Holdings: Infectious processes

Infectious processes: knowledge, discourse, and the politics of prions

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Bibliographic Details
Format:	Book
Language:	English
Published:	Houndmills [u.a.] Palgrave Macmillan 2004
Edition:	1. publ.
Series:	Science, technology, and medicine in modern history
Subjects:	Geschichte 1960-2004 Onderzoek Prionen Geschichte Prion diseases > History Prions > History Prionkrankheit Forschung Biomedizin Aufsatzsammlung
Online Access:	Contributor biographical information Publisher description Table of contents Inhaltsverzeichnis
Item Description:	Includes bibliographical references and index
Physical Description:	xiii, 191 S. Ill. 23 cm
ISBN:	1403932239

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MARC


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Record in the Search Index

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adam_text	Contents List of Figures vi List of Tables viii Acknowledgements ix Notes on the Contributors x List of Abbreviations xii Introduction: Prions? 1 Eve Seguin 1 The Early History of the Protein only Hypothesis: Scientific Change and Multidisciplinary Research 4 Maj Britt Juhl Poulsen and Hanne Andersen 2 Styles of Scientific Practice and the Prion Controversy 38 Ki Heung Kim 3 Paradigm Change? Explaining the Nature of the TSE Agent in Germany 73 Kerstin Dressel 4 Visualizing Prions: Graphic Representations and the Biography of Prions 99 Jerome Segal and Eric Francoeur 5 Prion Research and the Public Sphere in France 135 Brigitte Chamak 6 The UK BSE Crisis and the Prion Discursive Chain in Scientific Literature 161 Eve Seguin Conclusion: the Prion Case 186 Eve Seguin Index 189 V List of Figures 1.1 Diagrammatic illustrations of the model of replication proposed by the Prusiner group 21 1.2 Griffith s thermodynamical argument for the possibility of protein replication 26 1.3 Diagrammatic illustrations of the model of replication proposed by the Prusiner group 28 4.1 Micrographs used by the Prusiner group showing prions that reacted with antibodies 105 4.2 Three possible models of prion multiplication 107 4.3 Electron micrographs of polymerized peptides 108 4.4 Multiplication of PrPSc 109 4.5 Four kinds of helices for possible structures of PrPc 110 4.6 Stereoview of the predicted three dimensional structure of PrPc (the points of helix helix interactions are highlighted) 111 4.7 Schematic drawings of the six plausible structures ofPrPSc 112 4.8 Proposed three dimensional structure of PrPsc after correlation with genetic data on residues involved in species barrier 113 4.9 Conformational model for prion replication (PrP* is a rare partially unfolded, monomeric structure, that is an intermediate in the formation of PrPc) 114 4.10 Stereoviews of an NMR structure of a Syrian Hamster prion (the different views show different parts and, in the original publication, colours are used to highlight different secondary structures) 115 4.11 Schematic diagram showing the flexibility of the polypeptide chain for PrP (29 231) 116 4.12 The first protein structure designed by NMR 121 4.13 Tertiary structure of mouse PrP 122 4.14 Stereoviews of a part of Ure2p (part 95 354 (a) and 97 354 (b)) 125 4.15 Stereoview of the superposition of the Ure2p dimer with E. coli GST (above) and superposition of a monomer of Ure2p with a monomer of A. thaliana GST (below) 126 vi List of Figures vii 4.16 Structure of the yeast priori protein (Structure, front cover) 127 6.1 Annual numbers of papers published by Prusiner, 1982 95 168 6.2 Cumulative numbers of papers published by Prusiner, 1982 95 169 6.3 Cumulative numbers of different journals where Prusiner published, 1982 95 170 6.4 Annual numbers of journals where Prusiner published for the first time, 1982 95 171 6.5 Proportions of new journals where Prusiner published, 1982 95(%) 172 6.6 Numbers of citations received by 1982 paper, 1982 95 (including self citations) 173 6.7 Numbers of citations received by 1982 paper, 1982 95 (excluding self citations) 174 6.8 Partial overview of Prusiner s citations, 1982 95 176 6.9 Difference between citations and citing papers 176 6.10 Full overview of Prusiner s citations, 1982 95 177 6.11 Annual numbers of papers citing Prusiner, 1982 95 (excluding self citing papers) 177 6.12 Cumulative numbers of papers citing Prusiner, 1982 95 (excluding self citing papers) 178 6.13 Cumulative numbers of different journals that cited Prusiner, 1982 95 180 6.14 Annual numbers of journals that cited Prusiner for the first time, 1982 95 180 6.15 Proportions of new journals that cited Prusiner, 1982 95 (%) 181 List of Tables 1.1 Citation analysis of the core papers by Alper, Pattison and Griffith 22 1.2 Citation analysis of the core papers advancing the prion theory 22 1.3 Differences between Griffith the outsider and Prusiner the insider 29 2.1 Stylistic differences between the prion advocates and prion sceptics 60 5.1 TSE research funding in France, 1996 2001 145 6.1 Prusiner as first and sole author of his publications, 1982 95 167 6.2 Numbers of papers by TSE researchers, 1982 95 168 6.3 Journals where Prusiner published 10 or more papers, 1982 95 170 6.4 Mean numbers of citations received by 10 year old papers 175 6.5 Journals where 20 or more papers cited Prusiner, 1982 95 179 viii
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spelling	Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin 1. publ. Houndmills [u.a.] Palgrave Macmillan 2004 xiii, 191 S. Ill. 23 cm txt rdacontent n rdamedia nc rdacarrier Science, technology, and medicine in modern history Includes bibliographical references and index Geschichte 1960-2004 gnd rswk-swf Onderzoek gtt Prionen gtt Geschichte Prion diseases History Prions History Prionkrankheit (DE-588)4711087-9 gnd rswk-swf Forschung (DE-588)4017894-8 gnd rswk-swf Biomedizin (DE-588)4647152-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Prionkrankheit (DE-588)4711087-9 s Biomedizin (DE-588)4647152-2 s Forschung (DE-588)4017894-8 s Geschichte 1960-2004 z b DE-604 Seguin, Eve Sonstige oth http://www.loc.gov/catdir/bios/hol059/2004043624.html Contributor biographical information http://www.loc.gov/catdir/description/hol053/2004043624.html Publisher description http://www.loc.gov/catdir/toc/hol052/2004043624.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013112327&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Infectious processes knowledge, discourse, and the politics of prions Onderzoek gtt Prionen gtt Geschichte Prion diseases History Prions History Prionkrankheit (DE-588)4711087-9 gnd Forschung (DE-588)4017894-8 gnd Biomedizin (DE-588)4647152-2 gnd
subject_GND	(DE-588)4711087-9 (DE-588)4017894-8 (DE-588)4647152-2 (DE-588)4143413-4
title	Infectious processes knowledge, discourse, and the politics of prions
title_auth	Infectious processes knowledge, discourse, and the politics of prions
title_exact_search	Infectious processes knowledge, discourse, and the politics of prions
title_full	Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin
title_fullStr	Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin
title_full_unstemmed	Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin
title_short	Infectious processes
title_sort	infectious processes knowledge discourse and the politics of prions
title_sub	knowledge, discourse, and the politics of prions
topic	Onderzoek gtt Prionen gtt Geschichte Prion diseases History Prions History Prionkrankheit (DE-588)4711087-9 gnd Forschung (DE-588)4017894-8 gnd Biomedizin (DE-588)4647152-2 gnd
topic_facet	Onderzoek Prionen Geschichte Prion diseases History Prions History Prionkrankheit Forschung Biomedizin Aufsatzsammlung
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