Dopamine:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2005
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Handbook of chemical neuroanatomy
21 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 588 S. Ill., graph. Darst. |
| ISBN: | 0444517782 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV019665233 | ||
| 003 | DE-604 | ||
| 005 | 20050203 | ||
| 007 | t | ||
| 008 | 050120s2005 ad|| |||| 00||| eng d | ||
| 020 | |a 0444517782 |9 0-444-51778-2 | ||
| 035 | |a (OCoLC)57318691 | ||
| 035 | |a (DE-599)BVBBV019665233 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 050 | 0 | |a QM451 | |
| 082 | 0 | |a 612.8042 |2 22 | |
| 245 | 1 | 0 | |a Dopamine |c Ed.: S. B. Dunnett ... |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2005 | |
| 300 | |a XIX, 588 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of chemical neuroanatomy |v 21 | |
| 650 | 4 | |a Dopamine | |
| 650 | 4 | |a Dopamine |x physiology | |
| 650 | 4 | |a Nervous System |x drug effects | |
| 700 | 1 | |a Dunnett, Stephen B. |e Sonstige |4 oth | |
| 830 | 0 | |a Handbook of chemical neuroanatomy |v 21 |w (DE-604)BV000213802 |9 21 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012993543&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-012993543 | ||
Datensatz im Suchindex
| _version_ | 1804133046377512960 |
|---|---|
| adam_text | Contents
List of Contributors v
Foreword by Paul Greengard vii
Preface jx
I. THE ORGANIZATION AND CIRCUITS OF MESENCEPHALIC
DOPAMINERGIC NEURONS AND THE DISTRIBUTION OF DOPAMINE
RECEPTORS IN THE BRAIN M. BENTIVOGLIO AND M. MORELLI 1
1. Introduction 1
1.1. The old and the recent tormented history of
the mesencephalic dopaminergic cell groups and
their projections 3
2. The dopaminergic neurons of the ventral midbrain tegmentum 7
2.1. Criteria of nomenclature and subdivision 7
2.2. Cytoarchitectonic subdivisions and neuronal features 9
2.2.1. Midbrain nuclei containing dopaminergic cells 9
2.2.2. Substantia nigra 11
2.2.3. Ventral tegmental area 17
2.3. A8, A9 and A10 cell groups 20
2.4. The dorsal and ventral tiers 21
2.5. Synaptic features: dendritic release of dopamine and electrical synapses 24
2.5.1. Dendrodendritic synaptic contacts 24
2.5.2. Connexin 36 expression in midbrain dopaminergic cells and
gap junctions 25
2.6. Glial cells inhabiting dopaminergic cell groups in the midbrain 26
3. Neurochemical features of the midbrain dopaminergic cell groups and
their inputs 28
3.1. A territory with a rich molecular repertoire and targeted by diverse
afferent inputs 28
3.2. Dopamine transporter 30
3.3. Calcium binding proteins 31
3.4. Neuropeptides 32
3.5. Orexin/hypocretin containing innervation of midbrain dopaminergic cell
groups and their involvement in state dependent behavior 33
3.6. Nitric oxide 35
3.7. Constitutive expression in midbrain dopaminergic neurons of molecules
implicated in neural immune interactions 36
4. Neural Wiring in the basal ganglia 38
4.1. Extrapyramidal system , and basal ganglia components 38
4.2. Overview of basal ganglia circuitry 40
4.3. The direct, indirect and hyperdirect pathways of basal ganglia
information processing 42
4.4. Descending efferents of the midbrain dopaminergic cell groups 44
xi
5. Dopaminergic innervation of the striatum 44
5.1. The striatum, striatal compartments and functional subdivisions 44
5.2. The nigrostriatal pathway 46
6. Dopamine modulation of basal ganglia relays 51
6.1. Dopamine modulation of striatal output through the direct and
indirect pathways 51
6.2. Dopaminergic innervation of the globus pallidus and
subthalamic nucleus 52
7. The ventral striatum and the mesolimbic system 52
7.1. The nucleus accumbens 52
7.2. Mesolimbic pathways and the ventral striatopallidal system 54
7.2.1. Dopaminergic innervation of the habenula 56
7.3. The concept of extended amygdala in information processing within
dopaminergic circuits 57
8. Dopaminergic innervation of the thalamus and cerebral cortex 59
8.1. Dopaminergic innervation of the thalamus 59
8.2. Dopaminergic innervation of the cortical mantle 60
8.3. Dopaminergic innervation of the hippocampus and of the
subependymal zone and role of dopaminergic projections in neural
precursor proliferation 64
9. Dopamine receptors: introductory remarks 66
9.1. Gradients of density 66
9.2. Subtypes of dopamine receptors 66
9.3. Receptor detection and its pitfalls 66
10. D| receptors 67
10.1. Overview of D! receptors 67
10.2. Di receptor distribution in the rat basal ganglia 68
10.3. Di receptor distribution in the rat cerebral cortex 71
10.4. Di receptor distribution in the rat limbic system 71
10.5. D( receptor distribution in the human and nonhuman primate brain 73
11. D2 receptors 74
11.1. Overview of D2 receptors 74
11.2. D2 receptor distribution in the rat basal ganglia 76
11.3. D2 receptor distribution in the rat cerebral cortex 77
11.4. D2 receptor distribution in the rat limbic system 77
11.5. D2 receptor distribution in the human and nonhuman primate brain 78
12. D3 receptors 79
12.1. Overview of D3 receptors 79
12.2. D3 receptor distribution in the rat basal ganglia 80
12.3. D3 receptor distribution in the rat limbic system 80
12.4. D3 receptor localization in the human and nonhuman primate brain 82
13. D4 receptors 83
13.1. Overview of D4 receptors 83
13.2. D4 receptor distribution in the basal ganglia 84
13.3. D4 receptor distribution in the cerebral cortex 84
13.4. D4 receptor distribution in the limbic system 84
13.5. D4 receptor localization in the human and nonhuman primate brain 86
14. D1B,5 receptors 86
14.1. Overview of D1B 5 receptors 86
14.2. Dib 5 receptor distribution in the basal ganglia 86
14.3. D1B 5 receptor distribution in the neocortex 88
14.4. D,B/5 receptor distribution in the limbic system 88
xii
15. Concluding remarks 88
16. Abbreviations 89
17. Acknowledgments 89
18. References 90
II. SIGNAL TRANSDUCTION OF DOPAMINE RECEPTORS D. HERVE
AND J. A. GIRAULT 109
1. Introduction 109
2. Historical elements 110
3. Signal transduction of Dl type receptors 111
3.1. Dl type receptor stimulation of cAMP pathways 111
3.1.1. Coupling by G proteins 111
3.1.2. cAMP production and degradation 113
3.1.3. cAMP dependent protein kinase 114
3.2. D1 controlled regulation of protein phosphatase 1 115
3.2.1. DARPP 32 115
3.2.2. Protein phosphatase 1 117
3.3. Target proteins for Dl receptor regulated cAMP pathway 117
3.3.1. cAMP dependent phosphoproteins in the striatum 117
3.3.2. Sodium channels 118
3.3.3. Calcium channels 118
3.3.4. AMPA type glutamate receptors 119
3.3.5. NMDA type glutamate receptors 119
3.3.6. GABAA receptors 119
3.3.7. Na+/K+ dependent ATPase 120
3.3.8. Modulation of excitability of striatal neurons by Dl receptor 120
3.4. Alternative signal transduction of Dl receptors 121
3.4.1. Coupling of Dl type receptors with Gi/o and Gq protein 121
3.4.2. Protein protein interactions of Dl type receptors 121
3.4.3. Novel intracellular signaling triggered by Dl type
receptor stimulation 123
3.5. Conclusion 123
4. Signal transduction of D2 type receptors 124
4.1. D2 receptors 124
4.1.1. Coupling with G proteins 124
4.1.2. Effects on adenylyl cyclase 124
4.1.3. Effects on potassium channels 125
4.1.4. Effects on intracellular calcium 126
4.1.5. D2 receptor mediated protein phosphorylation 126
4.1.6. Action of D2 receptor on lipid metabolism 127
4.1.7. Do the short and long isoforms of D2 receptor regulate
different signaling pathways ? 128
4.2. Signal transduction of D3 receptors 128
4.2.1. Coupling to G proteins 129
4.2.2. D3 receptor inhibition of cAMP signaling 129
4.2.3. Action of D3 receptors on ion channels 130
4.2.4. Effects of D3 receptor on cell proliferation and
Na+/H+ exchange 130
4.2.5. Conclusion 131
4.3. D4 receptors 131
xiii
5. Regulation of gene expression by dopamine receptor signaling 132
5.1. Significance of dopamine regulated gene expression 132
5.2. The dopamine regulated genes 133
5.3. Role of the cAMP pathway and CREB 133
5.4. AP 1 complex 134
5.5. Regulation of neuropeptides expression 135
6. Conclusions 136
7. Abbreviations 137
8. References 138
III. THE USE OF DOPAMINE RECEPTOR KNOCKOUT MICE IN
UNDERSTANDING BRAIN DOPAMINE NEUROTRANSMISSION
AND SPROUTING IN THE NIGROSTRIATAL PATHWAY M.K. HORNE,
J. DRAGO AND J. NUNAN 153
1. Dopamine and dopamine receptors in the central nervous system 153
1.1. Dj dopamine receptor 155
1.2. D, dopamine receptor knockout mice (D^ / )) 156
1.3. D2 dopamine receptor 161
1.4. D2 dopamine receptor knockout mice (D2R( / )) 162
1.5. D3 dopamine receptor 166
1.6. D3 dopamine receptor knockout mice (D3R( /—)) 166
1.7. D4 dopamine receptor 168
1.8. D4 dopamine receptor knockout mice (D4R( / )) 169
1.9. D5 dopamine receptor 170
1.10. D5 dopamine receptor knockout mice (D5R( /—)) 170
2. Sprouting of dopaminergic axons 171
2.1. The role of dopamine receptors in regulating sprouting of
dopaminergic axons 171
2.2. Is postinjury sprouting and sprouting in the intact animal mediated
by the same mechanism? 174
2.3. Time course of sprouting 175
2.4. What cellular elements sprout? 177
2.5. Do sprouted terminals function normally? 179
2.6. Functional implications of sprouting 182
3. Summary 183
4. Abbreviations 184
5. References 184
IV. STRUCTURAL AND FUNCTIONAL INTERACTIONS IN
THE STRIATUM AT THE RECEPTOR LEVEL JR. WICKENS
AND G.W. ARBUTHNOTT 199
1. Context 199
2. The nature of the dopamine signal 200
2.1. Spatial relationship between dopamine release sites and receptors 202
2.1.1. Distance between release sites 203
2.1.2. Subcellular localization of dopamine receptors 204
2.1.3. Dopamine receptor labeling in terminals presynaptic to !
asymmetrical synapses 204
2.1.4. Dopamine receptor labeling in terminals presynaptic to
symmetrical synapses 206
2.1.5. Subcellular distribution of dopamine receptor labeling in
the postsynaptic cell 206
2.2. Spatiotemporal distribution of dopamine 207
2.3. Dopamine neurone firing patterns and dopamine release 209
2.4. Affinities and potencies of different types of receptors 213
2.4.1. Colocalization of dopamine receptor subtypes 213
3. Physiological effects of dopamine 215
3.1. Dopamine modulation of ion channels 217
3.1.1. Synthesis of channel effects on whole cell behavior 220
3.2. Dopamine effects on synaptic transmission 221
3.3. Dopamine dependent plasticity of corticostriatal synapses 222
3.4. Structural plasticity 225
4. Synthesis and conclusions 226
5. References 227
V. MOTOR FUNCTION(S) OF THE NIGROSTRIATAL DOPAMINE SYSTEM:
STUDIES OF LESIONS AND BEHAVIOR SB. DUNNETT 237
1. Introduction: the classical models 237
2. Spontaneous motor effects of dopaminergic drugs 239
2.1. Antagonists: akinesia and catalepsy 239
2.2. Agonists: hyperactivity and stereotypy 241
3. Bilateral nigrostriatal lesions in rats 243
3.1. The lateral hypothalamic syndrome 243
3.2. Intraventricular/bilateral nigrostriatal 6 OHDA lesion syndrome 246
3.3. Plasticity and recovery of function 248
3.4. Neonatal 6 OHDA and recovery of function 251
4. Unilateral nigrostriatal lesions in rats 253
4.1. Stereotaxic 6 OHDA (and other) lesions 253
4.2. Rotation 254
4.3. Simple motor and sensorimotor tests 259
4.4. Skilled motor control 261
5. Other toxin models 266
5.1. MPTP in man, monkey and mouse 266
5.2. Methamphetamine toxicity 270
5.3. Other toxin models 272
6. Genetic models 272
6.1. Spontaneous mutations 272
6.2. Transgenics and knockouts 275
7. Summary and conclusions 279
8. References 279
VI. DOPAMINE, MOTIVATION AND REWARD G. DI CHIARA 303
1. Introduction 303
2. General outline 304
3. Anatomical background 304
4. Terminology 307
4.1. Motivation, rewards, incentives and reinforcers 307
4.2. Pavlovian incentive learning and responding 308
4.3. Instrumental learning and responding 309
5. Experimental studies on the role of DA in motivation: methodological
considerations 310
5.1. Dopamine, reward and hedonia 311
5.1.1. Testing the original anhedonia hypothesis 313
5.1.2. The role of performance impairment 315
5.1.3. Testing the effect of DA receptor blockers in their absence 315
5.2. Dopamine and incentive motivation 317
5.2.1. Dopamine and the expression of incentive motivation 318
5.2.2. Dopamine and the acquisition of incentive motivation 326
5.3. N. Accumbens shell dopamine and the utilization of spatial memory for
goal oriented behavior 335
5.4. N. Accumbens core dopamine and acquisition of
instrumental responding 336
5.5. Dissociable functions of DA in the N. Accumbens core and shell in
instrumental responding for food 337
5.6. Dopamine and drug reward and reinforcement 337
5.6.1. Interpretation of changes in rates of drug self administration 338
5.6.2. Psychostimulant self administration 338
5.6.3. Opiate self administration 339
5.6.4. Nicotine self administration 340
5.6.5. Ethanol self administration 341
5.6.6. Role of dopamine in psychostimulant versus conventional and
non psychostimulant reinforcement 342
6. In vivo, monitoring of dopamine function: methodological issues 345
6.1. Stimulus response properties of dopamine neurons and dopamine
transmission 348
6.1.1. Dopamine transmission and aversive stimulation 350
6.1.2. Dopamine release in the N. Accumbens by conditioned stimuli 351
6.2. Drug motivated behavior: correlative studies 354
6.2.1. Microdialysis studies 354
6.2.2. In vivo monitoring of dopamine transmission
by electrochemistry during drug self administration 360
7. Drugs surrogates of natural rewards? 361
8. Dopamine and dependence theories of drug addiction 362
9. Nonincentive accounts of drug addiction 363
10. Drug addiction as abnormal motivation 364
10.1. Dopamine and the expression of drug addiction 365
10.1.1. Sensitization of drug induced activation of DA transmission:
the incentive sensitization theory 365
10.1.2. Does behavioral sensitization takes place in human addiction? 367
10.2. Dopamine and the acquisition of drug addiction: the Pavlovian incentive
learning hypothesis 368
11. A general theory of abnormal motivation as disadaptive responsiveness
of NAc shell DA 371
12. Conclusion 372
13. Abbreviations 373
14. Acknowledgments 373
15. References 373
VII. ROLE OF CORTICAL AND STRIATAL DOPAMINE IN
COGNITIVE FUNCTION T.W. ROBBINS 395
1. Introduction 395
2. A role for DA in learning and memory 396
2.1. Electrophysiological evidence 396
2.2. Neuropharmacological evidence: neurochemical monitoring 398
2.3. Psychopharmacological evidence 400
3. Role of DA in attention 403
3.1. Psychopharmacological evidence 403
3.2. Models of attention deficit and hyperactivity deficit (ADHD) 409
4. Working memory 409
4.1. Psychopharmacological evidence 410
4.2. Evolving interpretations of the role of the PFC in working memory: the
Yerkes Dodson principle 412
5. DA and cognition in humans 416
5.1. DA and cognition in clinical disorders 416
5.1.1. Parkinson s disease 416
5.1.2. Acute brain injury 418
5.1.3. Schizophrenia 419
5.1.4. Attention deficit/hyperactivity disorder 419
5.2. Effects of DA ergic drugs on cognition in normal human volunteers 420
6. Current foci and future directions 422
6.1. Cellular accounts of prefrontal DA function: electrophysiology and
computational modeling 423
6.2. Prefrontal DA and functional genomics 424
6.3. Interactions with other systems within the prefrontal cortex 425
7. Acknowledgments 426
8. References 426
VIII. FUNCTIONAL NEUROANATOMY OF HYPOTHALAMIC
DOPAMINERGIC NEUROENDOCRINE SYSTEMS K.J. LOOKINGLAND
AND K.E. MOORE 435
1. Introduction 435
2. Anatomy of diencephalic DA neuronal systems 436
2.1. Ontogeny of diencephalic DA neurons 438
2.2. Distribution of DA neurons in the diencephalon 439
2.2.1. Tuberoinfundibular DA neurons (A12) 439
2.2.2. Incertohypothalamic DA neurons (An) 441
2.2.3. Periventicular hypophysial (tuberohypophysial) DA neurons (A,4) 442
2.2.4. Periventricular hypothalamic DA neurons (A]4) 442
2.2.5. Ventrolateral hypothalamic DA neurons (A,5) 443
2.3. Diencephalic DA neurons and aging 444
3. Neurochemical and molecular characteristics of diencephalic DA neurons 445
3.1. Neurochemical events associated with DA synthesis, release and metabolism
in axon terminals of diencephalic DA neurons 445
3.2. Neurochemical estimation of the activity of diencephalic DA neurons 447
3.3. Molecular events associated with synthesis of tyrosine hydroxylase in
perikarya of diencephalic DA neurons 449
3.4. DA receptor mediated regulation of diencephalic DA neurons 451
4. DA regulation of pituitary hormone secretion 452
4.1. Direct action of DA on hormone secreting cells in the pituitary 452
4.1.1. Prolactin 453
4.1.2. ttMSH and/3 endorphin 454
4.1.3. Vasopressin and oxytocin 455
4.2. Indirect action of DA via hypothalamic neurosecretory neurons 458
4.2.1. Gonadotropins 458
4.2.2. Growth hormone 459
4.2.3. Thyrotropin 462
4.2.4. Adrenocorticotropin 464
5. Hormonal regulation of diencephalic DA neurons 465
5.1. Prolactin 466
5.1.1. Localization of prolactin receptors 466
5.1.2. Neurotrophic effects of prolactin on TIDA neuronal development 467
5.1.3. Prolactin feedback regulation of TIDA neuronal activity 468
5.1.4. Prolactin regulation of tyrosine hydroxylase in TIDA neurons 469
5.2. Sexual differences in the activity of diencephalic DA neurons 470
5.2.1. Estrogen 471
5.2.2. Androgens 472
6. Neuronal regulation of diencephalic DA neurons 472
6.1. Stimulatory neurotransmitters 473
6.1.1. Neurotensin 473
6.1.2. Bombesin and related peptides 477
6.1.3. Excitatory amino acids 480
6.2. Inhibitory neurotransmitters 481
6.2.1. Mu opioids 481
6.2.2. Kappa opioids 482
6.2.3. Delta opioids 484
6.2.4. GABA 486
7. Role of diencephalic DA neurons in the regulation of prolactin
secretion under various physiological states 488
7.1. Photoperiod 489
7.2. Estrous cycle 490
7.3. Pregnancy 491
7.4. Lactation 492
7.5. Stress 493
8. Summary and conclusions 494
9. Abbreviations 496
10. References 497
IX. HUMAN FOREBRAIN DOPAMINE SYSTEMS: CHARACTERIZATION
OF THE NORMAL BRAIN AND IN RELATION TO PSYCHIATRIC
DISORDERS Y.L. HURD AND H. HALL 525
1. Introduction 525
2. Anatomical organization of dopamine systems in the normal human brain 526
2.1. Dopamine synthesis/dopamine neurons 526
2.2. Dopamine pathways 529
2.3. Dopamine receptors 535
2.3.1. Dopamine Di receptor mRNA expression 535
2.3.2. Dopamine Dt receptor protein 539
2.3.3. Dopamine D2 receptor mRNA expression 540
2.3.4. Dopamine D2 receptor protein 541
2.3.5. Dopamine D3 mRNA expression 542
2.3.6. Dopamine D3 receptor protein 543
2.3.7. Dopamine D4 mRNA expression 544
2.3.8. Dopamine D4 receptor protein 544
2.3.9. Dopamine D5 mRNA expression 545
2.3.10. Dopamine D5 receptor protein 545
2.4. Dopamine transporters 546
2.4.1. DAT mRNA expression 546
2.4.2. DAT protein 546
3. The role of the dopamine system in addiction and psychiatric disorders 548
3.1. Dopamine systems in psychostimulant addiction 548
3.1.1. In vivo characterization 548
3.1.2. Postmortem characterization 552
3.2. Dopamine systems in schizophrenia 554
3.3. Dopamine systems in affective disorders 556
4. Conclusions 557
5. Acknowledgments 559
6. References 559
Subject Index 573
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV019665233 |
| callnumber-first | Q - Science |
| callnumber-label | QM451 |
| callnumber-raw | QM451 |
| callnumber-search | QM451 |
| callnumber-sort | QM 3451 |
| callnumber-subject | QM - Human Anatomy |
| ctrlnum | (OCoLC)57318691 (DE-599)BVBBV019665233 |
| dewey-full | 612.8042 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8042 |
| dewey-search | 612.8042 |
| dewey-sort | 3612.8042 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01257nam a2200361 cb4500</leader><controlfield tag="001">BV019665233</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20050203 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">050120s2005 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0444517782</subfield><subfield code="9">0-444-51778-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)57318691</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV019665233</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QM451</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612.8042</subfield><subfield code="2">22</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Dopamine</subfield><subfield code="c">Ed.: S. B. Dunnett ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Amsterdam [u.a.]</subfield><subfield code="b">Elsevier</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIX, 588 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Handbook of chemical neuroanatomy</subfield><subfield code="v">21</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dopamine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dopamine</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nervous System</subfield><subfield code="x">drug effects</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dunnett, Stephen B.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Handbook of chemical neuroanatomy</subfield><subfield code="v">21</subfield><subfield code="w">(DE-604)BV000213802</subfield><subfield code="9">21</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012993543&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-012993543</subfield></datafield></record></collection> |
| id | DE-604.BV019665233 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:02:29Z |
| institution | BVB |
| isbn | 0444517782 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012993543 |
| oclc_num | 57318691 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XIX, 588 S. Ill., graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Elsevier |
| record_format | marc |
| series | Handbook of chemical neuroanatomy |
| series2 | Handbook of chemical neuroanatomy |
| spelling | Dopamine Ed.: S. B. Dunnett ... 1. ed. Amsterdam [u.a.] Elsevier 2005 XIX, 588 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of chemical neuroanatomy 21 Dopamine Dopamine physiology Nervous System drug effects Dunnett, Stephen B. Sonstige oth Handbook of chemical neuroanatomy 21 (DE-604)BV000213802 21 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012993543&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dopamine Handbook of chemical neuroanatomy Dopamine Dopamine physiology Nervous System drug effects |
| title | Dopamine |
| title_auth | Dopamine |
| title_exact_search | Dopamine |
| title_full | Dopamine Ed.: S. B. Dunnett ... |
| title_fullStr | Dopamine Ed.: S. B. Dunnett ... |
| title_full_unstemmed | Dopamine Ed.: S. B. Dunnett ... |
| title_short | Dopamine |
| title_sort | dopamine |
| topic | Dopamine Dopamine physiology Nervous System drug effects |
| topic_facet | Dopamine Dopamine physiology Nervous System drug effects |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012993543&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000213802 |
| work_keys_str_mv | AT dunnettstephenb dopamine |