In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten: = In vivo antisense targeting on vasopressin mRNA in rats
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2003
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Text engl. - Jena, Univ., Diss., 2003 (Nicht für den Austausch) |
| Beschreibung: | VI, 63 Bl. Ill., graph. Darst. : 30 cm |
Internformat
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| 100 | 1 | |a Telleria Diaz, Alejandro |d 1969- |e Verfasser |0 (DE-588)12491165X |4 aut | |
| 245 | 1 | 0 | |a In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten |b = In vivo antisense targeting on vasopressin mRNA in rats |c von Alejandro Tellería Díaz |
| 246 | 1 | 1 | |a In vivo antisense targeting on vasopressin mRNA in rats |
| 264 | 1 | |c 2003 | |
| 300 | |a VI, 63 Bl. |b Ill., graph. Darst. : 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Text engl. - Jena, Univ., Diss., 2003 (Nicht für den Austausch) | ||
| 650 | 4 | |a Antisense-Oligonucleotide | |
| 650 | 4 | |a Genexpression | |
| 650 | 4 | |a Hochschulschrift | |
| 650 | 4 | |a Tierversuch | |
| 650 | 4 | |a Vasopressin | |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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Datensatz im Suchindex
| _version_ | 1816445303508697088 |
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TABLE OF CONTENTS
1. INTRODUCTION 1
1.1 THE ANTISENSE CONCEPT 2
1.2 UPTAKE AND INTRACELLULAR FATE OF ANTISENSE ODNS 4
1.3 PHARMACOKINETICS OF ANTISENSE ODNS 6
1.4 MECHANISM OF ACTION OF THE ANTISENSE ODNS 7
1.5 DESIGN OF ANTISENSE AGENTS AND TARGET SELECTION 10
1.6 TOXICOLOGICAL PROPERTIES OF THE ODNS 11
1.7 PROSPECTS FOR THE FUTURE 12
1.8 THE MAGNOCELLULAR NEURONS OF THE HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM
AS STANDARD
MODEL FOR THE STUDY OF NEUROPEPTIDERGIC SYSTEMS 13
1.9 THE HNS. ANATOMICAL AND PHYSIOLOGICAL REMARKS ON THE
VASOPRESSINERGIC SYSTEM 14
1.9.1 MORPHOLOGICAL ASPECTS OF THE SON AND THE PVN IN THE RAT
HYPOTHALAMUS 18
1.10 AIMS OF THE PRESENT STUDY 20
2. MATER IAL AND METHODS 21
2.1 ANIMALS AND HOUSING CONDITIONS 21
2.2 SURGERY 21
2.3 ANTISENSE OLIGO 22
2.4 INTRACEREBROVENTRICULAR INFUSIONS 22
2.5 WATER CONSUMPTION AND URINE OSMOLALITY ASSESSMENT 23
2.6 BLOOD COLLECTION FOR VASOPRESSIN DETERMINATION IN PLASMA 23
2.7 IMMUNOCYTOCHEMISTRY 24
2.7 STATISTICAL ANALYSIS 25
V
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/968875246
3. RESULTS
27
3.1 WATER CONSUMPTION AND URINE OSMOLALITY 27
3.2 VASOPRESSIN BLOOD LEVELS 27
3.3 IMMUNOCYTOCHEMISTRY 29
3.3.1 VASOPRESSIN IMMUNOSTAINING 29
3.3.2 OXYTOCIN IMMUNOFLUORESCENCE AND COLOCALIZATION OF VP AND OT 29
3.3.3 VP AND OT IN THE POSTERIOR LOBE 30
4. DISCUSION 37
4.1. BEHAVIORAL EFFECTS OF ANTISENSE TARGETING ON VP MRNA EXPRESSION 37
4.2. THE PHENOMENA OF VP AND OT COLOCALIZATION IN THE HNS 38
4.3. CONCLUSIONS 42
5. ZUSAMMEN.-ASSUNG 44
6. SUMMARY 45
PREFERENCES 46
8. ACKNOWLEDGMENTS
9. EHRENWORTLICHE ERKLARUNG
10. CURRICULUM VITAE
VI |
| any_adam_object | 1 |
| author | Telleria Diaz, Alejandro 1969- |
| author_GND | (DE-588)12491165X |
| author_facet | Telleria Diaz, Alejandro 1969- |
| author_role | aut |
| author_sort | Telleria Diaz, Alejandro 1969- |
| author_variant | d a t da dat |
| building | Verbundindex |
| bvnumber | BV019648441 |
| ctrlnum | (OCoLC)248979374 (DE-599)BVBBV019648441 |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV019648441 |
| illustrated | Illustrated |
| indexdate | 2024-11-22T17:40:31Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012977157 |
| oclc_num | 248979374 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | VI, 63 Bl. Ill., graph. Darst. : 30 cm |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
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| spelling | Telleria Diaz, Alejandro 1969- Verfasser (DE-588)12491165X aut In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats von Alejandro Tellería Díaz In vivo antisense targeting on vasopressin mRNA in rats 2003 VI, 63 Bl. Ill., graph. Darst. : 30 cm txt rdacontent n rdamedia nc rdacarrier Text engl. - Jena, Univ., Diss., 2003 (Nicht für den Austausch) Antisense-Oligonucleotide Genexpression Hochschulschrift Tierversuch Vasopressin (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012977157&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Telleria Diaz, Alejandro 1969- In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats Antisense-Oligonucleotide Genexpression Hochschulschrift Tierversuch Vasopressin |
| subject_GND | (DE-588)4113937-9 |
| title | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats |
| title_alt | In vivo antisense targeting on vasopressin mRNA in rats |
| title_auth | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats |
| title_exact_search | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats |
| title_full | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats von Alejandro Tellería Díaz |
| title_fullStr | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats von Alejandro Tellería Díaz |
| title_full_unstemmed | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten = In vivo antisense targeting on vasopressin mRNA in rats von Alejandro Tellería Díaz |
| title_short | In-vivo-antisense-Targeting von Vasopressin mRNA in Ratten |
| title_sort | in vivo antisense targeting von vasopressin mrna in ratten in vivo antisense targeting on vasopressin mrna in rats |
| title_sub | = In vivo antisense targeting on vasopressin mRNA in rats |
| topic | Antisense-Oligonucleotide Genexpression Hochschulschrift Tierversuch Vasopressin |
| topic_facet | Antisense-Oligonucleotide Genexpression Hochschulschrift Tierversuch Vasopressin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012977157&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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