Neurobiology of addiction:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2006
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 490 S. Ill., graph. Darst. |
| ISBN: | 0124192394 9780124192393 |
Internformat
MARC
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| 300 | |a VIII, 490 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804133264090202112 |
|---|---|
| adam_text | Preface ix
Acknowledgments xi
1. What is Addiction
Definitions of addiction 1
Neuroadaptational Views of Addiction 10
Summary 19
References 19
2. Animal Models of Drug Addiction
Definitions and Validation of Animal Models 23
Animal Models for the Binge/Intoxication Stage of the
Addiction Cycle 26
Animal Models for the Drug Withdrawal/Negative Affect
Stage of the Addiction Cycle 38
Animal Models for the Preoccupation/Anticipation
(Craving) Stage of the Addiction Cycle 41
Animal Models for the Transition to Addiction 50
Summary 60
References 60
3. Psychostimulants
Definitions 69
History of Psychostimulant Use, Abuse, and
Addiction 71
Behavioral Effects and Medical Uses 74
Pharmacokinetics 78
Abuse and Addiction Potential 79
Behavioral Mechanisms 82
Neurobiological Mechanism—Neurocircuitry 83
Neurobiological Mechanism—Cellular 96
Neurobiological Mechanism—Molecular 103
Summary 108
References 109
4. Opioids
Definitions 121
History of Opioid Use, Abuse, and Addiction 121
Medical Use and Behavioral Effects 122
Pharmacokinetics 124
Abuse and Addiction Potential 126
Behavioral Mechanism of Action 134
Neurobiological Mechanism—Neurocircuitry 135
Neurobiological Mechanism—Cellular 150
Neurobiological Mechanism—Molecular 154
Summary 159
References 159
5. Alcohol
Definitions 173
History of Alcohol Use, Abuse, and Alcoholism 174
Behavioral Effects of Alcohol 175
Pharmacokinetics 178
Abuse and Addiction Potential 181
Behavioral Mechanism of Action 190
Neurobiological Mechanism—Neurocircuitry 191
Neurobiological Mechanism—Cellular 206
Neurobiological Mechanism—Molecular 211
Summary 221
References 221
6. Nicotine
Definitions 243
History of Tobacco Use, Abuse, and Addiction 244
Medical Use and Behavioral Effects 248
Pharmacokinetics 251
Abuse and Addiction Potential 253
Behavioral Mechanism of Action 258
Neurobiological Mechanism—Neurocircuitry 260
Neurobiological Mechanism—Cellular 268
Neurobiological Mechanism—Molecular 270
Summary 275
References 276
viii
7. Cannabinoids
Definitions 289
History of Cannabinoid Use, Abuse, and
Addiction 293
Medical Use and Behavioral Effects 296
Pharmacokinetics 299
Cannabinoid Tolerance 300
Cannabinoid Withdrawal 301
Pathology and Psychopathology 304
Behavioral Mechanism of Action 307
Neurobiological Mechanism—Neurocircuitry 307
Neurobiological Mechanism—Cellular 316
Neurobiological Mechanism—Molecular 321
Summary 323
References 325
8. Imaging
Introduction 339
Basic Technical Principles of Neuroimaging 340
Brain Imaging of Drug Addiction 343
Integration of Imaging Studies in Humans with the
Neurocircuitry of Addiction 361
Summary 368
References 369
9. Neurobiological Theories of Addiction
Introduction 378
Neurocircuitry Hypotheses of Addiction—
Dopamine and Reward 378
Neurocircuitry Theories of Addiction—Executive
Function 381
Neurocircuitry Theories of Addiction—Relapse 387
Neurocircuitry Theories of Addiction—Reward and
Stress 394
CONTENTS
Cellular Hypotheses of Addiction 405
Molecular Hypotheses of Addiction 408
Synthesis: Common Elements of Most Neurobiological
Models of Addiction 414
References 416
10. Drug Addiction: Transition from
Neuroadaptation to Pathophysiology
Common Neurobiological Elements in
Addiction 429
Overall Conclusions—Neurobiology of
Addiction 434
Homeostasis versus Allostasis in Addiction 435
Drug Seeking to Addiction—An Allostatic View 437
The Allostatic View versus Incentive
Sensitization View 444
A NonDopamine centric View of Addiction 447
Pain and Addiction 448
Neurocircuitry of Compulsive Drug Seeking and
Drug Taking 450
Implications of the Allostatic View for Motivation and
Psychopathology 453
References 453
Appendix 1. Psychostimulants 463
Appendix 2. Opioids 471
Appendix 3. Alcohol 473
Appendix 4. Nicotine 481
Appendix 5. Cannabinoids 483
Index 485
|
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| discipline | Soziologie Psychologie Medizin |
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| language | English |
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| spelling | Koob, George F. Verfasser aut Neurobiology of addiction George F. Koob ; Michel Le Moal Amsterdam [u.a.] Elsevier 2006 VIII, 490 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neurobiologie - Drogenabhängigkeit Neurobiologie - Sucht Brain Neurobiology Substance abuse Physiological aspects Sucht (DE-588)4058361-2 gnd rswk-swf Neurobiologie (DE-588)4041871-6 gnd rswk-swf Drogenabhängigkeit (DE-588)4138597-4 gnd rswk-swf Drogenabhängigkeit (DE-588)4138597-4 s Neurobiologie (DE-588)4041871-6 s DE-604 Sucht (DE-588)4058361-2 s 1\p DE-604 Le Moal, Michel Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013106276&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Koob, George F. Le Moal, Michel Neurobiology of addiction Neurobiologie - Drogenabhängigkeit Neurobiologie - Sucht Brain Neurobiology Substance abuse Physiological aspects Sucht (DE-588)4058361-2 gnd Neurobiologie (DE-588)4041871-6 gnd Drogenabhängigkeit (DE-588)4138597-4 gnd |
| subject_GND | (DE-588)4058361-2 (DE-588)4041871-6 (DE-588)4138597-4 |
| title | Neurobiology of addiction |
| title_auth | Neurobiology of addiction |
| title_exact_search | Neurobiology of addiction |
| title_full | Neurobiology of addiction George F. Koob ; Michel Le Moal |
| title_fullStr | Neurobiology of addiction George F. Koob ; Michel Le Moal |
| title_full_unstemmed | Neurobiology of addiction George F. Koob ; Michel Le Moal |
| title_short | Neurobiology of addiction |
| title_sort | neurobiology of addiction |
| topic | Neurobiologie - Drogenabhängigkeit Neurobiologie - Sucht Brain Neurobiology Substance abuse Physiological aspects Sucht (DE-588)4058361-2 gnd Neurobiologie (DE-588)4041871-6 gnd Drogenabhängigkeit (DE-588)4138597-4 gnd |
| topic_facet | Neurobiologie - Drogenabhängigkeit Neurobiologie - Sucht Brain Neurobiology Substance abuse Physiological aspects Sucht Neurobiologie Drogenabhängigkeit |
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