Pharmacology:
Gespeichert in:
| Späterer Titel: | Rang & Dale's pharmacology |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Edinburgh [u.a.]
Churchill Livingstone
2003
|
| Ausgabe: | 5. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 797 S. |
| ISBN: | 0443071454 0443072027 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV019683602 | ||
| 003 | DE-604 | ||
| 005 | 20090923 | ||
| 007 | t | ||
| 008 | 050202s2003 |||| 00||| eng d | ||
| 020 | |a 0443071454 |9 0-443-07145-4 | ||
| 020 | |a 0443072027 |9 0-443-07202-7 | ||
| 035 | |a (OCoLC)248844001 | ||
| 035 | |a (DE-599)BVBBV019683602 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-19 |a DE-91 |a DE-634 |a DE-188 |a DE-578 | ||
| 082 | 0 | |a 615.1024613 | |
| 082 | 0 | |a 615.1 | |
| 084 | |a VT 5010 |0 (DE-625)147739: |2 rvk | ||
| 084 | |a MED 900f |2 stub | ||
| 084 | |a 15,3 |2 ssgn | ||
| 245 | 1 | 0 | |a Pharmacology |c H. P. Rang ... |
| 250 | |a 5. ed. | ||
| 264 | 1 | |a Edinburgh [u.a.] |b Churchill Livingstone |c 2003 | |
| 300 | |a XII, 797 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Pharmacology |2 cabt | |
| 650 | 0 | 7 | |a Pharmakologie |0 (DE-588)4045687-0 |2 gnd |9 rswk-swf |
| 655 | 4 | |a Lehrbuch - Pharmakologie | |
| 689 | 0 | 0 | |a Pharmakologie |0 (DE-588)4045687-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Rang, H. P. |e Sonstige |4 oth | |
| 785 | 0 | 0 | |i 6. Aufl. u.d.T. |t Rang & Dale's pharmacology |w (DE-604)BV022545448 |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013011541&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-013011541 | ||
Datensatz im Suchindex
| _version_ | 1804133125145493504 |
|---|---|
| adam_text | Contents
GENERAL PRINCIPLES
1. What is pharmacology? 2
Pharmacology in the 20th century 3
2. How drugs act: general principles 7
The binding of drug molecules to cells 7
Desensitisation and tachyphylaxis 19
3. How drugs act: molecular aspects 22
Targets for drug action 22
Receptor proteins 26
Ion channels as drug targets 45
Control of receptor expression 47
Receptors and disease 48
4. Cellular mechanisms: excitation, contraction and
secretion 51
Regulation of intracellular calcium levels 51
Excitation 55
Muscle contraction 62
Release of chemical mediators 64
Epithelial ion transport 66
5. Cellular mechanisms: cell proliferation and
apoptosis 69
Cell proliferation 69
Angiogenesis 74
Apoptosis and cell removal 74
Pathophysiological implications 77
Therapeutic implications 77
6. Method and measurement in pharmacology 80
Bioassay 80
Animal models of disease 84
Clinical trials 86
Balancing benefit and risk 89
7. Absorption and distribution of drugs 91
Translocation of drug molecules 91
Drug disposition 97
Drug absorption 98
Special drug delivery systems 104
8. Drug elimination and pharmacokinetics 106
Drug metabolism 106
Renal excretion of drugs and drug metabolites 1 1 1
Biliary excretion and enterohepatic circulation 1 13
Pharmacokinetics 114
I M
CHEMICAL MEDIATORS
9. Chemical mediators and the autonomic nervous
system 122
Historical aspects 122
The peripheral nervous system 123
Some general principles of chemical
transmission 126
Basic steps in neurochemical transmission: sites of drug
action 133
10. Cholinergic transmission 136
Muscarinic and nicotinic actions of
acetylcholine 136
Acetylcholine receptors 137
Physiology of cholinergic transmission 139
Effects of drugs on cholinergic transmission 143
11. Noradrenergic transmission 161
Classification of adrenoceptors 161
Physiology of noradrenergic transmission 164
Drugs acting on adrenoceptors 168
Drugs that affect noradrenergic neurons 176
12. Other peripheral mediators: 5 hydroxytryptamine and
purines 184
5 hydroxytryptamine 184
Purines 192
13. Peptides and proteins as mediators 198
General principles of peptide pharmacology 1 98
Biosynthesis and regulation of peptides 202
Peptide antagonists 204
Proteins and peptides as drugs 205
Concluding remarks 206
14. Nitric oxide 208
Biosynthesis of nitric oxide and its control 209
Degradation and carriage of nitric oxide 210
Effects of nitric oxide 212
Therapeutic approaches 213
Clinical conditions in which nitric oxide may play a
part 214
15. Local hormones, inflammation and immune
reactions 217
The components of the acute inflammatory
reaction 217
The outcome of the inflammatory response 228
Mediators of inflammation and immune
reactions 229
Current therapies based on manipulation of the
immune response 241
Potential new therapies 241
16. Anti inflammatory and immunosuppressant
drugs 244
Non steroidal anti inflammatory drugs 244
Antagonists of histamine 252
Drugs used in gout 254
Antirheumatoid drugs 255
Immunosuppressant drugs 257
Possible future developments 260
DRUGS AFFECTING MAJOR ORGAN SY
17. The heart 264
Physiology of cardiac function 264
Drugs that affect cardiac function 272
18. The vascular system 285
Vascular structure and function 285
Control of vascular smooth muscle tone 286
Vasoactive drugs 292
Clinical uses of vasoactive drugs 298
19. Atherosclerosis and lipoprotein metabolism 306
Atherogenesis 306
Lipoprotein transport in the blood 307
Lipid lowering drugs 309
20. Haemostasis and thrombosis 314
Blood coagulation 315
Drugs that act on the coagulation cascade 317
Platelet adhesion and activation 323
Fibrinolysis (thrombolysis) 327
21. The haemopoietic system 330
The haemopoietic system 330
Haematinic agents 331
Haemopoietic growth factors 336
22. The respiratory system 340
The regulation of respiration 340
Disorders of respiration and the drugs used in
treatment 341
23. The kidney 352
Outline of renal function 352
The structure and function of the nephron 352
Drugs acting on the kidney 362
Drugs which alter the pH of the urine 365
Drugs which alter the excretion of organic
molecules 365
24. The gastrointestinal tract 367
The innervation and the hormones of the
gastrointestinal tract 367
Gastric secretion 368
Vomiting 372
The motility of the gastrointestinal tract 375
Drugs for chronic inflammatory bowel disease 377
Drugs affecting the biliary system 378
STEMS
25. The endocrine pancreas and the control of blood
glucose 380
Pancreatic islet hormones 380
Control of blood glucose 385
Diabetes mellitus and the drugs used in
treatment 385
26. Obesity 394
The homeostatic mechanisms controlling energy
balance 394
Obesity as a health problem and possible
treatments 397
27. The pituitary and adrenal cortex 404
The pituitary and drugs used in therapy 404
The adrenal cortex and drugs used in therapy 41 1
28. The thyroid 421
Synthesis, storage and secretion of thyroid
hormones 421
Regulation of thyroid function 422
Actions of the thyroid hormones 423
Transport and metabolism 424
Abnormalities of thyroid function 424
Drugs used in diseases of the thyroid 425
29. The reproductive system 429
Endocrine control of reproduction and modulating
drugs 429
Drugs used for contraception 439
The uterus 441
Erectile dysfunction 443
30. Bone metabolism 446
Bone structure and composition 446
Bone remodelling 446
Disorders of bone and the drugs used in
treatment 451
THE NERVOUS SYSTEM
31. Chemical transmission and drug action in the central
nervous system 456
Chemical signalling in the nervous system 457
Targets for drug action 458
Drug action in the central nervous system 459
The classification of psychotropic drugs 460
32. Amino acid transmitters 462
Excitatory amino acids 462
Glutamate 463
Gamma aminobutyric acid 470
Glycine 473
33. Other transmitters and modulators 474
Noradrenaline 475
Dopamine 476
5 Hydroxytryptamine 480
Acetylcholine 483
Purines 485
Histamine 485
Other CNS mediators 485
A final message 488
34. Neurodegenerative disorders 490
Mechanisms of neuronal death 490
Ischaemic brain damage 493
Alzheimer s disease 494
Parkinson s disease 497
Huntington s disease 501
Neurodegenerative prion diseases 501
35. General anaesthetic agents 503
Mechanism of action of anaesthetic drugs 504
The effects of anaesthetics on nervous system 505
Effects on the cardiovascular respiratory systems 506
Inhalation anaesthetics 506
Individual inhalation anaesthetics 509
Intravenous anaesthetic agents 51 1
36. Anxiolytic and hypnotic drugs 515
The nature of anxiety and measurement of anxiolytic
activity 515
Classification of anxiolytic and hypnotic drugs 516
Benzodiazepines 517
Benzodiazepine antagonists 523
Buspirone 523
Barbiturates 523
Other potential anxiolytic drugs 524
37. Antipsychotic drugs 525
The nature of schizophrenia 525
Antipsychotic drugs 528
38. Drugs used in affective disorders 535
The nature of depression 535
Theories of depression 536
Antidepressant drugs 538
Electroconvulsive therapy 547
Clinical effectiveness of antidepressant
treatments 548
Mood stabilising drugs 548
39. Antiepilepric drugs 550
The nature of epilepsy 550
Mechanism of action of antiepileptic drugs 553
Antiepileptic drugs 554
Muscle spasm and centrally acting muscle
relaxants 559
40. Analgesic drugs 562
Neural mechanisms of pain 562
Analgesic drugs 572
New approaches 583
41. CNS stimulants and psychotomimetic drugs 585
Convulsants and respiratory stimulants 585
Psychomotor stimulants 587
Psychotomimetic drugs 591
42. Drug dependence and drug abuse 594
The nature of drug dependence 595
Nicotine and tobacco 598
Ethanol 603
Cannabis 608
43. Local anaesthetics 612
Local anaesthetics 612
Other drugs that affect sodium channels 616
DRUGS USED IN THE TREATMENT OF INF
44. Basic principles of chemotherapy 620
The molecular basis of chemotherapy 620
Resistance to antibacterial drugs 629
45. Antibacterial drugs 635
Antimicrobial agents that interfere with the synthesis or
action of folate 637
Beta lactam antibiotics 639
Antimicrobial agents affecting bacterial protein
synthesis 643
Antimicrobial agents affecting topoisomerase II 647
Miscellaneous antibacterial agents 648
Antimycobacterial agents 649
Possible new antibacterial drugs 652
46. Antiviral drugs 654
Background information about viruses 654
The host virus interaction 655
HIV and AIDS 657
Antiviral drugs 659
47. Antifungal drugs 666
Fungal infections 666
Drugs used for fungal infections 666
Potential new antifungal therapies 670
48. Antiprotozoal drugs 672
Host parasite interactions 672
Malaria 673
Pneumocystis pneumonia and its treatment 682
Amoebiasis and amoebicidal drugs 682
Leishmaniasis and leishmanicidal drugs 683
Trypanosomiasis and trypanosomicidal drugs 684
Trichomoniasis and trichomonicidal drugs 684
Toxoplasmosis and toxoplasmocidal drugs 684
New approaches to antiprotozoal therapy 685
ECTIONS AND CANCER
49. Anthelminthic drugs 687
Helminth infections 687
Anthelminthic drugs 688
Resistance to anthelminthic drugs 691
New approaches to anthelminthic therapy 691
50. Cancer chemotherapy 693
The pathogenesis of cancer 693
General principles of action of cytotoxic anticancer
drugs 696
Drugs used in cancer chemotherapy 698
Resistance to anticancer drugs 706
Treatment schedules 707
Techniques for dealing with emesis and
myelosuppression 707
Possible future strategies for cancer
chemotherapy 707
SPECIAL TOPICS
51. Individual variation and drug interaction 712
Effects of ethnicity 712
Effects of age 713
Effects of pregnancy 714
Genetic factors 714
Idiosyncratic reactions 716
Effects of disease 717
Drug interactions 718
52. Harmful effects of drugs 724
Types of adverse drug reaction 724
Drug toxicity 725
APPENDIX 753
INDEX 761
53. Gene therapy 738
Technical aspects 739
Safety 743
Therapeutic aspects 743
54. Drug discover/ and development 747
The preclinical stages 747
Clinical development 749
Commercial aspects 750
A final note 750
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV019683602 |
| classification_rvk | VT 5010 |
| classification_tum | MED 900f |
| ctrlnum | (OCoLC)248844001 (DE-599)BVBBV019683602 |
| dewey-full | 615.1024613 615.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1024613 615.1 |
| dewey-search | 615.1024613 615.1 |
| dewey-sort | 3615.1024613 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| edition | 5. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01470nam a2200421 c 4500</leader><controlfield tag="001">BV019683602</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20090923 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">050202s2003 |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0443071454</subfield><subfield code="9">0-443-07145-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0443072027</subfield><subfield code="9">0-443-07202-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)248844001</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV019683602</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-19</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-634</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.1024613</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.1</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VT 5010</subfield><subfield code="0">(DE-625)147739:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">MED 900f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">15,3</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Pharmacology</subfield><subfield code="c">H. P. Rang ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">5. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Edinburgh [u.a.]</subfield><subfield code="b">Churchill Livingstone</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XII, 797 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmacology</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="4"><subfield code="a">Lehrbuch - Pharmakologie</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rang, H. P.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="785" ind1="0" ind2="0"><subfield code="i">6. Aufl. u.d.T.</subfield><subfield code="t">Rang & Dale's pharmacology</subfield><subfield code="w">(DE-604)BV022545448</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013011541&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-013011541</subfield></datafield></record></collection> |
| genre | Lehrbuch - Pharmakologie |
| genre_facet | Lehrbuch - Pharmakologie |
| id | DE-604.BV019683602 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T20:03:44Z |
| institution | BVB |
| isbn | 0443071454 0443072027 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013011541 |
| oclc_num | 248844001 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-634 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-634 DE-188 DE-578 |
| physical | XII, 797 S. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Churchill Livingstone |
| record_format | marc |
| spelling | Pharmacology H. P. Rang ... 5. ed. Edinburgh [u.a.] Churchill Livingstone 2003 XII, 797 S. txt rdacontent n rdamedia nc rdacarrier Pharmacology cabt Pharmakologie (DE-588)4045687-0 gnd rswk-swf Lehrbuch - Pharmakologie Pharmakologie (DE-588)4045687-0 s DE-604 Rang, H. P. Sonstige oth 6. Aufl. u.d.T. Rang & Dale's pharmacology (DE-604)BV022545448 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013011541&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pharmacology Pharmacology cabt Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4045687-0 |
| title | Pharmacology |
| title_auth | Pharmacology |
| title_exact_search | Pharmacology |
| title_full | Pharmacology H. P. Rang ... |
| title_fullStr | Pharmacology H. P. Rang ... |
| title_full_unstemmed | Pharmacology H. P. Rang ... |
| title_new | Rang & Dale's pharmacology |
| title_short | Pharmacology |
| title_sort | pharmacology |
| topic | Pharmacology cabt Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Pharmacology Pharmakologie Lehrbuch - Pharmakologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013011541&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ranghp pharmacology |