Bioinformatics and molecular evolution:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Malden, MA [u.a.]
Blackwell Publ.
2005
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIII, 365 S. graph. Darst. |
| ISBN: | 1405106832 9781405106832 |
Internformat
MARC
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| 100 | 1 | |a Higgs, Paul G. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Bioinformatics and molecular evolution |c Paul G. Higgs and Teresa K. Attwood |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Malden, MA [u.a.] |b Blackwell Publ. |c 2005 | |
| 300 | |a XIII, 365 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 505 | 8 | |a The revolution in biological information -- Nucleic acids, proteins, and amino acids -- Molecular evolution and population genetics -- Models of sequence evolution -- Information resources for genes and proteins -- Sequence alignment algorithms -- Searching sequence databases -- Phylogenetic methods -- Patterns in protein families -- Probabilistic methods and machine learning -- Further topics in molecular evolution and phylogenetics -- Genome evolution -- DNA microarrays and the 'omes. | |
| 650 | 7 | |a Algoritmos e estruturas de dados |2 larpcal | |
| 650 | 4 | |a Bio-informatique | |
| 650 | 7 | |a Bioinformática |2 larpcal | |
| 650 | 4 | |a Évolution moléculaire | |
| 650 | 4 | |a aMolecular evolution |a xMathematical models | |
| 650 | 4 | |a aBioinformatics | |
| 650 | 4 | |a aComputational Biology | |
| 650 | 4 | |a aEvolution, Molecular | |
| 650 | 4 | |a aGenetics | |
| 650 | 0 | 7 | |a Bioinformatik |0 (DE-588)4611085-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekulare Evolution |0 (DE-588)4812902-1 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Molekulare Evolution |0 (DE-588)4812902-1 |D s |
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| 700 | 1 | |a Attwood, Teresa K. |e Verfasser |0 (DE-588)156768216 |4 aut | |
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Datensatz im Suchindex
| _version_ | 1804133130983964672 |
|---|---|
| adam_text | BIOINFORMATICS AND MOLECULAR EVOLUTION PAUL G. HIGGS AND TERESA K.
ATTWOOD UNIVOI-AITSL;.:.- UI:;I LARSDAS- BIBIIOIHEK DARMSTADT BIBLIOTHOK
EICLOGIE IFV.-NR. PUBLISHING SHORT CONTENTS PREFACE X CHAPTER PLAN XIII
1 INTRODUCTION: THE REVOLUTION IN BIOLOGICAL INFORMATION 1 2 NUCLEIC
ACIDS, PROTEINS, AND AMINO ACIDS 12 3 MOLECULAR EVOLUTION AND POPULATION
GENETICS 37 4 MODELS OF SEQUENCE EVOLUTION 58 5 INFORMATION RESOURCES
FOR GENES AND PROTEINS 81 6 SEQUENCE ALIGNMENT ALGORITHMS 119 7
SEARCHING SEQUENCE DATABASES 139 8 PHYLOGENETIC METHODS 158 9 PATTERNS
IN PROTEIN FAMILIES 195 10 PROBABILISTIC METHODS AND MACHINE LEARNING
227 11 FURTHER TOPICS IN MOLECULAR EVOLUTION AND PHYLOGENETICS 257 12
GENOME EVOLUTION 283 13 DNA MICROARRAYS AND THE OMES 313 MATHEMATICAL
APPENDIX 343 LIST OF WEB ADDRESSES 355 GLOSSARY 357 INDEX 363 COLOR
PLATES FALL BETWEEN PAGES 194 AND 195 FULL CONTENTS PREFACE X 1
INTRODUCTION: THE REVOLUTION IN BIOLOGICAL INFORMATION 1 1.1 DATA
EXPLOSIONS 1 1.2 GENOMICS AND HIGH-THROUGHPUT TECHNIQUES 5 1.3 WHAT IS
BIOINFORMATICS? 6 1.4 THE RELATIONSHIP BETWEEN POPULATION GENETICS,
MOLECULAR EVOLUTION, AND BIOINFORMATICS 7 SUMMARY * REFERENCES *
PROBLEMS 10 2 NUCLEIC ACIDS, PROTEINS, AND AMINO ACIDS 12 2.1 NUCLEIC
ACID STRUCTURE 12 2.2 PROTEIN STRUCTURE 14 2.3 THE CENTRAL DOGMA 16 2.4
PHYSICO-CHEMICAL PROPERTIES OF THE AMINO ACIDS AND THEIR IMPORTANCE IN
PROTEIN FOLDING 22 2.1 POLYMERASE CHAIN REACTION (PCR) 23 2.5
VISUALIZATION OF AMINO ACID PROPERTIES USING PRINCIPAL COMPONENT
ANALYSIS 2 5 2.6 CLUSTERING AMINO ACIDS ACCORDING TO THEIR PROPERTIES *
- 28 2.2 PRINCIPAL COMPONENT ANALYSIS IN MORE DETAIL 29 SUMMARY *
REFERENCES * SELF-TEST BIOLOGICAL BACKGROUND 34 3 MOLECULAR EVOLUTION
AND POPULATION GENETICS 37 3.1 WHAT IS EVOLUTION? 37 3.2 MUTATIONS 39
3.3 SEQUENCE VARIATION WITHIN AND BETWEEN SPECIES 40 3.4 GENEALOGICAL
TREES AND COALESCENCE 44 3.5 THE SPREAD OF NEW MUTATIONS 46 3.J3 NEUTRAL
EVOLUTION AND ADAPTATION 49 3.1 THE INFLUENCE OF SELECTION ON THE
FIXATION PROBABILITY * 50 3.2 A DETERMINISTIC THEORY FOR THE SPREAD OF
MUTATIONS 51 SUMMARY * REFERENCES * PROBLEMS 54 4 MODELS OF SEQUENCE
EVOLUTION 58 4.1 MODELS OF NUCLEIC ACID SEQUENCE EVOLUTION 58 14.1
SOLUTION OF THE JUKES-CANTOR MODEL 61 4.2 THE P AM MODEL OF PROTEIN
SEQUENCE EVOLUTION 65 14.2 PAM DISTANCES 70 4.3 LOG-ODDS SCORING
MATRICES FOR AMINO ACIDS 71 SUMMARY * REFERENCES * PROBLEMS * SELF-TEST
MOLECULAR EVOLUTION 76 5 INFORMATION RESOURCES FOR GENES AND PROTEINS 81
5.1 WHY BUILD A DATABASE? 81 5.2 DATABASE FILE FORMATS 82 VII NUCLEIC
ACID SEQUENCE DATABASES PROTEIN SEQUENCE DATABASES , PROTEIN FAMILY
DATABASES COMPOSITE PROTEIN PATTERN DATABASES PROTEIN STRUCTURE
DATABASES OTHER TYPES OF BIOLOGICAL DATABASE 5.3 5.4 5.5 5.6 5.7 5.8
SUMMARY * REFERENCES 6 SEQUENCE ALIGNMENT ALGORITHMS 6.1 WHAT IS AN
ALGORITHM? 6.2 PAIRWISE SEQUENCE ALIGNMENT - THE PROBLEM 6.3 PAIRWISE
SEQUENCE ALIGNMENT - DYNAMIC PROGRAMMING METHODS 6.4 THE EFFECT OF
SCORING PARAMETERS ON THE ALIGNMENT 6.5 MULTIPLE SEQUENCE ALIGNMENT
SUMMARY * REFERENCES * PROBLEMS 7 SEARCHING SEQUENCE DATABASES 7.1
SIMILARITY SEARCH TOOLS 7.2 ALIGNMENT STATISTICS (IN THEORY) 7.1 EXTREME
VALUE DISTRIBUTIONS 7.2 DERIVATION OF THE EXTREME VALUE DISTRIBUTION IN
THE WORD-MATCHING EXAMPLE 7.3 ALIGNMENT STATISTICS (IN PRACTICE) SUMMARY
* REFERENCES * PROBLEMS * SELF-TEST ALIGNMENTS AND DATABASE SEARCHING 8
PHYLOGENETIC METHODS 8.1 UNDERSTANDING PHYLOGENETIC TREES 8.2 CHOOSING
SEQUENCES 8.3 DISTANCE MATRICES AND CLUSTERING METHODS 8.1 CALCULATION
OF DISTANCES IN THE NEIGHBOR-JOINING METHOD 8.4 BOOTSTRAPPING 8.5 TREE
OPTIMIZATION CRITERIA AND TREE SEARCH METHODS 83 89 95 108 111 113 115
119 119 121 123 127 130 136 139 139 147 151 152 153 155 158 158 161 162
167 169 171 8.3 THE MAXIMUM-LIKELIHOOD CRITERION 173 8.2 CALCULATING THE
LIKELIHOOD OF THE DATA ON A GIVEN TREE 174 8.7 THE PARSIMONY CRITERION
177 8.8 OTHER METHODS RELATED TO MAXIMUM LIKELIHOOD 179 8.3 CALCULATING
POSTERIOR PROBABILITIES 182 SUMMARY * REFERENCES * PROBLEMS * SELF-TEST
PHYLOGENETIC METHODS 185 9 PATTERNS IN PROTEIN FAMILIES 195 9.1 GOING
BEYOND PAIRWISE ALIGNMENT METHODS FOR DATABASE SEARCHES 195 9.2 REGULAR
EXPRESSIONS 197 9.3 FINGERPRINTS 200 9.4 PROFILES AND PSSMS 205 9.5
BIOLOGICAL APPLICATIONS - G PROTEIN-COUPLED RECEPTORS 208 SUMMARY *
REFERENCES * PROBLEMS * SELF-TEST PROTEIN FAMILIES AND DATABASES 216 10
PROBABILISTIC METHODS AND MACHINE LEARNING 227 10.1 USING MACHINE
LEARNING FOR PATTERN RECOGNITION IN BIOINFORMATICS 227 10.2
PROBABILISTIC MODELS OF SEQUENCES- BASIC INGREDIENTS * 228 10.1
DIRICHLET PRIOR DISTRIBUTIONS 232 103 INTRODUCING HIDDEN MARKOV MODELS
234 10.2 THE VITERBI ALGORITHM 238 110.3 THE FORWARD AND BACKWARD
ALGORITHMS 239 10.4 PROFILE HIDDEN MARKOV MODELS 241 10.5 NEURAL
NETWORKS 244 10.4 THE BACK-PROPAGATION Y ALGORITHM 249 10.6 NEURAL
NETWORKS AND PROTEIN SECONDARY STRUCTURE PREDICTION 250 SUMMARY *
REFERENCES * PROBLEMS 253 VIII 11 FURTHER TOPICS IN MOLECULAR EVOLUTION
AND PHYLOGENETICS 11.1 RNA STRUCTURE AND EVOLUTION 11.2 FITTING
EVOLUTIONARY MODELS TO SEQUENCE DATA 11.3 APPLICATIONS OF MOLECULAR
PHYLOGENETICS SUMMARY * REFERENCES 12 GENOME EVOLUTION 12.1 PROKARYOTIC
GENOMES JFJRA 12.1 WEB RESOURCES FOR BACTERIAL GENOMES 12.2 ORGANELLAR
GENOMES SUMMARY * REFERENCES 13 DNA MICROARRAYSAND THE OMES 13.1 OMES
AND OMICS 13.2 HOW DO MICROARRAYS WORK? 13.3 NORMALIZATION OF
MICROARRAY DATA 13.4 PATTERNS IN MICROARRAY DATA 13.5 PROTEOMICS 13.6
INFORMATION MANAGEMENT FOR THE OMES 257 257 266 272 279 283 283 284 298
309 313 313 314 316 319 325 330 (IRA 1 3.1 EXAMPLES FROM THE GENE
ONTOLOGY SUMMARV * REFERENCES * SELF-TEST MATHEMATICAL APPENDIX M.I M.2
M.3 M.4 M.5 M.6 M.7 M.8 M.9 M.10 M.LL M.12 M.13 EXPONENTIALS AND
LOGARITHMS FACTORIALS SUMMATIONS PRODUCTS PERMUTATIONS AND COMBINATIONS
DIFFERENTIATION INTEGRATION DIFFERENTIAL EQUATIONS BINOMIAL
DISTRIBUTIONS NORMAL DISTRIBUTIONS POISSON DISTRIBUTIONS CHI-SQUARED
DISTRIBUTIONS GAMMA FUNCTIONS AND GAMMA DISTRIBUTIONS PROBLEMS *
SELF-TEST LIST OF WEB ADDRESSES GLOSSARY INDEX 335 337 343 343 344 344
345 345 346 347 347 348 348 350 35.1 352 353 355 357 363 IX
|
| any_adam_object | 1 |
| author | Higgs, Paul G. Attwood, Teresa K. |
| author_GND | (DE-588)156768216 |
| author_facet | Higgs, Paul G. Attwood, Teresa K. |
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| building | Verbundindex |
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| contents | The revolution in biological information -- Nucleic acids, proteins, and amino acids -- Molecular evolution and population genetics -- Models of sequence evolution -- Information resources for genes and proteins -- Sequence alignment algorithms -- Searching sequence databases -- Phylogenetic methods -- Patterns in protein families -- Probabilistic methods and machine learning -- Further topics in molecular evolution and phylogenetics -- Genome evolution -- DNA microarrays and the 'omes. |
| ctrlnum | (OCoLC)56481961 (DE-599)BVBBV019687438 |
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8 |
| dewey-search | 572.8 |
| dewey-sort | 3572.8 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Informatik |
| edition | 1. publ. |
| format | Book |
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| id | DE-604.BV019687438 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:03:50Z |
| institution | BVB |
| isbn | 1405106832 9781405106832 |
| language | English |
| lccn | 2004021066 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013015303 |
| oclc_num | 56481961 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-526 DE-29T DE-578 DE-19 DE-BY-UBM |
| owner_facet | DE-M49 DE-BY-TUM DE-526 DE-29T DE-578 DE-19 DE-BY-UBM |
| physical | XIII, 365 S. graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
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| publisher | Blackwell Publ. |
| record_format | marc |
| spelling | Higgs, Paul G. Verfasser aut Bioinformatics and molecular evolution Paul G. Higgs and Teresa K. Attwood 1. publ. Malden, MA [u.a.] Blackwell Publ. 2005 XIII, 365 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index The revolution in biological information -- Nucleic acids, proteins, and amino acids -- Molecular evolution and population genetics -- Models of sequence evolution -- Information resources for genes and proteins -- Sequence alignment algorithms -- Searching sequence databases -- Phylogenetic methods -- Patterns in protein families -- Probabilistic methods and machine learning -- Further topics in molecular evolution and phylogenetics -- Genome evolution -- DNA microarrays and the 'omes. Algoritmos e estruturas de dados larpcal Bio-informatique Bioinformática larpcal Évolution moléculaire aMolecular evolution xMathematical models aBioinformatics aComputational Biology aEvolution, Molecular aGenetics Bioinformatik (DE-588)4611085-9 gnd rswk-swf Molekulare Evolution (DE-588)4812902-1 gnd rswk-swf Bioinformatik (DE-588)4611085-9 s Molekulare Evolution (DE-588)4812902-1 s DE-604 Attwood, Teresa K. Verfasser (DE-588)156768216 aut http://www.loc.gov/catdir/toc/ecip0422/2004021066.html Table of contents HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013015303&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Higgs, Paul G. Attwood, Teresa K. Bioinformatics and molecular evolution The revolution in biological information -- Nucleic acids, proteins, and amino acids -- Molecular evolution and population genetics -- Models of sequence evolution -- Information resources for genes and proteins -- Sequence alignment algorithms -- Searching sequence databases -- Phylogenetic methods -- Patterns in protein families -- Probabilistic methods and machine learning -- Further topics in molecular evolution and phylogenetics -- Genome evolution -- DNA microarrays and the 'omes. Algoritmos e estruturas de dados larpcal Bio-informatique Bioinformática larpcal Évolution moléculaire aMolecular evolution xMathematical models aBioinformatics aComputational Biology aEvolution, Molecular aGenetics Bioinformatik (DE-588)4611085-9 gnd Molekulare Evolution (DE-588)4812902-1 gnd |
| subject_GND | (DE-588)4611085-9 (DE-588)4812902-1 |
| title | Bioinformatics and molecular evolution |
| title_auth | Bioinformatics and molecular evolution |
| title_exact_search | Bioinformatics and molecular evolution |
| title_full | Bioinformatics and molecular evolution Paul G. Higgs and Teresa K. Attwood |
| title_fullStr | Bioinformatics and molecular evolution Paul G. Higgs and Teresa K. Attwood |
| title_full_unstemmed | Bioinformatics and molecular evolution Paul G. Higgs and Teresa K. Attwood |
| title_short | Bioinformatics and molecular evolution |
| title_sort | bioinformatics and molecular evolution |
| topic | Algoritmos e estruturas de dados larpcal Bio-informatique Bioinformática larpcal Évolution moléculaire aMolecular evolution xMathematical models aBioinformatics aComputational Biology aEvolution, Molecular aGenetics Bioinformatik (DE-588)4611085-9 gnd Molekulare Evolution (DE-588)4812902-1 gnd |
| topic_facet | Algoritmos e estruturas de dados Bio-informatique Bioinformática Évolution moléculaire aMolecular evolution xMathematical models aBioinformatics aComputational Biology aEvolution, Molecular aGenetics Bioinformatik Molekulare Evolution |
| url | http://www.loc.gov/catdir/toc/ecip0422/2004021066.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013015303&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT higgspaulg bioinformaticsandmolecularevolution AT attwoodteresak bioinformaticsandmolecularevolution |