Microbial protein toxins:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin
Springer
2005
|
| Schriftenreihe: | Topics in Current Genetics
11 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 237 S. |
| ISBN: | 3540235620 |
Internformat
MARC
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| 245 | 1 | 0 | |a Microbial protein toxins |c Manfred J. Schmitt... (Eds.) |
| 264 | 1 | |a Berlin |b Springer |c 2005 | |
| 300 | |a XIII, 237 S. | ||
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| 490 | 1 | |a Topics in Current Genetics |v 11 | |
| 650 | 4 | |a Bacterial Proteins | |
| 650 | 4 | |a Bacterial Toxins | |
| 650 | 4 | |a Fungal Proteins | |
| 650 | 4 | |a Microbial toxins | |
| 650 | 4 | |a Mycotoxins | |
| 650 | 4 | |a Toxins | |
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Datensatz im Suchindex
| _version_ | 1804133119596429312 |
|---|---|
| adam_text | Table of contents
Diphtheria toxin, diphtheria related fusion protein toxins, and the
molecular mechanism of their action against eukaryotic cells 1
Ryan Ratts and John R. Murphy 1
Abstract 1
1 Diphtheria toxin 1
2 Catalytic domain delivery into the eukaryotic cytosol results in an
inhibition of protein synthesis 2
3 Receptor binding and substitution of the native diphtheria toxin
receptor binding domain with surrogate ligands 3
4 Intoxication of target cells requires the toxin to pass through a low pH
endosomal compartment 5
5 Internalization of the toxin by receptor mediated endocytosis 6
6 The early endosomal compartment 6
7 The transmembrane domain and channel formation 8
8 The interchain disulfide bond 9
9 Proposed mechanisms of diphtheria toxin C domain translocation 11
9.1 Unassisted spontaneous translocation of the diphtheria toxin C
domain 11
9.2 A cytosolic translocation factor facilitates the membrane
translocation of the diphtheria toxin C domain 12
References 14
Anthrax toxin and genetic aspects regulating its expression 21
Amy E. Tucker and Jimmy D. Ballard 21
Abstract 21
1 Introduction 21
2 Overview of anthrax toxin 22
3 pXOl, the plasmid encoding AT 23
4 The genes of anthrax toxin: pagA, lef, and cva 25
5 Environmental signals regulating AT expression 26
6 AtxA, a global regulator of AT expression 27
7 PagR, a negative regulator of PA expression 28
8 AbrB, a growth phase dependent regulator of AT production 29
9 Conclusions and outlook 29
References 31
Shiga toxins and their mechanisms of cell entry 35
Kirsten Sandvig, Sebastien Walchli, and Silje U. Lauvrak 35
Abstract 35
1 Introduction 35
2 Structure of Shiga toxins 37
3 Toxin interaction with cell surface receptors 39
4 Endocytosis of Shiga toxins 41
5 Endosome to Golgi transport of Shiga toxins 42
6 Toxin transport from the trans Golgi network to the ER 43
7 Furin induced cleavage and activation of toxins 43
8 Transport from ER to the cytosol 44
9 Shiga toxin stimulates secretion of cytokines/chemokines 44
10 Toxin induced apoptosis 45
11 Protection against Shiga toxin induced disease 46
12 Therapeutic use of Shiga toxins 46
13 Conclusions 47
Acknowledgements 47
References 47
Cholera toxin: mechanisms of entry into host cells 55
David E. Saslowsky, Michael Kothe, and Wayne I. Lencer 55
Abstract 55
1 Introduction 55
2 Toxin structure 56
4 Retrograde transport into the Golgi and ER 60
4.1 Possible mechanisms of ganglioside trafficking 60
4.2 A direct pathway from TGN to ER 61
5 Mechanisms of retro translocation across the ER membrane 61
6 Conclusions 63
Acknowledgements 64
References 64
ExoU: A cytotoxin delivered by the type III secretion system of
Pseudomonas aeruginosa 69
ShiraD. P. Rabin and Alan R. Hauser 69
Abstract 69
1 Introduction 69
2 Discovery 70
3 Activity 71
3.1 Cell biological activity 71
3.2 Enzymatic activity 72
3.3 Mechanism of cytotoxicity 75
4 Regulation 76
5 ExoU secretion as a variable trait 78
6 Role in virulence 81
7 Role in human disease 82
8 Conclusion 83
References 83
Staphylococcal alpha toxin 91
Sucharit Bhakdi, Iwan Walev, Matthias Husmann, and Angela Valeva 91
Abstract 91
1 Occurrence and biological significance 91
2 Properties of native toxin 92
3 Mechanism of action 93
3.1 Binding 93
3.2 Oligomerization 93
3.3 Pore formation 94
4 Structure 95
4.1 Structure of the heptameric pore formed in detergent solution 95
4.2 Structure of the membrane bound oligomer 98
4.3 Structurally related pore forming toxins 98
5 Cellular resistance and repair mechanisms 99
6 Biological effects 101
6.1 Cytocidal action 101
6.2 Secondary cellular reactions 101
6.3 Long range effects 104
6.4 Synergism between alpha toxin and other toxins 104
7 Use of alpha toxin in cell biology 104
8 Medical relevance 105
Acknowledgements 106
References 106
S. cerevisiae K28 toxin a secreted virus toxin of the A/B family of
protein toxins Ill
Susanne Leis, Jenny Spindler, Jochen Reiter, Frank Breinig, and
Manfred J. Schmitt 111
Abstract 111
1 Introduction 111
2 dsRNA viruses cause a killer phenotype in S. cerevisiae 112
2.1 Viral replication cycle 114
3 Preprotoxin processing and toxin secretion 115
4 Toxin uptake and retrograde transport 116
4.1 A single disulfide bond between a and (3 exposes the ER
targeting signal of the toxin 119
4.2 Toxin dislocation out of the ER 120
5 Mode of K28 toxin action 122
5.1 Toxin induced apoptotic host cell responses 124
6 Toxin immunity 125
7 Concluding remarks 126
Acknowledgements 126
References 127
Kluyveromyces lactis zymocin and other plasmid encoded yeast
killer toxins 133
Raffael Schaffrath and Friedhelm Meinhardt 133
Abstract 133
1 Introduction 133
2 The plasmid encoded killer system from Kluyveromyces lactis 134
2.1 Plasmid structures, genome organizations, and gene functions 134
2.2 Molecular genetic manipulation, gene shuffles, and applications .. 135
3 The K. lactis zymocin complex 136
3.1 Zymocin subunit composition and biogenesis 136
3.2 Functional assignment of individual zymocin subunits 137
3.3 Autoimmunity of K. lactis zymocin producers 137
4 The zymocin response pathway of S. cerevisiae 138
4.1 Target yeast spectrum and anti proliferative effects 138
4.2 Zymocin sensitivity conferring genes and zymocin resistance 138
4.3 Zymocin docking and early response events 139
4.4 Toxin target capacity of the RNA polymerase II Elongator
complex 141
4.5 Other factors linked to Elongator s TOT function 142
4.6 Zymocin mode of action: a working model 144
5 Zymocin related yeast killer systems 145
6 Conclusions 146
Acknowledgements 147
References 148
The Ustilago maydis killer toxins 157
Jeremy Bruenn 157
Abstract 157
1 Introduction 157
2KP1 toxin 159
2.1 Synthesis 159
2.2 Structure, mechanism of action, and heterologous expression 159
3 KP4 toxin 160
3.1 Synthesis 160
3.2 Structure 160
3.3 Mechanism of action 162
3.4 Heterologous expression 164
4 KP6 toxin 165
4.1 Synthesis 165
4.2 Structure 166
4.3 Mechanism of action 167
4.4 Heterologous expression 168
5 Summary 168
References 169
Zygocin a monomeric protein toxin secreted by virus infected
Zygosaccharomyces bailli 175
Frank Weiler and Manfred J. Schmitt 175
Abstract 175
1 Zygocin is genetically encoded by a dsRNA killer virus 175
2 Zygocin is synthesized as an inactive precursor 177
3 Zygocin toxicity involves disruption of cellular integrity 179
4 Identification of host genes conferring zygocin resistance 181
5 Zygocin as novel antimycotic 183
Acknowledgements 184
References 184
Acidophilic structure and killing mechanism of the Pichia farinosa killer
toxin SMKT 189
Chise Suzuki 189
Abstract 189
1 Introduction 189
2 Properties of a halotolerant killer yeast, Pichia farinosa 190
3 SMKT with an acidophilic subunit structure 191
3.1 SMKT consists of two distinct subunits 191
3.2 SMKT preprotoxin encoded by the chromosomal gene and the
maturation process 192
3.3 Lethal effect of expression of SMK1 in S. cerevi.siae 193
3.4 Crystal structure of SMKT 194
3.5 Stable state and dissociation process of SMKT 197
4 P type ATPase SPF1 required for sensitivity to SMKT 199
4.1 SPF1 encoding a novel P type ATPase 199
4.2 Feature of type V P type ATPases 199
4.3 Localization of Spflp 200
4.4 Phenotypes of disruptants of SPF1 201
4.5 Comparison of intracellular roles of Spflp and Pmrlp 202
5 Killing and resistant mechanism of SMKT 204
5.1 SMKT interacts with the cell surface of resistant cells 204
5.2 Interaction of SMKT with cell membranes 205
6 Concluding remarks 208
Acknowledgements 209
References 209
Ricin: structure, synthesis, and mode of action 215
J. Michael Lord and Lynne M. Roberts 215
Abstract 215
1 Discovery 215
2 Ricin structure 216
3 Function of the ricin subunits 217
4 Ricin biosynthesis 218
5 Ricin intoxication of mammalian cells 221
5.1 Endocytosis to the Golgi 221
5.2 Golgi to ER transport 222
6 Membrane translocation of ricin 224
7 Concluding comments 226
References 227
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| indexdate | 2024-07-09T20:03:39Z |
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| isbn | 3540235620 |
| language | English |
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| physical | XIII, 237 S. |
| publishDate | 2005 |
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| series | Topics in Current Genetics |
| series2 | Topics in Current Genetics |
| spelling | Microbial protein toxins Manfred J. Schmitt... (Eds.) Berlin Springer 2005 XIII, 237 S. txt rdacontent n rdamedia nc rdacarrier Topics in Current Genetics 11 Bacterial Proteins Bacterial Toxins Fungal Proteins Microbial toxins Mycotoxins Toxins Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Proteintoxin (DE-588)4811458-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mikroorganismus (DE-588)4039226-0 s Proteintoxin (DE-588)4811458-3 s DE-604 Schmitt, Manfred Sonstige oth Topics in Current Genetics 11 (DE-604)BV035420113 11 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013008112&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Microbial protein toxins Topics in Current Genetics Bacterial Proteins Bacterial Toxins Fungal Proteins Microbial toxins Mycotoxins Toxins Mikroorganismus (DE-588)4039226-0 gnd Proteintoxin (DE-588)4811458-3 gnd |
| subject_GND | (DE-588)4039226-0 (DE-588)4811458-3 (DE-588)4143413-4 |
| title | Microbial protein toxins |
| title_auth | Microbial protein toxins |
| title_exact_search | Microbial protein toxins |
| title_full | Microbial protein toxins Manfred J. Schmitt... (Eds.) |
| title_fullStr | Microbial protein toxins Manfred J. Schmitt... (Eds.) |
| title_full_unstemmed | Microbial protein toxins Manfred J. Schmitt... (Eds.) |
| title_short | Microbial protein toxins |
| title_sort | microbial protein toxins |
| topic | Bacterial Proteins Bacterial Toxins Fungal Proteins Microbial toxins Mycotoxins Toxins Mikroorganismus (DE-588)4039226-0 gnd Proteintoxin (DE-588)4811458-3 gnd |
| topic_facet | Bacterial Proteins Bacterial Toxins Fungal Proteins Microbial toxins Mycotoxins Toxins Mikroorganismus Proteintoxin Aufsatzsammlung |
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