR BIOLOGY
INTELLIGENCE
UNIT
Eukaryotic DNA Damage
Surveillance and Repair
Keith W Caldecott, Ph D
Genome Damage and Stability Centre
University of Sussex
Falmer Brighton, U K
LANDES BlOSCIENCE / EUREKAH COM
GEORGETOWN, TEXAS
USA
KLUWER ACADEMIC / PLENUM PUBUSHERS
NEW YORK, NEW YORK
U S A
CONTENTS
Preface VII
1 DNA Damage Surveillance in Saccharomyces cerevisiae 1
Geraldine W-L Toh, Stefano Maffini and Noel F Lowndes
Introduction 1
Sensing DNA Damage: A Complex Problem 4
From Checkpoint Genes to Protein Complexes 6
The Rad24 Epistasis Group: RFC-Like and PCNA-Like Complexes 7
Mecl/Ddc2: Signal Transduction and More 10
The Mrell Complex: DSBs and Checkpoint Signalling 12
The S Phase Checkpoint 15
Checkpoints and Genome Surveillance 16
Focal Recruitment of Checkpoint and Repair Complexes
to Damage Sites 17
The Chromatin Connection 18
Concluding Remarks 20
2 Mammalian Base Excision Repair 27
Grigory L Dianov, Sarah L Allinson, Helen Budworth and Kate Sleeth
Abstract 27
Introduction 27
Base Excision Repair Proteins 28
Coordination of Base Excision Repair 36
3 Detection and Repair of DNA Single-Strand Breaks 49
Keith W Caldecott
Abstract 49
The Origin and Structure of DNA Single-Strand Breaks 49
The Threat of Single-Strand Breaks to Genetic Stability
and Cell Death 50
Polypeptides Involved in DNA Single-Strand Break Repair 50
PARP-1, XRCC1 and the Detection of SSBs 50
AP Endonudease-1 (APE1) 53
Polynucleotide Kinase (PNK) 54
DNA Polymerase-B (Polp) 54
DNA Ligase III 55
SSBR Protein Complexes; Pre-Formed or Assembled at Breaks? 56
SSBR Pathways and the Cell Cycle 57
4 The Detection and Repair of Nudeotide Damage and Coupling
to Major Cellular Regulatory Processes in Mammalian Cells 63
James E Cleaver
Abstract 63
Introduction 63
Types of Damage Repaired by NER 66
Recognition of Damage in Nontranscribing Regions of the Genome 67
Recognition of Damage in Transcriptionally Active Regions
of the Genome 68
The Core Excision Process Common to GGR and TCR 70
Ubiquitination and Proteolysis in DNA Repair 73
Inducible Responses to UV Irradiation 74
Kinase Activation and Cellular Response to UV Damage 75
Replication of Damaged DNA 76
Differentiation and Tissue-Specific Expression of DNA
Repair Genes 78
Polymorphisms in DNA Repair Genes 78
5 Mammalian DNA Mismatch Repair 90
Helen M R Robinson and Robert Brown
Abstract 90
What Is DNA Mismatch Repair 90
The Mismatch Repair Mechanism 91
The Mismatch Repair Proteins 93
The MutS Homolog Proteins 96
Proteins That Interact with the MuL and MutS Homologues 98
Apoptosis and Drug Resistance 101
MMR and Apoptotic Pathways 102
Conclusions 103
6 Origin, Recognition, Signaling and Repair of DNA
Double-Strand Breaks in Mammalian Cells 107
Larry H Thompson and Charles L Limoli
Abstract 107
Replication-Independent Double-Strand Breaks (DSBs) 108
Replication Associated DSBs (One-Sided Breaks) 121
7 The Mechanism of DNA Non-Homologous End-Joining:
Lessons Learned from Biophysical, Biochemical
and Cellular Studies 146
PAJeggo
Abstract 146
Introduction 146
Nature of the DNA Ends to Be Rejoined 147
Structure and Biochemical Analysis of the Core NHEJ Proteins 148
Additional Proteins Implicated in DNANHEJ 150
Further Proteins Interacting with Core NHEJ Components 151
Model for NHEJ and Potential Additional Interacting Proteins 152
Index 159
EDITOR
Keith W Caldecott, Ph D
Genome Damage and Stability Centre
University of Sussex
Falmer Brighton, U K
k w caldecott@sussex ac uk
Chapter 3
CONTRIBUTORS^
Sarah L Allinson
Radiation and Genome Stability Unit
Medical Research Council
Harwell, Oxfordshire, U K
Chapter 2
Robert Brown
Cancer Research U K Department
Medical Oncology
Beacon Laboratories
Glasgow University
Glasgow, U K
Chapter 5
Helen Budworth
Radiation and Genome Stability Unit
Medical Research Council
Harwell, Oxfordshire, U K
Chapter 2
James E Cleaver
Departments of Dermatology
and Pharmaceutical Chemistry
Auerback Melanoma Laboratory
UCSF Cancer Center
University of California
San Francisco, California, U S A
Chapter 4
Grigory L Dianov
Radiation and Genome Stability Unit
Medical Research Council
Harwell, Oxfordshire, U K
Chapter 2
PA Jeggo
Genome Damage and Stability Centre
University of Sussex
Brighton, U K
Chapter 7
Charles L Limoli
Department of Radiation Oncololgy
University of California San Francisco
San Francisco, California, U S A
Chapter 6
Noel F Lowndes
Genome Stability Laboratory
Department of Biochemistry
National Centre for Biomedical
Engineering Science
National University of Ireland
Galway, Ireland
Chapter 1
Sterano Maffini
Genome Stability Laboratory
Department of Biochemistry
National Centre for Biomedical
Engineering Science
National University of Ireland
Galway, Ireland
Chapter 1
|
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| spelling | Eukaryotic DNA damage surveillance and repair [ed.:] Keith W. Caldecott Georgetown Landes Bioscience / Eurekah.com [u.a.] 2004 161 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Includes bibliographical references and index DNA damage DNA repair Eukaryotic cells DNA Damage physiology DNA Repair physiology Eukaryotic Cells metabolism DNS-Schädigung (DE-588)4150350-8 gnd rswk-swf Eukaryontische Zelle (DE-588)4153142-5 gnd rswk-swf DNS-Reparatur (DE-588)4150347-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Eukaryontische Zelle (DE-588)4153142-5 s DNS-Schädigung (DE-588)4150350-8 s DE-604 DNS-Reparatur (DE-588)4150347-8 s b DE-604 Caldecott, Keith W. Sonstige oth http://www.loc.gov/catdir/toc/ecip0410/2003022447.html Table of contents HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013182902&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Eukaryotic DNA damage surveillance and repair DNA damage DNA repair Eukaryotic cells DNA Damage physiology DNA Repair physiology Eukaryotic Cells metabolism DNS-Schädigung (DE-588)4150350-8 gnd Eukaryontische Zelle (DE-588)4153142-5 gnd DNS-Reparatur (DE-588)4150347-8 gnd |
| subject_GND | (DE-588)4150350-8 (DE-588)4153142-5 (DE-588)4150347-8 (DE-588)4143413-4 |
| title | Eukaryotic DNA damage surveillance and repair |
| title_auth | Eukaryotic DNA damage surveillance and repair |
| title_exact_search | Eukaryotic DNA damage surveillance and repair |
| title_full | Eukaryotic DNA damage surveillance and repair [ed.:] Keith W. Caldecott |
| title_fullStr | Eukaryotic DNA damage surveillance and repair [ed.:] Keith W. Caldecott |
| title_full_unstemmed | Eukaryotic DNA damage surveillance and repair [ed.:] Keith W. Caldecott |
| title_short | Eukaryotic DNA damage surveillance and repair |
| title_sort | eukaryotic dna damage surveillance and repair |
| topic | DNA damage DNA repair Eukaryotic cells DNA Damage physiology DNA Repair physiology Eukaryotic Cells metabolism DNS-Schädigung (DE-588)4150350-8 gnd Eukaryontische Zelle (DE-588)4153142-5 gnd DNS-Reparatur (DE-588)4150347-8 gnd |
| topic_facet | DNA damage DNA repair Eukaryotic cells DNA Damage physiology DNA Repair physiology Eukaryotic Cells metabolism DNS-Schädigung Eukaryontische Zelle DNS-Reparatur Aufsatzsammlung |
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