The organic chemistry of biological pathways:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Englewood, Colo.
Roberts and Co. Publ.
2005
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XXI, 490 S. graph. Darst. |
| ISBN: | 0974707716 |
Internformat
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| 264 | 1 | |a Englewood, Colo. |b Roberts and Co. Publ. |c 2005 | |
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Datensatz im Suchindex
| _version_ | 1804133305132515328 |
|---|---|
| adam_text | IMAGE 1
FOREWORD XV PREFACE XVII REVIEWERS XIX THE AUTHORS XXI
1 COMMON MECHANISMS IN BIOLOGICAL CHEMISTRY 1
2
BIOMOLECULES 43
3 LIPID METABOLISM 93
4 CARBOHYDRATE METABOLISM 161
5 AMINO ACID METABOLISM 221
6 NUCLEOTIDE METABOLISM 305
7 BIOSYNTHESIS OF SOME NATURAL PRODUCTS 339
8 A SUMMARY OF BIOLOGICAL TRANSFORMATIONS 409
APPENDIXES 429 A. VISUALIZING PROTEIN STRUCTURES USING THE SWISS PDB
VIEWER 429 B. USING THE KEGG AND BRENDA DATABASES 436
C. ANSWERS T O END-OF-CHAPTER PROBLEMS 441
D. ABBREVIATIONS USED IN THIS BOOK 474
INDEX 477
IMAGE 2
FOREWORD XV PREFACE XVII REVIEWERS XIX THE AUTHORS XXI
1 COMMON MECHANISMS IN BIOLOGICAL CHEMISTRY 1 1 . L FUNCTIONAL GROUPS IN
BIOLOGICAL CHEMISTRY 3 1.2 ACIDS AND BASES; ELECTROPHILES AND
NUCLEOPHILES 6 BRMNSTED-LOWRY
ACIDS AND BASES 6
LEWIS ACIDS AND BASES 10 ELECTROPHILES AND NUCLEOPHILES 11 1.3
MECHANISMS: ELECTROPHILIC ADDITION REACTIONS 12 1.4 MECHANISMS:
NUCLEOPHILIC SUBSTITUTION REACTIONS 14 1.5 MECHANISMS: NUCLEOPHILIC
CARBONYL ADDITION REACTIONS 17
NUCLEOPHILIC ADDITION REACTIONS 18 ALCOHOL FORMATION 20 LMINE (SCHIFF
BASE) FORMATION 20 ACETAL FORMATION 22
CONJUGATE (1,4) NUCLEOPHILIC ADDITIONS 24 1.6 MECHANISMS: NUCLEOPHILIC
ACYL SUBSTITUTION REACTIONS 26 1.7 MECHANISMS: CARBONYL CONDENSATION
REACTIONS 28 1.8 MECHANISMS: ELIMINATION REACTIONS 32 1.9 OXIDATIONS AND
REDUCTIONS 34 PROBLEMS 37
2 BIOMOLECULES 43 2.1 CHIRALITY AND BIOLOGICAL CHEMISTRY 44 ENANTIOMERS
45 DIASTEREOMERS, EPIMERS, AND
MESO
COMPOUNDS 47
PROCHIRALITY 50 2.2 BIOMOLECULES: LIPIDS 52 TRIACYLGLYCEROLS 52 OTHER
LIPIDS: TERPENOIDS, STEROIDS, AND PROSTAGLANDINS 54
IMAGE 3
X CONTENTS
2.3 BIOMOLECULES: CARBOHYDRATES 56 CARBOHYDRATE STEREOCHEMISTRY 57
MONOSACCHARIDE
ANOMERS
58
DISACCHARIDES AND POLYSACCHARIDES 61 DEOXY SUGARS AND AMINO SUGARS 62
2.4 BIOMOLECULES: AMINO ACIDS, PEPTIDES, AND PROTEINS 63 AMINO ACIDS 64
PEPTIDES
AND PROTEINS 68
2.5 BIOMOLECULES: NUCLEIC ACIDS 72 DNA: DEOXYRIBONUCLEIC ACID 75 RNA:
RIBONUCLEIC ACID 76 2.6 BIOMOLECULES: ENZYMES, COENZYMES, AND COUPLED
REACTIONS 77
ENZYMES 77 COENZYMES 80 COUPLED REACTIONS AND HIGH-ENERGY COMPOUNDS 83
PROBLEMS 86
3 LIPID METABOLISM 93 3.1 DIGESTION AND TRANSPORT OF TRIACYLGLYCEROLS 94
TRIACYLGLYCEROL HYDROLYSIS 95 A BRIEF NOTE ABOUT VISUALIZING ENZYME
STRUCTURES 97
TRIACYLGLYCEROL RESYNTHESIS 99 3.2 TRIACYLGLYCEROL CATABOLISM: THE FATE
OF GLYCEROL 102 3.3 TRIACYLGLYCEROL CATABOLISM: FATTY-ACID OXIDATION 106
3.4 FATTY-ACID BIOSYNTHESIS 11 5 3.5 TERPENOID BIOSYNTHESIS 125
THE MEVALONATE PATHWAY TO LSOPENTENYL DIPHOSPHATE 126 THE DEOXYXYLULOSE
PHOSPHATE PATHWAY T O LSOPENTENYL DIPHOSPHATE 132 CONVERSION OF
LSOPENTENYL DIPHOSPHATE T O TERPENOIDS 139 3.6 STEROID BIOSYNTHESIS 144
CONVERSION OF FARNESYL DIPHOSPHATE T O SQUALENE 144 CONVERSION OF
SQUALENE T O LANOSTEROL 148 REFERENCES 153 PROBLEMS 156
IMAGE 4
CONTENTS XI
4 CARBOHYDRATE METABOLISM 161 4.1 DIGESTION AND HYDROLYSIS OF COMPLEX
CARBOHYDRATES 162 4.2 GLUCOSE CATABOLISM: GLYCOLYSIS L64 4.3
TRANSFORMATIONS OF PYRUVATE L 7 8
CONVERSION OF PYRUVATE TO LACTATE 179 CONVERSION OF PYRUVATE T O ETHANOL
179 CONVERSION OF PYRUVATE T O ACETYL COA L81 4.4 THE CITRIC ACID CYCLE
185 4.5 GLUCOSE BIOSYNTHESIS: GLUCONEOGENESIS 193 4.6 THE PENTOSE
PHOSPHATE PATHWAY 203 4.7 PHOTOSYNTHESIS: THE REDUCTIVE PENTOSE
PHOSPHATE
(CALVIN)CYCLE 211 REFERENCES 21 6 PROBLEMS 218
5 AMINO ACID METABOLISM 221 5.1 DEAMINATION OF AMINO ACIDS 223
TRANSAMINATION OF AMINO ACIDS 223 OXIDATIVE DEAMINATION OF GLUTAMATE 227
5.2 THE UREA CYCLE 228 5.3 CATABOLISM OF AMINO ACID CARBON CHAINS 232
ALANINE, SERINE, GLYCINE, CYSTEINE, THREONINE, AND TRYPTOPHAN 234 A
BRIEF NOTE ABOUT OXIDATION STATES IN IRON COMPLEXES 241 A BRIEF NOTE
ABOUT PLP REACTIONS 251
ASPARAGINE AND ASPARTATE 252 GLUTAMINE, GLUTAMATE, ARGININE, HISTIDINE,
AND PROLINE 252 VALINE, ISOLEUCINE, AND LEUCINE 255 METHIONINE 259
LYSINE 264 PHENYLALANINE AND TYROSINE 265 5.4 BIOSYNTHESIS OF
NONESSENTIAL AMINO ACIDS 271 ALANINE, ASPARTATE, GLUTAMATE, ASPARAGINE,
GLUTAMINE, ARGININE,
AND
PROLINE 273
SERINE, CYSTEINE, AND GLYCINE 274
IMAGE 5
XII CONTENTS
5.5 BIOSYNTHESIS OF ESSENTIAL AMINO ACIDS 276 LYSINE, METHIONINE, AND
THREONINE 276 ISOLEUCINE, VALINE, AND LEUCINE 284 TRYPTOPHAN,
PHENYLALANINE, AND
TYROSINE
286
HISTIDINE 295 REFERENCES 297 PROBLEMS 301
6 NUCLEOTIDE METABOLISM 305 6.1 NUCLEOTIDE CATABOLISM 307 PYRIMIDINES:
CYTIDINE, URIDINE, AND THYMIDINE 307 PURINES: ADENOSINE AND GUANOSINE 31
1 6.2 BIOSYNTHESIS OF PYRIMIDINE RI BONUCLEOTIDES
31
3
URIDINE MONOPHOSPHATE 313 CYTIDINE TRIPHOSPHATE 318 6.3 BIOSYNTHESIS OF
PURINE RIBONUCLEOTIDES 319 LNOSINE MONOPHOSPHATE 319
ADENOSINE MONOPHOSPHATE AND GUANOSINE MONOPHOSPHATE 325 6.4 BIOSYNTHESIS
OF DEOXYRIBONUCLEOTIDES 327 DEOXYADENOSINE, DEOXYGUANOSINE,
DEOXYCYTIDINE, AND
DEOXYURIDINE DIPHOSPHATES 327 THYMIDINE MONOPHOSPHATE 329 REFERENCES 332
PROBLEMS 334
7 BIOSYNTHESIS OF SOME NATURAL PRODUCTS 339
7.1 BIOSYNTHESIS OF PENICILLINS AND CEPHALOSPORINS 342 PENICILLINS 344
CEPHALOSPORINS 349 7.2 BIOSYNTHESIS OF MORPHINE 352 7.3 BIOSYNTHESIS OF
PROSTAGLANDINS AND OTHER EICOSANOIDS 363 7.4 BIOSYNTHESIS OF
ERYTHROMYCIN 369
IMAGE 6
CONTENTS XIII
7.5 BIOSYNTHESIS OF COENZYME BI2 AND OTHER TETRAPYRROLES 379 URO GEN 1 1
1 380 HEME
384
COENZYME
BI2
387
REFERENCES 400 PROBLEMS 403
8 A SUMMARY OF BIOLOGICAL TRANSFORMATIONS 409 HYDROLYSES,
ESTERIFICATIONS, THIOESTERIFICATIONS, AND AMIDATIONS 409 CARBONYL
CONDENSATIONS 41 1 CARBOXYLATIONS
AND
DECARBOXYLATIONS 41 3
AMINATIONS AND DEAMINATIONS 41
6
L-CARBON TRANSFERS 417 REARRANGEMENTS
41 9
LSOMERIZATIONS AND EPIMERIZATIONS 420 OXIDATIONS AND REDUCTIONS OF
CARBONYL
COMPOUNDS 421
HYDROXYLATIONS
AND OTHER OXIDATIONS VIA METAL COMPLEXES 424
APPENDIXES 429 A. VISUALIZING PROTEIN STRUCTURES USING THE SWISS PDB
VIEWER 429 B. USING THE KEGG AND BRENDA DATABASES 436
C. ANSWERS T O END-OF-CHAPTER PROBLEMS 441
D. ABBREVIATIONS USED IN THIS BOOK 474
INDEX 477
|
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| contents | Common mechanisms in bioorganic chemistry -- Biomolecules -- Lipid metabolism -- Carbohydrate metabolism -- Amino acid metabolism -- Nucleotide metabolism -- Biosynthesis of some natural products -- A summary of biological transformations. |
| ctrlnum | (OCoLC)56405024 (DE-599)BVBBV019808158 |
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| id | DE-604.BV019808158 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:06:36Z |
| institution | BVB |
| isbn | 0974707716 |
| language | English |
| lccn | 2004020374 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013133628 |
| oclc_num | 56405024 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM |
| owner_facet | DE-M49 DE-BY-TUM |
| physical | XXI, 490 S. graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Roberts and Co. Publ. |
| record_format | marc |
| spelling | McMurry, John 1942- Verfasser (DE-588)128437790 aut The organic chemistry of biological pathways John E. McMurry, Tadhg P. Begley Englewood, Colo. Roberts and Co. Publ. 2005 XXI, 490 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Common mechanisms in bioorganic chemistry -- Biomolecules -- Lipid metabolism -- Carbohydrate metabolism -- Amino acid metabolism -- Nucleotide metabolism -- Biosynthesis of some natural products -- A summary of biological transformations. Bioquímica orgânica larpcal Biosynthèse rasuqam Chimie bio-organique Chimie bio-organique rasuqam Metabolismo (fisiologia) larpcal Métabolisme Métabolisme rasuqam aBioorganic chemistry aMetabolism aMetabolism xphysiology aEnzymes xmetabolism Stoffwechselphysiologie (DE-588)4183413-6 gnd rswk-swf Organische Chemie (DE-588)4043793-0 gnd rswk-swf Naturstoffchemie (DE-588)4171332-1 gnd rswk-swf Reaktionsmechanismus (DE-588)4177123-0 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Stoffwechselweg (DE-588)4240505-1 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 s Organische Chemie (DE-588)4043793-0 s DE-604 Naturstoffchemie (DE-588)4171332-1 s Stoffwechselphysiologie (DE-588)4183413-6 s Biochemie (DE-588)4006777-4 s Stoffwechselweg (DE-588)4240505-1 s Reaktionsmechanismus (DE-588)4177123-0 s 1\p DE-604 2\p DE-604 Begley, Tadhg P. Verfasser (DE-588)131577956 aut http://www.loc.gov/catdir/toc/ecip0422/2004020374.html Table of contents OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013133628&sequence=000007&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | McMurry, John 1942- Begley, Tadhg P. The organic chemistry of biological pathways Common mechanisms in bioorganic chemistry -- Biomolecules -- Lipid metabolism -- Carbohydrate metabolism -- Amino acid metabolism -- Nucleotide metabolism -- Biosynthesis of some natural products -- A summary of biological transformations. Bioquímica orgânica larpcal Biosynthèse rasuqam Chimie bio-organique Chimie bio-organique rasuqam Metabolismo (fisiologia) larpcal Métabolisme Métabolisme rasuqam aBioorganic chemistry aMetabolism aMetabolism xphysiology aEnzymes xmetabolism Stoffwechselphysiologie (DE-588)4183413-6 gnd Organische Chemie (DE-588)4043793-0 gnd Naturstoffchemie (DE-588)4171332-1 gnd Reaktionsmechanismus (DE-588)4177123-0 gnd Stoffwechsel (DE-588)4057699-1 gnd Stoffwechselweg (DE-588)4240505-1 gnd Biochemie (DE-588)4006777-4 gnd |
| subject_GND | (DE-588)4183413-6 (DE-588)4043793-0 (DE-588)4171332-1 (DE-588)4177123-0 (DE-588)4057699-1 (DE-588)4240505-1 (DE-588)4006777-4 |
| title | The organic chemistry of biological pathways |
| title_auth | The organic chemistry of biological pathways |
| title_exact_search | The organic chemistry of biological pathways |
| title_full | The organic chemistry of biological pathways John E. McMurry, Tadhg P. Begley |
| title_fullStr | The organic chemistry of biological pathways John E. McMurry, Tadhg P. Begley |
| title_full_unstemmed | The organic chemistry of biological pathways John E. McMurry, Tadhg P. Begley |
| title_short | The organic chemistry of biological pathways |
| title_sort | the organic chemistry of biological pathways |
| topic | Bioquímica orgânica larpcal Biosynthèse rasuqam Chimie bio-organique Chimie bio-organique rasuqam Metabolismo (fisiologia) larpcal Métabolisme Métabolisme rasuqam aBioorganic chemistry aMetabolism aMetabolism xphysiology aEnzymes xmetabolism Stoffwechselphysiologie (DE-588)4183413-6 gnd Organische Chemie (DE-588)4043793-0 gnd Naturstoffchemie (DE-588)4171332-1 gnd Reaktionsmechanismus (DE-588)4177123-0 gnd Stoffwechsel (DE-588)4057699-1 gnd Stoffwechselweg (DE-588)4240505-1 gnd Biochemie (DE-588)4006777-4 gnd |
| topic_facet | Bioquímica orgânica Biosynthèse Chimie bio-organique Metabolismo (fisiologia) Métabolisme aBioorganic chemistry aMetabolism aMetabolism xphysiology aEnzymes xmetabolism Stoffwechselphysiologie Organische Chemie Naturstoffchemie Reaktionsmechanismus Stoffwechsel Stoffwechselweg Biochemie |
| url | http://www.loc.gov/catdir/toc/ecip0422/2004020374.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013133628&sequence=000007&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mcmurryjohn theorganicchemistryofbiologicalpathways AT begleytadhgp theorganicchemistryofbiologicalpathways |