pH-sensitive polymer blends used as coating materials in controlled drug delivery systems:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English German |
| Veröffentlicht: |
2004
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Berlin, Freie Univ., Diss., 2004. - Enth. engl. und dt. Zsfassung |
| Beschreibung: | III, 181 S. Ill., graph. Darst. 21 cm |
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Datensatz im Suchindex
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| adam_text | PH-SENSITIVE POLYMER BLENDS USED AS COATING MATERIALS IN CONTROLLED DRUG
DELIVERY SYSTEMS DISSERTATION ZUR ERLANGUNG DES AKADEMISCHEN GRADES DES
. DOKTORS DER NATURWISSENSCHAFTEN IM FACHBEREICH BIOLOGIE, CHEMIE,
PHARMAZIE DER FREIEN UNIVERSITAT BERLIN VORGELEGT VON FLORENCE LECOMTE
BERLIN 2004 TABLE OF CONTENTS CHAPTERS PAGE 1. INTRODUCTION 1 1.1.
GENERAL. X 1.2. PHYSICOCHEMICAL CHARACTERIZATION OF POLYMER BLENDS, ,3.
1.3. POLYMER BLENDS USED AS COATING MATERIALS IN DRUG DELIVERY SYSTEMS
.6. 1.3.1. BLENDS OF TWO GIT-INSOLUBLE POLYMERS 6 1.3.2. BLENDS OF
GIT-SOLUBLE AND GIT-INSOLUBLE POLYMERS 2 1.3.3. BLENDS OF TWO
GIT-SOLUBLE POLYMERS G 1.3.4. SPECIAL POLYMER BLENDS 2 1.4. BLENDS OF
GIT-INSOLUBLE AND ENTERIC POLYMERS USED AS COATING MATERIALS IN DRUG
DELIVERY SYSTEMS. %. 1.5. RELEASE MECHANISMS FROM COATED CONTROLLED
DRUG DELIVERY SYSTEMS J.6. 1.5.1. DIFFUSION THROUGH INTACT FILM
COATINGS, J.6., 1.5.2. DIFFUSION THROUGH WATER-FILLED CHANNELS .1$.
1.5.3. CONVECTION THROUGH WATER-FILLED CHANNELS, X9, 1.6. EFFECTS OF
FORMULATION AND PROCESSING PARAMETERS 2X 1.7. PURPOSES OF THIS WORK 2A
2. MATERIALS AND METHODS, .2.5 2.1. MATERIALS 6. 2.2. EXPERIMENTAL
METHODS ,2.8 2.2.1. PREPARATION OF COATED PELLETS 2& 2.2.2. PREPARATION
OF THIN FILMS 3.1. 2.2.3. CHARACTERIZATION OF COATED PELLETS 32.
2.2.3.1. IN VITRO DRUG RELEASE .3.2 2.2.3.2. CHANGES IN PELLET DIAMETER
.3.2 2.2.3.3. DETERMINATION OF THE SUCCINOYL GROUP CONTENT OF HPMCAS
.3.2 2.2.3.4. SCANNING ELECTRON MICROSCOPY 3.3. 2.2.4. CHARACTERIZATION
OF THIN FILMS. 33. 2.2.4.1. WATER UPTAKE AND WEIGHT LOSS. .3.3. 2.2.4.2.
SWELLING BEHAVIOR 3.3. I 2.2.4.3. PLASTICIZER LEACHING .3.4 2.2.4.4.
MECHANICAL PROPERTIES 3.4 2.2.4.5. IN VITRO DRUG RELEASE 3.5 2.2.4.6.
DIFFUSION CELL STUDIES 3.5. 2.2.4.7. FOURIER TRANSFORM INFRARED
SPECTROSCOPY (FTIR) 3.6 2.3. THEORETICAL METHODS .3.7 2.3.1. DRUG
DIFFUSION OUT OF THIN FILMS 37 2.3.2. DRUG DIFFUSION THROUGH THIN FILMS
38 2.3.2.1. STEADY-STATE APPROACH 39 2.3.2.2. EXACT SOLUTION OF FICK S
SECOND LAW OF DIFFUSION .39 3. RESULTS AND DISCUSSION. 41 3.1. EFFECTS
OF THE POLYMER BLEND RATIO 42 3.1.1. DRUG RELEASE FROM COATED PELLETS ;
42 3.1.2. WATER UPTAKE OF THIN FILMS 43 3.1.3. DRY WEIGHT LOSS OF THIN
FILMS 4.7 3.1.4. DRUG DIFFUSION THROUGH THIN FILMS 49 3.1.5. DRUG
RELEASE FROM PROPRANOLOL HCL-CONTAINING FILMS 54 3.1.6. CONCLUSIONS 58
3.2. EFFECTS OF THE TYPE OF COATING TECHNIQUE (AQUEOUS VS. ORGANIC) 60
3.2.1. DRUG RELEASE FROM COATED PELLETS 60 3.2.2. WATER UPTAKE OF THIN
FILMS 60 3.2.3. DRY WEIGHT LOSS OF THIN FILMS 67 3.2.4. MECHANICAL
PROPERTIES OF THIN FILMS IN THE DRY STATE 67 3.2.5. MECHANICAL
PROPERTIES OF THIN FILMS IN THE WET STATE 70 3.2.6. CONCLUSIONS 75 3.3.
EFFECTS OF THE TYPE OF PLASTICIZER .76 3.3.1. DRUG RELEASE FROM COATED
PELLETS 7.(3 3.3.2. WATER UPTAKE AND DRY WEIGHT LOSS BEHAVIOR OF THIN
FILMS 76 3.3.3. MECHANICAL PROPERTIES OF THIN FILMS IN THE DRY STATE 8.1
3.3.4. MECHANICAL PROPERTIES OF THIN FILMS IN THE WET STATE 83 3.3.5.
POTENTIAL PLASTICIZER REDISTRIBUTION AND CURING TIME EFFECTS 85 3.3.6.
STORAGE STABILITY 89 3.3.7. CONCLUSIONS 92 II 3.4. EFFECTS OF THE TYPE
OF CORE 3. 3.4.1. DRUG RELEASE FROM COATED PELLETS. 93 3.4.2.
PHYSICOCHEMICAL PROPERTIES OF THIN FILMS 96 3.4.3. DRUG RELEASE
MECHANISMS 100 3.4.4. INCREASE IN PELLET DIAMETER 102 3.4.5. EFFECTS OF
THE OSMOLALITY OF THE RELEASE MEDIUM 103 3.4.6. CONCLUSIONS 106 3.5.
EFFECTS OF THE TYPE OF POLYMER BLEND 108 3.5.1. ETHYLCELLULOSE:EUDRAGIT
L VS. EUDRAGITNE:EUDRAGITL 108 3.5.1.1. DRUG RELEASE FROM COATED
PELLETS 108 3.5.1.2. WATER UPTAKE AND DRY WEIGHT LOSS BEHAVIOR OF THIN
FILMS. 11.0 3.5.1.3. MECHANICAL PROPERTIES OF THIN FILMS J.J.3. 3.5.1.4.
DRUG DIFFUSIVITY WITHIN THE POLYMERIC SYSTEMS 1.1.8 3.5.1.5. CHANGES IN
PELLET DIAMETER DURING DRUG RELEASE _ J.22 3.5.1.6. CONCLUSIONS 1.23
3.5.2. ETHYLCELLULOSE:EUDRAGITL VS. ETHYLCELLULOSE:HPMCAS 124 3.5.2.1.
OPTIMIZATION OF FORMULATION AND PROCESSING PARAMETERS FOR PURE HPMCAS
COATINGS 124 3.5.2.2. DRUG RELEASE FROM COATED PELLETS 1.39 3.5.2.3.
WATER UPTAKE AND DRY WEIGHT LOSS BEHAVIOR OF THIN FILMS 141 3.5.2.4.
MECHANICAL PROPERTIES AND STRUCTURE OF THIN FILMS 144 3.5.2.5. DRUG
RELEASE AT INTERMEDIATE PH VALUES 148 3.5.2.6. STORAGE STABILITY. 1.51
3.5.2.7. CONCLUSIONS 1.53 4. SUMMARY 155 5. ZUSAMMENFASSUNG 15?
PREFERENCES 165 7. PUBLICATIONS & PRESENTATIONS RESULTING FROM THIS
WORK. 177 8. CURRICULUM VITAE 181 III
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| indexdate | 2024-07-09T20:07:19Z |
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| language | English German |
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| physical | III, 181 S. Ill., graph. Darst. 21 cm |
| publishDate | 2004 |
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| spelling | Lecomte, Florence 1975- Verfasser (DE-588)129687383 aut pH-sensitive polymer blends used as coating materials in controlled drug delivery systems von Florence Lecomte 2004 III, 181 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2004. - Enth. engl. und dt. Zsfassung Berlin, Freie Univ., Diss., 2004 Polymergebundener Stoff (DE-588)4175238-7 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Polymergebundener Stoff (DE-588)4175238-7 s Wirkstofffreisetzung (DE-588)4190018-2 s DE-188 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013164489&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lecomte, Florence 1975- pH-sensitive polymer blends used as coating materials in controlled drug delivery systems Polymergebundener Stoff (DE-588)4175238-7 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| subject_GND | (DE-588)4175238-7 (DE-588)4190018-2 (DE-588)4113937-9 |
| title | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems |
| title_auth | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems |
| title_exact_search | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems |
| title_full | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems von Florence Lecomte |
| title_fullStr | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems von Florence Lecomte |
| title_full_unstemmed | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems von Florence Lecomte |
| title_short | pH-sensitive polymer blends used as coating materials in controlled drug delivery systems |
| title_sort | ph sensitive polymer blends used as coating materials in controlled drug delivery systems |
| topic | Polymergebundener Stoff (DE-588)4175238-7 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| topic_facet | Polymergebundener Stoff Wirkstofffreisetzung Hochschulschrift |
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