Chronotherapeutics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Pharmaceutical Press
2003
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 426 S. Ill., graph. Darst. |
| ISBN: | 0853694885 |
Internformat
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| 245 | 1 | 0 | |a Chronotherapeutics |c ed. by Peter Redfern |
| 264 | 1 | |a London [u.a.] |b Pharmaceutical Press |c 2003 | |
| 300 | |a XVII, 426 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Chronopharmacology | |
| 650 | 4 | |a Chronotherapie | |
| 650 | 4 | |a Clinical chronobiology | |
| 700 | 1 | |a Redfern, Peter H. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804133034911334400 |
|---|---|
| adam_text | CHRONOTHERAPEUTICS EDITED BY PETER REDFERN BPHARM, PHD, DSC, FRPHARMS
PROFESSOR OF PHARMACOLOGY DEPARTMENT OF PHARMACY AND PHARMACOLOGY,
UNIVERSITY OF BATH, UK (RP) LONDON. CHICAGO PHARMACEUTICAL PRESS
CONTENTS PREFACE XII ABOUT THE EDITOR XIV CONTRIBUTORS XV AN
INTRODUCTION TO CIRCADIAN RHYTHMS AND THEIR MEASUREMENT IN HUMANS 1 1.1
CONSTANCY AND RHYTHMICITY 1 1.2 ENDOGENOUS AND EXOGENOUS COMPONENTS OF A
RHYTHM 3 1.2.1 CONSTANT ROUTINES 3 1.2.2 FRACTIONAL DESYNCHRONISATION 5
1.2.3 DIFFERENCES BETWEEN VARIABLES IN THE NATURE AND STRENGTH OF THEIR
EXOGENOUS COMPONENT 6 1.2.4 VARIANTS OF CONSTANT ROUTINES 7 1.3 SOME
PROPERTIES OF THE BODY CLOCK IN HUMANS 8 1.3.1 FREE-RUNNING RHYTHMS 8
1.3.2 ZEITGEBERS IN HUMANS 9 1.4 WIDESPREAD EFFECTS OF THE BODY CLOCK 11
1.4.1 METABOLISM 12 1.4.2 MENTAL AND PHYSICAL PERFORMANCE 12 1.4.3 SLEEP
15 1.5 FIELD STUDIES 16 1.5.1 PROBLEMS WITH CONSTANT ROUTINES AND THE
FORCED DESYNCHRONISATION PROTOCOLS 16 1.5.2 THE CHOICE OF A MARKER FOR
FIELD STUDIES 16 1.5.3 PURIFYING FIELD DATA 19 1.6 SUMMARY 27
ACKNOWLEDGEMENTS 27 REFERENCES 28 THE BIOLOGICAL CLOCK: LOCATION,
NEUROANATOMY AND NEUROCHEMISTRY 31 2.1 INTRODUCTION: THE CIRCADIAN
TIMING SYSTEM 31 2.2 THE SUPRACHIASMATIC NUCLEI (SCN) 32 2.2.1 SCN
NEUROCHEMISTRY 32 2.3 CLOCK INPUTS 32 VI CONTENTS 2.3.1 THE
RETINOHYPOTHALAMIC TRACT (RHT) 33 2.3.2 THE GENICULOHYPOTHALAMIC TRACT
(GHT) 36 2.3.3 THE RAPHE-HYPOTHALAMIC TRACT (RAHT) 39 2.3.4 CONVERGING
PHOTIC AND NONPHOTIC SIGNALS 41 2.4 CLOCK OUTPUTS 41 2.5 COMMENT 45
REFERENCES 45 THE MOLECULAR BIOLOGY OF THE MAMMALIAN CIRCADIAN CLOCK 53
3.1 INTRODUCTION 53 3.2 MOLECULAR ASPECTS OF THE CIRCADIAN CLOCK 54 3.3
WHICH PHOTOPIGMENT IS MEDIATING CIRCADIAN PHOTORECEPTION? 63 3.4 ROLE OF
CLOCK GENES IN PERIPHERAL TISSUES 65 3.5 RELEVANCE OF THE MOLECULAR
CLOCK MECHANISM TO HUMAN BIOLOGY 68 3.6 CONCLUSION 69 ACKNOWLEDGEMENTS
69 REFERENCES 69 RHYTHMS AND PHARMACOKINETICS 75 4.1 INTRODUCTION AND
OBJECTIVES 75 4.2 RHYTHMS IN PHARMACOKINETICS 76 4.2.1
CHRONOPHARMACOKINETIC STUDIES IN HUMANS 76 4.2.2 RHYTHMS,
PHYSICOCHEMICAL PROPERTIES AND FORMULATION OF DRUGS 85 4.2.3 RHYTHMS AND
ROUTES OF DRUG ADMINISTRATION 86 4.3 MECHANISMS OF
CHRONOPHARMACOKINETICS 88 4.3.1 RHYTHMS IN DRUG ABSORPTION 88 4.3.2
RHYTHMS IN DRUG DISTRIBUTION 90 4.3.3 RHYTHMS IN HEPATIC DRUG METABOLISM
94 4.3.4 RHYTHMS IN DRUG EXCRETION 100 4.4 CONCLUSIONS 103 REFERENCES
103 RHYTHMS AND PHARMACODYNAMICS 111 5.1 PRINCIPLES OF DRUG ACTION 111
5.2 RHYTHMS IN RECEPTORS AND THEIR SIGNALLING PATHWAYS 111 5.2.1 PI-AD
RE NO RECEPTORS IN THE HEART 111 5.2.2 P-ADRENORECEPTORS IN THE CNS 116
5.2.3 5-HT-RECEPTOR SUBTYPES IN THE CNS 116 5.3 RHYTHMS IN ENZYME
SYSTEMS 117 5.3.1 THE RENIN-ANGIOTENSIN SYSTEM 117 5.3.2 THE NITRIC
OXIDE-CYCLIC GMP SYSTEM 11 8 5.3.3 THE SYNTHESIS OF CHOLESTEROL 120
CONTENTS VII 5.4 RHYTHMS IN ION CHANNEL ACTIVITY 121 5.5 SUMMARY AND
CONCLUSIONS 122 ACKNOWLEDGEMENTS 123 REFERENCES 123 RHYTHMS AND
THERAPEUTICS OF DISEASES OF THE GASTROINTESTINAL TRACT 127 6.1
INTRODUCTION 127 6.2 GASTROINTESTINAL MOTILITY RHYTHMS 127 6.2.1
PHARMACOLOGICAL AND THERAPEUTIC IMPLICATIONS 130 6.2.2 OTHER RHYTHMS
INFLUENCING DRUG BIOAVAILABILITY 131 6.3 RHYTHMS IN GASTRIC ACID
SECRETION 134 6.3.1 PHARMACOLOGICAL IMPLICATIONS 138 6.3.2 THERAPEUTIC
IMPLICATIONS 143 6.4 SEASONAL RHYTHMS IN PEPTIC ULCER DISEASE 144 6.5
RHYTHMS IN GASTRIC MUCOSAL DEFENCE 145 ACKNOWLEDGEMENTS 147 REFERENCES
148 RHYTHMS AND THERAPEUTICS OF ASTHMA 153 7.1 INTRODUCTION 153 7.2
CHRONOBIOLOGY OF ASTHMA 154 7.2.1 CIRCADIAN VARIATION IN LUNG FUNCTION
154 7.2.2 MECHANISMS OF NOCTURNAL WORSENING OF ASTHMA 159 7.3
CHRONOTHERAPEUTIC APPROACH TO ASTHMA TREATMENT 167 7.3.1 THEOPHYLLINE
169 7.3.2 ORAL P2 A DRENORECEPTOR AGONISTS 171 7.3.3 INHALED
P2-ADRENORECEPTOR AGONISTS 172 7.3.4 ORAL AND INHALED CORTICOSTEROIDS
176 7.3.5 LEUKOTRIENE MODIFIERS 182 7.3.6 SODIUM CROMOGLICATE AND
NEDOCROMIL 184 7.3.7 ACETYLCHOLINE MUSCARINIC RECEPTOR (ACH MR)
ANTAGONISTS 184 7.4 SUMMARY 185 REFERENCES 185 RHYTHMS IN THERAPEUTICS
OF CARDIOVASCULAR DISEASE 193 8.1 INTRODUCTION 193 8.1.1 CHRONOBIOLOGY
OF THE CARDIOVASCULAR SYSTEM 193 8.1.2 RHYTHMS IN CARDIOVASCULAR EVENTS
194 8.2 CHRONOPHARMACOLOGY OF HYPERTENSION 195 8.2.1 (3-ADRENORECEPTOR
ANTAGONISTS 195 8.2.2 CALCIUM CHANNEL BLOCKERS 196 8.2.3
ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS 198 VIII CONTENTS 8.2.4
OTHER ANTIHYPERTENSIVES 200 8.2.5 DURATION OF THE ANTIHYPERTENSIVE
EFFECT 202 8.3 CHRONOPHARMACOLOGY OF CORONARY HEART DISEASE 202 8.3.1
ORAL NITRATES 202 8.3.2 P-ADRENORECEPTOR ANTAGONISTS 203 8.3.3 CALCIUM
CHANNEL BLOCKERS 205 8.4 SUMMARY 205 REFERENCES 206 9 RHYTHMS, PAIN AND
PAIN MANAGEMENT 211 9.1 INTRODUCTION 211 9.2 CHRONOBIOLOGY OF PAIN 212
9.2.1 RHYTHMS IN ENDOGENOUS OPIOID PEPTIDE LEVELS 212 9.2.2 RHYTHMS IN
EXPERIMENTAL PAIN 213 9.2.3 PAIN RHYTHMS IN CLINICAL SITUATIONS 213 9.3
CHRONOPHARMACOLOGY OF ANALGESICS 219 9.3.1 LOCAL ANAESTHETICS 219 9.3.2
ANTI-INFLAMMATORY AGENTS 221 9.3.3 OPIOID ANALGESICS 224 9.3.4 PLACEBO
228 9.4 GUIDELINES FOR CHRONOTHERAPEUTIC USE 228 9.5 CONCLUSIONS 229
REFERENCES 230 10 RHYTHMS OF CANCER CHEMOTHERAPY 235 10.1 INTRODUCTION
235 10.2 GENETIC AND MOLECULAR BIOLOGY 235 10.3 CIRCADIAN COORDINATION,
CARCINOGENESIS AND TUMOUR OUTCOME 238 10.4 BIOLOGICAL RHYTHMS IN HOST
AND/OR TUMOURS 240 T 0.4.1 ANIMAL DATA 240 10.4.2 HUMAN DATA 243 10.5
CHRONOTOXICITY AND CHRONOPHARMACOLOGY IN ANIMALS 245 10.5.1
CHRONOPHARMACOLOGY OF SINGLE AGENTS 245 10.5.2 CHRONOPHARMACOLOGY OF
COMBINATION TREATMENT 250 10.6 CHRONOTOXICITY AND CHRONOPHARMACOLOGY IN
HUMANS 251 10.6.1 FLUOROPYRIMIDINE DERIVATIVES 251 10.6.2 OTHER DRUGS
261 10.7 DISRUPTION OF SPONTANEOUS RHYTHMICITY OF THE HOST WITH TUMOUR
DEVELOPMENT OR TUMOUR TREATMENT 262 10.7.1 INFLUENCE OF TUMOUR
DEVELOPMENT ON HOST CIRCADIAN RHYTHMICITY 262 10.7.2 INFLUENCE OF
ANTICANCER TREATMENT ON HOST CIRCADIAN RHYTHMICITY 264 CONTENTS IX 10.8
CHRONOEFFICACY 265 10.8.1 ANIMAL DATA 265 10.8.2 HUMAN DATA 268 10.8.3
ORGANISATION OF CHRONOTHERAPY CENTRES WITHIN THE EORTC CHRONOTHERAPY
GROUP 271 10.9 CONCLUSION 273 REFERENCES 274 11 CHRONOPHARMACEUTICAL
DRUG DELIVERY 283 11.1 INTRODUCTION 283 11.2 TIME-DELAYED TABLET
FORMULATIONS 285 11.2.1 OSMOTIC CONTROL 285 1 1.2.2 GELLABLE BARRIER
LAYERS USING HYDROPHILIC POLYMERS 287 11.2.3 ERODIBLE BARRIER LAYERS 289
11.2.4 TABLETS THAT RUPTURE 290 11.2.5 THREE-DIMENSIONAL PRINTING
TECHNIQUES 291 11.3 TIME-DELAYED PELLET FORMULATIONS 291 1 1.3.1 PELLET
FORMULATION WITH A SIGMOIDAL RELEASE PROFILE 291 11.3.2 PELLETS THAT
RUPTURE 292 11.4 TIME-DELAYED CAPSULE FORMULATIONS 293 11.4.1 PLUG
SEPARATION FROM PERMEABLE CAPSULES 293 11.4.2 IMPERMEABLE CAPSULES WITH
SEPARABLE COMPONENTS 295 11.4.3 IMPERMEABLE CAPSULES FITTED WITH
ERODIBLE PLUGS 297 11.4.4 PRESSURE-CONTROLLED SYSTEMS 300 11.4.5
HYDROPHILIC SANDWICH CAPSULE 300 11.5 THE POTENTIAL USE OF PH-BASED
SYSTEMS USING GASTRORESISTANT COATINGS 302 11.6 CONCLUSIONS 303
REFERENCES 303 12 CIRCADIAN RHYTHM ABNORMALITIES 309 12.1 NORMAL
VARIATIONS IN THE PHASE OF CIRCADIAN RHYTHMS 309 12.2 ABNORMAL
VARIATIONS IN THE PHASE OF CIRCADIAN RHYTHMS 312 12.3 OCCUPATIONAL
HEALTH AND LONG-HAUL TRAVELLERS; JET LAG 314 12.3.1 DIFFERENCES BETWEEN
INDIVIDUALS 315 12.4 OCCUPATIONAL HEALTH AND NIGHT WORKERS;
SHIFT-WORKERS MALAISE 317 12.4.1 ACCIDENTS AND SHORT-TERM EFFECTS 318
12.4.2 LONG-TERM EFFECTS 319 12.4.3 DIFFERENCES BETWEEN INDIVIDUALS 320
12.4.4 ADJUSTMENT OF THE BODY CLOCK 321 X CONTENTS 12.5 TREATMENT OF
CIRCADIAN RHYTHM DISORDERS 323 12.5.1 TREATMENT OF JET LAG 323 12.5.2
TREATMENT OF SHIFT-WORKERS MALAISE 329 12.5.3 TREATMENT OF CLINICAL
PROBLEMS ASSOCIATED WITH CIRCADIAN RHYTHM DISORDERS 331 12.6 SUMMARY 336
ACKNOWLEDGEMENTS 337 REFERENCES 337 13 DRUG EFFECTS ON SUPRACHIASMATIC
NUCLEI FUNCTION 343 13.1 INTRODUCTION 343 13.1.1 WHAT ARE THE
CHALLENGES? 344 13.1.2 INNERVATION OF THE SCN 344 13.1.3 GENERATION OF
THE ENDOGENOUS PERIOD 345 13.1.4 RHYTHM AMPLITUDE 346 13.1.5 PHASE
RESPONSE 346 13.2 METHODOLOGY 347 13.2.1 IN VITRO METHODOLOGY 347 13.2.2
IN VIVO METHODOLOGY 348 13.2.3 SCN C-FOS INDUCTION 350 13.3
NEUROTRANSMITTER AND DRUG EFFECTS ON RHYTHMS 350 13.3.1 EXCITATORY AMINO
ACIDS 350 13.3.2 SEROTONIN 352 13.3.3 GABA 357 13.3.4 MELATONIN 358
13.3.5 ACETYLCHOLINE 359 13.3.6 PURINERGIC 359 13.3.7 HISTAMINE 360
13.3.8 DOPAMINE 361 13.4 CONCLUSION 361 ACKNOWLEDGEMENTS 362 REFERENCES
362 14 THE EFFECT OF AGEING ON MELATONIN SECRETION: CLINICAL ASPECTS 36
9 14.1 MELATONIN SECRETION AND CONTROL 369 14.1.1 SYNTHESIS 369 14.1.2
NORADRENERGIC CONTROL 369 14.1.3 LIGHT CONTROL 371 14.1.4 CIRCADIAN
RHYTHM 371 14.1.5 METABOLISM 372 14.2 PHARMACOKINETICS AND TOXIC EFFECTS
372 14.3 MELATONIN AND AGEING: PHYSIOLOGICAL EFFECTS 374 14.3.1 FETAL
PERIOD AND INFANCY 374 14.3.2 MELATONIN IN THE ELDERLY 374 CONTENTS XI
14.4 EFFECTS OF MELATONIN ON SLEEP 381 14.5 MELATONIN AS A
RESYNCHRONISING AGENT 383 14.6 MELATONIN AS A FREE-RADICAL SCAVENGER 384
14.7 CONCLUSION 385 REFERENCES 386 15 CHRONOBIOLOGICAL MECHANISMS IN
SEASONAL AFFECTIVE DISORDER 393 15.1 INTRODUCTION 393 15.2 DIAGNOSIS OF
SAD AND LIGHT THERAPY 393 15.3 BIOLOGICAL RHYTHMS IN SAD 396 15.3.1
SEASONALITY AND BRAIN SEROTONIN FUNCTION 396 15.3.2 PHOTOPERIOD AND
MELATONIN SECRETION 399 15.3.3 CIRCADIAN PHASE SHIFT 400 15.4 CONCLUSION
403 ACKNOWLEDGEMENT 403 REFERENCES 403 INDEX 409
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| isbn | 0853694885 |
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| physical | XVII, 426 S. Ill., graph. Darst. |
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| spelling | Chronotherapeutics ed. by Peter Redfern London [u.a.] Pharmaceutical Press 2003 XVII, 426 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chronopharmacology Chronotherapie Clinical chronobiology Redfern, Peter H. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012985493&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chronotherapeutics Chronopharmacology Chronotherapie Clinical chronobiology |
| title | Chronotherapeutics |
| title_auth | Chronotherapeutics |
| title_exact_search | Chronotherapeutics |
| title_full | Chronotherapeutics ed. by Peter Redfern |
| title_fullStr | Chronotherapeutics ed. by Peter Redfern |
| title_full_unstemmed | Chronotherapeutics ed. by Peter Redfern |
| title_short | Chronotherapeutics |
| title_sort | chronotherapeutics |
| topic | Chronopharmacology Chronotherapie Clinical chronobiology |
| topic_facet | Chronopharmacology Chronotherapie Clinical chronobiology |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012985493&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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