The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2004
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 121 Bl. Ill., graph. Darst. 31 cm |
Internformat
MARC
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| 100 | 1 | |a Breugel, Mark van |d 1975- |e Verfasser |0 (DE-588)128841141 |4 aut | |
| 245 | 1 | 0 | |a The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins |c von van Breugel, Mark |
| 264 | 1 | |c 2004 | |
| 300 | |a 121 Bl. |b Ill., graph. Darst. |c 31 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Dresden, Techn. Univ., Diss., 2004 | ||
| 650 | 0 | 7 | |a MAPs |0 (DE-588)4382958-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Mikrotubulus |0 (DE-588)4169864-2 |2 gnd |9 rswk-swf |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-013115926 | |
Datensatz im Suchindex
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|---|---|
| adam_text |
TABLE
OF
CONTENTS:
TABLE
OF
CONTENTS:
_
2
ACKNOWLEDGEMENTS:
-------------------------------------------------------------------------------------------
4
ABSTRACT:
_
5
INTRODUCTION:
_
6
M
ICROTUBULE
STRUCTURE
AND
FUNCTION
.
6
MICROTUBULE
POLYMERISATION
.
6
MECHANISM
OF
DYNAMIC
INSTABILITY
.
7
DYNAMIC
INSTABILITY
IN
VITRO
VERSUS
IN
VIVO
.
8
M
ICROTUBULE
ASSOCIATED
PROTEINS
(MAPS)
.
8
MICROTUBULE
STABILISERS
.
8
MICROTUBULE
DESTABILISERS
.
9
MAPS
AND
MICROTUBULE
END
BINDING
.
9
T
HE
DLSL
FAMILY
OF
MAPS
.
10
STRUCTURE
OF
THE
DISL
FAMILY
MEMBERS
.
11
LOCALISATION
OF
THE
DISL
FAMILY
MEMBERS
IN
VIVO
.
11
FUNCTION
OF
THE
DISL
FAMILY
MEMBERS
IN
VIVO
.
12
MICROTUBULE
BINDING
OF
THE
DISL
FAMILY
MEMBERS
IN
VITRO
.
12
INFLUENCE
OFXMAP215
ON
MICROTUBULE
DYNAMICS
IN
VITRO
.
13
INFLUENCE
OFXMAP215
ON
MICROTUBULE
DYNAMICS
IN
VIVO
.
13
REGULATION
OF
MICROTUBULE
DYNAMICS
BY
A
DISL/KINI
FAMILY
MEMBER
MODULE
.
13
EFFECT
OF
OTHER
DISL
FAMILY
MEMBERS
ON
MICROTUBULE
DYNAMICS
.
14
REGULATION
OF
THE
DISL
FAMILY
MEMBERS
.
15
DISL
FAMILY
MEMBERS:
COMMON
ROLES
OR
DIFFERENT
FUNCTIONS
?
.
15
G
OAL
OF
MY
P
H
D
THESIS
.
16
F
IGURES
FOR
INTRODUCTION
:
.
18
RESULTS
PART
I:
_
24
F
IGURES
FOR
PART
I:
.
29
RESULTS
PART
II:
43
F
IGURES
FOR
PART
II:
.
47
RESULTS
PART
III:
--------------------------------------------------------------------------------------------------
65
F
IGURES
FOR
PART
III:
.
71
DISCUSSION:
83
PARTI:
.
83
DIMERISATION
OFSTU2P:
.
83
MICROTUBULE
BINDING
BY
STU2P:
.
83
MICROTUBULE
DESTABILISATION
BY
STU2P:
.
83
MODEL
OF
MICROTUBULE
DESTABILISATION
BY
STU2P:
.
84
COMPARISON
OF
THE
IN
VITRO
AND
THE
IN
VIVO
ACTIVITY
OFSTU2P:
.
84
MICROTUBULE
END
BINDING
OF
STU2P:
.
85
PART
II:
.
86
DIMERISATION
DOMAIN
MAPPING
OFSTU2P:
.
86
MAPPING
OFSTU2P
'
S
MICROTUBULE
BINDING
DOMAIN:
.
86
ORIENTATION
OF
THE
STU2P
DIMER:
.
87
MECHANISM
OFSTU2P
'
S
MICROTUBULE
END
BINDING:
.
87
END
BINDING
AND
MICROTUBULE
DESTABILISATION
BY
STU2P:
.
88
FUNCTION
OF
THE
N-TERMINUS
IN
THEDISL
FAMILY:
.
88
P
ART
III:
.
89
INTRACELLULAR
CONCENTRATION
OFSTU2P:
.
89
STU2P
CONCENTRATION
DURING
THE
CELL
CYCLE:
.
89
ASSOCIATION
OFSTU2P
WITH
OTHER
PROTEINS:
.
90
CELL
CYCLE
DEPENDENT
PHOSPHORYLATION
OFSTU2P:
.
90
PHOSPHORYLATION
SITE
MAPPING
OFSTU2P:
.
90
FUNCTION
OFSTU2P
PHOSPHORYLATION:
.
91
F
IGURES
FOR
DISCUSSION
:
.
92
MATERIALS
AND
METHODS:
-----------------------------------------------------------------------------------
96
REFERENCE
LIST:
_
112
ERKLARUNG
UND
VERSICHERUNG:
_
121
3 |
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| author | Breugel, Mark van 1975- |
| author_GND | (DE-588)128841141 |
| author_facet | Breugel, Mark van 1975- |
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| ctrlnum | (OCoLC)249873863 (DE-599)BVBBV019790148 |
| discipline | Biologie |
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| indexdate | 2024-11-22T17:41:11Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013115926 |
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| physical | 121 Bl. Ill., graph. Darst. 31 cm |
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| spelling | Breugel, Mark van 1975- Verfasser (DE-588)128841141 aut The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins von van Breugel, Mark 2004 121 Bl. Ill., graph. Darst. 31 cm txt rdacontent n rdamedia nc rdacarrier Dresden, Techn. Univ., Diss., 2004 MAPs (DE-588)4382958-2 gnd rswk-swf Mikrotubulus (DE-588)4169864-2 gnd rswk-swf Polymerisation (DE-588)4046704-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Mikrotubulus (DE-588)4169864-2 s Polymerisation (DE-588)4046704-1 s MAPs (DE-588)4382958-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013115926&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Breugel, Mark van 1975- The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins MAPs (DE-588)4382958-2 gnd Mikrotubulus (DE-588)4169864-2 gnd Polymerisation (DE-588)4046704-1 gnd |
| subject_GND | (DE-588)4382958-2 (DE-588)4169864-2 (DE-588)4046704-1 (DE-588)4113937-9 |
| title | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins |
| title_auth | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins |
| title_exact_search | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins |
| title_full | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins von van Breugel, Mark |
| title_fullStr | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins von van Breugel, Mark |
| title_full_unstemmed | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins von van Breugel, Mark |
| title_short | The regulation of microtubule dynamics by Stu2p, the budding yeast member of the evolutionarily conserved Dis1 family of microtubule associated proteins |
| title_sort | the regulation of microtubule dynamics by stu2p the budding yeast member of the evolutionarily conserved dis1 family of microtubule associated proteins |
| topic | MAPs (DE-588)4382958-2 gnd Mikrotubulus (DE-588)4169864-2 gnd Polymerisation (DE-588)4046704-1 gnd |
| topic_facet | MAPs Mikrotubulus Polymerisation Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013115926&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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