Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets:
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| Format: | Buch |
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| Sprache: | English |
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New York, NY
New York Acad. of Sciences
2004
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| Schriftenreihe: | Annals of the New York Academy of Sciences
1030 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 674 S. Ill., graph. Darst. |
| ISBN: | 1573315745 |
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Datensatz im Suchindex
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| adam_text | Volume 1030
December 2004
Signal Transduction Pathways,
Chromatin Structures, and Gene
Expression Mechanisms as
Therapeutic Targets
Editor
Marc Diederich
Conference Organizers
Marc Diederich, Franck Morceau, Sylvie Delhalle, Romain Blasius,
Michael Schnekenburger, Estelle Henry, and Marjorie Fougere
This volume incudes the proceedings of Science Week 2004 held on January 25 31, 2004 at the
European Confrence Center in Luxembourg.
CONTENTS
Preface. By Marc Diederich xiii
Part I. Cell Signaling Pathways in Health and Disease
A Beginner s Guide to NF kB Signaling Pathways. By Sylvie Delhalle,
romain Blasius, Mario Dicato, and Marc Diederich 1
The Vascular Endothelial Growth Factor Induced Disruption of Gap Junctions
Is Relayed by an Autocrine Communication via ATP Release
in Coronary Capillary Endothelium. By DOMINIQUE THURINGER 14
Exogenous Tissue Inhibitor of Metalloproteinase 1 Promotes Endothelial Cell
Survival Through Activation of the Phosphatidylinositol 3 Kinase/Akt Pathway.
by gwenola boulday, juliette fltau, stephanie coupel,
Jean Paul Soulillou, and Beatrice Charreau 28
The Cyclooxygenase Inhibitor Flurbiprofen Reduces Radiation Induced Angiogenic
Growth Factor Secretion of Squamous Cell Carcinoma Cell Lines.
By JORGEN BRIEGER, PETRA SCHROEDER, JAN GOSEPATH, AND
Wolf J. Mann 37
Spontaneous Generation of Reactive Oxygen Species in the Mixture of Cyanide
and Glycerol. By Yang Sook Chun, Eun Jin Yeo, Hwa Jin Suh, and
Jong Wan Park 43
Design and Characterization of a New Class of Inhibitors of Ras Activation.
By Sonia Colombo, Francesco Peri, Renata Tisi, Francesco Nicotra,
AND ENZO MARTEGANI 52
Endogenous Oxidative Stress Induces Distinct Redox Forms of Tumor Necrosis
Factor Receptor 1 in Melanoma Cells. By S. Dominici, L. Pieri,
A. Paolicchi, V. de Tata, F. Zunino, and A. Pompella 62
Epidermal Growth Factor Receptor as a Novel Therapeutic Target in Anaplastic
Thyroid Carcinomas. By C. Ensinger, G. Spizzo, P. Moser, I. Tschoerner,
R. Prommegger, M. Gabriel, G. Mikuz, and K.W. Schmid 69
Analysis of the Effects of Different Alcohols on MCF 7 Human Breast Cancer Cells.
By Nicolas Etique, Dominique Chardard, Amand Chesnel,
Stephane Flament, and Isabelle Grillier Vuissoz 78
Redox Signaling by Ionizing Radiation in Mouse Liver. By Jeung Hee An,
Jiyoung Kim, and Jinsil Seong 86
Enhancement of Tumor Response by Farnesyltransferase Inhibitor in C3H/HeJ
Hepatocarcinoma. By Jiyoung Kim, Jinsil Seong, and Sung Hee Kim ... 95
Three Dimensional Bioreactor Cultures: A Useful Dynamic Model for the Study
of Cellular Interactions. By Spiro M. Konstantinov, Mina M. Mindova,
Panayot T. Gospodinov, and Penka I. Genova 103
Platelet Activating Factor Receptor Signals in Rat Osteoblasts during Spaceflight.
By Yasuhiro Kumei, Sadao Morita, Hiroshi Nakamura,
Hideo Akiyama, Hisako Katano, Hitoyata Shimokawa, and
Kei ichi Ohya 116
Osteoblast Responsiveness to loc,25 Dihydroxyvitamin D3 during Spaceflight.
By Yasuhiro Kumei, Sadao Morita, Hiroshi Nakamura,
Hisako Katano, Kei ichi Ohya, Hitoyata Shimokawa,
Clarence F. Sams, and Peggy A. Whitson 121
Low Grade Inflammation with Aging Has Consequences for T Lymphocyte
Signaling. By Anis Larbi, Gilles Dupuis, Nadine Douziech,
Abdelouahed Khalil, and Tamas Fulop, jr 125
Role of the Hedgehog/Patched Signaling Pathway in Oncogenesis: A New
Polymorphism in the PTCH Gene in Ovarian Fibroma. By Sonja Levanat,
Vesna Musani, Arijana Komar, and S. Oreskovic 134
Effects of Oxalate on IMCD Cells: A Line of Mouse Inner Medullary Collecting
Duct Cells. By Paul D. Maroni, Sweaty Koul, Randall B. Meacham,
Paramjit S. Chandhoke, and Hari K. Koul 144
Supervision of Multiple Signaling Protein Kinases by the CK2 Cdc37 Couple,
a Possible Novel Cancer Therapeutic Target. By Yoshihiko Miyata and
Eisuke Nishida 150
Hypergravity Stimulates Osteoblast Phenotype Expression: A Therapeutic Hint
for Disuse Bone Atrophy. By Sadao Morita, Hiroshi Nakamura,
Yasuhiro Kumei, Hitoyata Shimokawa, Keiichi Ohya, and
Kenichi Shinomiya 158
CXCR4 Activation Induces Epidermal Growth Factor Receptor Transactivation
in an Ovarian Cancer Cell Line. By Carola Porcile, Adriana BAJETTO,
Simone Barbero, Paolo Pirani, and Gennaro Schettini 162
Downregulation of Angiogenic Factors in Ewing Tumor Xenografts by the
Combination of Human Interferon a or Interferon P with Ifosfamide.
By JOSIANE SANCEAU AND JUANA WlETZERBIN 170
Radiation Induced Alteration of Pain Related Signals in an Animal Model
with Bone Invasion from Cancer. By Jinsil Seong, Hee Chul Park,
Jiyoung Kim, Un Jung Kim, and Bae Whan Lee 179
Analysis of the Signal Transduction Pathway Leading to Human Immunodeficiency
Virus 1 Induced Interferon Regulatory Factor 1 Upregulation.
By Marco Sgarbanti, Giulia Marsili, Anna Lisa Remoli,
Barbara Ridolfi, Emilia Stellacci, Alessandra Borsetti,
Barbara Ensoli, and Angela Battistini 187
Macrophage Hemoglobin Scavenger Receptor and Ferritin Accumulation in Human
Atherosclerotic Lesions. By Wei Li, Li Hua Xu, and Xi Ming Yuan 196
Enhanced Expression of Natural Resistance Associated Macrophage Protein 1
in Atherosclerotic Lesions May Be Associated with Oxidized Lipid Induced
Apoptosis. By Wei Li, Anna Hellsten, Jerome Dinga Nyhalah,
and Xi Ming Yuan 202
Part II. MAP Kinase Pathways as Therapeutic Targets
Regulation of Tumor Cell Motility by ERK Mitogen Activated Protein Kinases.
By Emmanuel Vial and Jacques Pouyssegur 208
Role of Constitutively Activated and Insulin Like Growth Factor Stimulated
ERK1/2 Signaling in Human Hepatoma Cell Proliferation and Apoptosis:
Evidence for Heterogeneity of Tumor Cell Lines. By Catherine Alexia,
Malika Lasfer, and Andre Groyer 219
Cooperative Effects between Protein Kinase A and p44/p42 Mitogen Activated
Protein Kinase to Promote cAMP Responsive Element Binding Protein
Activation after p Cell Stimulation by Glucose and Its Alteration Due to
Glucotoxicity. By Safia Costes, Christine Longuet, Christophe Broca,
Omar Faruque, El Habib Hani, Dominique Bataille, and
Stephane Dalle 230
p42/p44 Mitogen Activated Protein Kinase Signal Transduction Pathway: A Novel
Target for the Treatment of Hormone Resistant Prostate Cancer?
By Hari K. Koul, Paul D. Maroni, Randall B. Meacham,
David Crawford, and Sweaty Koul 243
p42/p44 Mitogen Activated Protein Kinase Signal Transduction Pathway Regulates
Interleukin 6 Expression in PC3 Cells, a Line of Hormone Refractory Prostate
Cancer Cells. By Sweaty Koul, Mei Huang, Lakshmi Chaturvedi,
Randall B. Meacham, and Hari K. Koul 253
p38 Is a Key Signaling Molecule for H ras Induced Inhibition of Gap Junction
Intercellular Communication in Rat Liver Epithelial Cells. By Kl Won Lee,
Ji Won Jung, Kyung Sun Kang, and Hyong Joo Lee 258
The Phosphotyrosine Phosphatase T| Mediates Somatostatin Inhibition of Glioma
Proliferation via the Dephosphorylation of ERK1/2. By Alessandro Massa,
Federica Barbieri, Cinzia Aiello, Rodolfo Iuliano, Sara Arena,
Alessandra Pattarozzi, Alessandro Corsaro, Valentina Villa,
Alfredo Fusco, Gianluigi Zona, Renato Spaziante,
Gennaro Schettini, and Tullio Florio 264
Blockade by SB203580 of Cyplal Induction by 2,3,7,8 Tetrachlorodibenzo p dioxin,
and the Possible Mechanism: Possible Involvement of the p38 Mitogen Activated
Protein Kinase Pathway in Shuttling of Ah Receptor Overexpressed in
COS 7 Cells. By Masahiko Shibazaki, Takahashi Takeuchi,
Sohel Ahmed, and Hideaki Kikuchi 275
Part III. Signal Transduction Pathways in Neurodegenerative Diseases
Functional Characterization of Amyloid p Precursor Protein Regulatory Elements:
Rationale for the Identification of Genetic Polymorphism.
By Debomoy K. Lahiri 282
Increased Intracellular Ionic Content Is Correlated with a Decreased Perichromatin
Granule Density in Old Neurons. By CARLO BERTONI FREDDARI,
Patrizia Fattoretti, and Manuela Malatesta 289
Lack of NIL Gene Expression Results in a Significant Decrease of Vaccinia Virus
Replication in Mouse Brain. By B. BILLINGS, S.A. SMITH, Z. ZHANG,
D.K. Lahiri, and G.J. Kotwal 297
Increased Mitochondrial and Nuclear Gene Expression of Cytochrome Oxidase
Subunits I and IV in Neuronal Aging. By PATRIZIA FATTORETTI,
Carlo Bertoni Freddari, Belinda Giorgetti, and Marta Balietti .. 303
Role of the APP Promoter in Alzheimer s Disease: Cell Type Specific Expression
of the P Amyloid Precursor Protein. By Debomoy K. Lahiri
and Yuan Wen Ge 310
Protective Effects of Oligomers of Grape Seed Polyphenols Against
P Amyloid Induced Oxidative Cell Death. By Mei Hua Li, Jung Hee Jang,
Buxiang Sun, and Young Joon Surh 317
BACE1 Overexpression Regulates Amyloid Precursor Protein Cleavage and
Interaction with the ShcA Adapter. By Emanuela Repetto,
Claudio Russo, Valentina Venezia, Mario Nizzari,
Roger M. Nitsch, and Gennaro Schettini 330
Apoptotic Cell Death and Amyloid Precursor Protein Signaling in Neuroblastoma
SH SY5Y Cells. By Valentina Venezia, Claudio Russo,
Emanuela Repetto, Mario Nizzari, Elisabetta Violani, Pia Carlo,
Bianca Marchetti, and Gennaro Schettini 339
Part IV. Apoptotic Signaling Pathways
Effect of Metal Complexes on Thioredoxin Reductase and the Regulation of
Mitochondrial Permeability Conditions. By M. BRAGADIN, G. SCUTARI,
A. FOLDA, A. BlNDOLI, AND M.P. RlGOBELLO 348
The Antiapoptotic Protein ICBP90 Is a Target for Protein Kinase 2.
By Christian Bronner, Marie Aline Trotzier, Odile Filhol,
Claude Cochet, Cecile Rochette Egly, Marie Scholler Guinard,
Jean Paul Klein, and Marc Mousli 355
Docosahexaenoic Acid from a Cultured Microalga Inhibits Cell Growth and Induces
Apoptosis by Upregulating Bax/Bcl 2 Ratio in Human Breast Carcinoma
MCF 7 Cells. By LAWRENCE C. M. CHIU, ELAINE Y. L. WONG, AND
Vincent E.C. Ooi 361
Plasma Membrane Alteration Is an Early Signaling Event in Doxorubicin Induced
Apoptosis in the Yeast Candida utilis. By EZZATOLLAH Keyhani AND
Jacqueline Keyhani 369
Expression of the Insulin Like Growth Factor I Receptor and Proapoptotic Bax and
Bak Proteins in Human Colorectal Cancer. By MARIUSZ Koda,
Joanna Reszec, Mariola Sulkowska, Luiza Kanczuga Koda, and
Stanislaw Sulkowski 377
Inhibition of B16 Mouse Melanoma Cell Growth and Induction of Apoptotic
Cell Death with 8 Chloroadenosine 3 ,5 monophosphate and Tiazofurin.
By Lela B. Koricanac, Danijela V. Todorovic, Natasa M. Popovic,
Miroslav A. Demajo, Sabera D. Ruzdijic, and
Aleksandra M. Ristic Fira 384
Alterations in Protein Expression in HL 60 Cells during Etoposide Induced
Apoptosis Modulated by the Caspase Inhibitor ZVAD.fmk.
by ruta navakauskiene, grazina treigyte, jurate savickiene,
Arunas Gineitis, and Karl Eric Magnusson 393
Mitochondria of Human Spermatozoa Are Preferentially Susceptible to Apoptosis.
By Uwe Paasch, Sonja Grunewald, Sylvia Dathe,
and Hans Juergen Glander 403
Proapoptotic Potentials of Genistein Under Growth Stimulation by Estrogen.
By Ock Jin Park and Jang In Shin 410
Expression of Cell Proliferation and Apoptosis Markers in Papillomas and
Cancers of Conjunctiva and Eyelid. By JOANNA RESZEC,
Mariola Sulkowska, Mariusz Koda, Luiza Kanczuga Koda,
and Stanislaw Sulkowski 419
Increased Expression and Translocation of Lysosomal Cathepsins Contribute
to Macrophage Apoptosis in Atherogenesis. By Wei Li and
Xi Ming Yuan 427
Part V. Chemopreventive Agents Interfering with Cell Signaling Pathways
Suppression of the Nuclear Factor KB Activation Pathway by Spice Derived
Phytochemicals: Reasoning for Seasoning. By Bharat B. AGGArwal and
Shishir Shishodia 434
Curcumin Stability and Its Effect on Glutathione S Transferase Pl 1 mRNA
Expression in K562 Cells. By Romain Blasius, Annelyse Duvoix,
Franck Morceau, Michael Schnekenburger, Sylvie Delhalle,
Estelle Henry, Mario Dicato, and Marc Diederich 442
Hypoxia/Anoxia as Signaling for Increased Alcohol Dehydrogenase Activity in
Saffron (Crocus sativus L.) Corm. By EZZATOLLAH KEYHANI
and Jacqueline Keyhani 449
Prevention Against Oxidative Stress of Eukaryotic Cell Membranes by Selenium
Compounds of the Rat. By A. Kyriakopoulos, K. Bukalis,
D. ROETHLEIN, B. HOPPE, A. GRAEBERT, AND D. BEHNE 458
Effect of Dietary Restriction on DNA Synthesis in Vitamin E Deficient Rats.
By Fausto Moroni, Rina Recchioni, Fiorella Marcheselli,
Patrizia Fattoretti, and Carlo Bertoni Freddari 462
Part VI. Gene Expression Mechanisms as Therapeutic Targets
Alternatively Spliced Protein Variants as Potential Therapeutic Targets for Male
Infertility and Contraception. By Margarida Fardilha, Wenjuan Wu,
Rosalia Sa, Sara Fidalgo, Cristina Sousa, Catarina Mota,
Odete A.B. da Cruz e Silva, and Edgar F. da Cruz e Silva 468
Relaxin and Phosphodiesterases Collaborate during Decidualization.
By Olaf Bartsch and Richard Ivell 479
Effects of Cyclopentenone Prostaglandins on the Expression of
Heme Oxygenase 1 in MCF 7 Cells. By Eun Hee Kim, Do Hee Kim,
Hye Kyung Na, and Young Joon Surh 493
Inhibition of Cyclooxygenase 2 Expression and Restoration of Gap Junction
Intercellular Communication in H ras Transformed Rat Liver Epithelial Cells
by Caffeic Acid Phenethyl Ester. By Ki Won Lee, Kyung Soo Chun,
Jeong Sang Lee, Kyung Sun Kang, Young Joon Surh,
and Hyong Joo Lee 501
Comparison of Gene Expression in Intra Abdominal and Subcutaneous Fat: A Study
of Men with Morbid Obesity and Nonobese Men Using Microarray and
Proteomics. By Abdominal Obesity Study Group: Finn Edler von Eyben,
Jens Peter Kroustrup, Jens Fromholt Larsen, and Julio Celis 508
Part VII. Transcriptional Control Mechanisms as Therapeutic Targets
GATA 1: Friends, Brothers, and Coworkers. By Franck Morceau,
Michael Schnekenburger, Mario Dicato, and Marc Diederich 537
Tetramethoxy Hydroxyflavone p7F Downregulates Inflammatory Mediators via the
Inhibition of Nuclear Factor kB . By Hee Gu Lee, Hyoson Kim,
Won Keun Oh, Kyung Ae Yu, Yong Kyung Choe, Jong Seog Ahn,
Dong Soo Kim, Soo Hyun Kim, Charles A. Dinarello,
Kilhyoun Kim, and Do Young Yoon 555
Spl and NF kB Transcription Factor Activity in the Regulation of the p21 and FasL
Promoters during Promyelocytic Leukemia Cell Monocytic Differentiation
and Its Associated Apoptosis. By Jurate Savickiene, Grazina Treigyte,
Augustas Pivoriunas, Ruta Navakauskiene, and
Karl Eric Magnusson 569
Effects of Curcumin (Diferuloylmethane) on Nuclear Factor kB Signaling in
Interleukin lpS Stimulated Chondrocytes. By Gundula Schulze Tanzil,
Ali Mobasheri, Judith Sendzik, Thilo John, and Mehdi Shakibaei ... 578
The Hinge Region of the Androgen Receptor Plays a Role in Proteasome Mediated
Transcriptional Activation. By Tamzin Tanner, Frank Claessens,
and Annemie Haelens 587
Part VIII. Chromatin Structure as a Therapeutic Target
Polynucleosomal Synthesis of Poly(ADP ribose) Causes Chromatin Unfolding as
Determined by Micrococcal Nuclease Digestion.
By Maria A. Perez Lamigueiro and Rafael Alvarez Gonzalez 593
From Electrophysiology to Chromatin: A Bottom Up Approach to Angelman
Syndrome. By Bernard Dan, Laurent Servais, Stewart G. Boyd,
Joseph Wagstaff, and Guy Cheron 599
Repetitive Treatments of Colon HT 29 Cells with Diallyl Disulfide Induce a
Prolonged Hyperacetylation of Histone H3 K14. By NATHALIE DRUESNE,
Anthony Pagniez, Camille Mayeur, Muriel Thomas, Claire Cherbuy,
Pierre Henri Duee, Paule Martel, and Catherine Chaumontet 612
Thymocyte Apoptosis Induced by Various Compounds Including YO 2 Is
Accompanied by a Change in Chromatin Structure. By RlYO Enomoto,
Chiyoko Sugahara, YukoTsuda, YoshioOkada, andEibai Lee 622
Defining the Chemotherapeutic Targets of Histone Deacetylase Inhibitors.
By Brian Gabrielli, Robyn Warrener, Andrew Burgess,
and Heather Beamish 627
Role of Acetylases and Deacetylase Inhibitors in IRF 1 Mediated HIV 1 Long
Terminal Repeat Transcription. By Giulia Marsili, Anna Lisa Remoli,
Marco Sgarbanti, and Angela Battistini 636
Histone Structures: Targets for Modifications by Molecular Assemblies.
By James M. Nicholson, Christopher M. Wood, Colin D. Reynolds,
Alan Brown, Stanley J. Lambert, Laurent Chantalat, and
John P. Baldwin 644
HDAC 3 Participates in the Repression of e2/ Dependent Gene Transcription in
Primary Differentiated Neurons. By Irina Panteleeva, Caroline Rouaux,
Yves Larmet, Stephanie Boutillier, Jean Philippe Loeffler,
and Anne Laurence Boutillier 656
Plants Contain a High Number of Proteins Showing Sequence Similarity to the
Animal SUV39H Family of Histone Methyltransferases.
By Zhong Zhao and Wen Hui Shen 661
Index of Contributors 671
Financial assistance was received from:
• FONDATION DE RECHERCHE CANCER ET SANG
• NOVARTIS LUXEMBOURG
• Q8 PETROLEUM
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums.
|
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| callnumber-sort | Q 211 |
| callnumber-subject | Q - General Science |
| ctrlnum | (OCoLC)57143754 (DE-599)BVBBV019794888 |
| dewey-full | 615/.7 500 615.7 |
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| discipline | Allgemeine Naturwissenschaft Medizin |
| format | Book |
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| genre | (DE-588)1071861417 Konferenzschrift 2004 Luxemburg Stadt gnd-content Electronic books |
| genre_facet | Konferenzschrift 2004 Luxemburg Stadt Electronic books |
| id | DE-604.BV019794888 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:06:17Z |
| institution | BVB |
| isbn | 1573315745 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013120574 |
| oclc_num | 57143754 |
| open_access_boolean | |
| owner | DE-20 DE-12 |
| owner_facet | DE-20 DE-12 |
| physical | XIII, 674 S. Ill., graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | Annals of the New York Academy of Sciences |
| series2 | Annals of the New York Academy of Sciences |
| spelling | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets ed. by Marc Diederich New York, NY New York Acad. of Sciences 2004 XIII, 674 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 1030 Apoptose - Congrès Chromatine - Congrès Chromatine gtt Chromatine rasuqam Cible thérapeutique rasuqam Expression génétique rasuqam Genexpressie gtt Pharmacologie moléculaire - Congrès Pharmacologie moléculaire rasuqam Régulation génétique - Congrès Régulation génétique rasuqam Signalen gtt Transduction du signal cellulaire - Congrès Transduction du signal rasuqam Apoptosis Congresses Cellular signal transduction Congresses Chromatin Congresses Gene Expression Regulation Congresses Gene Expression Congresses Genetic regulation Congresses Molecular pharmacology Congresses Signal Transduction Congresses Chromatin (DE-588)4010152-6 gnd rswk-swf Molekularpharmakologie (DE-588)4170397-2 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2004 Luxemburg Stadt gnd-content Electronic books Signaltransduktion (DE-588)4318717-1 s Chromatin (DE-588)4010152-6 s Genexpression (DE-588)4020136-3 s Molekularpharmakologie (DE-588)4170397-2 s DE-604 Diederich, Marc Sonstige oth Annals of the New York Academy of Sciences 1030 (DE-604)BV002532608 1030 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013120574&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets Annals of the New York Academy of Sciences Apoptose - Congrès Chromatine - Congrès Chromatine gtt Chromatine rasuqam Cible thérapeutique rasuqam Expression génétique rasuqam Genexpressie gtt Pharmacologie moléculaire - Congrès Pharmacologie moléculaire rasuqam Régulation génétique - Congrès Régulation génétique rasuqam Signalen gtt Transduction du signal cellulaire - Congrès Transduction du signal rasuqam Apoptosis Congresses Cellular signal transduction Congresses Chromatin Congresses Gene Expression Regulation Congresses Gene Expression Congresses Genetic regulation Congresses Molecular pharmacology Congresses Signal Transduction Congresses Chromatin (DE-588)4010152-6 gnd Molekularpharmakologie (DE-588)4170397-2 gnd Signaltransduktion (DE-588)4318717-1 gnd Genexpression (DE-588)4020136-3 gnd |
| subject_GND | (DE-588)4010152-6 (DE-588)4170397-2 (DE-588)4318717-1 (DE-588)4020136-3 (DE-588)1071861417 |
| title | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets |
| title_auth | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets |
| title_exact_search | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets |
| title_full | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets ed. by Marc Diederich |
| title_fullStr | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets ed. by Marc Diederich |
| title_full_unstemmed | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets ed. by Marc Diederich |
| title_short | Signal transduction pathways, chromatin structure, and gene expression mechanisms as therapeutic targets |
| title_sort | signal transduction pathways chromatin structure and gene expression mechanisms as therapeutic targets |
| topic | Apoptose - Congrès Chromatine - Congrès Chromatine gtt Chromatine rasuqam Cible thérapeutique rasuqam Expression génétique rasuqam Genexpressie gtt Pharmacologie moléculaire - Congrès Pharmacologie moléculaire rasuqam Régulation génétique - Congrès Régulation génétique rasuqam Signalen gtt Transduction du signal cellulaire - Congrès Transduction du signal rasuqam Apoptosis Congresses Cellular signal transduction Congresses Chromatin Congresses Gene Expression Regulation Congresses Gene Expression Congresses Genetic regulation Congresses Molecular pharmacology Congresses Signal Transduction Congresses Chromatin (DE-588)4010152-6 gnd Molekularpharmakologie (DE-588)4170397-2 gnd Signaltransduktion (DE-588)4318717-1 gnd Genexpression (DE-588)4020136-3 gnd |
| topic_facet | Apoptose - Congrès Chromatine - Congrès Chromatine Cible thérapeutique Expression génétique Genexpressie Pharmacologie moléculaire - Congrès Pharmacologie moléculaire Régulation génétique - Congrès Régulation génétique Signalen Transduction du signal cellulaire - Congrès Transduction du signal Apoptosis Congresses Cellular signal transduction Congresses Chromatin Congresses Gene Expression Regulation Congresses Gene Expression Congresses Genetic regulation Congresses Molecular pharmacology Congresses Signal Transduction Congresses Chromatin Molekularpharmakologie Signaltransduktion Genexpression Konferenzschrift 2004 Luxemburg Stadt Electronic books |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013120574&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT diederichmarc signaltransductionpathwayschromatinstructureandgeneexpressionmechanismsastherapeutictargets |