Infectious processes: knowledge, discourse, and the politics of prions
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Houndmills [u.a.]
Palgrave Macmillan
2004
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Science, technology, and medicine in modern history
|
| Schlagworte: | |
| Online-Zugang: | Contributor biographical information Publisher description Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xiii, 191 S. Ill. 23 cm |
| ISBN: | 1403932239 |
Internformat
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| 245 | 1 | 0 | |a Infectious processes |b knowledge, discourse, and the politics of prions |c ed. by Eve Seguin |
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| 650 | 7 | |a Prionen |2 gtt | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
List of Figures vi
List of Tables viii
Acknowledgements ix
Notes on the Contributors x
List of Abbreviations xii
Introduction: Prions? 1
Eve Seguin
1 The Early History of the Protein only Hypothesis:
Scientific Change and Multidisciplinary Research 4
Maj Britt Juhl Poulsen and Hanne Andersen
2 Styles of Scientific Practice and the Prion Controversy 38
Ki Heung Kim
3 Paradigm Change? Explaining the Nature of the TSE
Agent in Germany 73
Kerstin Dressel
4 Visualizing Prions: Graphic Representations and
the Biography of Prions 99
Jerome Segal and Eric Francoeur
5 Prion Research and the Public Sphere in France 135
Brigitte Chamak
6 The UK BSE Crisis and the Prion Discursive Chain
in Scientific Literature 161
Eve Seguin
Conclusion: the Prion Case 186
Eve Seguin
Index 189
V
List of Figures
1.1 Diagrammatic illustrations of the model of replication
proposed by the Prusiner group 21
1.2 Griffith s thermodynamical argument for the possibility
of protein replication 26
1.3 Diagrammatic illustrations of the model of replication
proposed by the Prusiner group 28
4.1 Micrographs used by the Prusiner group showing prions
that reacted with antibodies 105
4.2 Three possible models of prion multiplication 107
4.3 Electron micrographs of polymerized peptides 108
4.4 Multiplication of PrPSc 109
4.5 Four kinds of helices for possible structures of PrPc 110
4.6 Stereoview of the predicted three dimensional
structure of PrPc (the points of helix helix interactions
are highlighted) 111
4.7 Schematic drawings of the six plausible structures
ofPrPSc 112
4.8 Proposed three dimensional structure of PrPsc after
correlation with genetic data on residues involved in
species barrier 113
4.9 Conformational model for prion replication (PrP* is a
rare partially unfolded, monomeric structure, that is an
intermediate in the formation of PrPc) 114
4.10 Stereoviews of an NMR structure of a Syrian Hamster
prion (the different views show different parts and, in
the original publication, colours are used to highlight
different secondary structures) 115
4.11 Schematic diagram showing the flexibility of the
polypeptide chain for PrP (29 231) 116
4.12 The first protein structure designed by NMR 121
4.13 Tertiary structure of mouse PrP 122
4.14 Stereoviews of a part of Ure2p (part 95 354 (a)
and 97 354 (b)) 125
4.15 Stereoview of the superposition of the Ure2p dimer
with E. coli GST (above) and superposition of a monomer of
Ure2p with a monomer of A. thaliana GST (below) 126
vi
List of Figures vii
4.16 Structure of the yeast priori protein (Structure,
front cover) 127
6.1 Annual numbers of papers published by Prusiner,
1982 95 168
6.2 Cumulative numbers of papers published by Prusiner,
1982 95 169
6.3 Cumulative numbers of different journals where Prusiner
published, 1982 95 170
6.4 Annual numbers of journals where Prusiner published
for the first time, 1982 95 171
6.5 Proportions of new journals where Prusiner published,
1982 95(%) 172
6.6 Numbers of citations received by 1982 paper, 1982 95
(including self citations) 173
6.7 Numbers of citations received by 1982 paper, 1982 95
(excluding self citations) 174
6.8 Partial overview of Prusiner s citations, 1982 95 176
6.9 Difference between citations and citing papers 176
6.10 Full overview of Prusiner s citations, 1982 95 177
6.11 Annual numbers of papers citing Prusiner, 1982 95
(excluding self citing papers) 177
6.12 Cumulative numbers of papers citing Prusiner,
1982 95 (excluding self citing papers) 178
6.13 Cumulative numbers of different journals that cited
Prusiner, 1982 95 180
6.14 Annual numbers of journals that cited Prusiner for
the first time, 1982 95 180
6.15 Proportions of new journals that cited
Prusiner, 1982 95 (%) 181
List of Tables
1.1 Citation analysis of the core papers by Alper, Pattison
and Griffith 22
1.2 Citation analysis of the core papers advancing the
prion theory 22
1.3 Differences between Griffith the outsider and Prusiner
the insider 29
2.1 Stylistic differences between the prion advocates and
prion sceptics 60
5.1 TSE research funding in France, 1996 2001 145
6.1 Prusiner as first and sole author of his publications,
1982 95 167
6.2 Numbers of papers by TSE researchers, 1982 95 168
6.3 Journals where Prusiner published 10 or more papers,
1982 95 170
6.4 Mean numbers of citations received by 10 year old
papers 175
6.5 Journals where 20 or more papers cited Prusiner, 1982 95 179
viii
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| spelling | Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin 1. publ. Houndmills [u.a.] Palgrave Macmillan 2004 xiii, 191 S. Ill. 23 cm txt rdacontent n rdamedia nc rdacarrier Science, technology, and medicine in modern history Includes bibliographical references and index Geschichte 1960-2004 gnd rswk-swf Onderzoek gtt Prionen gtt Geschichte Prion diseases History Prions History Prionkrankheit (DE-588)4711087-9 gnd rswk-swf Forschung (DE-588)4017894-8 gnd rswk-swf Biomedizin (DE-588)4647152-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Prionkrankheit (DE-588)4711087-9 s Biomedizin (DE-588)4647152-2 s Forschung (DE-588)4017894-8 s Geschichte 1960-2004 z b DE-604 Seguin, Eve Sonstige oth http://www.loc.gov/catdir/bios/hol059/2004043624.html Contributor biographical information http://www.loc.gov/catdir/description/hol053/2004043624.html Publisher description http://www.loc.gov/catdir/toc/hol052/2004043624.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013112327&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Infectious processes knowledge, discourse, and the politics of prions Onderzoek gtt Prionen gtt Geschichte Prion diseases History Prions History Prionkrankheit (DE-588)4711087-9 gnd Forschung (DE-588)4017894-8 gnd Biomedizin (DE-588)4647152-2 gnd |
| subject_GND | (DE-588)4711087-9 (DE-588)4017894-8 (DE-588)4647152-2 (DE-588)4143413-4 |
| title | Infectious processes knowledge, discourse, and the politics of prions |
| title_auth | Infectious processes knowledge, discourse, and the politics of prions |
| title_exact_search | Infectious processes knowledge, discourse, and the politics of prions |
| title_full | Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin |
| title_fullStr | Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin |
| title_full_unstemmed | Infectious processes knowledge, discourse, and the politics of prions ed. by Eve Seguin |
| title_short | Infectious processes |
| title_sort | infectious processes knowledge discourse and the politics of prions |
| title_sub | knowledge, discourse, and the politics of prions |
| topic | Onderzoek gtt Prionen gtt Geschichte Prion diseases History Prions History Prionkrankheit (DE-588)4711087-9 gnd Forschung (DE-588)4017894-8 gnd Biomedizin (DE-588)4647152-2 gnd |
| topic_facet | Onderzoek Prionen Geschichte Prion diseases History Prions History Prionkrankheit Forschung Biomedizin Aufsatzsammlung |
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